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Alzheimer's Disease in People with Down Syndrome

https://www.nia.nih.gov/health/alzheimers-disease-people-down-syndrome
Many, but not all, people with Down syndrome develop Alzheimer’s disease when they get older. People with Down syndrome are born with an extra copy of chromosome 21, which carries the APP gene. This gene produces a specific protein called amyloid precursor protein (APP). Too much APP protein leads ...

Alzheimer's Disease in People with Down Syndrome Fact Sheet

https://order.nia.nih.gov/.../2018-09/alzheimers-disease-in-people-with-down-syndrome.pdf
Down Syndrome FACT SHEET National Institute on Aging Eunice Kennedy Shriver. National Institute of Child Health and Human Development. Alzheimer’s and Down Syndrome — Get the Facts The Connection between Down Syndrome and Alzheimer’s Disease Alzheimer’s Disease Symptoms Down Syndrome and Alzheimer’s Research Participating in Research

Down Syndrome (ABC-DS) - nia.nih.gov

https://www.nia.nih.gov/research/abc-ds
Adults with Down syndrome (DS) are at high risk for early onset of Alzheimer's disease (AD). Virtually all adults with DS have neuropathological changes consistent with AD by age 40, including deposition of Aβ in diffuse and neuritic plaques, and most will develop clinical dementia by their late ...

ABC-DS Information for Patients and Families

https://www.nia.nih.gov/health/abc-ds-information-patients-and-families
For more information about the connection between Alzheimer's and Down syndrome, please visit these resources: Alzheimer's Disease in People with Down Syndrome Fact Sheet (NIH) An Introduction to Alzheimer's Disease (National Down Syndrome Society) A Caregiver's Guide to Down Syndrome & Alzheimer's Disease (National Down Syndrome Society)

Down syndrome | National Institute on Aging

https://www.nia.nih.gov/health/topics/down-syndrome
Many, but not all, people with Down syndrome develop Alzheimer's disease when they get older. Learn about the connection between the two and how to participate in research studies exploring this relationship.

ACI-24 Vaccine in Adults with Down Syndrome

https://www.nia.nih.gov/alzheimers/clinical-trials/aci-24-vaccine-adults-down-syndrome
This Phase I study will test the ACI-24 vaccine in adults with Down syndrome to assess whether the vaccine is safe, tolerable, and able to stimulate an immune response. People with Down syndrome have an extra copy of chromosome 21, which carries the gene that leads to amyloid precursor protein (APP ...

Natural History of Amyloid Deposition in Adults with Down ...

https://www.nia.nih.gov/.../natural-history-amyloid-deposition-adults-down-syndrome
People with Down syndrome are at high risk of developing Alzheimer's disease due to amyloid plaques and tau tangles developing in their brains at a relatively early age. In this study, researchers will use PET scans to assess and compare amyloid deposition in three age groups: 30-39, 40-49, and 50 and older.

Down Syndrome Memantine Follow-up Study

https://www.nia.nih.gov/alzheimers/clinical-trials/down-syndrome-memantine-follow-study
This study will determine if the Alzheimer's disease drug memantine hydrochloride can improve learning and memory in adolescents and young adults with Down syndrome. Memantine is approved to treat memory and thinking problems in people with Alzheimer's disease, but little is known about its effects ...

RG1662 in Individuals with Down Syndrome

https://www.nia.nih.gov/alzheimers/clinical-trials/rg1662-individuals-down-syndrome
The purpose of this study is to assess the safety and tolerability of the experimental drug RG1662 in individuals with Down syndrome. ++Males and nonpregnant, nonlactating females with a diagnosis of Down syndrome (confirmed by karyotype)++Parent or legal guardian/representative and caregiver ...

Alzheimer's Disease in People with Down Syndrome ...

https://order.nia.nih.gov/publication/alzheimers-disease-in-people-with-down-syndrome
Alzheimer's Disease. Alzheimer's Disease in People with Down Syndrome. Many people with Down syndrome develop Alzheimer's when they get older. Learn about memory changes and other symptoms and participating in research.

Amyloid Plaque and Tangle Imaging in Alzheimer's Disease ...

https://www.nia.nih.gov/alzheimers/clinical-trials/amyloid-plaque-and-tangle-imaging...
Home Clinical Trials Amyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down Syndrome. Amyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down Syndrome. ... Clinical evaluations and brain scans will be performed on 20 people with Down syndrome (DS) as well as 20 healthy controls across a range of ages. ...

Site Search - nia.nih.gov

https://www.nia.nih.gov/site-search/ZG93biBzeW5kcm9tZQ==
Most people with Down syndrome develop Alzheimer’s. This may be because people with Down syndrome have an extra copy of chromosome 21, which contains the gene that generates harmful amyloid. For more about Alzheimer’s genetics research, see NIA’s Alzheimer’s Disease Genetics Fact Sheet.

Causes of Alzheimer’s Disease | National Institute on Aging

https://www.nia.nih.gov/health/alzheimers/causes
Many, but not all, people with Down syndrome develop Alzheimer's disease when they get older. Learn about the connection between the two and how to participate in research studies exploring this relationship.

Milestone 1.A - nia.nih.gov

https://www.nia.nih.gov/research/milestones/population-studies-precision-medicine...
Enable precision medicine research by supporting deep and longitudinal molecular endophenotyping of existing and new at-risk cohorts as well cohorts and/or individuals who resist disease despite high genetic risk (e.g. Down Syndrome, ApoE 4 homozygous, FAD mutation carriers). Ensure that these efforts include and prioritize molecular profiling in cohorts from special populations and patients ...

NIH supports new studies to find Alzheimer's biomarkers in ...

https://www.nia.nih.gov/news/nih-supports-new-studies-find-alzheimers-biomarkers-down...
The National Institutes of Health has launched a new initiative to identify biomarkers and track the progression of Alzheimer’s in people with Down syndrome. Many people with Down syndrome have Alzheimer’s-related brain changes in their 30s that can lead to dementia in their 50s and 60s. Little is known about how the disease progresses in this vulnerable group.

Researchers develop “epigenetic clock” to measure aging in ...

https://www.nia.nih.gov/news/researchers-develop-epigenetic-clock-measure-aging-down...
Researchers at UCLA’s David Geffen School of Medicine recently published the first study that provides definitive evidence that people with Down syndrome age at a faster rate. In the Feb. 9, 2015, online issue of Aging Cell, researchers led by Dr. Steve Horvath reported that they have applied an “epigenetic clock” developed for normal aging to tissues from people with Down syndrome.

Alzheimer's Disease Fact Sheet - nia.nih.gov

https://www.nia.nih.gov/health/alzheimers-disease-fact-sheet
Most people with Down syndrome develop Alzheimer’s. This may be because people with Down syndrome have an extra copy of chromosome 21, which contains the gene that generates harmful amyloid. For more about Alzheimer’s genetics research, see NIA’s Alzheimer’s Disease Genetics Fact Sheet. Health, Environmental, and Lifestyle Factors

Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down ...

https://www.nia.nih.gov/alzheimers/clinical-trials/glucose-metabolic-amyloid-and-tau...
This is a naturalistic study in which clinical evaluations and brain scans will be performed on 72 people with Down syndrome (DS), 36 non-demented and 36 with dementia, as well as 36 age-matched healthy controls.

All Publications | Publication Ordering System and Contact ...

https://order.nia.nih.gov/view-all-publications
All Publications. A Good Night's Sleep. Advance Care Planning. Aging and Your Eyes. Alzheimer's Disease Fact Sheet. Alzheimer's Disease in People with Down Syndrome. Alzheimer's Disease Medications Fact Sheet. Biomarkers for Dementia Detection and Research. Caring for a Person with Alzheimer's Disease: Your Easy-to-Use Guide ...

Site Search - nia.nih.gov

https://www.nia.nih.gov/site-search/down syndrome and alzheimers
The National Institute on Aging’s ADEAR Center offers information and free print publications about Alzheimer’s disease and related dementias for families, caregivers, and health professionals. ADEAR Center staff answer telephone, email, and written requests and make referrals to local and ...