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NIA Small Business Funding Opportunities

NIA participates in a broad range of funding opportunities, research and development (R&D) programs, and technical assistance that address innovations in healthy aging as well as Alzheimer’ disease (AD) and AD-related dementias (ADRD).

NIA Entrepreneurial Development Funding Opportunities
Title Links Key Details

Research and Entrepreneurial Development Immersion (REDI): Mentored Entrepreneurial Career Development Award

RFA-AG-22-004

Clinical trial not allowed

Due date: September 29, 2021

Budget limits: $90,000/year in salary; $50,000/year in other program-related expenses

OSBR contact: Saroj Regmi

REDI: Entrepreneurship Enhancement Award

RFA-AG-22-003

NOT-OD-19-109

Clinical trial not allowed

Due date: October 4, 2021

Budget limits: $150,000/year in direct costs

OSBR contact: Saroj Regmi

REDI: Entrepreneurial Small Business Transition Award 

SBIR RFA-AG-22-007

STTR RFA-AG-22-014

Clinical trial optional

Due date: October 26, 2021

Budget limits: Phase I $400,000; Fast-Track $2 million 

OSBR contact: Saroj Regmi

REDI Funding Information

Aims to increase university startups in the fields of aging and aging-related diseases, including Alzheimer’s disease, by providing bio-entrepreneurship training for early-career scientists that builds additional nonacademic skills for success; individuals from diverse backgrounds are encouraged to apply. Learn more about REDI and view the pre-application webinar recording.

NIA SBIR and STTR Omnibus Funding

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Key Details

2021 NIH SBIR/STTR Omnibus Solicitation

SBIR (PA-21-260)

STTR (PA-21-261)

Clinical trial required

Standard due dates: January 5, April 5, September 5

Budget limits: Phase I $300,000; Phase II $2 million

OSBR contact: Michael-David A.R.R. Kerns

2021 NIH SBIR/STTR Omnibus Solicitation

SBIR (PA-21-259)

STTR (PA-21-262)

Clinical trial not allowed

Standard due dates: January 5, April 5, September 5

Budget limits: Phase I $300,000; Phase II $2 million

OSBR contact: Michael-David A.R.R. Kerns

Omnibus Funding Information

2022 NIH SBIR Contracts Solicitation

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Key Details

2022 NIH SBIR Contracts Solicitation

PHS 2022-1

Due date: October 28, 2021

Budget limits: See below

Informational webinar recording

Informational webinar slides

OSBR contact: Karen Mahon

SBIR Contracts Funding Information

NIA participates in the annual NIH SBIR contracts solicitation, which aims to spur development of specific R&D innovations that address key priorities. For 2022, NIA has requested proposals for three topics:

  1. NIH/NIA 004 - Improving Central Nervous System Gene Delivery Systems for Alzheimer’s Disease and Related Dementias Therapy Development: Improve gene delivery systems to overcome current challenges.
    • Number of anticipated awards: 2 to 5
    • Budget (total costs, per award): Phase I: $500,000 for 12 months; Phase II: $2,500,000 for 2 years
  2. NIH/NIA 005 - Geroscience-Based Chronic Wound Treatment Product Development: Develop wound treatment that incorporates geroscience-based therapeutic modalities such as stem cell therapies, senolytics, inflammation modulators.
    • Number of anticipated awards: 1 to 2
    • Budget (total costs, per award): Phase I: $350,000 for 12 months; Phase II: $2,500,000 for 2 years (Phase II information is provided for informational purposes only, to assist Phase I offerors with their long-term strategic planning.)
  3. NIH/NIA 006 - The Development of Mechanism-Based Adult Stem Cell Treatments to Combat Aging Pathologies: Develop a stem cell-based therapeutic with a defined mechanistic understanding of how it promotes regeneration and/or rejuvenation of aging tissues.
    • Number of anticipated awards: 1 to 2
    • Budget (total costs, per award): Phase I: $350,000 for 12 months; Phase II: $2,000,000 for 2 years
NIA SBIR and STTR Opportunities Targeting AD/ADRD

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Advancing Research on AD and ADRD

SBIR PAS-19-316

STTR PAS-19-317

Clinical trial optional

Standard due dates: January 5, April 5, September 5

Budget limits: Phase I $500,000; Phase II $2.5 million

OSBR contact: Michael-David A.R.R. Kerns

 

NIH Commercialization Readiness Pilot (CRP) Program

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Key Details

CRP Technical Assistance

SBIR & STTR PA-20-128

Clinical trial not allowed

Standard due dates: January 5, April 5, September 5

Budget limit: $300,000

OSBR contact: Michael-David A.R.R. Kerns

CRP Technical Assistance and Late Stage Development

SBIR & STTR PA-20-129

Clinical trial not allowed

Standard due dates: January 5, April 5, September 5

Budget limit: $1.75 million/year for 2 years ($3.3 million total)

OSBR contact: Michael-David A.R.R. Kerns

CRP Technical Assistance and Late Stage Development

SBIR & STTR PA-20-130

Clinical trial required

Standard due dates: January 5, April 5, September 5

Budget limit: $1.75 million/year for 2 years ($3.3 million total)

OSBR contact: Michael-David A.R.R. Kerns

 

CRP Funding Information

 

Supports Phase II and Phase IIB awardees with technical assistance to help develop regulatory strategy and submissions to the U.S Food and Drug Administration and other agencies as well as support manufacturing, replication of key studies, compliance activities, and other commercialization readiness research.

 

Other NIH Technical Assistance Programs

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NIH Applicant Assistance Program (AAP)

A free 10-week program for first-time and never-funded applicants

More Information

Application portal opens: August 30, 2021

Informational webinar: August 30, 2021, 12:30-2 p.m. ET

Q&A office hours: September 8th, 2021, 2-3:30 p.m. ET

Application deadline: September 22, 2021, 5 p.m. ET

OSBR contact: Joy Toliver

Innovation Corps (I-Corps™) at NIH Program

An 8-week entrepreneurial training course for active Phase I SBIR and STTR awardees

To be determined

Due date: To be announced

OSBR contact: Saroj Regmi

Commercializing Innovation (C3i) Program

A 24-week entrepreneurial training course for all active SBIR and STTR awardees developing medical devices

More Information

Annual due date: July 1

OSBR contact: Saroj Regmi

SBIR Technology Transfer

Funding to help commercialize technologies from the NIH Intramural Research Program

SBIR PA-18-705

Clinical trial not allowed

Standard due dates: January 5, April 5, September 5

Budget limits: Phase I $300,000; Phase II $2 million

OSBR contact: Michael-David A.R.R. Kerns

 

NIH Special Initiatives

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Key Details

Non-Viral Technologies for In Vivo Delivery of Genome Editors

SBIR PAR-20-098

STTR PAR-20-109

Clinical trial not allowed

Standard due dates: January 5, April 5, September 5

Budget limits: Phase I $300,000; Phase II $2 million

OSBR contact: Michael-David A.R.R. Kerns

HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management

SBIR RFA-NS-20-010

STTR RFA-NS-20-008

Clinical trial required

Standard due dates: January 5, April 5, September 5

Budget limits: Phase I $300,000; Phase II $2 million

OSBR contact: Michael-David A.R.R. Kerns

HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management

SBIR RFA-NS-20-011

STTR RFA-NS-20-009

Clinical trial not allowed

Standard due dates: January 5, April 5, September 5

Budget limits: Phase I $300,000; Phase II $2 million

OSBR contact: Michael-David A.R.R. Kerns

BRAIN Initiative: Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research

SBIR PA-18-871

STTR PA-18-870

Clinical trial not allowed

Standard due dates: January 5, April 5, September 5

Budget limits: Phase I $300,000; Phase II $2 million

OSBR contact: Michael-David A.R.R. Kerns

 

NIH Administrative Supplements and Notices

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Key Details

Promoting Diversity in Research and Development

SBIR & STTR PA-18-837

Clinical trial not allowed

Due dates: Rolling submissions accepted until September 5, 2021

Budget limit: $250,000 in direct costs

OSBR contact: Saroj Regmi

Promoting Re-Entry into Biomedical and Behavioral Research Careers

SBIR & STTR PA-18-592

Clinical trial not allowed

Due dates: Rolling submissions accepted until September 8, 2021

Budget limit: $250,000 in direct costs

OSBR contact: Saroj Regmi

Existing NIH Grants and Cooperative Agreements

PA-20-272

Clinical trial optional

Due dates: Rolling submissions accepted until October 8, 2023

Budget limit: $250,000 in direct costs

OSBR contact: Saroj Regmi

Notice of Special Interest: SBIR and STTR Applications Directed at the Adoption of the Fast Healthcare Interoperability Resources (FHIR®) Standard

NOT-OD-19-127

Budget limits: Phase I $300,000; Phase II $2 million

OSBR contact: Michael-David A.R.R. Kerns

 

For additional guidance and information on preparing your application:

 

 

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