Use the NIA Research Resources database to find NIA-supported scientific resources, datasets, informatics resources, and more. Search by keyword, resource type, or NIA Division or IRP.
To facilitate aging research on cells in culture, the NIA provides support for the NIA Aging Cell Repository, located at the Coriell Institute for Medical Research in Camden, NJ. Included are skin fibroblast cultures from individuals with premature aging syndromes, including Werner and Hutchinson-Guilford (progeria), cultures from clinically documented and at-risk individuals from families exhibiting familial Alzheimer's disease, differentiated cell lines, and cell lines from animals. The repository also has DNA from many of the cell lines, available individually or in panels such as the Primate DNA panel, Aging Syndrome DNA panel, Characterized Alzheimer's disease mutation DNA panel, Early and Late Onset Alzheimer's disease DNA panels, and Aged Sib Pairs DNA panel.
Comparative Biology of Aging Resource Sharing Network
This webpage describes a network of NIA grantees willing to share resources that support comparative biology of aging studies.
Human Biospecimen Collections
NIA supports studies of human aging that have collections of biospecimens available for sharing. The Virtual Repository is a website that provides a central portal to these studies, with introductory information on participating studies.
Interventions Testing Program (ITP)
NIA supports a multi-institutional study investigating diets and dietary supplements purported to extend lifespan and delay disease and dysfunction. ITP allows investigators to submit proposals for interventions to be tested for their ability to decelerate aging and extend lifespan in mice.
NIA maintains approximately 150 nonhuman primates (Macaca mulatta) at three regional primate centers for conducting research on aging for NIA funded scientists. These animals range in age from 18 to 35 years. Please contact Dr. Manuel Moro for additional information.
The Nonhuman Primate Tissue Bank provides a source of archived tissue from aged nonhuman primates, primarily rhesus monkeys. The tissue is donated by primate centers and universities with primate colonies and is available as frozen tissue chunks, slides of fixed tissue sections, and OTC-embedded frozen tissues.
The NIA supports the Primate Aging Database (PAD), a searchable database that contains basic health and husbandry data from primates across the lifespan and from numerous research institutions. PAD, hosted by the Wisconsin National Primate Center, is a password-secured site. For information, go to http://ipad.primate.wisc.edu.
NIA maintains colonies of aged rats and mice for use by the scientific community for research directly related to aging and age-related diseases. The animals are housed behind specific pathogen-free barriers and monitored for genetic purity and health status, and a health report accompanies each shipment of animals. In addition, NIA supports a tissue bank of flash-frozen tissues from mice and rats from the aged rodent colonies and tissue arrays containing punches of multiple ages and multiple tissues per slide. Please note that there are restrictions on eligibility to use the NIA aged rodent colonies.
- Aged Rodent Colonies Handbook
- Aged Rodent Tissue Bank Handbook
- Oldest Ages Available in NIA Aged Rodent Colonies
- Rodent and Tissue Bank Resources Information
IND Toxicology Service
The NIA sponsors the Investigational New Drug (IND) Toxicology program to identify compounds for use in symptoms of Alzheimer’s and other aging-related diseases. The program provides toxicology services to academic and small business investigators who believe they have promising compounds for the treatment or prevention of Alzheimer’s disease, but lack the resources to perform the required toxicology studies. NIA will give investigators access to toxicological evaluations required by the Food and Drug Administration (FDA) as part of requests for IND designations for clinical studies. NIA hopes this preclinical drug-development program will expand the potential range of drug therapies for Alzheimer’s and other aging-related diseases by making these resources available to a larger and more diverse group of investigators.
SRI International provides services for this program in four general categories:
- analytical chemistry,
- pharmacokinetics and bioavailability,
- preliminary toxicity screens, and
- IND-directed toxicology studies, including safety pharmacology.
National Cell Repository for Alzheimer's Disease (NCRAD)
National Cell Repository for Alzheimer’s Disease (NCRAD). This NIH-funded repository provides resources that help researchers identify the genes that contribute to Alzheimer’s and other types of dementia. NCRAD collects and maintains biological specimens and associated data on study volunteers from a variety of sources, primarily people enrolled at ADCs, as well as those in the Alzheimer’s Disease Neuroimaging Initiative, the Alzheimer’s Disease Genetics Consortium, and other studies. NCRAD also houses DNA samples and data from more than 900 families with multiple members affected by Alzheimer’s. Since it was funded 22 years ago, more than 150,000 biological samples have been requested and sent to more than 120 investigators and research centers across the world.
NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS)
NIAGADS is the NIA Genetics of Alzheimer's Disease Data Storage Site, a national genetics data repository that facilitates access to data by qualified investigators. NIAGADS archives, processes and distributes data related to the genetics and genomics of Alzheimer’s disease. NIAGADS provides an integrated tool set for examining and comparing the genomes of affected and unaffected individuals. With it, you can locate single nucleotide polymorphisms (SNPs) and sequences on the reference genome.
There is a variety of data available from NIAGADS and sites that partner with NIAGADS.
genomic data from NIA-funded genetic studies
deep phenotype data and biomarkers
primary and secondary analyses including CHIP-Seq, RNA-Seq, and expression data
genome wide association studies
genetic data from case-control, family-based, and epidemiologic studies
a variety of basic science and clinical research approaches
next generation and targeted genome sequencing
International Alzheimer's Disease Research Portfolio (IADRP)
A new database created to capture the full spectrum of current Alzheimer’s disease research investments and resources—both in the U.S. and internationally—is now publicly available. The International Alzheimer’s Disease Research Portfolio (IADRP), developed by the NIA, in collaboration with the Alzheimer’s Association, will enable public and private funders of Alzheimer’s research to coordinate research planning, leverage resources, avoid duplication of funding efforts and identify new opportunities in promising areas of growth. The newly developed resource, currently hosted and maintained by NIA, helps to track and implement research goals of the National Plan to Address Alzheimer’s Disease (NAPA).