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NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS)

NIAGADS organizes, stores, and shares genetic, genomic, and phenotypic data, including clinical and neuropathology data, from NIH-funded genetic studies in a secure environment. NIAGADS currently hosts 76 high-quality human genetics datasets in addition to Alzheimer’s Disease Sequencing Project (ADSP) data, corresponding to 55,241 participants, and has a genomics database for cross-referencing and visualizing known genomic variants and annotations with Alzheimer’s Disease (AD) genetic analysis findings.

The ADSP provides genetic data from large numbers of genetically informative, multi-ethnic, phenotypically well-characterized families having multiple individuals affected with AD, and includes Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD) cases and controls. NIAGADS is the ADSP Data Coordinating Center that supports ADSP data production, management, and sharing. A partial list of NIAGADS’s many responsibilities includes scheduling, preparing, and maintaining public data releases. NIAGADS also maintains the ADSP website and facilitates community access to ADSP data.

NIAGADS was charged with developing a fully featured data-sharing service for ADSP using cloud technology that was compliant with both Health Insurance Portability & Accountability Act (HIPAA) and the Federal Information Security Management Act of 2002 (FISMA). The NIAGADS Data Sharing Service (DSS) was launched in July 2018 and facilitates the deposition and sharing of genomic data from the ADSP and other NIA-funded AD/ADRD genomic studies with approved users in the research community. NIAGADS provides qualified investigators with several different types of data from genetic/genomic studies, including high-density genotyping and sequencing data, extensive phenotype data, and summary statistics from published genetic studies.

The DSS currently hosts 16,905 whole genomes and 20,503 whole exomes from the ADSP. Later in 2022 there will be a total of ~37,000 ADSP whole genomes available through NIAGADS DSS.

Division of Neuroscience DNA/Genetics Alzheimer’s Disease DN NIA Genetics of Alzheimer's Disease Data Storage Site Biological Resources

An official website of the National Institutes of Health