Use the NIA Research Resources database to find NIA-supported scientific resources, datasets, informatics resources, and more. Search by keyword, resource type, or NIA Division or IRP.
IND Toxicology Service
The NIA sponsors the Investigational New Drug (IND) Toxicology program to identify compounds for use in symptoms of Alzheimer’s and other aging-related diseases. The program provides toxicology services to academic and small business investigators who believe they have promising compounds for the treatment or prevention of Alzheimer’s disease, but lack the resources to perform the required toxicology studies. NIA will give investigators access to toxicological evaluations required by the Food and Drug Administration (FDA) as part of requests for IND designations for clinical studies. NIA hopes this preclinical drug-development program will expand the potential range of drug therapies for Alzheimer’s and other aging-related diseases by making these resources available to a larger and more diverse group of investigators.
SRI International provides services for this program in four general categories:
- analytical chemistry,
- pharmacokinetics and bioavailability,
- preliminary toxicity screens, and
- IND-directed toxicology studies, including safety pharmacology.
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)
National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD). This NIH-funded repository provides resources that help researchers identify the genes that contribute to Alzheimer’s and other types of dementia. NCRAD collects and maintains biological specimens and associated data on study volunteers from a variety of sources, primarily people enrolled at ADCs, as well as those in the Alzheimer’s Disease Neuroimaging Initiative, the Alzheimer’s Disease Genetics Consortium, and other studies. NCRAD also houses DNA samples and data from more than 900 families with multiple members affected by Alzheimer’s. Since it was funded 22 years ago, more than 150,000 biological samples have been requested and sent to more than 120 investigators and research centers across the world.
NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS)
NIAGADS is the NIA Genetics of Alzheimer's Disease Data Storage Site, a national genetics data repository that facilitates access to data by qualified investigators. NIAGADS archives, processes and distributes data related to the genetics and genomics of Alzheimer’s disease. NIAGADS provides an integrated tool set for examining and comparing the genomes of affected and unaffected individuals. With it, you can locate single nucleotide polymorphisms (SNPs) and sequences on the reference genome.
There is a variety of data available from NIAGADS and sites that partner with NIAGADS.
genomic data from NIA-funded genetic studies
deep phenotype data and biomarkers
primary and secondary analyses including CHIP-Seq, RNA-Seq, and expression data
genome wide association studies
genetic data from case-control, family-based, and epidemiologic studies
a variety of basic science and clinical research approaches
next generation and targeted genome sequencing
The Center for Inherited Disease Research
The Center for Inherited Disease Research (CIDR) provides high quality, next-generation sequencing, genotyping, and supporting statistical genetics services for qualifying NIH-funded investigators seeking to identify genes that contribute to human health and disease. NIA is one of 10 member institutes at NIH that support the CIDR program. Both intramural and extramural investigators may apply for access to CIDR services through a competitive, peer-reviewed process. Information about the CIDR program and how to apply for CIDR services is available.
The AgingResearchBiobank is a central biorepository to provide a state-of-the-art inventory system for the storage and distribution of these collections to the broader scientific community.
The AgingResearchBiobank has two components:
- Biologic Specimens (Biorepository) – Using best practices, this component receives, stores, maintains, and distributes biospecimens from different study collections to qualified investigators.
- Data Repository – Serving as the data coordinating center for the Biobank, the Data Repository receives, archives, maintains, and distributes databases from different study collections. It also analyzes stored data in response to inquiries, assists ongoing studies in preparing data for eventual archiving, assists in the selection of appropriate biospecimens for proposed secondary research, and coordinates cross-referencing between the two components of the Biobank.
International Alzheimer's Disease Research Portfolio (IADRP)
A new database created to capture the full spectrum of current Alzheimer’s disease research investments and resources—both in the U.S. and internationally—is now publicly available. The International Alzheimer’s Disease Research Portfolio (IADRP), developed by the NIA, in collaboration with the Alzheimer’s Association, will enable public and private funders of Alzheimer’s research to coordinate research planning, leverage resources, avoid duplication of funding efforts and identify new opportunities in promising areas of growth. The newly developed resource, currently hosted and maintained by NIA, helps to track and implement research goals of the National Plan to Address Alzheimer’s Disease (NAPA).
National Alzheimer's Coordinating Center (NACC)
Funded by NIA, the National Alzheimer's Coordinating Center (NACC) has developed and maintains a large relational database of standardized clinical and neuropathological research data. NACC provides a valuable resource for both exploratory and explanatory Alzheimer's disease research. NACC data are freely available to all researchers.
The NIH Toolbox is a multidimensional set of brief measures assessing cognitive, emotional, motor and sensory function from ages 3 to 85, meeting the need for a standard set of measures that can be used as a “common currency” across diverse study designs and settings.
CALERIE Intensive Intervention Database
CALERIE (Comprehensive Assessment of Long term Effects of Reducing Intake of Energy) was a study designed to determine the biological effects of two years of prolonged caloric restriction (CR) in humans. The CALERIE database contains information from study participants on physiological and immune functions, physical performance, psychological outcomes, dietary records, disease risk factors, blood chemistry, and hematology. The biospecimen repository includes serum, plasma, urine, muscle, and fat.
The CALERIE Intensive Intervention Database is a toolkit that allows investigators to identify the major factors affecting individual participants’ interventions and adherence over the course of the trial. A computer-based algorithm provides specific strategies in Behavioral/Environmental and Nutritional/Dietary Toolboxes. Researchers can use these resources to identify key pathways that respond to CR, and for targets for novel interventions in aging research. Investigators can also examine a variety of risk factors, aging-related outcomes, and psychological and behavioral factors that interact with lowered caloric intake and weight loss.
Clinical Research Resources
Clinical Research Study Investigators Toolbox
The NIA Clinical Research Study Investigators Toolbox provides a web-based information repository for investigators and staff involved in clinical research. The Toolbox contains templates, sample forms, guidelines, regulations and information materials to assist investigators in the development and conduct of high quality clinical research studies.