Skip to main content

Research Resources

Use the NIA Research Resources database to find NIA-supported scientific resources, datasets, informatics resources, and more. Search by keyword, resource type, or NIA Division or IRP. 

Biological Resources

Comparative Biology of Aging Resource Sharing Network

This webpage describes a network of NIA grantees willing to share resources that support comparative biology of aging studies.


Comparative Biology of Aging Resource Sharing Network

This webpage describes a network of NIA grantees willing to share resources that support comparative biology of aging studies.


Human Biospecimen Collections

NIA supports studies of human aging that have collections of biospecimens available for sharing. The Virtual Repository is a Web site that provides a central portal to these studies, with introductory information on participating studies.


Human Biospecimen Collections

NIA supports studies of human aging that have collections of biospecimens available for sharing. The Virtual Repository is a website that provides a central portal to these studies, with introductory information on participating studies.


Informatics

Complex LCR Detector and Analyzer

The program LCRSimulationAnalysis was created by Alexander Maltsev at the Laboratory of Cardiovascular Science at the National Institute of Aging, National Institutes of Health. The program detects and analyses complex Local Ca Releases in numerical simulations of intracellular Ca dynamics in cardiac pacemaker cells (sinoatrial node cells) using Stern et al. model published in 2014 in Journal of General Physiology 2014 May;143(5):577-604.


Clinical Research Resources

Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE)

The CALERIE (Comprehensive Assessment of Long Term Effects of Reducing Intake of Energy) was a two phases trial focused on testing the effects of caloric restriction (CR) in humans. Preliminary evidence suggests that caloric CR might increase lifespan and delay or slow the progression of a wide variety of age-related morbidities and chronic conditions. The goal of CALERIE Phase I was to retrieve information to assess feasibility and safety of a longer study. CALERIE Phase 2 was a three-site randomized controlled trial in young and middle-aged non-obese, healthy men and women to assess the effects of a two-year 25% CR regimen vs. an ad libitum diet control group. In CALERIE Phase 2, CR group participants achieved 12% CR and sustained 10% weight loss over two years. Research questions addressed posed particular emphasis on the adaptive responses thought to be involved in slowing aging and protecting against age-related disease processes. A further aim was to identify potential adverse effects of CR in humans. The CALERIE database contains physiological and immune functions, physical performance, psychological outcomes, dietary records, disease risk factors, blood chemistry and hematology.

The biospecimen repository includes serum, plasma, urine, buffy coat, muscle (vastus lateralis), and fat (subcutaneous abdominal).


Health Databases

English Longitudinal Study of Ageing (ELSA)

The English Longitudinal Study of Ageing (ELSA) is a longitudinal study that collects multidisciplinary data from a representative sample of the English population aged 50 and older. The survey data are designed to be used for the investigation of a broad set of topics relevant to understanding the aging process. Both objective and subjective data are collected covering themes such as: health trajectories, disability and healthy life expectancy, the determinants of economic position in older age; the links between economic position, physical health, cognition, and mental health; the nature and timing of retirement and post-retirement labor market activity; household and family structure, social networks and social supports; patterns, determinants, and consequences of social, civic, and cultural participation and predictors of well-being. ELSA is led by Professor Sir Michael Marmot and is jointly run by teams at University College London (UCL), the Institute for Fiscal Studies (IFS), National Centre for Social Research, and the University of Manchester.


Gateway to Global Aging Data

The Gateway to Global Aging is a platform for population survey data on aging around the world. You can access data from 11 longitudinal studies on aging through this site, which is hosted by the University of Southern California’s Program on Global Aging, Health, and Policy. The project’s goal is to provide the resources to support cross-national research on aging: a comprehensive digital library of survey questions, a search engine that finds concordance information across surveys, and a set of harmonized or identically defined variables for analysis. You can also use a data manipulation tool on the website.


Health and Retirement Study (HRS)

The University of Michigan Health and Retirement Study (HRS) is a longitudinal panel study that surveys a representative sample of more than 26,000 Americans over the age of 50 every two years. Supported by the National Institute on Aging (NIA U01AG009740) and the Social Security Administration, the HRS explores the changes in labor force participation and the health transitions that individuals undergo toward the end of their work lives and in the years that follow. Since its launch in 1992, the study has collected information about income, work, assets, pension plans, health insurance, disability, physical health and functioning, cognitive functioning, and health care expenditures. Through its unique and in-depth interviews, the HRS provides an invaluable and growing body of multidisciplinary data that researchers can use to address important questions about the challenges and opportunities of aging


Health and Retirement Study Sister Studies

The Health and Retirement Study (HRS), funded by NIA and the Social Security Administration, has become the model for a growing network of longitudinal aging studies around the world. Learn more about HRS international sister studies: https://hrs.isr.umich.edu/about/international-sister-studies