Use the NIA Research Resources database to find NIA-supported scientific resources, datasets, informatics resources, and more. Search by keyword, resource type, or NIA Division or IRP.
National Cell Repository for Alzheimer's Disease (NCRAD)
National Cell Repository for Alzheimer’s Disease (NCRAD). This NIH-funded repository provides resources that help researchers identify the genes that contribute to Alzheimer’s and other types of dementia. NCRAD collects and maintains biological specimens and associated data on study volunteers from a variety of sources, primarily people enrolled at ADCs, as well as those in the Alzheimer’s Disease Neuroimaging Initiative, the Alzheimer’s Disease Genetics Consortium, and other studies. NCRAD also houses DNA samples and data from more than 900 families with multiple members affected by Alzheimer’s. Since it was funded 22 years ago, more than 150,000 biological samples have been requested and sent to more than 120 investigators and research centers across the world.
NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS)
NIAGADS is the NIA Genetics of Alzheimer's Disease Data Storage Site, a national genetics data repository that facilitates access to data by qualified investigators. NIAGADS archives, processes and distributes data related to the genetics and genomics of Alzheimer’s disease. NIAGADS provides an integrated tool set for examining and comparing the genomes of affected and unaffected individuals. With it, you can locate single nucleotide polymorphisms (SNPs) and sequences on the reference genome.
There is a variety of data available from NIAGADS and sites that partner with NIAGADS.
genomic data from NIA-funded genetic studies
deep phenotype data and biomarkers
primary and secondary analyses including CHIP-Seq, RNA-Seq, and expression data
genome wide association studies
genetic data from case-control, family-based, and epidemiologic studies
a variety of basic science and clinical research approaches
next generation and targeted genome sequencing
The Center for Inherited Disease Research
The Center for Inherited Disease Research (CIDR) provides high quality, next-generation sequencing, genotyping, and supporting statistical genetics services for qualifying NIH-funded investigators seeking to identify genes that contribute to human health and disease. NIA is one of 10 member institutes at NIH that support the CIDR program. Both intramural and extramural investigators may apply for access to CIDR services through a competitive, peer-reviewed process. Information about the CIDR program and how to apply for CIDR services is available.
The NIH Toolbox is a multidimensional set of brief measures assessing cognitive, emotional, motor and sensory function from ages 3 to 85, meeting the need for a standard set of measures that can be used as a “common currency” across diverse study designs and settings.
CALERIE Intensive Intervention Database
CALERIE (Comprehensive Assessment of Long term Effects of Reducing Intake of Energy) was a study designed to determine the biological effects of two years of prolonged caloric restriction (CR) in humans. The CALERIE database contains information from study participants on physiological and immune functions, physical performance, psychological outcomes, dietary records, disease risk factors, blood chemistry, and hematology. The biospecimen repository includes serum, plasma, urine, muscle, and fat.
The CALERIE Intensive Intervention Database is a toolkit that allows investigators to identify the major factors affecting individual participants’ interventions and adherence over the course of the trial. A computer-based algorithm provides specific strategies in Behavioral/Environmental and Nutritional/Dietary Toolboxes. Researchers can use these resources to identify key pathways that respond to CR, and for targets for novel interventions in aging research. Investigators can also examine a variety of risk factors, aging-related outcomes, and psychological and behavioral factors that interact with lowered caloric intake and weight loss.
Clinical Research Resources
Clinical Research Study Investigators Toolbox
The NIA Clinical Research Study Investigators Toolbox provides a Web-based information repository for investigators and staff involved in clinical research. The Toolbox contains templates, sample forms, guidelines, regulations and information materials to assist investigators in the development and conduct of high quality clinical research studies.
Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE)
The CALERIE (Comprehensive Assessment of Long Term Effects of Reducing Intake of Energy) was a two phases trial focused on testing the effects of caloric restriction (CR) in humans. Preliminary evidence suggests that caloric CR might increase lifespan and delay or slow the progression of a wide variety of age-related morbidities and chronic conditions. The goal of CALERIE Phase I was to retrieve information to assess feasibility and safety of a longer study. CALERIE Phase 2 was a three-site randomized controlled trial in young and middle-aged non-obese, healthy men and women to assess the effects of a two-year 25% CR regimen vs. an ad libitum diet control group. In CALERIE Phase 2, CR group participants achieved 12% CR and sustained 10% weight loss over two years. Research questions addressed posed particular emphasis on the adaptive responses thought to be involved in slowing aging and protecting against age-related disease processes. A further aim was to identify potential adverse effects of CR in humans. The CALERIE database contains physiological and immune functions, physical performance, psychological outcomes, dietary records, disease risk factors, blood chemistry and hematology.
The biospecimen repository includes serum, plasma, urine, buffy coat, muscle (vastus lateralis), and fat (subcutaneous abdominal).
Kaiser Permanente (KP) Research Bank
The Kaiser Permanente (KP) Research Bank is a nationwide research bank that facilitates studies related to the prevention, diagnosis and treatment of disease. The KP Research Bank includes information from three sources—genetic information from a blood sample, comprehensive medical record information, and survey data on lifestyle and health issues not captured in the medical record. By combining data from seven regions nationwide reflecting the general population, the KP Research Bank has the scale to reflect population diversity. KP Research Bank may share de-identified information through secure databases–such as online database of the NIH. Any genetic information is de-identified to protect the participant's privacy.
Lifestyle Interventions and Independence For Elders (LIFE)
The LIFE Study was a Phase III clinical trial in 1635 sedentary persons age 70-89 at high risk for developing major mobility disability (defined as the inability to walk 400 meters). The primary aim was to assess the long-term effects of the proposed interventions on the primary outcome of major mobility disability, defined as inability to walk 400 m. The secondary aims focused on assessing the relative effects of the interventions on the following outcomes: cognitive function; serious fall injuries; persistent mobility disability; the combined outcome of major mobility disability or death; disability in activities of daily living; cardiovascular and pulmonary events; and cost-effectiveness. Tertiary aims related to assessing the relative effects of the interventions on (a) the combined outcome of mild cognitive impairment or dementia and (b) physical performance within pre-specified subgroups defined on the basis of race, gender and baseline physical performance.
Multicenter Osteoarthritis Study (MOST)
The Multicenter Osteoarthritis Study (MOST) is a longitudinal, prospective, observational study of knee osteoarthritis (OA) in older Americans with OA disease or at increased risk of developing it. The study is comprised of two clinical centers, a data coordinating center, and an analysis center.
The overall aims of MOST are to identify novel and modifiable biomechanical factors (including physical activity-related factors), bone and joint structural factors (including those assessed by MRI of the knee), and nutritional factors that affect the occurrence and progression of OA-related knee symptoms and radiographic knee OA. Additionally, MOST investigators aim to determine whether risk factors for new disease differ from those for OA progression. The MOST cohort has been followed through 84 months with three investigative themes: mechanical risk factors, causes of knee symptoms and pain, and the long term disease trajectory of knee OA.