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Alzheimer's Disease in People with Down Syndrome ...

https://www.nia.nih.gov/health/alzheimers-disease-people-down-syndrome
People with Down syndrome are born with an extra copy of chromosome 21, which carries the APP gene. This gene produces a specific protein called amyloid precursor protein (APP). Too much APP protein leads to a buildup of protein clumps called beta-amyloid plaques in the brain.

Down syndrome | National Institute on Aging

https://www.nia.nih.gov/health/topics/down-syndrome
Many, but not all, people with Down syndrome develop Alzheimer's disease when they get older. Learn about the connection between the two and how to participate in research studies exploring this relationship.

ABC-DS Policies for Publications

https://www.nia.nih.gov/sites/default/files/2020-01/ABC-DS Policies for publications.v2...
Effectively balancing these priorities will support broader collaborations demonstrating promise of advancing knowledge about the association between Down syndrome and Alzheimer’s disease, specifically, and about Alzheimer’s disease more generally.

ABC-DS Information for Patients and Families | National ...

https://www.nia.nih.gov/health/abc-ds-information-patients-and-families
People with Down syndrome are born with three copies of the chromosome, rather than two. The chromosome carries a gene that produces a protein called amyloid precursor protein (APP). Too much APP can lead to a buildup of protein clumps called beta-amyloid plaques in the brain.

Down Syndrome Clinical Trials Network-Study of Alzheimer's ...

https://www.nia.nih.gov/alzheimers/clinical-trials/down-syndrome-clinical-trials...
The Longitudinal Investigation for the Enhancement of Down Syndrome Research (LIFE-DSR) is an observational study with the goal of better understanding the cognitive and behavioral changes and health issues found in adults with Down syndrome as they progress toward Alzheimer's disease.

Alzheimer's Biomarkers Consortium — Down Syndrome (ABC-DS ...

https://www.nia.nih.gov/research/abc-ds
Adults with Down syndrome (DS) are at high risk for early onset of Alzheimer's disease (AD). Virtually all adults with DS have neuropathological changes consistent with AD by age 40, including deposition of Aβ in diffuse and neuritic plaques, and most will develop clinical dementia by their late ...

NIH supports new studies to find Alzheimer's biomarkers in ...

https://www.nia.nih.gov/news/nih-supports-new-studies-find-alzheimers-biomarkers-down...
The National Institutes of Health has launched a new initiative to identify biomarkers and track the progression of Alzheimer’s in people with Down syndrome. Many people with Down syndrome have Alzheimer’s-related brain changes in their 30s that can lead to dementia in their 50s and 60s. Little is known about how the disease progresses in this vulnerable group.

ACI-24 Vaccine in Adults with Down Syndrome

https://www.nia.nih.gov/alzheimers/clinical-trials/aci-24-vaccine-adults-down-syndrome
This Phase I study will test the ACI-24 vaccine in adults with Down syndrome to assess whether the vaccine is safe, tolerable, and able to stimulate an immune response. People with Down syndrome have an extra copy of chromosome 21, which carries the gene that leads to amyloid precursor protein (APP ...

Alzheimer's Disease in People with Down Syndrome ...

https://order.nia.nih.gov/publication/alzheimers-disease-in-people-with-down-syndrome
Alzheimer's Disease. Alzheimer's Disease in People with Down Syndrome. Many people with Down syndrome develop Alzheimer's when they get older. Learn about memory changes and other symptoms and participating in research.

Down Syndrome Memantine Follow-up Study

https://www.nia.nih.gov/alzheimers/clinical-trials/down-syndrome-memantine-follow-study
This study will determine if the Alzheimer's disease drug memantine hydrochloride can improve learning and memory in adolescents and young adults with Down syndrome. Memantine is approved to treat memory and thinking problems in people with Alzheimer's disease, but little is known about its effects ...

Researchers develop “epigenetic clock” to measure aging in ...

https://www.nia.nih.gov/news/researchers-develop-epigenetic-clock-measure-aging-down...
Researchers at UCLA’s David Geffen School of Medicine recently published the first study that provides definitive evidence that people with Down syndrome age at a faster rate. In the Feb. 9, 2015, online issue of Aging Cell, researchers led by Dr. Steve Horvath reported that they have applied an “epigenetic clock” developed for normal aging to tissues from people with Down syndrome.

Amyloid Plaque and Tangle Imaging in Alzheimer's Disease ...

https://www.nia.nih.gov/alzheimers/clinical-trials/amyloid-plaque-and-tangle-imaging...
Neurological changes and emotional functioning in adults with Down Syndrome. J Intellect Disabil Res. 2001 Oct;45(Pt 5):450-6. Small GW, Kepe V, Ercoli LM, Siddarth P, Bookheimer SY, Miller KJ, Lavretsky H, Burggren AC, Cole GM, Vinters HV, Thompson PM, Huang SC, Satyamurthy N, Phelps ME, Barrio JR.

Milestone 1.A | National Institute on Aging

https://www.nia.nih.gov/research/milestones/population-studies-precision-medicine...
Enable precision medicine research by supporting deep and longitudinal molecular endophenotyping of existing and new at-risk cohorts as well cohorts and/or individuals who resist disease despite high genetic risk (e.g. Down Syndrome, ApoE 4 homozygous, FAD mutation carriers). Ensure that these efforts include and prioritize molecular profiling in cohorts from special populations and patients ...

Natural History of Amyloid Deposition in Adults with Down ...

https://www.nia.nih.gov/.../natural-history-amyloid-deposition-adults-down-syndrome
People with Down syndrome are at high risk of developing Alzheimer's disease due to amyloid plaques and tau tangles developing in their brains at a relatively early age. In this study, researchers will use PET scans to assess and compare amyloid deposition in three age groups: 30-39, 40-49, and 50 and older.

Alzheimer's Disease in People with Down Syndrome Fact Sheet

https://order.nia.nih.gov/.../2018-09/alzheimers-disease-in-people-with-down-syndrome.pdf
Alzheimer’s Disease in People with Down Syndrome FACT SHEET National Institute on Aging Eunice Kennedy Shriver. National Institute of Child Health and Human Development. Alzheimer’s and Down Syndrome — Get the Facts The Connection between Down Syndrome and Alzheimer’s Disease Alzheimer’s Disease Symptoms Down Syndrome and Alzheimer’s

Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down ...

https://www.nia.nih.gov/alzheimers/clinical-trials/glucose-metabolic-amyloid-and-tau...
This is a naturalistic study in which clinical evaluations and brain scans will be performed on 72 people with Down syndrome (DS), 36 non-demented and 36 with dementia, as well as 36 age-matched healthy controls.

Alzheimer's Disease Fact Sheet | National Institute on Aging

https://www.nia.nih.gov/health/alzheimers-disease-fact-sheet
Alzheimer’s disease is complex, and it is unlikely that any one drug or other intervention can successfully treat it. Current approaches focus on helping people maintain mental function, manage behavioral symptoms, and slow down certain problems, such as memory loss.

All Publications | Publication Ordering System and Contact ...

https://order.nia.nih.gov/view-all-publications
All Publications. A Good Night's Sleep. Advance Care Planning. Aging and Your Eyes. Alzheimer's Disease Fact Sheet. Alzheimer's Disease in People with Down Syndrome. Alzheimer's Disease Medications Fact Sheet. Biomarkers for Dementia Detection and Research. Caring for a Person with Alzheimer's Disease: Your Easy-to-Use Guide ...

Site Search | National Institute on Aging

https://www.nia.nih.gov/site-search/ZG93biBzeW5kcm9tZQ==
The National Institutes of Health has launched a new initiative to identify biomarkers and track the progression of Alzheimer’s in people with Down syndrome. Many people with Down syndrome have Alzheimer’s-related brain changes in their 30s that can lead to dementia in their 50s and 60s. Little is known about how the disease progresses in ...

Site Search - National Institute on Aging

https://www.nia.nih.gov/site-search/down syndrome and alzheimers
The National Institute on Aging’s ADEAR Center offers information and free print publications about Alzheimer’s disease and related dementias for families, caregivers, and health professionals. ADEAR Center staff answer telephone, email, and written requests and make referrals to local and ...