CALERIE Intensive Intervention Database
CALERIE (Comprehensive Assessment of Long term Effects of Reducing Intake of Energy) was a study designed to determine the biological effects of two years of prolonged caloric restriction (CR) in humans. The CALERIE database contains information from study participants on physiological and immune functions, physical performance, psychological outcomes, dietary records, disease risk factors, blood chemistry, and hematology. The biospecimen repository includes serum, plasma, urine, muscle, and fat.
The CALERIE Intensive Intervention Database is a toolkit that allows investigators to identify the major factors affecting individual participants’ interventions and adherence over the course of the trial. A computer-based algorithm provides specific strategies in Behavioral/Environmental and Nutritional/Dietary Toolboxes. Researchers can use these resources to identify key pathways that respond to CR, and for targets for novel interventions in aging research. Investigators can also examine a variety of risk factors, aging-related outcomes, and psychological and behavioral factors that interact with lowered caloric intake and weight loss.