Use the NIA Research Resources database to find NIA-supported scientific resources, datasets, informatics resources, and more. Search by keyword, resource type, or NIA Division or IRP.
IND Toxicology Service
The NIA sponsors the Investigational New Drug (IND) Toxicology program to identify compounds for use in symptoms of Alzheimer’s and other aging-related diseases. The program provides toxicology services to academic and small business investigators who believe they have promising compounds for the treatment or prevention of Alzheimer’s disease, but lack the resources to perform the required toxicology studies. NIA will give investigators access to toxicological evaluations required by the Food and Drug Administration (FDA) as part of requests for IND designations for clinical studies. NIA hopes this preclinical drug-development program will expand the potential range of drug therapies for Alzheimer’s and other aging-related diseases by making these resources available to a larger and more diverse group of investigators.
SRI International provides services for this program in four general categories:
- analytical chemistry,
- pharmacokinetics and bioavailability,
- preliminary toxicity screens, and
- IND-directed toxicology studies, including safety pharmacology.
Interventions Testing Program (ITP)
NIA supports a multi-institutional study investigating diets and dietary supplements purported to extend lifespan and delay disease and dysfunction. ITP allows investigators to submit proposals for interventions to be tested for their ability to decelerate aging and extend lifespan in mice.
Integrative Analysis of Longitudinal Studies on Aging (IALSA)
The IALSA research network is a collaborative research infrastructure for coordinated interdisciplinary, cross-national research aimed at the integrative understanding of within-person aging-related changes in health and cognition. The IALSA network is currently comprised of over 25 longitudinal studies on aging, spanning eight countries, with a combined sample size of approximately 70,000 individuals. These studies represent a mix of population representative, volunteer, and special population samples. Within the network, data have been collected on individuals aged 18 to over 100, with birth cohorts ranging from 1880 to 1980, and historical periods from 1956 to the present. Between-occasion intervals range from 6 months to 17 years (the majority 1-5 years), with between 2 and 32 (mainly 3-5) measurement occasions spanning 4 to 48 years of within-person assessment.
International Alzheimer's Disease Research Portfolio (IADRP)
A new database created to capture the full spectrum of current Alzheimer’s disease research investments and resources—both in the U.S. and internationally—is now publicly available. The International Alzheimer’s Disease Research Portfolio (IADRP), developed by the NIA, in collaboration with the Alzheimer’s Association, will enable public and private funders of Alzheimer’s research to coordinate research planning, leverage resources, avoid duplication of funding efforts and identify new opportunities in promising areas of growth. The newly developed resource, currently hosted and maintained by NIA, helps to track and implement research goals of the National Plan to Address Alzheimer’s Disease (NAPA).
International Network for the Demographic Evaluation of Populations and their Health (INDEPTH)
INDEPTH is a global network of HDSSs. Its 41 member centres observe the life events of millions of people in 20 LMICs in Africa, Asia and Oceania. Since its inception in 1998, the network has gathered a treasure trove of robust data, and is uniquely positioned both to answer the most pressing questions on health, population dynamics and development, and to provide policy-makers and donors with evidence on the impact of interventions.
This network of health and demographic surveillance systems (HDSSs) collects data from whole communities over extended time periods that reflect health and population problems in LMICs. By monitoring new health threats, tracking population changes through fertility rates, death rates and migration, and measuring the effect of policy interventions on communities, HDSSs provide information that enables policy-makers to make informed decisions and to adapt their programs to changing conditions.
Interplay of Genes and Environment Across Multiple Studies (IGEMS)
The Interplay of Genes and Environment across Multiple Studies (IGEMS) group is a consortium of eight longitudinal twin studies established to explore the nature of social context effects and gene-environment interplay in late-life functioning. The resulting analysis of the combined data from over 17,500 participants aged 25–102 at baseline (including nearly 2,600 monogygotic and 4,300 dizygotic twin pairs and over 1,700 family members) aims to understand why early-life adversity, and social factors such as isolation and loneliness, are associated with diverse outcomes including mortality, physical functioning (health, functional ability), and psychological functioning (well-being, cognition), particularly in later life.
Korean Longitudinal Study of Aging (KLoSA)
Korea became an aging society in 2000, as the proportion of those 65 or older reached 7% of the population. Lacking in basic data on ageing, Korea needs a structured set of statistical data. Institutional reform and policy making in preparation against the aged society requires systematic build-up of data that can track individuals' labor participation, income and asset status, spending patterns, retirement decisions, impact of social welfare, health, and intra-family transfer of income, among others. The purpose of KLoSA is to create the basic data needed to devise and implement effective social, economic policies to address the trends that emerge in the process of population ageing. The data will help identify and observe different dimensions of an aged society, build datasets that enable studies in different fields, and generate data comparable with similar panel studies in other countries (e.g., U.S., Europe) that can provide the basis for policy making and academic studies.
Longitudinal Aging Study in India (LASI)
Data are lacking on the health, social support, and economic security of India’s growing elderly population, and concern is mounting about the well-being of this expanding group. By assembling a research team of demographers, economists, medical doctors, sociologists, and public health and policy experts, LASI aims to supply the data needed to take stock of the situation of India’s elderly population. It is hopedhttps://www.hsph.harvard.edu/pgda/major-projects/lasi-2/ that this evidence base will contribute to cross-national studies of aging and will inform the design of policies that can protect and support the growing elderly community.
Clinical Research Resources
Kaiser Permanente (KP) Research Bank
The Kaiser Permanente (KP) Research Bank is a nationwide research bank that facilitates studies related to the prevention, diagnosis and treatment of disease. The KP Research Bank includes information from three sources—genetic information from a blood sample, comprehensive medical record information, and survey data on lifestyle and health issues not captured in the medical record. By combining data from seven regions nationwide reflecting the general population, the KP Research Bank has the scale to reflect population diversity. KP Research Bank may share de-identified information through secure databases–such as online database of the NIH. Any genetic information is de-identified to protect the participant's privacy.
Lifestyle Interventions and Independence For Elders (LIFE)
The LIFE Study was a Phase III clinical trial in 1635 sedentary persons age 70-89 at high risk for developing major mobility disability (defined as the inability to walk 400 meters). The primary aim was to assess the long-term effects of the proposed interventions on the primary outcome of major mobility disability, defined as inability to walk 400 m. The secondary aims focused on assessing the relative effects of the interventions on the following outcomes: cognitive function; serious fall injuries; persistent mobility disability; the combined outcome of major mobility disability or death; disability in activities of daily living; cardiovascular and pulmonary events; and cost-effectiveness. Tertiary aims related to assessing the relative effects of the interventions on (a) the combined outcome of mild cognitive impairment or dementia and (b) physical performance within pre-specified subgroups defined on the basis of race, gender and baseline physical performance.