Osteoarthritis Initiative (OAI)
The Osteoarthritis Initiative (OAI) was a multi-center, longitudinal, prospective observational study of knee osteoarthritis (OA). The overall aim of the OAI was to develop a public domain research resource to facilitate the scientific evaluation of biomarkers for osteoarthritis as potential surrogate endpoints for disease onset and progression. The OAI established and maintains a natural history database for osteoarthritis that will include clinical evaluation data, radiological (x-ray and magnetic resonance) images, and a biospecimen repository from 4796 men and women ages 45-79 enrolled between February 2004 and May 2006. Four 3.0 Tesla MRI scanners, one at each clinical center, were dedicated to imaging the knees of OAI participants annually over four years. The seven-year project recruited participants who had, and those who are at high risk for developing, symptomatic knee osteoarthritis. All data and images collected are available to researchers worldwide to help quicken the pace of biomarker identification, scientific investigation and OA drug development. Access to biospecimens will be by application to the National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS).