NIA-Funded Active Alzheimer’s and Related Dementias Clinical Trials and Studies
The National Institute on Aging (NIA) is currently supporting 488 active clinical trials on Alzheimer’s disease and related dementias (AD/ADRD). These trials reflect diverse drug and mechanistic targets, as well as diversity in the stages of AD/ADRD they address. NIA’s active trials include: Clinical Drug Development – Phase I and II (59), Clinical Drug Development – Phase II/III and Phase III (14), Non-drug (171), Dementia Care and Caregiving (213), Diagnostic Tools, Assessment, & Imaging Studies (23), and Treatments for Neuropsychiatric Symptoms (8). Please see the tables below for more details about these trials.*
Please note: The data in the graphics are from September 2023.
On this page:
- Section 1: Clinical Drug Development – Phase I and II (59 trials)
- Section 2: Clinical Drug Development – Phase II/III and Phase III (14 trials)
- Section 3: Non-drug (171 trials)
- Section 4: Dementia Care and Caregiver (213 trials)
- Section 5: Diagnostic Tools, Assessment, & Imaging Studies (23 trials)
- Section 6: Treatments for Neuropsychiatric Symptoms (8 trials)
*The data in the tables below are from September 2023
Section 1: Clinical Drug Development – Phase I and II
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Clinical Trials to Prevent Alzheimer's Disease in Down Syndrome | Trial-Ready Cohort-Down Syndrome (TRC-DS) (TRC-DS) | Michael S. Rafii, University of Southern California | Anti-Aβ immunotherapy to remove amyloid plaques | Non-demented adults with down syndrome (Ages 35 - 55) | 2025 |
| A Single Ascending Dose, Multiple Ascending Dose Phase I Study of the GSM 776890 in Healthy Normal Subjects | TBD | Douglas Galasko, University of California San Diego | Gamma secretase modulator (GSM)776890, an Allosteric modulator of amyloid precursor protein (APP) processing, to attenuate Alzheimer's disease pathology | Healthy adult participants | 2025 |
| A Seamless Phase 2A-B Randomized Double Blind Placebo Controlled Trial to Evaluate the Efficacy and Safety of PQ 912 in Patients with Early Alzheimer's Disease | A Trial to Evaluate the Efficacy and Safety of PQ912 in Patients With Early AD (VIVA-MIND) | Howard Feldman, University of California San Diego | PQ 912, a small molecule glutaminyl cyclase (QC) inhibitor to treat both amyloidopathy and neuroinflammation | Adults with mild cognitive impairment or mild probable Alzheimer's disease (Ages 50 - 89) | 2024 |
| A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2 Study to Evaluate the Safety and Efficacy of CT1812 in Subjects with Dementia with Lewy Bodies | Study to Evaluate the Safety, Tolerability and Efficacy of CT1812 in Subjects With Mild to Moderate Dementia With Lewy Bodies (COG1201) | Anthony Caggiano, Cognition Therapeutics Inc | CT1812, a small molecule sigma2 receptor antagonist that displaces Aß oligomers bound to neuronal receptors at synapses | Individuals with mild to moderate Lewy Body Dementia | 2024 |
| A Pilot Electroencephalography (EEG) Study to Evaluate the Effect of CT1812 Treatment on Synaptic Activity in Subjects with Mild to Moderate Alzheimer's Disease | Pilot Clinical Study of CT1812 in Mild to Moderate Alzheimer’s Disease Using EEG | Anthony Caggiano, Cognition Therapeutics, Inc. | CT1812, a small molecule sigma2 receptor antagonist that displaces Aß oligomers bound to neuronal receptors at synapses | Adults with mild to moderate Alzheimer's disease (Ages 50 - 80) | 2023 |
| Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase II Study to Evaluate the Safety and Efficacy of CT1812 in Subjects with Mild to Moderate Alzheimer's Disease | A Study to Evaluate the Safety and Efficacy of CT1812 in Subjects With Mild to Moderate Alzheimer's Disease | Anthony Caggiano, Cognition Therapeutics, Inc. | CT1812, a small molecule sigma2 receptor antagonist that displaces Aß oligomers bound to neuronal receptors at synapses | Adults with Mild to Moderate Alzheimer's Disease (Ages 50 - 85) | 2024 |
| Safety/Tolerability/Immunogenicity of First-in-Human Aβ DNA Vaccine, AV-1959D Phase 1 Trials in Early-Stage AD Subjects: Based on IND18953 Cleared by FDA | Study of AV-1959, an Amyloid Beta Vaccine | Michael Agadjanyan, Institute For Molecular Medicine | AV-1959D, a DNA based vaccine targeting amyloid beta to reduce amyloid plaque | Early Alzheimer's disease participants (Ages 60 - 85 | 2027 |
| Randomized Double Blind, Placebo Controlled, Parallel Group Trial to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease over 18 Months | A Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease | Anthony Caggiano, Cognition Therapeutics, Inc. | CT1812, a small molecule sigma2 receptor antagonist that displaces Aß oligomers bound to neuronal receptors at synapses | Older adults with early Alzheimer's disease, late mild cognitive impairment, and mild Alzheimer's disease dementia | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Evaluating the Disease-Modifying Potential of a Sleep Intervention for Alzheimer's Disease Outcomes | Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging | Natalie Denburg, University of Iowa | Melatonin, a hormone that regulates sleep, to improve cognition in older adults | Older adults (Ages 60 - 75) | 2024 |
| Improving Sleep and AD Biomarkers: A Pilot RCT of Citicoline | TBD | Victoria Pak, Emory University | Examine whether Citicoline (a dietary choline supplement) can significantly increase choline levels and decrease inflammatory and potentially Alzheimer's disease (AD)-associated biomarkers during a prodromal stage of AD (mild cognitive impairment due to AD) | Mild cognitive impairment (Ages 60+) | 2025 |
| Effect of Suvorexant on Alzheimer's Disease Biomarkers | TBD | Brendan Lucey, Washington University in St. Louis | Suvorexant, a dual orexin receptor antagonist (DORA), to decrease cerebrospinal fluid tau and phosphorylated tau and to prevent Alzheimer's disease | Cognitively healthy, amyloid-positive people with symptomatic insomnia (Ages 65+) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Clinical Trial of AAV2-BDNF Gene Therapy in Alzheimer's Disease | A Clinical Trial of AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment | Mark Tuszynski, University of California San Diego | Brain Derived Neurotrophic Factor (BDNF) Gene Therapy to potentially slow or even reverse cognitive decline in Alzheimer’s disease | Adults with early Alzheimer's disease and/or mild cognitive impairment | 2026 |
| The LUCINDA Trial | The LUCINDA Trial: LeUprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's (LUCINDA) | Tracy Butler, Joan and Sanford I Weill Medical College of Cornell University | Lupron, a small molecule gonadotropin-releasing hormone (GnRH) receptor agonist to slow cognitive decline in women with mild to moderate Alzheimer's disease | Women with mild-moderate Alzheimer's disease who are also taking acetylcholinesterase (AChE) inhibitors (Ages 65 - 90) | 2025 |
| PhytoSERM for Menopausal Hot Flashes and Sustained Brain Health | TBD | John Rinehart, Neutherapeutics, Llc | PhytoSERM, a selective estrogen receptor beta (ERß) modulator; a rationally designed formulation of 3 phytoestrogens, genistein, daidzein, and S-equol | Peri- and post-menopausal women (Ages 45 - 60) | 2024 |
| PhytoSERM Efficacy to Prevent Menopause Associated Decline in Brain Metabolism and Cognition: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Clinical Trial | TBD | Roberta Brinton, University of Arizona | PhytoSERM, a selective estrogen receptor beta (ERß) modulator to improve brain metabolism and cognitive function | Peri- and post-menopausal women (Ages 45 - 60) | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| First-in-Human (Phase 1) Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of IBC-Ab002 in Persons with Early Alzheimer's Disease (AD) | A First in Human Study of IBC-Ab002 in Persons With Early Alzheimer's Disease (AD) | Eti Yoles, Immunobrain Checkpoint Inc. | IBC-Ab002, an antibody therapy targeting the peripheral immune system | Individuals with early Alzheimer's disease (Ages 50 - 75) | 2024 |
| Development of a Stress Kinase Inhibitor Therapeutic Candidate for Alzheimer's Disease and Related Dementia | MW150 Stress Kinase Inhibitor in Mild to Moderate Alzheimer's Disease (SKI-AD) | Jeffrey Pelletier, Neurokine Therapeutics | MW150, a small molecule inhibitor of p38alphaMAPK serine/threonine protein kinase to reduce neuroinflammation and improve synaptic function. | Mild to Moderate Alzheimer's Disease (Ages 50 - 85) | 2024 |
| GM-CSF/Sargramostim Treatment to Improve Cognition in Down Syndrome | Trial to Evaluate Safety and Efficacy of GM-CSF /Sargramostim in Down Syndrome | Huntington Potter, University of Colorado Anschutz Medical Campus | Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Sargrammostim, an immune system modulator to improve cognition | Young adults with Down Syndrome | 2024 |
| MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI Patients | MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI Patients (MCLENA-1) | Marwan Sabbagh, Dignity Health's St. Joseph's Hospital and Medical Center | Lenalidomide, a small molecule Anti-inflammatory immunomodulator to reduce neuroinflammation and slow or prevent Alzheimer's disease | Adults with amnestic Mild Cognitive Impairment (Ages 50+) | 2024 |
| Phase II Trial of GM-CSF/sargramostim in Alzheimer's Disease | Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease (SESAD) | Huntington Potter, University Of Colorado Denver | Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Sargrammostim, an immune system modulator to improve cognition | Older adults with mild-to-moderate Alzheimer's disease | 2024 |
| BEACH: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage Phase 2a Trial | Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH) (BEACH) | Daniel Hanley, Johns Hopkins Bayview Medical Center | MW150, a small molecule inhibitor of p38alphaMAPK serine/threonine protein kinase to reduce neuroinflammation and improve synaptic function | Participants with spontaneous, non-traumatic, Intracranaial Hemorrhage | 2025 |
| Central and Peripheral Immune Cross-Talk in Alzheimer's disease and their Modulation by a Novel Immunotherapy | TBD | Alireza Faridar, Houston Methodist Hospital Research Institute | Low-dose Interleukin-2 (IL-2) immunotherapy to reduce neuroinflammation and ameliorate Alzheimer's disease pathology | Participants with Alzheimer's disease (Ages 55 - 86) | 2025 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Effects of Orally Administered Nicotinamide Riboside on Bioenergetic Metabolism, Oxidative Stress and Cognition in Mild Cognitive Impairment and Mild Alzheimer's Dementia | Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia | Fei Du, McLean Hospital | Nicotinamide riboside (NR), an orally bioavailable precursor of NAD+, to enhance mitochondrial function, and improve cognition | Adults with mild cognitive impairment and mild Alzheimer’s disease (Ages 55 - 89) | 2025 |
| Phase 2 Randomized, Double-Blind, Placebo-Controlled Clinical Trial of T3D-959 in Mild to Moderate Alzheimer's Disease Subjects | Clinical Study Evaluating Efficacy and Safety of T3D-959 in Mild-to-moderate AD Subjects | John Didsbury, T3D Therapeutics, Inc. | T3D-959, a small molecule peroxisome proliferator-activated receptor (PPAR)-delta and PPAR-gamma agonist to improve cognition in Alzheimer's disease | Adults with mild to severe Alzheimer's disease (Ages 50 - 90) | 2023 |
| Phase II Randomized Controlled Trial of Benfotiamine in Early Alzheimer's Disease | TBD | Gary Gibson, Winifred Masterson Burke Medical Research Institute | Benfotiamine, a small molecule thiamine derivative to improve cognition and overall global function | Individuals with early Alzheimer's disease, including mild cognitive impairment and mild dementia with plasma evidence of amyloid positivity | 2027 |
| Effects of NAD Restoration on Neurovascular Coupling in Community Dwelling Older Adults | The Effect of NAD Supplementation on Brain Vascular Health in Aging | Andriy Yabluchanskiy, University of Oklahoma | Nicotinamide Adenine Dinucleotide (NAD) supplementation to improve brain health and memory | Older adults (Ages 60 - 85) | 2027 |
| NAD+ Therapy for Improving Memory & Cerebrovascular Function in Patients with MCI | NAD Therapy for Improving Memory and Brain Blood Flow in Older Adults with Mild Cognitive Impairment | Christopher Martens, University of Delaware | Nicotinamide Riboside, a precursor molecule of Nicotinamide adenine dinucleotide (NAD+) to improve cerebrovascular function and improve memory in patients with mild cognitive impairment | People with amnestic mild cognitive impairment (Ages 60 - 90) | 2024 |
| The Benefits of Nicotinamide Riboside Upon Cognition and Sleep in Older Veterans | Benefits of Nicotinamide Riboside Upon Cognition and Sleep | Carleara Weiss, State University of New York at Buffalo | Nicotinamide riboside (NR) supplementation to enhance cognition by improving objective sleep duration and sleep quality in older persons | Older adults with poor sleep quality (Ages 65 - 85) | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Senolytics to Improve Cognition and Mobility in Older Adults at Risk of Alzheimer’s Disease | Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease (STAMINA) | Lewis Lipsitz, Hebrew SeniorLife / Hebrew Rehabilitation Center | Quercetin and Dasatinib, a senolytic combination, to improve brain blood flow | Older adults with slow gate speed and Mild Cognitive Impairment (Ages 70 - 90) | 2024 |
| A Proof of Concept Trial of a Sirtuin-NAD+ Activator in Alzheimer's Disease | Sirtuin-NAD Activator in Alzheimer's Disease | Shalender Bhasin, Brigham and Women's Hospital | ß nicotinamide mononucleotide (ßNMN): An NAD+ precursor to slow Alzheimer's disease progression and improve cognition | Mild Alzheimer's disease dementia participants | 2024 |
| Repurposing Siponimod for Alzheimer's Disease | TBD | Marwan Sabbagh, Dignity Health's St. Joseph's Hospital and Medical Center | Siponimod, an immunomodulatory small molecule used to treat multiple sclerosis and serves as a neuroprotective | Individuals with early Alzheimer's disease (Ages 60 - 85) | 2026 |
| Citalopram as a Posterior Cortical Protective Therapy in Parkinson Disease | Citalopram as a Posterior Cortical Protective Therapy in Parkinson Disease | Vikas Kotagal, University of Michigan | Citalopram, a selective serotonin-reuptake inhibitor to test effect on amyloid-beta levels in the visuospatial cortex and visuospatial cognitive abilities in patients with Parkinson’s disease | Older adults with Parkinson's disease diagnosis and no active depression (Ages 65+) | 2025 |
| Allopregnanolone as Regenerative Therapeutic for Alzheimer's: Phase 2 Clinical Trial | Allopregnanolone Regenerative Therapeutic for Mild Alzheimer's Disease (REGEN-BRAIN©) | Roberta Brinton, University of Arizona | Allopregnanolone, a small molecule that stimulates anti-inflammatory mechanisms and mitochondrial function to regenerate neurons and restore cognition in Alzheimer's disease | Adults who are APOE e4 positive and diagnosed with mild Alzheimer's disease (Ages 55+) | 2025 |
| Phase 1 Clinical Trial of CMS121, a Novel Therapeutic Candidate for Alzheimer's Disease | Safety, Tolerability and Pharmacokinetics of CMS121, a Drug Candidate for Alzheimer's Disease, in Healthy Subjects (CMS121) | William Raschke, Virogenics, Inc. | CMS121, a small molecule therapy to reduce neuroinflammation | Healthy adult volunteers | 2024 |
| Cannabidiol for Individuals at Risk for Alzheimer's Disease: A Randomized Placebo Controlled Trial | TBD | Kent Hutchison, University of Colorado Anschutz Medical Campus | An intervention with full spectrum hemp-derived cannabidiol (CBD) and CBD to determine the influence on Alzheimer's disease biomarkers | Older adults with mild cognitive impairment (Ages 55 - 85) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Age-Related Mild Cognitive Impairment and Novel Protective Role of Glutathione: Implications for Alzheimer's Disease | Glutathione in Mild Cognitive Impairment | Rajagopal Sekhar, Baylor College of Medicine | Glutathione supplementation to improve cognition in Alzheimer's disease | Adults with mild cognitive impairment (Ages 65 - 80) | 2024 |
| Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease | Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease | Rajagopal Sekhar, Baylor College of Medicine | Glutathione supplementation to improve cognition in Alzheimer's disease | Adults with mild cognitive impairment and mild Alzheimer’s disease (Ages 55 - 85) | 2025 |
| Veri-T: A Phase 1 Placebo-Controlled Trial of Verdiperstat in Semantic Variant Primary Progressive Aphasia Due to Underlying FTLD-TDP | Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology (Veri-T-001) | Peter Ljubenkov, University of California San Francisco | Verdiperistat, a microglial myeloperoxidase inhibitor that modulates proinflammatory microglia | Participants with Semantic variant primary progressive aphasia (Ages 18 - 80) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| The Delivery of Essential Fatty Acids to the Brain in Alzheimer's Disease | DHA Brain Delivery Trial (PreventE4) | Hussein Yassine, University of Southern California | Docosahexaenoic acid (DHA) supplementation, a dietary lipid to improve cognition in Alzheimer's disease | Healthy adult carriers and non-carriers of APOE e4 (Ages 60 - 80) | 2024 |
| Long Term Nicotine Treatment of Mild Cognitive Impairment | Memory Improvement Through Nicotine Dosing (MIND) Study (MIND) | Paul Newhouse, Vanderbilt University Medical Center | Nicotine to improve cognition in Alzheimer's disease | People with mild cognitive impairment (Ages 55+) | 2024 |
| A Phase 1b Multiple Ascending Dose Study of the Safety and Tolerability of BMS-984923 in Alzheimer's Disease | Multiple Ascending Dose Study of the Safety and Tolerability of BMS-984923 | Adam Mecca, Yale University | BMS-984923, blocks aberrant Amyloid beta activation of mGluR5 | Adults with early Alzheimer's disease (Ages 50 - 80) | 2024 |
| Health of the Cholinergic System and Risk for Alzheimer's Disease in Postmenopausal Women | Cholinergic Health After Menopause (CHAMP) | Julie Dumas, University of Vermont and State Agricultural College | Mecamylamine, a cholinergic antagonist, to study the relations between the cholinergic system's functional integrity, cognition, and known Alzheimer's disease biomarkers | Postmenopausal women (Ages 50 - 70) | 2024 |
| Preclinical and Early Clinical Development of a GABA-A a5 PAM | TBD | Sharon Rosenzweig-Lipson, AgeneBio, Inc. | BPN-27473, a potent, selective and orally active GABA-A a5 Positive Allosteric Modulator (PAM) for the treatment of mild cognitive impairment due to Alzheimer's disease | Healthy Older Adults | 2026 |
| A Randomized Double-blind Placebo Controlled Phase 1 SAD Study in Male and Female Healthy Volunteers to Assess Safety, Pharmacokinetics, and Transient Biomarker Changes by the ABCA1 Agonist CS6253 | A Phase 1 Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Safety and Pharmacokinetics of Single Ascending Doses of CS6253 in Healthy Volunteer | Jan Johansson, Artery Therapeutics, Inc. | CS6253, an ABCA1 transporter agonist to treat APOE4 associated dementia | Healthy young adults | 2023 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| (-)-Phenserine Inhibition of Neuronal Death in Alzheimer’s Disease and Developing Brain-Labeled Plasma Exosomes Assays as Biomarkers for a Phenserine Phase 1b Ascending Dose Trial | TBD | Lon S. Schneider, University of Southern California | (-)-PHENSERINE, a small molecule that inhibits neuronal pre-programmed cell death, to prevent neuronal dysfunction and death | Adults with probable Alzheimer's disease (Ages 70 - 82) | 2024 |
| Treating Hyperexcitability in Alzheimer’s Disease with Levetiracetam to Improve Brain Function and Cognition | Treating Hyperexcitability in AD With Levetiracetam (LeAD) | Mouhsin Shafi, Beth Israel Deaconess Medical Center | Levetiracetam, a small molecule synaptic vesicle protein (SV2A) modulator, to improve cognition in Alzheimer's disease | Adults with probable Alzheimer's disease (Ages 50 - 90) | 2023 |
| A Randomized, Double Blind, Placebo-Controlled Study to Evaluate the Impact of Nilotinib Treatment on Safety, Tolerability, Pharmacokinetics and Biomarkers in Dementia with Lewy Bodies (DLB) | Impact of Nilotinib on Safety, Tolerability, Pharmacokinetics and Biomarkers in Dementia With Lewy Bodies | Charbel Moussa, Georgetown University | Nilotinib, a small molecule inhibitor of Abelson kinase to facilitate degradation of neurotoxic proteins and promote survival of neurons | Adults with clinical diagnosis of Lewy body dementia with both dementia and Parkinsonism (Ages 25 - 90) | 2024 |
| Development of a Small-molecule that Enhances Tripartite Synapses for Alzheimer's Disease | TBD | Chien-Liang Glenn Lin, Ohio State University | A single ascending dose (SAD) study to determine safety and tolerability of a novel compound that has the potential for modifying Alzheimer's disease progression/onset | Healthy men and women (Ages 18 - 60) | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| First in Human Study of a Tau Self-Association Small Molecule Inhibitor in Healthy Volunteers | TBD | William Erhardt, Oligomerix, Inc | OLX-07010 is a tau self-association inhibitor small molecule that targets tau, a protein involved in disease progression | Healthy adults (ages 18 - 50) and healthy older adults (ages 51 - 75) | 2024 |
| The Alzheimer's Disease Tau Platform Clinical Trial | TBD | Adam Boxer, University of California San Francisco | Tau-directed therapies, alone and in combination with an anti-amyloid therapy, to slow Alzheimer's disease progression | Older adults with elevated brain amyloid and tau (Ages 60 - 75) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid and Tau in Older Adults (IPAT-study) | Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study) (IPAT) | Rong Zhang, University of Texas Southwestern Medical Center | Intensive lowering of systolic blood pressure (SBP) using antihypertensive medications to reduce Alzheimer's disease pathology (i.e., excessive brain amyloid and tau protein deposition) in older adults at high risk for memory decline or dementia | Older adults who have hypertension (SBP=130 mmHg), family history of dementia, and/or subjective memory complaints (Ages 60 - 80) | 2027 |
| Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging (SMArT–HS) | Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging (SMArT-HS) | Gregory Jicha, University of Kentucky | Nicorandil, a small molecule agonist for sulfonyl urea receptor 2 protein (SUR2), to improve cognition and hippocampal pathology | Adults with probable Hippocampal sclerosis (HS)-aging (Ages 75+) | 2025 |
| Hypertension, Intracranial Pulsatility and Brain A-beta Accumulation in Older Adults | Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial) (HIPAC) | Rong Zhang, University of Texas Southwestern Medical Center | Amlodipine (calcium channel blocker), Losartan (angiotensin II receptor blocker), and other antihypertensive drugs to reduce systolic blood pressure and alter brain function | Older adults with hypertension (Ages 55 - 79) | 2024 |
| Arterial Stiffness, Cognition, and Equol (ACE) | Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers (ACE) | Akira Sekikawa, University of Pittsburgh | Equol supplementation as an intervention to improve cognitive decline by targeting arterial stiffness and white matter lesions in the brain | Older adults (Ages 65+) | 2027 |
| The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults | The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults (Mito-Frail) | Oh Sung Kwon, University Of Connecticut Storrs | Determine if MitoQ supplementation will affect peripheral vasodilation, peripheral and cerebral nitric oxide (NO) bioavailability and mitochondrial reactive oxygen species (mtROS), cognitive function and gait speed | Older adults who are healthy, frail with slow walking speed (0.4m/s based on a 4m walk), and those who meet criteria for mild cognitive impairment (Ages 65 - 80) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Phase II RCT of High-Dose Vitamin D Supplements in Older Adults Without Dementia | High-dose Vitamin D Supplements in Older Adults | John Olichney, University of California Davis | Vitamin D supplements, to improve cognitive outcomes in elderly groups at risk for dementia | People with mild cognitive impairment or mild Alzheimer’s disease (Ages 65 - 90) | 2024 |
| Anti-Viral Therapy in Alzheimer's Disease | Anti-viral Therapy in Alzheimer's Disease | Davangere Devanand, Columbia University | Valacyclovir, an Antiviral (Herpes Simplex Virus drug) to examine if HSV contributes to the pathology of Alzheimer's disease and whether antiviral treatment can improve cognition | People with mild Alzheimer's disease | 2024 |
| The Use of Deferiprone to Improve Subarachnoid Hemorrhage Cognitive Outcome: U-DISCO | Ferritin and Iron Burden in SAH sIRB | David Hasan, Duke University | Deferiprone to improve cognitive outcomes | Adults with aneurysmal subarachnoid hemorrhage at risk for cognitive decline (Ages 18 - 70) | 2025 |
| Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM Sleep Behavior Disorder | TBD | Michael Howell, University of Minnesota Twin Cities | Compare serotonergic rapid eye movement (REM) sleep Behavior Disorder (5-HT RBD) participants and to adults without RBD who are taking a serotonergic antidepressants in order to: (1) detect systemic alpha-synuclein pathology; (2) examine for evidence of brainstem neurodegeneration using 7T magnetic resonance imaging; (3) quantify evolving speech deficits | Adults with serotonergic rapid eye movement (REM) sleep Behavior Disorder (5-HT RBD) and adults without RBD who take serotonergic antidepressants (Ages 18 - 75) | 2028 |
Section 2: Clinical Drug Development – Phase II/III and Phase III
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| The A3 Study: Ante-Amyloid Prevention of Alzheimer's Disease | AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid | Reisa Sperling, University of Southern California | BAN2401 , anti-amyloidß antibody to prevent cognitive decline in Alzheimer's disease by preventing amyloid accumulation | Cognitively healthy older adults with "intermediate" amyloid levels on screening PET (Ages 55 - 80; adults 55 - 64 must also carry at least one APOE e4 allele) | 2024 |
| Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) Open-Label Extension Study | Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss (A4) | Reisa Sperling, Brigham And Women's Hospital | Solanezumab, an anti-amyloidß antibody to prevent cognitive decline associated with early Alzheimer's disease pathology | Cognitively healthy older adults who are amyloid positive on brain imaging (Ages 65+) | 2024 |
| Combination Anti-amyloid Therapy for Preclinical Alzheimer's Disease (A-45) | AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid | Paul Aisen, University of Southern California | BAN2401, anti-amyloidß antibody to slow or prevent cognitive decline in cognitively normal preclinical individuals with Alzheimer's disease | Cognitively healthy older adults with "elevated" amyloid levels on screening PET (Ages 55 - 80; adults ages 55 - 64 must have an additional risk factor) | 2025 |
| Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study | An Efficacy and Safety Study of ALZ-801 in APOE4/4 Early AD Subjects (APOLLOE4) | Susan Abushakra, Alzheon Inc. | ALZ-801 (tramiprosate pro-drug), an inhibitor of Aß oligomer formation | Individuals with APOE e4 and early Alzheimer's disease diagnosis | 2025 |
| DIAN-TU Primary Prevention Trial | TBD | Eric Mcdade, Washington University in St. Louis | Anti-amyloid therapy to prevent Alzheimer's disease | Cognitively healthy adults who are Alzheimer's disease genetic mutation carriers | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| RCT Targeting Cognition in Early Alzheimer's Disease by Improving Sleep with Trazodone (Rest) | Targeting Cognition in Early Alzheimer's Disease by Improving Sleep with Trazodone (REST) | Barry Greenberg, Johns Hopkins Bayview Medical Center | Trazadone, an antidepressant to treat sleep disturbance and improve cognitive outcomes | Individuals with prodromal Alzheimer's disease or amnestic Mild Cognitive Impairment and sleep complaints | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Phase 2b Clinical Study of the P38 Alpha Kinase Inhibitor Neflamapimod in Patients with Mild-to-Moderate Dementia with Lewy Bodies (DLB) | A Clinical Study of Neflamapimod in Patient with Dementia with Lewy Bodies | JJohn Alam, Eip Pharma, Inc. | Neflamapimod, inhibitor of p38 mitogen activated protein kinase alpha (p38a), to reduce neuronal degeneration | Mild-to-moderate dementia with Lewy bodies (Ages 55+) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Metformin in Alzheimer's Dementia Prevention | Metformin in Alzheimer's Dementia Prevention (MAP) | Jose Alejandro Luchsinger, Columbia University | Metformin, a medication with proven efficacy in decreasing hyperinsulinemia and preventing diabetes, repurposed for the prevention of Alzheimer’s dementia | Adults with amnestic mild cognitive impairment (Ages 55 - 90) | 2025 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Evaluation of Brain and Cognitive Changes in Older Adults with MCI Taking Lithium to Prevent Alzheimer Type Dementia | Lithium As a Treatment to Prevent Impairment of Cognition in Elders (LATTICE) | Ariel Gildengers, University of Pittsburgh | Lithium, a GSK3a and GSK3ß inhibitor to prevent or slow cognitive decline in older adults with mild cognitive impairment | People with mild cognitive impairment (Ages 60+) | 2024 |
| Depression Treatment and Aβ dynamics: A Study of Alzheimer’s Disease Risk | Aß Dynamics in LLMD | Nunzio Pomara, New York University School of Medicine | Escitalopram Oxalate, a SSRI antidepressant to examine effects of Alzheimer's disease biomarkers | Older cognitively unimpaired adults with Major Depressive Disorder (Ages 60+) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Cognitive, Urinary, and Functional Trajectories of Older Women Using Pharmacologic Treatment Strategies for Urgency Incontinence | TReating Incontinence for Underlying Mental and Physical Health (TRIUMPH) | Alison Huang, University of California San Francisco | Tolterodine and Mirabegron, anticholinergic bladder medications | Older women with urinary incontinence and without pre-existing dementia | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| DIAN-TU: Tau Next Generation Prevention Trial (Fourth Drug Arm) and DIAN-TU: Tau Next Generation Prevention Trial (Fifth and Sixth Drug Arm) | Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. (DIAN-TU) | Randall Bateman, Washington University in St. Louis | Anti-tau therapy to prevent AD | Cognitively healthy or mildly impaired adults who are Alzheimer's disease genetic mutation carriers | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| PRagmatic EValuation of evENTs And Benefits of Lipid-Lowering in oldEr Adults (PREVENTABLE) | Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults (PREVENTABLE) | Karen Alexander, Duke University | Atorvastatin, a statin to reduce death, dementia, and persistent disability | Community-dwelling adults without clinically evident cardiovascular disease, significant disability, or dementia (Ages 75+) | 2027 |
| Effectiveness of Implementing an Intensive Blood Pressure Reduction Intervention on Cognitive Decline in Low-income and Minority Hypertensive Patients | Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control in Minimize Cognitive Decline (IMPACTS-MIND) | Katherine Mills, Tulane University | Multifaceted intensive blood pressure intervention to reduce blood pressure-related cognitive decline in underserved populations | Adults with hypertension who receive primary care from clinics that predominately manage underserved populations with health disparities | 2025 |
Section 3: Non-drug
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Losing specificity: The Role of the Locus Coeruleus in Age-Related Distractibility | The Role of the Locus Coeruleus in Age-related Distractibility | Tae-Ho Lee, Virginia Polytechnic Institute and State University | Two interventions to facilitate neural plasticity in the brain, either multi-modal adaptive attention training or practice on a training version of the criterion attention task, to examine how this may modulate locus coeruleus-salience network connectivity and mitigate distractibility | Healthy participants from the Roanoke and Blacksburg metropolitan area in Virginia (Ages 55 – 75) | 2027 |
| Developing a Mobile App-Based Intervention to Promote Cognitive Health in Older Chinese Americans | Cognitive Training RCT for Older Chinese Americans | Hanzhang Xu, Duke University | A mobile app-based cognitive training (aka mHealth) intervention that is culturally and linguistically relevant to older Chinese Americans to, ultimately, enhance cognitive function in the population. Includes dementia knowledge education, culturally-appropriate app content, cognitive training activities, and training reminders. | Older Chinese Americans without cognitive impairment and adult children of older Chinese Americans | 2024 |
| Understanding Individual Differences in Working Memory Training and Transfer in Older Adults at Risk of Alzheimer's Disease and Related Dementias | Understanding Individual Differences in Working Memory Training and Transfer in Older Adults | Aaron Seitz, University of California Riverside | Cognitive training program focused on working memory systems and the role of inhibitory control, to promote health and general cognition | Older adults at risk for Alzheimer's disease and related dementias (AD/ADRD) | 2023 |
| Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) | Improving Neurological Health in Aging Via Neuroplasticity-based Computerized Exercise (INHANCE) | Mouna Attarha, Posit Science Corporation | INHANCE, a computerized cognitive training program based on neuroplasticity principles to reduce long-term risk of dementia | Healthy older adults (Ages 65+) | 2024 |
| ACTIVE MIND: An Adaptive Clinical Trial of Cognitive Training to Improve Function and Delay Dementia | The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia | Jerri Edwards, University of South Florida | Combination of cognitive training exercises to modify the functional trajectories of adults with mild cognitive impairment | Older adults with mild cognitive impairment (Ages 65 - 89) | 2027 |
| Elucidating the Necessary Components and Mechanisms of Cognitive Training | Elucidating the Necessary Active Components of Training (ENACT) | Lesley Ross, Clemson University | Bottom-up driven process-based training (BUD) and top-down driven training (TDD), two types of strategy-based cognitive training to improve cognition | Adults (Ages 45-90) | 2023 |
| Cognitive Training and Neuroplasticity in Mild Cognitive Impairment | Cognitive Training and Neuroplasticity in Mild Cognitive Impairment (CogTraining) | Davangere Devanand, Columbia University | Computerized cognitive training to improve cognitive performance | People with Mild Cognitive Impairment (Ages 55 - 95) | 2024 |
| Patient-Centered Serious Games for Remote Cognitive Training in Older Adults with Mild Cognitive Impairment | Serious Game-based Interventions in Patients With Mild Cognitive Impairment Outside the Clinic | Ivan Lee, University of Massachusetts Boston | Serious games (Neuro-World), to stimulate working memory and improve cognition | Older adults with Mild Cognitive Impairment | 2024 |
| Mitigating Cancer-related Cognitive Dysfunction in Older Adults With Breast Cancer | Feasibility of the Memory and Attention Adaptation-Training Geriatrics Intervention in Older Cancer Survivors With Mild Cognitive Impairment | Allison Magnuson, University of Rochester | Memory and Attention Adaptation Training-Geriatrics (MAAT-G), a cognitive behavioral therapy-based intervention comprised of a series of videoconferencing workshops | Older cancer survivors with Mild Cognitive Impairment (Ages 65+) | 2024 |
| The Adherence Promotion with Person-centered Technology (APPT) Project: Promoting Adherence to Enhance the Early Detection and Treatment of Cognitive Decline | Smart Reminders to Promote Home-based Cognitive Training | Walter Boot, Florida State University | Mobile platform-based support system intervention to improve adherence to home-based cognitive assessment | Non-cognitively impaired adults (Ages 65+) | 2024 |
| Prospective Memory Impairment in Parkinson Disease-related Cognitive Decline: Intervention and Mechanisms | Everyday Memory Impairment in PD-related Cognitive Decline (PMT2) | Erin Foster, Washington University in St. Louis | Memory encoding strategies to improve prospective memory | Adults who meet criteria for typical idiopathic Parkinson's disease (Ages 50+) | 2025 |
| Early Cognitive Training and Rehabilitation to Prevent Cognitive Decline in Older Hospitalized Adults with Delirium | Early Cognitive Intervention in Delirium (ECID) | Jin Han, Vanderbilt University Medical Center | Cognitive training rehabilitation program for individuals with delirium to improve working memory | Hospitalized older delirious patients with and without Alzheimer's disease and related dementias (Ages 65+) | 2025 |
| Transferring Speed of Processing Gains to Everyday Cognitive Tasks After Stroke | Transferring Speed of Processing Gains to Everyday Cognitive Tasks After Stroke | Edward Taub, University of Alabama at Birmingham | Web-based computer game that trains cognitive processing speed to improve everday activities | Stroke Patients | 2025 |
| Cognitive Training to Reduce Incidence of Cognitive Impairment in Older Adults | Preventing Alzheimer's Disease with Cognitive Training (PACT) | Jerri Edwards, University of South Florida | Speed of processing training intervention to reduce incidence of mild cognitive impairment or dementia | Older adults who are cognitively normal | 2026 |
| Use of the KF Modified Story Memory Technique to Improve New Learning and Memory in Individuals with Mild Cognitive Impairment | Improve New Learning and Memory in Individuals With Mild Cognitive Impairment | Nancy Chiaravalloti, Kessler Foundation, Inc. | Kessler Foundation modified Story Memory Technique (KF-mSMT), a 10-session structured cognitive rehabilitation treatment composed of the application of imagery and context to facilitate learning | Older adults with mild cognitive impairment and no evidence of dementia (Ages 60+) | 2027 |
| Web-Based Technology and Cognitive Training: Improving Executive Control in Cognitively Healthy Older Adults | Using Teleneuropsychology to Optimize Cognition in Healthy Aging: The Web-based Breakfast Game | Sharon Sanz Simon, Columbia University | The intervention includes a web-based cognitive training of Executive Control (EC) using an ecological Emphasis Change (EmCh) approach with a task named the Breakfast Game (B-Game) | Cognitively healthy older adult participants (Ages 60 - 75) | 2024 |
| Neuromechanisms of Falls in Older Adults with MCI: Targeting Assessment and Training of Reactive Balance Control | Dual Task Perturbation Training for OAwMCI | Tanvi Bhatt, University of Illinois at Chicago | A novel four-week perturbation-based cognitive-motor intervention for improving reactive balance control and cognition | Older adults with mild cognitive impairment or cognitively intact older adults (Ages 55+) | 2026 |
| Using Artificial Intelligence to Predict Cognitive Training Response in Amnestic Mild Cognitive Impairment | Training Response Artificial Intelligence Network (TRAIN) | Joseph Gullett, University of Florida | Use of artificial intelligence in cognitive training for memory deficit-based disorders, which may increase the risk of Alzheimer’s disease | Adults with amnestic mild cognitive impairment (Ages 55 - 100) | 2028 |
| Develop an ANS-based Personalized Cognitive Training for Mild Cognitive Impairment | CogT pSOPT Intervention Study | Feng Lin, Stanford University | Personalized cognitive training program to slow cognitive decline; intervention is tailored using a participant's biofeedback and cognitive performance | People with mild cognitive impairment due to Alzheimer's disease (Ages 60 - 89) | 2026 |
| Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure | Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure | Miyeon Jung, Indiana University-Purdue University Indianapolis | Preliminary efficacy study of a combined intervention involving virtual reality-based cognitive restoration (Vita) coupled with computerized cognitive training (Com), compared to each intervention alone, and standard of care in a 4-group randomized controlled trial using a 2X2 factorial design | Dyads composed of older (65+ years) patients with HF (chronic HF Stage C validated from echocardiography or comparable measure) and MCI (MoCA score 23 and lower) and their informants | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training in MCI (The ACT Trial) | The ACT Trial: Effects of Combined Aerobic Exercise and Cognitive Training in MCI | Fang Yu, Arizona State University | Aerobic exercise (cycling) and a specific type of cognitive training (speed of processing training) intervention to improve reasoning and memory, as well as to improve brain structure and function | People with Mild Cognitive Impairment (Ages 65 - 74) | 2024 |
| MIND Food and Speed of Processing Training in Older Adults with Low Education | MINDSpeed Food and Brain Training RCT (MINDSpeed) | Daniel Clark, Indiana University-Purdue University Indianapolis | Nutrition intervention (with foods high in polyphenols) combined with cognitive training exercises to test impact on cognitive performance | Older adults (60+) | 2024 |
| Influence of Strategy Training on Disability for Older Adults with Mild Cognitive Impairment | Facilitating Optimal Routines in Aging (ForAging) | Juleen Rodakowski, University of Pittsburgh | Strategy Training to slow the emergence of disability and decline in cognition | People with Mild Cognitive Impairment (Ages 60+) | 2023 |
| Digital Multidomain Lifestyle Intervention to Address Cognitive Health and Modifiable Risk Factors for Alzheimer's Disease | Reducing Dementia Risk With Digital Health Coaching (DC-MARVEL) | Jordan Glenn, Neurotrack Technologies | MindMate + Health Coaching, a digital intervention consisting of the MindMate cognitive health app (digital multi-domain lifestyle intervention designed to address modifiable risk factors for dementia) and Neurotrack's personalized health coaching platform | At-risk adults (Ages 45 - 64) | 2024 |
| Neuro-exergaming for the Prevention and Remediation of Decline Due to Alzheimer's Disease and Related Dementias: A Clinical Trial of the Interactive Physical and Cognitive Exercise System (iPACES v3) | The Interactive Physical and Cognitive Exercise System (v3) for Mild Cognitive Impairment (MCI) (iPACES) | Cay Anderson-Hanley, iPACES LLC | iPACES v3, a physical and cognitive exercise system that can be used at home | People with Mild Cognitive Impairment or subjective cognitive complaints (Ages 50+) | 2024 |
| Targeted Physical and Cognitive Activity in a VR Environment in Older Adults at Risk for Alzheimer's Disease | TBD | Judy Pa, University of California San Diego | Physical and cognitive activity program in a virtual reality environment to improve cognition | People with early Mild Cognitive Impairment (Ages 55 - 80) | 2026 |
| Sleep Interventions and Neurocognitive Outcomes in Amnestic Mild Cognitive Impairment | Sleep Interventions and Neurocognitive Outcomes | Hyun Kim, New York State Psychiatric Institute Research Foundation For Mental Hygiene, Inc. | Assess the neurocognitive effects of two sleep interventions (cognitive behavioral therapy for insomnia [CBTI] and acoustic slow-wave activity enhancement [SWAE]) and their underlying mechanisms in individuals with amnestic mild cognitive impairment | Older adults with sleep disturbance who meet criteria for amnestic mild cognitive impairment (Ages 60 - 85) | 2028 |
| MIND Foods and Aerobic Training in Black Adults with HTN: An ADRD Prevention Pilot RCT (MAT) | TBD | Daniel Clark, Indiana University-Purdue University Indianapolis | Mediterranean-Dash Intervention for Neurodgenerative Delay (MIND) and aerobic training (MAT) | Non-Hispanic black adults with hypertension (Ages 40 - 64) | 2027 |
| Behavioral Interventions for the Treatment of Early Onset Alzheimer's Disease | Lifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease Study (LITES) | Dustin Hammers, Indiana University-Purdue University Indianapolis | To conduct behavioral interventions for the management of patients with early-onset Alzheimer’s disease | Adults with a Clinical Dementia Rating scale of 0.5 to 1.0 at the time of enrollment (Ages 40 - 64) | 2028 |
| Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults | TBD | David Clark, University of Florida | Brain electrical stimulation intervention to improve walking performance and executive function in older adults with cognitive decline | Older adults with age-related cognitive decline (Ages 65 – 89) | 2027 |
| A Multi-modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors | TBD | Maya Elias, University of Washington | Daily 30-minute cognitive training sessions and/or sleep promotion intervention to improve cognitive function and sleep | Older adults with no diagnosis of dementia and an intensive care unit stay of 24+ hours (Ages 60+) | 2027 |
| Midwest Roybal Center for Health Promotion and Translation: Piloting the i-PROACTIF Program to Preserve Functioning and Prevent Cognitive Decline (Pilot) | Piloting the IPROACTIF Program to Preserve Functioning and Prevent Cognitive Decline | Mansha Mirza, University of Illinois at Chicago | IPROACTIF is an occupational therapist-delivered primary care intervention for aging and chronic disease management | Community-dwelling adults (Ages 55+) | 2024 |
| Resilience and Brain Health of Older Adults During the COVID-19 Pandemic | Resilience and Brain Health of Older Adults During the COVID-19 Pandemic (MEDEX-2) (MEDEX-2) | Eric Lenze, Washington University in St. Louis | Exercise and mindfulness interventions to measure the effects of COVID-induced stress on AD-related cognitive decline | Healthy, sedentary, community living individuals, (Age 65 - 84) | 2026 |
| Cognitive and Physical Exercise to Improve Outcomes After Surgery in the Elderly | Cognitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study (COPEiOS) | Christopher Hughes, Vanderbilt University Medical Center | A comprehensive cognitive and physical training program compared to active control to improve outcomes after surgery in the elderly | Patients ≥60 years old undergoing elective major non-cardiac surgery with expected hospitalization ≥3 days and high likelihood of ICU admission | 2025 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Novel Food-based Approach for Prevention of Age-associated Cognitive Decline in Older Adults with Obesity | Nutrition for Brain and Body Health (BB-Health) Feasibility Trial (BB-Health) | Susan Roberts, Tufts University Medical School | Nutrition-based intervention to improve cognitive and brain functioning | Older adults who are overweight/ obese | 2024 |
| Modified Ketogenic Diet Effects on Alzheimer's Disease Biomarkers and Cognition in Mild Cognitive Impairment | Brain Energy for Amyloid Transformation in Alzheimer's Disease Study (BEAT-AD) | Suzanne Craft, Wake Forest University | Ketogenic diet to improve cognitive symptoms and pathology in Mild Cognitive Impairment | People with amnestic Mild Cognitive Impairment (Ages 55 - 85) | 2024 |
| Multicultural Healthy Diet to Reduce Cognitive Decline & Alzheimer's Disease Risk | Multicultural Healthy Diet to Reduce Cognitive Decline (MHD) | Yasmin Mossavar-Rahmani, Albert Einstein College of Medicine | An anti-inflammatory, multicultural health diet (MHD) to improve cognitive function in a culturally diverse population of adults | Adults (Ages 40 - 65) | 2024 |
| Dietary Modulation of Neuroinflammation in Age-Related Memory Disorders | Dietary Modulation of Neuroinflammation in Age-Related Memory Disorders | Richard Sloan, Columbia University | Cocoa-flavanol supplement to reduce systemic inflammation, improve cerebral blood volume to the hippocampus, and improve cognition | Adults (Ages 50 - 69) | 2024 |
| Enhanced Mediterranean Diet for Alzheimer's Disease Prevention | Nutrition Interventions for Cognitive Enhancement (NICE) | Debra Sullivan, University of Kansas Medical Center | To investigate the effects of a Mediterranean diet (MedD) that is enhanced with extra virgin olive oil (EVOO), almonds, and omega-3 supplements (Med+O) on cognition, brain volume, cerebral antioxidant status, and cardiometabolic biomarkers in adults without cognitive impairment | Adults (Ages 65+) | 2024 |
| Validation and Mechanistic Interrogation of Metabolism Targeting for AD | Therapeutic Diets in Alzheimer's Disease (TDAD) | Russell Swerdlow, University of Kansas Medical Center | Ketogenic diet (KD) to test whether manipulating brain energy metabolism through the KD will benefit individuals with Alzheimer's disease | People with Alzheimer's disease (Ages 50 - 90) | 2024 |
| Brain Healthy Soul Food Diet Intervention Among Older African Americans | Brain Healthy Soul Food Diet Intervention Among Older African Americans (MIND+SOUL Diet) | Ashley Shaw, University of Kansas Medical Center | Culturally-adapted, brain-healthy diet to assess body composition, cardiovascular risk, nutritional health status, and changes in cognition among older African American adults | Older African American adults (Ages 55+) | 2025 |
| MIND Diet and Dementia Prevention in Ischemic Stroke Patients | Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients | Neelum Aggarwal, Rush University Medical Center | Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND), to test impact on cognition and brain biomarkers related to dementia in patients who are recovering from acute ischemic stroke | Individuals who have suffered acute stroke (Ages 60 - 80) | 2026 |
| APOE Genotype Effects on Triglycerides and Blood Flow in the Human Brain | Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain | Angela Hanson, University of Washington | Ingestion of a high fat drink (heavy dairy cream) to gain a more in-depth understanding of how high fat feeding (HFF) exerts influence on brain function and metabolism for APOE e4 carriers and non-carriers, and identify brain regions which are particularly vulnerable to the acute effects of HFF | Older adults with and without APOE E4 (Ages 55+) | 2025 |
| Caffeine and Postoperative Neurocognitive Recovery | The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study | Phillip Vlisides, University of Michigan | Test the effects of caffeine on neurocognitive and clinical recovery after major surgery | Adult surgical patients presenting for major non-cardiac, non-intracranial, non-major vascular surgery (Ages 70+) | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Investigating Gains in Neurocognition in an Intervention Trial of Exercise | Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE) | Kirk Erickson, University of Pittsburgh | Exercise program to decrease cognitive decline associated with aging | Sedentary adults (Ages 65 - 80) | 2024 |
| Mechanisms of Adherence to Light Intensity Physical Activity to Prevent Alzheimer's Disease and Related Dementias | Daily Goal Setting to Increase Everyday Physical Activity and Promote Cognitive Health in Midlife | Jonathan Hakun, Penn State Health Milton S. Hershey Medical Center |
Adaptive Step Goals with Interim Goal Setting: participants receive daily step goals, self-monitoring, and interim goal setting on study smart phone to promote increased goal maintenance |
Middle-aged adults with increased risk for Alzheimer's disease and related dementia due to obesity | 2027 |
| Exercise to Improve Hippocampal Connectivity and Learning in Older Adults | Exercise Effects on Brain Health and Learning From Minutes to Months (EXTEND) | Michelle Voss, University of Iowa | Exercise program to improve learning and increase functional hippocampal-cortical communication that otherwise declines with aging | Sedentary Adults (Ages 55 - 80) | 2024 |
| Exercise for Brain Health with Increased Genetic Risk for Alzheimer's Disease | Exercise for Brain Health in the Fight Against Alzheimer's Disease | Jerome Smith, University of Maryland | Exercise and flexibility training programs to improve quality of life and physical function | Physically inactive adults (Ages 60 - 80) | 2024 |
| Mechanical Integrity of Memory Systems in Mild Cognitive Impairment | Aging Brain Structure and Memory in Response to Exercise | Curtis Johnson, University of Delaware | To study how the mechanical integrity of the brain changes during aging and in response to 3 months of exercise therapy, measured by determining viscoelastic properties through magnetic resonance elastography (MRE) | Healthy participants and participants with amnestic Mild Cognitive Impairment (Ages 65+) | 2024 |
| The Effect of Physical Activity on Cognition Relative to APOE Genotype (PAAD-II) | Physical Activity, Alzheimer's Disease and Cognition Relative to APOE Genotype (PAAD-2) | Jennifer Etnier, University of North Carolina at Greensboro | Physical Activity program intervention to delay the onset of Alzheimer's disease | Adults with a family history of Alzheimer's disease (Ages 40 - 65) | 2024 |
| Rhythm Experience and Africana Culture Trial | Rhythm Experience and Africana Culture Trial (REACT) | Kirk Erickson, University of Pittsburgh | To investigate whether African Dance improves cognitive, neurological, physical, psychosocial, and mood outcomes in 60- to 80-year-old African Americans | African Americans (Ages 60 - 80) | 2024 |
| Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE) | Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE) | Robert Newton, Louisiana State Univ Pennington Biomedical Research Center | Aerobic exercise & strength training programs to promote cognitive function in older African American adults | African American adults (Ages 65 - 85) | 2025 |
| FitMi AD: A Safe and Motivating Computer-guided Exercise System for Individuals with MCI or Mild Dementia Due to Alzheimer's Disease | FitMi AD Home Therapy for Individuals With MCI or Mild Dementia Due to Alzheimer's Disease | Daniel Zondervan, Flint Rehabilitation Devices (FlintRehab) | FitMi AD system, a wireless, sensorized at-home exercise device | Individuals with mild cognitive impairment or mild dementia | 2024 |
| Goal Setting to Promote Physical Activity Adherence in Midlife to Reduce Risk of Alzheimer's Disease and Related-Dementias: A Randomized Mechanistic Proof-of-Concept Trial | Goal Setting to Promote Physical Activity Adherence | Molly Maxfield, Arizona State University | The intervention is a Physical Activity (PA) Goal Setting Technique | Adults with BMI of 30 kg/m2 or greater (Ages 45 - 65) | 2024 |
| Brain Health Together: A Live-streaming Group-based Digital Program | TBD | Cynthia Benjamin, RH Studio 2 OpCo 22, Inc. | Brain Health Together, a 12-week, group-based, live streaming, digital program focused on addressing physical activity and social isolation to improve cognitive function | People living with mild cognitive impairment | 2024 |
| Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older Adults | Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment | Fuzhong Li, Oregon Research Institute | Tai Ji Quan (martial arts practice) intervention to slow cognitive decline in older adults with mild cognitive impairment | People with Amnestic Mild Cognitive Impairment (Ages 65+) | 2024 |
| Partnered Rhythmic Rehabilitation for Enhanced Motor-Cognition in Prodromal Alzheimer's Disease | Partnered Rhythmic Rehabilitation in Prodromal Alzheimer's Disease | Madeleine Hackney, Emory University | Partnered Rhythmic Rehabilitation, an intervention that simultaneously targets cardiovascular, social and motor-cognitive domains, to improve motor-cognitive function, and neuronal, vascular and inflammatory intermediaries | Adults with prodromal Alzheimer's disease (Ages 50 - 80) | 2024 |
| The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults with Down Syndrome | The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome | Lauren Ptomey, University of Kansas Medical Center | Moderate-to-vigorous physical activity in adults with down syndrome to prevent Alzheimer's disease | Adults with down syndrome (Ages 18+) | 2024 |
| Modulation Effects of Baduanjin Mind-body Exercise on Subjective Cognitive Decline | Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline (BDJ) | Jian Kong, Massachusetts General Hospital | Baduanjin (BDJ), a mind-body exercise to reduce cognitive decline | Adults (Ages 50 - 80) | 2024 |
| A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos | A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos | G. Adriana Perez, University of Pennsylvania | "Tiempo Juntos para la Salud," a multilevel intervention for Latino adults with mild cognitive impairment that includes empowerment education for behavior change and individual motivation, building support network, and promoting community resources for safe walking to reduce inactivity | Spanish language dominant Latino adults with mild cognitive impairment (Ages 55+) | 2024 |
| Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease | Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease (AEROBIC) | Jill Morris, University of Kansas Medical Center | Exercise intervention to characterize the brain metabolic response to different exercise intensity levels and measure changes in cognition | People with Alzheimer's Disease (Ages 60+) | 2025 |
| Yoga, Aerobic and Stretching Exercise Effects on Neurocognitive Performance: A Randomized Controlled Trial | Yoga, Aerobic and Stretching Exercise Effects on Neurocognition | Neha Gothe, University of Illinois | Yoga training and aerobic exercise programs to test effects on cognitive functions, neural activity and structure, and physiological parameters | Adults with normal cognition (Ages 55 - 79) | 2025 |
| CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimer's Disease | CYCLE-AD (CYcling to Cease or Limit the Effects of Alzheimer's Disease) (CYCLE AD) | Stephen Rao, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University | Indoor Cycling (high intensity; 60-90% of heart rate reserve) to slow or delay disease onset | Healthy elders at genetic risk for Alzheimer's disease; APOE e4 carriers (Ages 65 - 80) | 2025 |
| Determinants of Individual Differences in the Efficacy of Aerobic Exercise to Improve Brain Health and Reduce Alzheimer Disease Risk in Older African Americans | Exercise to Improve Brain Health in Older African Americans | Mark Gluck, Rutgers University Newark | Cardio Dance Fitness (CDF) intervention, and a Strength, Flexibility, & Balance intervention | Sedentary older African Americans (Ages 60+) | 2027 |
| Reducing African Americans Alzheimer's Disease Risk Through Exercise-MCI Cohort (RAATE-MCI) | Reducing African American's Alzheimer's Risk Through Exercise-Mild Cognitive Impairment (RAATE-MCI) (RAATE-MCI) | Robert Newton, Louisiana State Univ Pennington Biomedical Research Center | Exercise intervention to reduce risk in African Americans with Mild Cognitive Impairment | African Americans with mild cognitive impairment (Ages 65 - 85) | 2026 |
| Differential Effects of Exercise Modality on Cognition and Brain in Older Adults | Combined Exercise Trial (COMET) | Eric Vidoni, University of Kansas Medical Center | Aerobic and resistance exercise programs, to test combined and independent effects on cognitive, neural, and physical function | Healthy individuals (Ages 65 - 80) | 2026 |
| Establishing the Optimal Frequency of Dance Movement for Neurocognitive and Physical Outcomes in People at Risk of Alzheimer's Disease | Effects of Dance and Music Appreciation on Brain Health and Fitness in People at Risk for Alzheimer's Disease (IGROOVE) | Christina Hugenschmidt, Wake Forest University | Dance movement and music appreciation classes to improve cardiorespiratory fitness and cognition | Adults at risk for Alzheimer's disease due to subjective cognitive decline (Ages 65+) | 2027 |
| Influence of Exercise Training and Intensity on Cerebral Blood Flow Regulation and Cognitive Function in Mid-Life Adults With Cardiovascular Disease | Cardiac Rehab and Cerebral Blood Flow Study | Jenna-Lee Taylor, Mayo Clinic Rochester | Exercise intervention, comparing effects of High Intensity Interval Training (HIIT) vs. Medium Intensity Continuous Training (MICT) on cognitive function | Mid-life adults with cardiovascular disease | 2024 |
| Development of a Personalized Intervention to Motivate Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease | Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease | Laura Korthauer, Rhode Island Hospital | A 24-session healthy living education program, with enhanced content about health beliefs and mechanisms of behavior change | Cognitively healthy/normal adults with at least two Alzheimer's disease risk factors (Ages 45 - 69) | 2024 |
| Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity (EXEC-study) | Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity (EXEC) | Ulf Bronas, University of Illinois at Chicago | Home-based walking program to improve cognitive function in patients with co-morbid chronic kidney disease and mild cognitive impairment | Older adults with mild cognitive impairment and chronic kidney disease | 2027 |
| Dual-Task Training Exercise to Reduce Falls in Older Adults with Mild Cognitive Impairment | TBD | Fuzhong Li, Oregon Research Institute | A three-arm, single-blind, randomized controlled trial comparing efficacy of the two tai ji quan fall prevention interventions (Dual-TJQMBB, standard TJQMBB) relative to a stretching control for reducing the incidence of falls among older adults with mild cognitive impairment | Adults with mild cognitive impairment (Ages 65+) | 2028 |
| TeleExergame: An Interactive Tele-Rehabilitation Platform for Improving Motor Function in Older Adults with Cognitive Deficit | Remote Game-based Exercise Program for Cognitive and Motor Function Improvement | Bijan Najafi, BioSensics | A tele-exercise system that allows a qualified therapist to remotely supervise and interact with the patient during goal-oriented game-like and low risk exercise tasks that have been designed to improve balance and cognition | Individuals with Mild Cognitive Impairment and/or mild dementia | 2024 |
| Natives Engaged in Alzheimer's Research: IKE Kupuna (Elder Wisdom) Project | Natives Engaged in Alzheimer's Research - 'Ike Kupuna (NEAR) | Joseph Kaholokula, Washington State University | A tailored Hula dance program to prevent or slow cognitive decline | Older Native Hawaiians Pacific Islanders with uncontrolled hypertension (Ages 55+) | 2026 |
| Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease: LEAN | Lactate for Energy and Neurocognition (LEAN) | Jill Morris, University of Kansas Medical Center | Aerobic exercise and lactate infusions to understand changes in brain glucose metabolism and promote cognition | Cognitively normal people and people with Alzheimer's disease (Ages 60 - 90) | 2025 |
| Precision Medicine in Alzheimer’s Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-fitness Responses | A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses (SMART) | Fang Yu, Arizona State University | Aerobic exercise program to improve cognition and memory | People with mild Alzheimer’s disease (Ages 65+) | 2028 |
| Midwest Roybal Center for Health Promotion and Translation: Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis (Pilot) | Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis | Peixuan Zheng, University of Illinois at Chicago | Remotely-delivered aerobic and resistance exercise training to improving cognitive and physical function | Adults diagnosed with multiple sclerosis who have cognitive and walking impairment (Ages 50+) | 2024 |
| Boston Roybal Center for Active Lifestyle Interventions: Intergenerational Behavioral Intervention to Enhance Physical Activity in Older Adults at Risk for Alzheimer's Disease (HABS) (Pilot) | Intergenerational Behavioral Intervention to Enhance Physical Activity in Older Adults at Risk for Alzheimer's Disease (HABS) | Maiya Geddes, Douglas Mental Health University Institute | The Intergenerational Social Motivation Behavioral Intervention is a technology-based platform to enhance physical activity in older adults at risk for Alzheimer’s disease | Cognitively normal older adults with a first-degree family history of Alzheimer's disease (Ages 60+) | 2024 |
| mHealth-facilitated Physical Activity Toward Health (mPATH) for Cognitive Function and Sleep in Low-income Older Adults | mPATH for Low-income Older Adults | Junxin Li, Johns Hopkins Bayview Medical Center | Personalized physical activity intervention to improve cognition and sleep | Sedentary low-income older adults with sleep difficulties (Ages 65+) | 2028 |
| Midwest Roybal Center for Health Promotion and Translation: We Walk Plus Study: A Walking Program using Physical Activity Monitors and Social Network for Older Adults with Intellectual Disabilities (Pilot) | We Walk Plus Study for Older Adults With Intellectual Disabilities | Kueifang Hsieh, University of Illinois at Chicago | We Walk Plus intervention to promote physical activity and improve cognition for older adults with intellectual disabilities | Older adults with intellectual disabilities | 2024 |
| A Stage 1 Pilot Test for Feasibility and Efficacy of a Multi-level Intervention to Increase Physical Activity in Adults with Intellectual Disability: Step it Up+ | TBD | Brianne Tomaszewski, University of North Carolina at Chapel Hill | Fitness classes and coaching for persons with intellectual disabilities to increase physical activity | People with intellectual disabilities and no clinically elevated symptoms of Alzheimer's disease or related dementias (Ages 18+) | 2028 |
| Developing of a Computer-based Multimodal Mind and Body Approach for Mild Cognitive Decline | TBD | Jian Kong, Brain Thrive Technology LLC | Digital self-directed multimodal mind and body approach intervention that integrates Baduanjin, acupressure, and relaxation to improve the cognitive function for mild cognitive impairment | Individuals with mild cognitive impairment (Ages 55+) | 2024 |
| Examining the Effect of High-intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living with HIV (HEALTH-Cog) | TBD | Pariya Wheeler, University of Alabama at Birmingham | Physical activity (High-intensity interval training versus continuous moderate exercise) and coaching interventions (psychotherapy, lifestyle counseling) to test the effects on cognitive function. | People living with HIV who are stable on HIV antiretroviral therapy (Ages 50+) | 2028 |
| Breaking Prolonged Sitting with High-intensity Interval Training to Improve Cognitive and Brain Health in Older Adults | TBD | Dominika Pindus, University of Illinois | Feasibility trial of brief high intensity interval training (HIIT) exercise breaks to interupt sitting and improve cognitive function | Healthy, sedentary older adults without dementia (Ages 60 - 75) | 2025 |
| Exercise Adherence and Cognitive Decline: Engaging with the Black Community to Develop and Test a Goal Setting and Exercise Intensity Intervention | TBD | Angela Bryan, University of Colorado Anschutz Medical Campus | Moderate to vigorous physical activity intervention with goal setting that aims to target biomarkers associated with cognitive decline | Middle aged and older adults (Ages 45+) | 2025 |
| Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging Among Mid-life Adults | TBD | Laura Martin, University of Kansas Medical Center | The application will develop and refine guided imagery exercise and test whether it increases adherence to exercise among mid-life adults | Older adults able to participate in high-intensity interval training (HIIT) exercise (Ages 65 - 85) | 2027 |
| Locomotion Adaptation Deficits in Older Adults with Mild Cognitive Impairment and Alzheimer's Disease | TBD | Trisha Kesar, Emory University | Walking intervention to improve cognition and mobility | Adults with or without mild cognitive impairment or Alzheimer's disease diagnosis (Ages 50 - 90) | 2025 |
| Unraveling the Mechanisms of a Novel Music Intervention for Physical Activity Promotion in Older Adults | TBD | Jennifer Etnier, University of North Carolina at Greensboro | Rhythmic Auditory Stimulation that promotes physical activity behavior change in low-active older adults | Older adults (Ages 65+) | 2025 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Impact of Music Improvisation Training on Brain Function and Cognition among Older Adults | TBD | Julene Johnson, University of California San Francisco | Music improvisation intervention to promote improvements in self-regulation and facilitate late-life engagement in cognitively challenging activities | Neurologically healthy older and younger adults | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Adaptive Neuromodulation of Working Memory Networks in Aging and Dementia | Neuromodulation of Memory in Aging (TMS-AD) | Simon Davis, Duke University | Closed-loop transcranial magnetic stimulation (TMS) to establish parameters that can reliably control brain states during normal memory functioning in healthy aging and mild cognitive impairment | Healthy older adults and individuals with mild cognitive impairment (Ages 60 - 75) | 2027 |
| Gamma-Music Based Intervention for Mild Alzheimer's Disease | TBD | Psyche Loui, Northeastern University | Non-invasive gamma-frequency (40 Hz) light-flickering and auditory tone-stimulation | Participants with mild Alzheimer’s disease (Ages 55 - 90) | 2027 |
| Individualized Closed-Loop Neuromodulation Therapy for Alzheimer's Disease | Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease | Joan Camprodon, Massachusetts General Hospital | Closed-loop transcranial Alternating Current Stimulation (tACS) at 40 Hz to modulate brain oscillations and cognition, as an individualized and potential disease-modifying precision therapy for Alzheimer's disease | Participants with Alzheimer's disease (Ages 50 - 80) | 2024 |
| Treating Mild Cognitive Impairment with Transcranial Direct Current Stimulation | Stimulation to Improve Memory (STIM) | Benjamin Hampstead, University of Michigan | Transcranial direct current stimulation (tDCS) to treat mild cognitive impairment | People with mild cognitive impairment (Ages 65+) | 2024 |
| Treating Mild Cognitive Impairment with Transcranial Direct Current Stimulation | STIM+: PET Biomarker Education & Disclosure (STIM+) | Benjamin Hampstead, University of Michigan | Transcranial direct current stimulation | Older adults with mild cognitive impairment | 2024 |
| Gamma Induction for Amyloid Clearance in Alzheimer's Disease | Gamma Induction for Alzheimer's Disease | Emiliano Santarnecchi, Massachusetts General Hospital | Transcranial Alternating Current Stimulation (tACS) to induce increase in gamma oscillations, and assess acute and long-lasting changes in Aß and p-tau levels via PET imaging to investigate the clinical, neurophysiological and cognitive impact | Adults with mild to moderate Alzheimer's disease (Ages 45+) | 2023 |
| Treating Primary Progressive Aphasia And Elucidating Neurodegeneration In the Language Network Using Transcranial Direct Current Stimulation | Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS | Roy Hamilton, University of Pennsylvania | High definition transcranial direct stimulation (tDCS) of the left frontal lobe with the goal of developing a potential treatment for primary progressive aphasia (PPA) | Adults with either nonfluent/agrammatic primary progressive aphasia (PPA) or logopenic variant PPA (Ages 45 - 80) | 2025 |
| Evaluating the Neurocomputational Mechanisms of Explore-Exploit Decision Making in Older Adults | Evaluating the Neurocomputational Mechanisms of Explore-Exploit Decision Making in Older Adults | Robert Wilson, University of Arizona | Transcranial Magnetic Stimulation (TMS) to vertex, right inferior frontal gyrus, and right frontal pole to explore effects on decision-making | Healthy younger adults (Ages 18 - 30) and older adults (Ages 65 - 74), with no subjective memory complaints. | 2024 |
| Improving Working Memory in Older Adults by Restoring Large-Scale Cortical Interactions | Improving Working Memory in Older Adults | Robert Reinhart, Boston University | High-definition transcranial alternating-current stimulation of the frontal and temporal cortex, to improve working memory and cognition | Younger adults (Ages 18 - 30) and older adults (Ages 68 - 80) | 2024 |
| Revitalizing Cognition in Older Adults at Risk for Alzheimer's Disease with Near-Infrared Photobiomodulation | The Revitalize Study in Older Adults at Risk for Alzheimer's Disease | Dawn Bowers, University of Florida | Infrared stimulation to assess improvements in cognition function and network connectivity | Older adults with subjective cognitive complains and family history of Alzheimer's disease (Ages 65 - 89) | 2024 |
| Enhancement of Hippocampal Plasticity Using Repetitive Transcranial Magnetic Stimulation | Enhancement of Hippocampal Plasticity Using Repetitive Transcranial Magnetic Stimulation | Ying-Hui Chou, University of Arizona | Repetitive Transcranial Magnetic Stimulation (rTMS) in hippocampus to determine its therapeutic effect on memory function and brain plasticity | People with Amnestic Mild Cognitive Impairment (Ages 50 - 80) | 2025 |
| Non-Invasive Home Neurostimulation for Mild to Moderate Alzheimer's Disease: Double-Blind, Sham Controlled Randomized Clinical Trial | NeurostImulation for Cognitive Enhancement in Alzheimer's Disease (NICE-AD) | Joe Verghese, Albert Einstein College of Medicine | Transcranial direct current neurostimulation (tDCS) at home intervention to improve cognitive performance and symptoms in patients with mild to moderate Alzheimer’s Disease | People with Alzheimer's disease (Ages 60+) | 2025 |
| Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD) | Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD) | Dan Iosifescu, New York University School of Medicine | Transcranial Photobiomodulation (t-PBM), which penetrates robustly into the cerebral cortex, stimulating the mitochondrial respiratory chain, and significantly increasing cerebral blood flow, to improve cognitive deficits | People with Amnestic Mild Cognitive Impairment (Ages 65 - 85) | 2025 |
| Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment | Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment | Nanthia Suthana, University of California Los Angeles | Theta burst transcranial magnetic stimulation, a non-invasive neuromodulation method applied to brain areas that are functionally connected to the hippocampus in order to improve/restore memory function | People with Amnestic Mild Cognitive Impairment (Ages 60 - 90) | 2025 |
| Transcranial Direct Current Stimulation in Typical and Atypical Alzheimer's Disease | Effects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer's Disease | Kyrana Tsapkini, Johns Hopkins Bayview Medical Center | Transcranial direct current neurostimulation (tDCS) to improve clinical symptoms of mild cognitive impairment | People with probable Alzheimer's disease (Ages 50+) | 2025 |
| The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance | The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance (WALLe) | Heidi Jacobs, Massachusetts General Hospital | Transcutaneous vagus nerve stimulation (tVNS) to improve cognitive function | At-risk older adults (Ages 60 - 85) | 2026 |
| Targeting Language-Specific and Executive-Control Networks with Transcranial Direct Current Stimulation in Aphasic AD | Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA | Kyrana Tsapkini, Johns Hopkins Bayview Medical Center | Transcranial direct current stimulation (tDCS) applied to brain networks that underlie several language-specific vs. executive cognitive functions to maximize the benefits of tDCS in the treatment of neurodegenerative disease | Individuals with primary progressive aphasia (Ages 50 - 80) | 2027 |
| The Power of 40 Hz Sound/Music for Older Adults with Mild Cognitive Impairment | Sound and Music for Mild Cognitive Impairment | Junxin Li, Johns Hopkins Bayview Medical Center | Feasibility and preliminary efficacy of 40 Hz music (Condition A), 40 Hz sound (Condition B) and preferred music (Condition C) on neural gamma activity and cognitive function in community-dwelling older adults with amnestic mild cognitive impairment | Older adults with amnestic MCI (65+ years of age) | 2024 |
| Interleaved TMS-fMRI for Hippocampal Stimulation: Modeling Dose-Response Relationship in Amnestic Mild Cognitive Impairment | Interleaved TMS-fMRI for Hippocampal Stimulation: Modeling Dose-Response Relationship in Amnestic Mild Cognitive Impairment (TMS-fMRI) | Ying-Hui Chou, University of Arizona | Spaced Theta burst stimulation (TBS) to improve memory performance and hippocampal function in mild cognitive impairment | Individuals with amnestic mild cognitive impairment | 2024 |
| Multifocal Transcranial Current Stimulation for Cognitive and Motor Dysfunction in Dementia | Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia (ACDCStim) | Alvaro Pascual-Leone, Hebrew SeniorLife and Hebrew Rehabilitation Center | Transcranial alternating current stimulation targeting the left angular gyrus (tACS) at gamma frequency and transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex | Older adults with mild dementia (Ages 55+) | 2027 |
| Phase II Clinical Trial of Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia | Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia | Kyrana Tsapkini, Johns Hopkins Bayview Medical Center | Transcranial direct current stimulation (tDCS) therapy in primary progressive aphasia (PPA) | Older adults with primary progressive aphasia (Ages 50 - 80) | 2027 |
| Accelerating Cognitive Gains from Digital Meditation with Noninvasive Brain Stimulation: A Pilot Study in MCI | TBD | David Ziegler, University of California San Francisco | Closed-loop digital meditation (MediTrain) and transcranial alternating current stimulation (tACS) to improve cognition and wellbeing in adults with mild cognitive impairment | Mild cognitive impairment (Ages 60 - 85) | 2025 |
| Modulation of Hippocampal Circuitry and Memory Function with Focused Ultrasound in Amnestic MCI | Modulation of Hippocampal Circuitry and Memory Function With Focused Ultrasound in Amnestic MCI (LIFUP-MCI) | Susan Bookheimer, University of California Los Angeles | Low intensity focused ultrasound pulsation (LIFUP) to improve learning and memory | Adults (Ages 75+) | 2026 |
| Multimodal Musical Stimulation for Healthy Neurocognitive Aging | TBD | Psyche Loui, Northeastern University | Gamma frequency stimulation is administered via lights, and tuned to user-defined music; participants receive the intervention by listening to music while watching lights | Neurologically healthy older and younger adults | 2024 |
| Transcranial Magnetic Stimulation for MCI: A Phase II Dose-response Study | Transcranial Magnetic Stimulation for MCI (PUSH2) | Andreana Benitez, Medical University of South Carolina | Intermittent theta-burst repetitive transcranial magnetic stimulation (iTBS-rTMS) to improve cognitive function and depression | People with Mild Cognitive Impairment and Major Depressive Disorder (Ages 60 – 85) | 2028 |
| Neuromodulation of Brain Network Function in Preclinical and Prodromal Alzheimer's Disease | TBD | Alexandra Touroutoglou, Massachusetts General Hospital | Repetitive transcranial magnetic stimulation (rTMS) to improve brain function and improve symptoms in Alzheimer's disease | Amyloid-positive people with and without amnestic mild cognitive impairment (Ages 65 – 85) | 2025 |
| Personalized Synchronization of Cortical Rhythms to Improve Memory in Alzheimer's Disease | TBD | Robert Reinhart, Boston University | Personalized non-invasive brain stimulation to improve memory | Cognitively healthy older adults, persons with mild cognitive impairment, or persons with Alzheimer's disease (Ages 50 - 100) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Light, Metabolic Syndrome and Alzheimer’s Disease: A Non-Pharmacological Approach | Light and the Effect on Metabolic Syndrome and Alzheimer's Disease | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | 8-week Tailored Lighting intervention (TLI). The active TLI will provide high circadian stimulation during the day produced by light sources that provide moderate light levels of spectra that are tuned to the sensitivity of the circadian system | Older adults with mild to moderate Alzheimer's Disease diagnosis and Type 2 diabetes (Ages 55+) | 2024 |
| Understanding Circadian Responses to Light in Persons with Mild Cognitive Impairment and Alzheimer's Disease | Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Lighting interventions to suppress melatonin and promote better sleep and cognition | Older adults with mild cognitive impairment | 2024 |
| A Non-pharmacological Multi-Modal Therapy to Improve Sleep and Cognition and Reduce Mild Cognitive Impairment Risk | Enhanced CBTi for Older Adult Sleep and Cognition | Daniel Gartenberg, Proactive Life, Inc | Internet of Things (IoT) devices, such as the FitBit, Apple Watch, and Oura Ring, to improve sleep and reduce mild cognitive impairment | Cognitively healthy older adults (Ages 65+) | 2023 |
| Primary Prevention of Alzheimer's Disease: Examining the Effects of Cognitive Behavioral Therapy on Cognitive Function and Amyloid-beta in Older Adults with Symptoms of Insomnia | SIESTA: Sleep Intervention to Enhance Cognitive Status and Reduce Beta Amyloid | Catherine Siengsukon, University of Kansas Medical Center | CBT-I, cognitive behavioral therapy for insomnia | People with difficulty falling asleep, maintaining sleep, or waking up too early at least 3 nights per week for the past 3 months (Ages 60 - 85) | 2024 |
| Personalized OSA Treatment and Effects on AD Biomarkers and Cognition Among Blacks | TBD | Girardin Jean-Louis, University of Miami School of Medicine | Personalized OSA Treatment Adherence Model (PRAISE), a personalized obstructive sleep apnea (OSA) treatment adherence model; participants will be exposed to either personalized OSA videos (intervention arm) or standard online videos (control arm) | Older black adults newly diagnosed with obstructive sleep apnea (Ages 60 – 85) | 2027 |
| The Long-Term Impact of Light Intervention on Sleep Physiology and Cognition in Mild Cognitive Impairment | The Long-term Impact of a Light Intervention on Sleep and Cognition in Mild Cognitive Impairment | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Light intervention to improve sleep and mild cognitive impairment | People with amnestic mild cognitive impairment or mild Alzheimer's disease (Ages 65+) | 2024 |
| The Impact of Sex Hormones on Sleep-Dependent Memory in Young and Midlife Men and Women | TBD | Fiona Baker and Sara Mednick, SRI International | Closed-loop targeted memory reactivation (CL-TMR) uses targeted auditory cueing during the precise phase of the slow oscillation to enhance sleep spindles and boost memory | Women (Ages 46 – 54) | 2024 |
| Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease | Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease | Atul Malhotra, University of California San Diego | Supplemental oxygen and Continuous Positive Airway Pressure (CPAP) machine to determine if oxygen is a viable therapeutic strategy to improve memory | Cognitively healthy older adults (Ages 65-85) | 2025 |
| Slow-wave Sleep Enhancement in Those At-Risk for Alzheimer's Disease: Links with Memory, Excitotoxicity, and Plasma A-beta | Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease (ALPS) | Kristine Wilckens, University of Pittsburgh | Habitual slow-wave sleep enhancement to improve cognition | Older adults (Ages 65 - 85) | 2026 |
| The Use of Rhythmic Light Therapy to Entrain Gamma Oscillations and the Circadian System in Patients with Alzheimer's Disease and Related Dementias (ADRD) | Rhythmic Light Therapy for Alzheimer's Disease Patients | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Rhythmic Light Therapy to improve sleep and cognition | Older adults with mild cognitive impairment | 2026 |
| Home Sleep Therapy System for Mild Cognitive Impairment | TBD | Don Tucker, Brain Electrophysiology Laboratory Company, Llc | Neurosom® Electric Sleep Therapy (NEST) system to allow researchers to conduct transcranial electrical stimulation (TES) studies to improve sleep in seniors with mild cognitive impairment | Adults with amnestic mild cognitive impairment (Ages 55 - 85) | 2023 |
| Internet-Based Insomnia Intervention to Prevent Cognitive Decline in Older Adults with Mild Cognitive Impairment | Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND) | Meghan Mattos, University of Virginia | Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention | Older adults with mild cognitive impairment and insomnia (Ages 65+) | 2027 |
| Light, Metabolic Syndrome And Alzheimer's Disease: A Non-Pharmacological Approach | Light, Metabolic Syndrome and Alzheimer's Disease - Aim 2 | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Tailored Lighting Intervention to improve sleep disturbances, inflammation, insulin sensitivity (Si) and glucose disposal (Sg) and cognition in patients with mild cognitive impairment or mild Alzheimer's disease and related dementias (AD/ADRD) and sleep disturbances | Adults with Alzheimer's disease and related dementias (AD/ADRD) who live in controlled environments (i.e., assisted living facilities and nursing homes) | 2024 |
| Use of 7T Multimodal Imaging to Detect Brain Changes Associated with Light Therapy in Persons with Mild Cognitive Impairment and Mild Alzheimer's Disease | 7T MRI for Light Therapy in Patients With Mild Cognitive Impairment and Mild AD | Priti Balchandani, Icahn School of Medicine at Mount Sinai | High-resolution multi-modal 7T imaging to investigate the impact of lighting intervention therapy (LIT) on sleep physiology and brain structure, function, and connectivity in people with mild cognitive impairment and mild Alzheimer's disease | Amnestic mild cognitive impairment or mild Alzheimer's disease patients with a confirmed Aß+ PET scan | 2024 |
| Methodology Issues in a Tailored Light Treatment for Persons with Dementia - Aim 2 | Methodology Issues in a Tailored Light Treatment for Persons With Dementia - Aim 2 | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Light exposure treatment to investigate the effect on sleep, mood, and agitation in persons with Alzheimer's disease or related dementias living in assisted living and nursing home settings | Individuals with Alzheimer's disease or related dementias and sleep problems (Ages 65+) | 2025 |
| Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL) | TBD | Katie Stone, California Pacific Medical Center (Sutter Health) | Obstructive sleep apnea therapies including positive airway pressure, oral appliance therapy, and positional therapy, to promote cognitive function in older adults | Cognitively normal older adults with moderate to severe obstructive sleep apnea (Ages 55 - 75) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Enhancing Social Engagement through Online Gameplay for Older Adults with and without Mild Cognitive Impairment | TBD | Dillon Myers, Potluck, LLC | OneClick, an online social engagement platform, to benefit health outcomes affected by social engagement (survival, onset of dementia) | Adults with mild cognitive impairment | 2024 |
| Center for Research and Education on Aging and Technology Enhancement - CREATE: Virtual Reality to Support Cognitive Health and Engagement and Socialization Among Aging Adults | Virtual Reality to Support Aging Adults | Sara Czaja, Joan and Sanford I Weill Medical College of Cornell University | Virtual reality program for social activity and cognitive engagement | Community dwelling older adults with mild cognitive impairment | 2027 |
| Center for Research and Education on Aging and Technology Enhancement - CREATE: Technology Support for Cognition and Social Engagement for Aging Adults with Mild Cognitive Impairment (MCI) | A Software System to Support Aging Adults With A Cognitive Impairment | Sara Czaja, Joan and Sanford I Weill Medical College of Cornell University | Intelligent Adaptive System, an innovative intelligent adaptive software package aimed at providing social and cognitive support to older adults with mild cognitive impairment | Cognitively diverse older adults | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Association of Perceived Stress and Cognition | PRogram to Improve Stress-levels and Enhance Memory (PRISEM) | Ambar Kulshreshtha, Emory University | A web-based multidisciplinary stress reduction program to examine the association of stress and cognition, role of cardiovascular disease risk factors, and related health disparities | African Americans and White adults with mild cognitive impairment | 2025 |
| Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease | Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease (Stress-AD) | Cynthia Munro, Johns Hopkins Bayview Medical Center | Response to an acute stressor (trier social stress test) in mild cognitive impairment | Adults with mild cognitive impairment | 2027 |
| Optimizing a Closed-loop Digital Intervention for Remediating Cognitive Decline and Reducing Stress in Older Adults | TBD | David Ziegler, University of California San Francisco | MediTrain, a digital meditation intervention to reduce cogntiive decline and emotional stress | Older adults | 2027 |
| PATH-Pain: A Primary Care-Based Psychosocial Intervention to Improve Cognitive and Depression Outcomes in Older Adults with MCI and Early Stage AD | A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD (PATH-Pain) | Dimitris Kiosses, Joan and Sanford I Weill Medical College of Cornell University | Problem Adaptation Therapy for Pain (PATH-Pain) primary-care based psychosocial intervention designed to reduce stress | Adults with mild cognitive impairment or early stage Alzheimer's disease (Ages 60+) | 2026 |
| Targeting Cognitive Function and Interoceptive Awareness to Improve Self-management in Patients with Co-morbid Heart Failure and Cognitive Impairment | Mind Your Heart-II (MYH-II) | Elena Salmoirago-Blotcher, Miriam Hospital | A mindfulness training intervention to improve cognitive function in patients with co-morbid heart failure and cognitive impairment | Individuals with mild cognitive impairment and heart failure | 2027 |
| Effects of Acute Stress Exposure on Plasma Beta-Amyloid Levels | Acute Alzheimer's Disease Biomarker Responses | Mara Mather, University of Southern California | Measure the plasma beta-amyloid response to an acute laboratory stressor using the socially evaluated cold pressor test (SECPT) to aid in understanding how stress contributes to Alzheimer's disease development and progression in people | Healthy adults (Ages 18-65) | 2024 |
| A Pilot Study of the Impact of Personalized Digital Meditation on Improving Cognition and Sleep and Reducing Stress in MCI | TBD | David Ziegler, University of California San Francisco | Closed-loop digital meditation to improve cognitive function, sleep, and stress in older adults | Older adults with mild cognitive impairment and cognitively normal older adults (Ages 60 - 85) | 2025 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Addressing the Chronic Pain-Early Cognitive Decline Comorbidity Among Older Adults; The Active Brains Study | Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain | Ana-Maria Vranceanu, Massachusetts General Hospital | Two symptom management programs, Active Brains-Digital (AB-D) and Health Enhancement Program (HEP), to assess how each program may help in improving multimodal physical, cognitive, and emotional function | Older adults with nonmalignant chronic pain for more than 3 months and early cognitive decline (Ages 60+) | 2027 |
| Hyperbaric Oxygen Therapy for Cognition in Diabetic Elderly at High Dementia Risk | Hyperbaric Oxygen Therapy for Cognition in Diabetic Elderly at High Dementia Risk | Michal Schnaider Beeri, Icahn School of Medicine at Mount Sinai | Hyperbaric oxygen therapy intervention to improve cognitive function and increase cerebral blood flow and glucose utilization in people with mild cognitive impairment | People with mild cognitive impairment and diabetes (Ages 65+) | 2024 |
| Long-Term Effects of Hearing Intervention on Brain Health in the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) Randomized Study | ACHIEVE Brain Health Follow-Up Study (ACHIEVE-BHFU) | Frank Lin, Johns Hopkins Bayview Medical Center | Follow up of ACHIEVE cohort for an additional three years to determine the long- term effects of hearing intervention (i.e., participants randomized to hearing intervention at Year 0) versus successful aging/delayed hearing intervention control (i.e., participants randomized to successful aging intervention at Year 0 and offered the hearing intervention after their Year 3 visit) on cognitive and brain outcomes | Older adults with mild-to-moderate hearing loss and a MMSE score greater than or equal to 23 (Ages 73 - 89) | 2027 |
| Development and Evaluation of Computerized Olfactory Training Program (COT) for Cognitive Decline in Early Alzheimer's Disease (AD) | Development and Evaluation of Computerized Olfactory Training Program for Cognitive Decline in Early Alzheimer's Disease | Sumeet Seth, EvON Medics | Computerized Olfactory Training Program (COT), a portable, home-based product to prevent progressive cognitive decline and progressive dementia in early Alzheimer's Disease | Adults with diagnosis of probable mild Alzheimer's disease (Ages 65 - 85) | 2024 |
| Optimizing Anesthesia to Prevent Postoperative Cognitive and Functional Decline in Older Adults | TBD | Katie Schenning, Oregon Health and Science University | IV vs. inhalational anesthesia on post-operative delirium, post-operative cognitive dysfunction, functional status, and patient-reported outcomes | Older adults undergoing elective inpatient non-cardiac surgery (Ages 75+) | 2027 |
| Brain Safe: Consumer Intervention to Reduce Exposure to Drugs Linked to Alzheimer's Disease | Brain Safe: Consumer Intervention to Reduce Exposure to Drugs Linked to Alzheimer's Disease | Richard Holden, Indiana University | Digital Brain Safe mobile app to reduce exposure to anticholinergic drugs | Adults who have taken at least 1 anticholinergic medication within the past 90 days (Ages 65+) | 2024 |
| Reducing Risk of Dementia through De-prescribing (R2D2) | Reducing Risk of Dementia Through Deprescribing (R2D2) | Noll Campbell, Purdue University | Pharmacist-driven de-prescribing protocol focused only on targeted anticholinergic medications | Older adults with subjective cognitive dysfunction and at least one order for a strong anticholinergic medication in the previous 12 months (Ages 65+) | 2024 |
| Impacts of Receiving Alzheimer's Disease Genetic Risk Information Among Latinos in Northern Manhattan | Information About Alzheimer's Disease for Latinos in New York City (IDEAL) | Ruth Ottman, Columbia University | Information about risk of Alzheimer's disease given to participants based on their APOE genotypes, in addition to Latino ethnicity and family history, to assess the psychosocial and behavioral impacts | Latino or Hispanic adults (Ages 40 - 64) | 2024 |
| RETAIN: A Digital Therapeutic for Alzheimer's Risk Reduction | TBD | Mark Mcinnis, RETAIN Health, Inc. | Digital therapeutic designed to reduced risk of Alzheimer's disease | Normal healthy volunteers with a family history of Alzheimer's disease | 2024 |
| Returning Research Results that Indicate Risk of Alzheimer's Disease to Healthy Participants in Longitudinal Studies | Returning Research Results That Indicate Risk of Alzheimer's Disease Dementia to Healthy Participants in Longitudinal Studies (WeSHARE) | Sarah Hartz, Washington University in St. Louis | Returning research results to participants to measure impact on cognitive and psychosocial outcomes | Cognitively normal individuals who have had imaging studies within 18 months, APOE genotyping, and are scheduled for annual visits | 2025 |
| Neurocognitive Impairment Assessment in Symptomatic Carotid Occlusion Recanalized Endovascularly: NIA SCORE | NeuroCognition After Carotid Recanalization (NIA-SCORE | David Hasan, Duke University | Endovascular techniques (or hybrid of carotid endarterectomy and endovascular techniques) to improve cognitive outcomes in individuals with complete occlusion of the internal carotid artery (COICA) | Adults with complete occlusion of the Internal carotid artery (ICA) due to atherosclerotic disease, a recent history of a transient ischemic attack or stroke, and a MoCA < 26 (Ages 21 - 70) | 2024 |
| Enhancing Gamma Band Response to Improve Working Memory in Individuals with Mild Cognitive Impairment | Neurofeedback to Improve Working Memory in Mild Cognitive Impairment | Fiza Singh, University of California San Diego | EEG-neurofeedback (EEG-NFB) computer-based brain training program to improve working memory in individuals with amnestic mild cognitive impairment | People with Amnestic Mild Cognitive Impairment (Ages 60 - 85) | 2025 |
| Health Beliefs, Glycemic Control, and Preventing Cognitive Decline in African Americans with Diabetes and Mild Cognitive Impairment: A Randomized Clinical Trial | Health Beliefs, Glycemic Control, and Preventing Cognitive Decline in African Americans With Diabetes and Mild Cognitive Impairment: A Randomized Clinical Trial (DREAM) | Barry Rovner, Thomas Jefferson University | Diabetes Mellitus-Specific Behavioral Activation (DM-BA) to prevent decline in verbal memory in African American adults with amnestic multiple-domain mild cognitive impairment | African-American adults with amnestic mild cognitive impairment and poorly controlled diabetes mellitus (Ages 65+) | 2025 |
| Compensation Training and Lifestyle Modifications to Promote Healthy Aging in Persons at Risk for Alzheimer's Disease: A Digital Application Supported Intervention | Brain Boosters 2 in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention (BB2) | Sarah Tomasweski-Farias, University of California Davis | Digital Memory Notebook intervention, an interactive application used to facilitate behavioral change and enhanced motivation | People with Alzheimer's disease or mild cognitive impairment (Ages 65 - 90) | 2025 |
| ADRD Prevention Messaging to Increase Smoking Cessation Attempts in Older Adult Smokers | Motivating Change in Aging Smoker | Adrienne Johnson, University of Wisconsin - Madison | Motivation to Quit Intervention to increase motivation to quit, quit attempts, and use of evidence-based smoking treatments (EBSTs) for older adult smokers | Older adult smokers (Ages 50 - 80) | 2026 |
| Clinical Trial of Vestibular Therapy to Reduce Falls in Patients with Alzheimer's Disease | Vestibular Therapy in Alzheimer's Disease | Yuri Agrawal, Johns Hopkins Bayview Medical Center | Vestibular therapy to reduce falls and improve balance in older adults with mild to moderate Alzheimer's disease and vestibular loss | Adults with mild-moderate Alzheimer's disease & vestibular loss (Ages 60+) | 2026 |
| Characterizing and Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging | Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging | Natalie Ebner, University of Florida | Neurofeedback training using real time fMRI to increase activity in the anterior cingulate gyrus to improve learning | Healthy older adults (Ages 60 - 85) | 2027 |
| Intermittent Hypoxia Training: A Novel Therapy for Mild Cognitive Impairment | IHT for Mild Cognitive Impairment | Xiangrong Shi, University of North Texas Health Science Center | An intermittent-hypoxia training (IHT) program to prevent or reverse cognitive decline and neurodegeneration in mild cognitive impairment | Individuals with amnestic mild cognitive impairment | 2025 |
| Mediators and Moderators of Auditory Training | TBD | Aaron Seitz, Northeastern University | An auditory training intervention to mitigate hearing issues that promote dementia risk | Older adults (ages 60 - 85) with no more than typical hearing loss for their age, no evidence of dementia and comparison younger adults (ages 18 - 30) with normal hearing | 2027 |
| Center for Research and Education on Aging and Technology Enhancement - CREATE: Technology Tools for Cognitive Support for Health Management Activities for Aging Adults With and Without Mild Cognitive Impairment | Digital Tools to Support Healthcare Decision Making | Sara Czaja, Joan and Sanford I Weill Medical College of Cornell University | Intelligent Decision Support Tool, an innovative intelligent decision tool for health decisions aims at providing health management support for older adults with and without mild cognitive impairment | Cognitively diverse older adults | 2027 |
| My Healthy Brain: A Mindfulness-Based Lifestyle Intervention to Modify Early Risk of Dementia in Older Adults | Brain Health Program for Older Adults With Subjective Cognitive Decline | Ryan Mace, Massachusetts General Hospital | My Healthy Brain (MHB) teaches education, mindfulness skills, and behavior change principles. All MHB skills were adapted to account for commonly reported Subjective Cognitive Decline symptoms (e.g., forgetfulness) and co-morbid psychological barriers (e.g., low motivation) that can interfere with lifestyle behavior change. | Medical providers and older adults at risk for Alzheimer's disease and related dementia (Ages 60+) | 2027 |
| Early Age-Related Hearing Loss Investigation (EARHLI): A Randomized Controlled Trial to Assess Mechanisms Linking Early Age-Related Hearing Loss and Alzheimer's Disease and Related Dementia | TBD | Justin Golub, Columbia University | Hearing aids to prevent cognitive decline in those at risk for Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) | Older adults with early-stage age-related hearing loss (ARHL) and amnestic mild cognitive impairment (55 - 75 years of age) | 2027 |
| Effects of Resonance-Frequency Breathing on Preclinical Alzheimer’s Disease Biomarkers and Cognition | TBD | Mara Mather, University of Southern California | Ten weeks of daily paced breathing sessions to determine whether resonance breathing improves plasma Alzheimer's disease (AD) biomarkers, identify how resonance-frequency breathing affects plasma AD biomarkers, assess whether daily resonance-frequency breathing accelerates consolidation of new learning, and compare effects in African Americans vs. European Americans | Cognitively normal African-American and European-American adults (Ages 50 - 70) | 2028 |
| Assessing the Feasibility and Acceptability of a Time Restricted Feeding Intervention Among Older Adults With Mild Cognitive Impairment | TBD | Patrick Smith, University of North Carolina at Chapel Hill | Time restricted fasting intervention to improve metabolic and cognitive health | Amnestic mild cognitive impairment (Ages 65 - 80) | 2025 |
| Remote Monitoring and Virtual Collaborative Care for Hypertension Control to Prevent Cognitive Decline | Remote Monitoring and Virtual Collaborative Care For Hypertension Control to Prevent Cognitive Decline Phase II (vCCC 2) | Jeffrey Burns, University of Kansas Medical Center | Remote blood pressure monitoring and management through a virtual Collaborative Care Clinic (vCCC) | Older adults with hypertension | 2025 |
| Bilingual Factors Associated with Cognitive Reserve and Linguistic Resilience in Hispanics with Primary Progressive Aphasia | Bilingual Factors Associated with Cognitive Reserve and Linguistic Resilience in Hispanics with Primary Progressive Aphasia | Stephanie Grasso, University of Texas at Austin | Naming intervention for individuals with logopenic or semantic variant primary progressive aphasia (PPA) or script training intervention for individuals with nonfluent/agrammatic PPA | Bilingual individuals with PPA | 2027 |
| The Use of Rhythmic Light Therapy to Entrain Gamma Oscillations and the Circadian System in Patients with Alzheimer's Disease and Related Dementias (ADRD) | Phase 2 - Rhythmic Light Therapy for Alzheimer’s Disease | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Gamma oscillation entrainment for persons with amnestic mild cognitive impairment or mild Alzheimer's disease to improve sleep and cognition | People with amnestic mild cognitive impairment or mild Alzheimer's disease (Ages 55+) | 2026 |
| Attentional Mechanisms of Cognitive Compensation in Subjective Cognitive Decline and AD Risk | Attentional Mechanisms in SCD (AMoCC-SCD) | Kimberly Albert, Vanderbilt University Medical Center | Mecamylamine, a centrally and peripherally active non-competitive antagonist of acetylcholine at C6 (ganglionic) type nicotinic receptors, to better identify older adults at risk for Alzheimer’s Disease | Community-dwelling Chinese American older adults (Ages 55+) | 2028 |
| Time Restricted Eating for Prevention of Age-Related Vascular Cognitive Decline in Older Adults | The Effect of Intermittent Fasting on Brain Health | Andriy Yabluchanskiy, University of Oklahoma | Time restricted eating intervention to improve neurovascular function and cognitive performance | Older adults (Ages 55 - 80) | 2025 |
| Feasibility of Improving Glycemia to Prevent Alzheimer's Disease | TBD | Jill Morris, University of Kansas Medical Center | Heat therapy to improve systemic blood glucose metabolism to reduce risk for Alzheimer's disease | Cognitively healthy people (Ages 65+) | 2028 |
Section 4: Dementia Care and Caregiver
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Preparation for End of Life Decision Making in Mild Alzheimer's Disease | Two-Phased Study of SPIRIT in Mild Dementia | Mi-Kyung Song Emory University | SPIRIT (Sharing Patient's Illness Representation to Increase Trust), a patient- and family-centered advanced care planning (ACP) intervention based on the Representational Approach to Patient Education to promote cognitive and emotional preparation for end-of-life decision making | Patient (mild Alzheimer's disease)-surrogate dyads (Ages 18+) | 2024 |
| Pragmatic Trial to Improve Communication for Primary Care Patients with ADRD | Improving Communication for Primary Care Patients | Jennifer Wolff, Johns Hopkins Bayview Medical Center | SHARING Choices (Sharing access to Health records, Agenda setting and RespectING Choices to Engage Families), a multicomponent communication intervention that seeks to proactively engage family members and support advance care planning (ACP) in primary care | Adults with Alzheimer's disease and related dementias (AD/ADRD) (Ages 65+) | 2024 |
| POST Facilitation for Community Dwelling Older Adults with and without Dementia | POST Facilitation for Community Dwelling Older Adults (POST-RCT) | Alexia Torke, Indiana University-Purdue University Indianapolis | Physician Orders for Scope of Treatment (POST), a virtual at-home advanced care planning (ACP) intervention to make decisions about care goals and to record preferences in writing | Frail, older community dwelling adults (Ages 65+) and their surrogate decision maker | 2024 |
| Involving Family to Improve Advance Care Planning for Primary Care Patients with ADRD | SHARE: Sharing Healthcare Wishes in Primary Care | Jennifer Wolff, Johns Hopkins Bayview Medical Center | Sharing Healthcare Wishes in Primary Care (SHARE), a multicomponent communication intervention to proactively engage family members or friends to support advance care planning in primary care | Persons with cognitive impairment (Ages 80+) and family dyads | 2024 |
| Decision Making and Implementation of Aging-in-Place/Long Term Care Plans among Older Adults | Decision Making and Implementation of Aging-in-Place/Long Term Care Plans Among Older Adults | Lee Lindquist, Northwestern University | Plan Your Lifespan, a web-based decision-making and planning tool to examine the mediating/moderating factors involved in decision-making, timing of decision implementation, and goal concordance for older adults aging-in-place/long term care | Community-dwelling older adults (Ages 55+) | 2024 |
| Effectiveness of Engaging in Advance Care Planning Talks (ENACT) Group Visits Intervention in Primary Care for Older Adults with and without Alzheimer's Dementia | Effectiveness of Engaging in Advance Care Planning Talks (ENACT) Group Visits in Primary Care for Older Adults With and Without Alzheimer's Disease (ENACT) | Hillary Lum, University of Colorado Anschutz Medical Campus | ENgaging in Advance Care planning Talks (ENACT) Group Visits intervention to increase advance care planning (ACP) documentation among older adults in primary care settings, including older adults with cognitive impairment | Older adults that have at least one primary care clinic visit in the past 12 months (Ages 70+) | 2026 |
| Implementation Strategies to Promote Advance Care Planning among Persons Living with ADRD and Those with Mild Cognitive Impairment in Outpatient Primary Care Practices | TBD | Jennifer Gabbard, Wake Forest University | ACPdSmart is a dementia-specific portal-based tool for advance care planning engagement | Adults with recognized or probable mild cognitive impairment or mild dementia, yet retain decisional capacity to complete advance care planning (Ages 65+) | 2027 |
| Hybrid Efficacy/Effectiveness Trial to Promote Goals-of-Care Discussions for Patients with Alzheimer's Disease and Related Dementias and their Family Caregivers | Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers (PICSI-M) | Erin Kross, University of Washington | "Jumpstart", a one-page guide using patient-specific information to prompt and guide clinicians in goals-of-care discussions | Adults with an ICD10 code for Alzheimer's disease and related dementias (AD/ADRD) in the electronic health record (EHR) in the prior two years (Ages 55+) | 2027 |
| Meeting the Challenges of COVID-19 by Expanding the Reach of Palliative Care: Proactive Advance Care Planning with Videos for the Elderly and all Patients with Dementia | Palliative Care Educator (VIDEO-PCE) | Michael Paasche-Orlow, Tufts Medical Center | COVID-19 advance care planning (ACP) Educator-led, video-assisted palliative care intervention to improve patient-clinician communication, increase ACP documentation, and lead to more patient-centered care at the end of life | Hospitalized patients and any patient with Alzheimer's disease and related dementias, as well as proxy decision-makers (Ages 65+) | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| The PorchLight Project | The PorchLight Project | Joseph Gaugler, University of Minnesota Twin Cities | The Porchlight Project is multicomponent training delivered to volunteers and includes three established online training modules on person-centered dementia care; a four-session online training program that demonstrates to volunteers how to apply person-centered dementia care knowledge to their interactions with persons with dementia and their caregivers; and ongoing monthly coaching sessions | Family caregivers, persons with dementia, and senior volunteers | 2027 |
| Developing a Distance Education System to Train Savvy Caregiver Program Interventionists: Extending Access and Capacity in Community-Based Delivery of Evidence-Based Interventions | Savvy System Project | Ken Hepburn, Emory University | Web-based system to train interventionists on Savvy Caregiver, a dementia family caregiver psychoeducation program | Dementia family caregivers (Ages 18+) | 2023 |
| Developing a Screening Protocol for Family Caregivers of Older Persons with and without Dementia Seen in Primary Care | Implementing a Family Caregiver Checklist in Primary Care: A Pilot Study | Catherine Riffin, Joan and Sanford I Weill Medical College of Cornell University | Caregiver screening-referral protocol for family caregivers who accompany older adults to their primary care visits | Patient-caregiver dyads and healthcare providers | 2024 |
| The Caregiver Resource Room: Enhancing Support for Caregivers of Alzheimer's Disease and Related Dementias (ADRD) | TBD | Francesca Falzarano, University of Southern California | Online self-assessment and tailored referral platform to support caregivers of individuals with Alzheimer's disease and related dementia | Caregivers of individuals with Alzheimer's disease and related dementia | 2026 |
| Evaluating the Effectiveness of an Online Small-Group Self-Management Workshop for Rural Caregivers of Individuals with Alzheimer's Disease and Related Dementias | Rural Dementia Caregiver Project | Veronica Yank, University of California, San Francisco | Building Better Caregivers, an online, self-management and skills building intervention to support isolated dementia caregivers in rural areas | Rural dementia caregivers (Ages 18+) | 2024 |
| GamePlan4Care: Web-based Delivery System for REACH II | GamePlan4Care: Online Support for Family Caregivers (GP4C) | Alan Stevens, Baylor Research Institute | GamePlan4Care (GP4C), an internet-based system designed to provide immediate, tailored education and skills training to caregivers | Caregivers of veterans with Alzheimer's disease and related dementias (AD/ADRD) admitted to the inpatient general medicine service at MEDVAMC | 2024 |
| GamePlan4Care: Web-based Delivery System for REACH II | TBD | Alan Stevens, Baylor Research Institute | Hospital GamePlan4Care (GP4C), an internet-based system designed to provide immediate, tailored education and skills training to caregivers in a hospital setting | Dementia caregivers in a hospital setting (Ages 18+) | 2024 |
| Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders: Primary Progressive Aphasia (PPA) Tele-Savvy (Pilot) | PPA Tele-Savvy: A Pilot Study of an Online Intervention for Caregivers of Persons Living With PPA | Darby Morhardt, Northwestern University | Psychoeducational program for caregivers of persons with primary progressive aphasia | Caregivers of persons living with a documented diagnosis of primary progressive aphasia (PPA) | 2024 |
| Efficacy of the WeCareAdvisor: An Online Tool to Help Caregivers Manage Behavioral and Psychological Symptoms in Persons with Dementia | WeCareAdvisor Study for Caregivers of People Living With Dementia | Laura Gitlin, Drexel University | WeCareAdvisor, an online tool to help caregivers manage behvioral and psychological symptoms in persons with dementia | Caregivers (Ages 21+) | 2024 |
| Developing and Testing the Enhancing Active Caregiver Training (EnACT) Intervention for Dementia Family Caregivers | Developing and Testing the Enhancing Active Caregiver Training (EnACT) Intervention for Dementia Family Caregivers (EnACT) | Jacqueline Eaton, University of Utah | Enhancing Active Caregiver Training intervention to manage common behavioral symptoms associated with Alzheimer's disease and related dementias | Caregivers of persons living with Alzheimer's disease and related dementias | 2025 |
| Impact of Adult Day Services on Psychosocial and Physiological Measures of Stress Among African American Dementia Family Caregivers | TBD | Lauren Parker, Johns Hopkins Bayview Medical Center | Mechanism study to identify how adult day services influences caregiving related stressors and needs for African American caregivers of individuals with Alzheimer's disease and related dementias | African American Caregivers | 2025 |
| Using Technology to Support Care Partners for Persons with Alzheimer's Disease: Tele-STELLA | Using Technology to Support Care Partners for Persons With Alzheimer's Disease: Tele-STELLA (Tele-STELLA) | Allison Lindauer, Oregon Health and Science University | Telehealth intervention using education and peer support to reduce stress and behavioral symptoms for family care partners for those with Alzheimer's disease and related dementias | Rural, African American, and White care partners for those living with Alzheimer's disease and related dementias | 2026 |
| Testing Dementia Caregiver TeleCoaching to Reduce Episodes of Abuse and Neglect by Recognizing and Managing Care-Resistant Behaviors | Coaching Dementia Caregivers to Master Care-Resistant Behavior (CuRB-IT) | Rita Jablonski, University of Alabama at Birmingham | Care-Resistant Behavior Internet Training (CuRB-IT) to enhance coping skills of family caregivers and reduce elder abuse and neglect (EAN) | Caregivers for persons with Alzheimer's disease and related dementias (AD/ADRD) | 2026 |
| An Assistive-Technology Based Caregiver Training Program (CTP) to Enhance Caregiver Effectiveness, Well-being, and Quality of Life, Which Will Improve Overall Care for Individuals Living with AD/ADRD | Efficacy of Caregiver Training Program in Enhancing Caregiver and Patient Outcomes | Matthew Golden, MapHabit, Inc. | MapHabit System and Caregiver Training Program (CTP) to improve caregiver quality of life and overall patient care | Dyads, caregivers and individuals living with dementia | 2025 |
| Emergency Preparedness and Support of Caregivers of Persons with Dementia: The Disaster PrepWise Study | Emergency Preparedness for Caregivers of Persons With Dementia: Disaster PrepWise (DPW-Caregiver) | Sato Ashida, University of Iowa | Disaster PrepWise (DPW), an intervention program to enhance emergency preparedness and support networks to increase caregiver resilience and minimize distress | Caregivers of individuals with Alzheimer's disease and related dementias (AD/ADRD) | 2027 |
| Learning Skills Together: A Randomized Controlled Trial of a Complex Care Skills Intervention to Improve AD/ADRD Caregiver Self-Efficacy | TBD | Kylie Meyer, Case Western Reserve University | Learning Skills Together (LST), a complex care skills intervention to improve caregiver self-efficacy | Caregivers to persons living with mid-stage Alzheimer's disease and related dementia (AD/ADRD) | 2027 |
| Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders: VOCALE LBD+ for Caregivers of Persons With Lewy Body Dementia (Pilot) | VOCALE LBD+ for Caregivers of Persons With Lewy Body Dementia | Annie Chen and Oleg Zaslavsky, University of Washington | Virtual Online Communities for Aging Life Experiences (VOCALE), an 8-week online intervention that uses a web-based discussion platform and involves moderation, peer-to-peer support, didactic training, and problem-solving skill enactment | Family caregivers (Ages 18+) of persons with Lewy Body Dementia | 2024 |
| Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders: Study of the Aliviado DSD Caregiving Mastery Program (Pilot) | Study of the Aliviado DSD Caregiving Mastery Program | Shih-Yin Lin, New York University | Aliviado DSD Caregiving Mastery Program includes Family-centered training on delirium superimposed dementia (DSD) plus an mHealth app-based care plan of DSD prevention, detection, and management tasks and tailored mobile push notification task reminders and encouragements | Family caregivers for individuals living with Alzheimer's disease and related dementias (AD/ADRD) | 2024 |
| Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders: The Couple in Control (Pilot) | The Couple in Control | Lindsay Prizer, Emory University | Couple in Control (CiC), a toolkit of communication skills and decisional strategies to help couples experiencing mild cognitive impairment cope with various challenges | Dyads of individuals diagnosed with mild cognitive impairment and their care partners | 2024 |
| The Pain Identification and Communication Toolkit: A Training Program to Support Family Caregivers of Persons with ADRD | TBD | Catherine Riffin, Joan and Sanford I Weill Medical College of Cornell University | Pain Identification and Communication Toolkit (PICT), a multicomponent intervention for caregivers of people with Alzheimer's disease and related dementias to provide training in observational pain assessment and coaching in effective pain communication techniques | Patients with moderate/severe Alzheimer's disease and related dementia and their caregivers | 2028 |
| Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders: WECARE (WellnessEnhancement for Caregivers) (Pilot) | WECARE (WellnessEnhancement for Caregivers) | Alicia Hong, Emory University | Wellness Enhance for Caregivers (WECARE) is a 7-week social media-based behavioral intervention designed for Chinese American family caregivers of persons with Alzheimer’s disease and related dementias | Chinese American family caregivers of persons with dementia | 2024 |
| ORCASTRAIT Oregon Roybal Center for Care Support Translational Research Advantaged by Integrating Technology: An AI-Embedded Intervention to Promote Financial Wellbeing Among Latino Family Caregivers (Pilot) | TBD | Kylie Meyer, Case Western Reserve University | An AI-Embedded Intervention that increases caregiver resourcefulness and displaces out-of-pocket caregiving costs with community and other resources to help mitigate financial strain | Adult Latino/Hispanic family caregivers to persons living with dementia (Ages 18+) | 2024 |
| Rochester Roybal Center for Social Ties and Aging Research: TLC for Latino Caregivers (Pilot) | TBD | Kathi Heffner, University of Rochester | Latino Caregiver Thrive, Learn & Connect (TLC) is a Spanish telehealth caregiver educational and skill-building program to improve caregiver experience | Latino caregivers (Ages 45+) | 2024 |
| Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders: Improving Care through Improv: Promoting Mastery in the Moment (Pilot) | TBD | Candace Kemp, Emory University | The intervention, “Improving Care though Improv,” involves four highly interactive weekly two-hour sessions delivered over a one-month designed to build care partner skills and improve mastery and care experiences and outcomes | Care partners of persons living with dementia | 2024 |
| Caregiver as Navigator-Developing Skills Online (CAN-DO): Developing Dementia Family Caregiver Mastery for Navigating Complex Health, Social Service, Legal, Financial, and Family Systems | TBD | Carolyn Clevenger, Emory University | Psychoeducation program that seeks to enhance caregivers’ knowledge, skills and mastery of the many tasks they perform and responsibilities they assume in assisting the person living with dementia | Individuals serving as caregivers for family members and friends living with Alzheimer’s disease and related dementias | 2028 |
| PERSEVERE in Lewy Body Dementia: A Randomized, Controlled Trial of Peer Mentor Support and Caregiver Education | TBD | Jori Fleisher, Rush University Medical Center | A caregiver education and peer mentor program comprised of discussion and coaching through specific Lewy Body Dementia knowledge and social support topics | Lewy Body Dementia family caregivers | 2028 |
| Reducing Burden in Care Partners of Community-Dwelling Persons with Dementia and Oropharyngeal Dysphagia | TBD | Liron Sinvani, Feinstein Institutes for Medical Research | A comprehensive repository for Oropharyngeal Dysphagia related information for care partners of persons with Alzheimer’s disease and AD-related dementias and Oropharyngeal Dysphagia | Care partners of hospitalized patients with Alzheimer’s disease and related dementias and Oropharyngeal Dysphagia (Ages 65+) | 2025 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Creating a Faith-Based Toolbox for African Americans Living with Moderate and Severe Dementia | Faith-Based Toolbox for African Americans With Dementia | Fayron Epps, Emory University | Faith-based home activity toolkit (Faith-HAT), meaningful religious and spiritual activities for persons living with dementia to engage in at home with their family caregiver | Dyads of persons living with dementia and caregiver (Ages 18+) | 2024 |
| STAR Caregivers - Virtual Training and Follow-up | STAR Caregivers - Virtual Training and Follow-up (STAR-C-VTF) | Robert Penfold, Kaiser Foundation Hospitals - Washington | STAR Virtual Training and Follow-up (STAR- VTF), a training using web-based Electronic Health Record portal to help in expand access to and delivery of empirically supported behavioral health services for caregivers and people with dementia | Dyads of people with dementia (Ages 55+) and their caregiver | 2024 |
| A Training and Fidelity Model to Move and Scale Evidence-based Dementia Care and Caregiver Support Programs into Practice: The Case for COPE in PACE service settings | Care of Persons With Dementia in Their Environments (COPE) in Programs of All-Inclusive Care of the Elderly (PACE) | Nancy Hodgson, University of Pennsylvania | Care of Persons in the Environments (COPE), an online training program for caregivers and care staff of persons with dementia to improve care for persons with dementia | Dyads from PACE sites (Ages 21 - 100) | 2024 |
| Resilient Together for Dementia: A Live Video Resiliency Dyadic Intervention for Persons with Dementia and their Care-Partners Early after Diagnosis | TBD | Sarah Bannon, Icahn School of Medicine at Mount Sinai | Resilient Together for Dementia (RT-D), a live video dyadic resiliency intervention | Persons Living With Dementia, and Spousal Partner (SP) dyads, along with staff employed at MGH Department of Neurology | 2027 |
| Development and Pilot Testing of a Behavioral Economics Mobile Health Digital Tool to Improve Adherence to Non-Pharmacologic Strategies for Behavioral and Psychological Symptoms of Dementia | TBD | Hayley Belli, New York University School of Medicine | Behavioral economics mobile health (BE-mHealth) digital tool that will incorporate BE nudges into 2-3 evidence-based non-pharmacologic strategies for managing behavioral and psychological symptoms of dementia (BPSD) | Persons living with dementia and their primary care partners | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Mindfulness Based Stress Reduction for Family Caregivers of Dementia | Improving Well-Being for Older Adult Family Dementia Caregivers | Kathi Heffner, University of Rochester | Mindfulness Based Stress Reduction (MBSR) and the Living Well program to see if the programs might be associated with better immune function (response to current influenza vaccine), physical and emotional health, and well-being for family caregivers | Adults who currently live with and are the primary caregivers for a community dwelling dementia patient (Ages 60+) | 2023 |
| The Caregiver Outcomes of Alzheimer's Disease Screening (COADS) Trial | Caregiver Outcomes of Alzheimer's Disease Screening (COADS) | Nicole Fowler, Indiana University-Purdue University Indianapolis | An early screening intervention involving sending letters to dyads and the primary care physician informing them of the results of the screening of Alzheimer's disease for earlier diagnosis | Dyads of older adults (Ages 65+) and family members (Ages 21+) | 2024 |
| The Mindful and Self-Compassionate Care Program (MASC): Reducing Stress for Caregivers of Persons with Dementia - Aim 2 | MASC: Reducing Stress for Caregivers (MASC) - AIM 2 | Christine Ritchie, Massachusetts General Hospital |
A randomized control trial with two arms: 1. The Intervention arm (MASC): Mindful and Self-Compassionate Care Program (MASC) to help caregivers of persons with Alzheimer disease and related dementias (AD/ADRD) manage stress associated with the general caregiver experience; MASC is delivered by a social worker with expertise working with AD/ADRD caregivers and content includes education around stress and caregiving, educational information on strategies to manage stress including exercise, sleep, and social support 2. Control arm (HEP): will receive HEP which is time-, dose-, and attention-matched to MASC however this program will not include any skills. |
Caregivers of persons living with dementia | 2025 |
| To Reduce the Burden of Caregiving on Health Outcomes of Midlife Women: Asian American Family Caregivers of Persons Living with Alzheimer's Disease | Technology-based Information and Coaching Program Tailored for Asian American Midlife Women Who Are Family Caregivers of Persons With Alzheimer's Disease (TACAD) | Eun-Ok Im, Emory University | The intervention is BC-Care (BrainCheck), a cognitive care planning tool that integrates patient, provider, and caregiver input to generate personalized Alzheimer's disease and related dementias (AD/ADRD) recommendations and follow-up care to be implemented during an AD/ADRD's patient's medical visit | Asian American women who are family caregivers of persons living with Alzheimer’s disease, and experts in gerontology/geriatrics | 2024 |
| LEAF 2.0: Randomized trial of a technology-based positive emotion intervention for informal caregivers of individuals with Alzheimer's disease | Life Enhancing Activities for Family Caregivers (LEAF 2.0) | Judith Moskowitz, Northwestern University | LEAF, Life Enhancing Activities technology-based intervention to reduce burden and increase well-being for family caregivers of persons living with Alzheimer's disease or related dementias | Caregivers (Ages 34 - 87) | 2024 |
| Mobile, Web-based Behavioral Intervention for Improving Caregiver Well-being | Mobile Web-based Behavioral Intervention for Improving Caregiver Well-being | Brent Mausbach, University of California San Diego | Mobile Pleasant Events Program (mPEP), a Behavioral Activation Therapy program to increase caregiver's engagement in pleasant activities | Dementia caregivers (Ages 40 - 90) | 2024 |
| Virtual Coaching to Maximize Dementia Caregivers Respite Time-Use: A Stage 1 Pilot Test for Feasibility and Efficacy | Virtual Coaching to Maximize Dementia Caregivers' Respite Time Use (TLC) | Rebecca Utz, University of Utah | Time for Living & Caring (TLC), an online, self-administered intervention to provide informal family caregivers with resources, support, and education to improve their respite time-use (respite is defined as planned time away from caregiving | Caregivers (Ages 18+) | 2024 |
| Mindfulness-based Cognitive Coping Mobile App Intervention for Caregivers of Individuals with Alzheimer's Disease | Mindfulness-based Cognitive Coping for ADRD Caregivers | Bruno Kajiyama, Photozig, Inc. | Caring Mind App, a mindfulness-based Cognitive Coping intervention to reduce caregiver stress and depressive symptoms | Caregivers of individuals living with Alzheimer's disease and related dementia (AD/ADRD) | 2023 |
| Midwest Roybal Center for Health Promotion and Translation: OCEAN: Optimizing Cognition via Exercise and Nutrition (Pilot) | Optimizing Cognition Via Exercise and Nutrition (OCEAN) | Susan Aguinaga, University of Illinois at Chicago | A Latin dance program (BAILAMOS™) and Mediterranean diet (MIND) to improve cognitive function | Older Latino adults (Ages 50+) | 2024 |
| Rochester Roybal Center for Social Ties and Aging Research: Social-Life Enhancing Activities for Caregivers (Pilot) | Social-Life Enhancing Activities for Caregivers | Benzi Kluger, University of Rochester | Social LEAF (Life Enhancing Activities for Family Caregivers), a group video-conference intervention to teach caregivers coping skills to improve social relationships and social connection | Caregivers of community-dwelling family member with dementia with Lewy Bodies (DLB) | 2024 |
| Rochester Roybal Center for Social Ties and Aging Research: Study of a Behavioral Intervention for Older Advanced Cancer Patients and Their Caregivers (Pilot) | Study of a Behavioral Intervention for Older Advanced Cancer Patients and Their Caregivers | Lee Kehoe, University of Rochester | Life Review therapy, a behavioral intervention to address social connection in caregivers by focusing on the caregiving relationship | Caregivers and care receiver with mild cognitive impairment and advanced cancer (Ages 50+) | 2024 |
| Caregiver Speaks: A Technologically Mediated Storytelling Intervention for Family Caregivers of Individuals with Alzheimer's Disease and Other Dementias | Caregiver Speaks: A Technologically Mediated Storytelling Intervention | Debra Parker Oliver, Washington University in St. Louis | Caregiver Speakers, a technologically-mediated storytelling intervention using photos to illustrate various feelings and meanings | Adult hospice family caregivers of person's living with dementia (Ages 18 - 120) | 2024 |
| Using Twitter to Enhance the Social Support of Hispanic and Black Dementia Caregivers (Tweet-SS) | Twitter Based Social Support for Hispanic and Black Dementia Caregivers (Tweet-S2) | Sunmoo Yoon, Columbia University Health Sciences | Twitter-based intervention to enhance the social support (informational, instrumental, emotional, appraisal) for Hispanic and Black dementia caregivers | Black or Hispanic dementia caregivers (Ages 18+) | 2024 |
| Advancing Alzheimer’s Family Caregiving Interventions and Research Capacity in Vietnam | A Multidomain Intervention Program for Older People With Dementia | Walter Hinton, University of California Davis | Multidomain intervention program that includes physical and cognitive exercises led by physiotherapists and management of metabolic and vascular risk factors by a cardiologist to address cognitive decline, quality of life, and functional ability | Individuals living in the community who have a diagnosis of mild-moderate vascular dementia (Ages 60+) | 2024 |
| Supplement-Advancing Alzheimer's Family Caregiving Interventions and Research Capacity in Vietnam | A Phone Intervention for Family Dementia Caregivers in Vietnam | Walter Hinton, University of California Davis | Adapted (i.e., Distant REACH VN) intervention training protocol for distance delivery to provide support for family caregivers of people living with dementia | Caregiver-care recipient dyads and other staff | 2024 |
| Advancing Alzheimer’s Family Caregiving Interventions and Research Capacity in Vietnam | Efficacy of a Dementia Family Caregiver Support Intervention in Vietnam | Walter Hinton, University of California Davis | Vietnam Resources for Enhancing Alzheimer’s Caregiver’s Health (REACH VN), a culturally adapted behavioral intervention to support family caregivers of persons with dementia in Vietnam | Family caregivers (Ages 18+) | 2024 |
| Advancing Alzheimer’s Family Caregiving Interventions and Research Capacity in Vietnam | Efficacy of Paper-based Cognitive Training in Vietnamese Patients With Early Alzheimer's Disease | Walter Hinton, University of California Davis | Paper-based cognitive training | Vietnamese patients with early Alzheimer's disease and their caregivers | 2024 |
| Advancing Alzheimer’s Family Caregiving Interventions and Research Capacity in Vietnam | Evaluating the Feasibility of a Mobile Phone-based Intervention on Depression, Anxiety, and Stress of the Dementia Patients' Caregivers | Walter Hinton, University of California Davis | Information including knowledge and skills related to dementia patient care administered to the participants via a smartphone app (Zalo app) | Primary caregivers of patients with dementia | 2024 |
| CommunityRx-Dementia | CommunityRx-Dementia (CRx-D) | Stacy Lindau, University of Chicago | Community Rx-Caregiver Resources, tailored resources addressing health-related social needs (HRSN) for caregivers | Alzheimer's disease and related dementias caregivers (Ages 18+) | 2024 |
| Fostering Caregiver Connections via Intentional Technology Pairing for Caregivers of Patients with Alzheimer's Disease and Other Types of Dementia | A Study of Caregiver Connections Via Technology in Dementia | Matthew Knutson, Minnesota HealthSolutions Corporation | Algorithm to connect caregivers of people with dementia to each other for emotional support | Caregivers of persons living with dementia, such as Alzheimer’s disease, Lewy Body dementia and Frontotemporal degeneration | 2024 |
| Culturally Responsive Support Programming for Black Caregivers of Persons with Dementia | Culturally Responsive Caregiver Support | Sheria Robinson-Lane, University of Michigan | Culturally tailored support intervention for African American caregivers of persons living with dementia to reduce health disparities | African American caregivers of a person living with dementia (Ages 55+) | 2025 |
| Mobile App Delivered Mentalizing Imagery Therapy to Augment Remote Family Dementia Caregiver Skills Training | Mobile App Psychological Interventions for Family Dementia Caregivers | Felipe Jain, Massachusetts General Hospital | Guided imagery and mindfulness therapy delivered via mobile app to augment dementia caregiver skills training | Primary caregivers (ages 60+) for a relative with Alzheimer's disease and related dementias (AD/ADRD) that uses a smartphone at least 5 days/week | 2025 |
| A Home-based, Culturally and Language Specific Intervention for Dementia Family Caregivers: Stress Reduction and Education with Wearable Technology for Health | Dementia Family Caregiver Study | Jung-Ah Lee, University of California Irvine | Stress reduction and dementia education intervention with wearable technology to measure behavioral and physiological measures | Adult family caregivers of persons living with dementia | 2025 |
| Web-based CBT for Insomnia in Rural Dementia Caregivers: Examination of Sleep, Arousal, Mood, Cognitive, and Immune Outcomes | NiteCAPP: Web-based Interventions for Insomnia in Rural Dementia Caregivers (NiteCAPP) | Christina Mccrae, University of South Florida | NiteCAPP, a web cognitive behavioral treatment for insomnia (CBT-I) for rural dementia caregivers to improve caregiver health, mood, burden and cognition | Rural dementia caregivers and persons living with dementia | 2026 |
| Supporting Family Caregivers of Persons with Dementia | Supporting Family Caregivers of Persons With Dementia (ENCODE) | George Demiris, University of Pennsylvania | ENCODE (Empowering Caregivers of Patients with Dementia) is a behavioral intervention to support family caregivers in pain management for their hospice patients based on the transcriptional theory of stress and coping | Caregivers of hospice patients with Alzheimer's disease and related dementias (AD/ADRD) | 2026 |
| Addressing the Double Jeopardy of Stress and Hypertension Among African American Female Caregivers of Persons Living with Alzheimer's Disease and Related Dementias | Stress and Hypertension in Dementia Caregivers (MIM-DASH) | Kathy Wright, Ohio State University | Mindfulness in Motion (MIM) plus the Dietary Approaches to Stop Hypertension (DASH) interventions to improve caregiver stress and quality of life | African American female caregivers with hypertension (Ages 40+) | 2024 |
| Biobehavioral Mechanisms of Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons with Alzheimer's Disease | TBD | Bryan Denny, Rice University | A smartphone-based cognitive emotion regulation training to improve caregiver health and well-being | Caregivers of individuals with Alzheimer's disease and related dementia (AD/ADRD) | 2027 |
| Caring4Caregivers: A Theory-driven Mobile Solution to Promote Self-care and Well-being Among Caregivers of Individuals with Alzheimer’s and Related Dementias | TBD | Kerry Evers, Pro-Change Behavior Systems, Inc. | Caring4Caregivers (C4C), a theory-driven mobile solution to promote self-care and well-being among caregivers | Caregivers for individuals living with Alzheimer's disease and related dementia (AD/ADRD) | 2024 |
| Increasing Meaning to Reduce Loneliness in Care Partners of Persons with AD/ADRD | Reduce Loneliness in Care Partners of Persons With AD/ADRD | Allison Marziliano, Feinstein Institutes for Medical Research | RELOAD-C, an intervention leveraging concepts from Meaning-Centered Psychotherapy to reduce loneliness | Individuals with Alzheimer's disease and related dementias (AD/ADRD) and their care partners | 2027 |
| Midwest Roybal Center for Health Promotion and Translation: Time Restricted Eating Plus Exercise for Weight Management (Pilot) | Time Restricted Eating Plus Exercise for Weight Management | Kelsey Gabel, University of Illinois at Chicago | An intermittent fasting intervention (time restricted eating, TRE), which involves confining the eating window to 8-10 hours and fasting for the remaining hours of the day, in combination with either resistance training (TRE-RT) or aerobic training (TRE-AT) to examine the effects on body weight, body composition, metabolic disease risk, and cognition in overweight and pre-diabetic adults | Adults who are overweight/obese and pre-diabetic (Ages 50 - 85) | 2024 |
| Midwest Roybal Center for Health Promotion and Translation: Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis (Pilot) | Promoting Physical Activity at a Memory & Aging Clinic | Naoko Muramatsu, University of Illinois Chicago | Pro-Home MeC, a 12-week in-home physical activity (PA) program, delivered using an app on a tablet hat has built-in motivational enhancement (e.g., music), that consists of: motivational enhancement components, including initial PA discussion between the patient and the memory care clinician, and goal setting with the interventionist; 5 moves for aerobics, strength, flexibility, and balance exercises that target daily functions | Adults diagnosed with mild cognitive impairment or mild dementia (Ages 50+) | 2024 |
| Rochester Roybal Center for Social Ties and Aging Research: The M&M Study (Pilot) | The M&M Study | Kathi Heffner, University of Rochester | Social Engage Coaching (S-ENG), a behavioral intervention that involves one-on-one coaching with a care manager to increase social engagement and reduce loneliness | Caregivers for individuals living with Alzheimer's disease and related dementia (AD/ADRD) | 2024 |
| Writing to Heal: Developing an Internet-Based Cognitive-Behavioral Writing Intervention for Alzheimer’s Disease Spousal Caregivers | TBD | Angie Leroy, Baylor University | An internet-based cognitive-behavioral writing intervention to improve caregiver health and well-being | Spousal caregivers for individuals living with Alzheimer's disease and related dementia (AD/ADRD) | 2027 |
| Developing a Culturally Immersive Psychoeducational Intervention for Black Immigrant Older Adults with Dementia and Their Caregivers: The Black Immigrant Project | TBD | Manka Nkimbeng, University of Minnesota Twin Cities | The proposed intervention is The Active Caregiving Empowering Skills (ACES) intervention which is a psychoeducational program that is based on Cognitive Behavioral Therapy (CBT) to decrease caregiver stress and decrease behavioral distress in persons living with dementia | Black older adult immigrants (ages 50+) living with dementia and their informal caregivers | 2027 |
| I-CARE 2 RCT: Mobile Telehealth to Reduce Alzheimer's-Related Symptoms for Caregivers and Patients | I-CARE 2: Mobile Telehealth to Reduce Alzheimer'S-related Symptoms (I-CARE 2) | Richard Holden, Indiana University | Brain CareNotes app, a mobile telehealth app used by informal caregivers for behavioral and psychological symptoms of dementia (BPSD) management | Informal caregivers of people living with Alzheimer's disease and related dementias (AD/ADRD), and the care-recipients | 2027 |
| Using Mobile Technology to Reduce Stress in Caregivers of Persons with Dementia. A Scalable Solution to A Growing Problem | STRIDE: Stress Reduction in Dementia Caregivers | Ana-Maria Vranceanu, Massachusetts General Hospital | "CALM ", a smartphone-based meditation app that teaches users the basics of mindfulness and how to integrate it into daily life to promote sustained practice and provides 10- to 12-minute guided meditations with embedded behavioral principles [e.g., reminders] to facilitate adherence | Older adults with with chronic pain comorbid with early cognitive decline (Ages 60+) | 2024 |
| The Mindful and Self-Compassionate Care Program (MASC): Reducing Stress for Caregivers of Persons with Dementia (Pilot Trial) | TBD | Christine Ritchie, Massachusetts General Hospital |
MASC combines evidence-based skills from mindfulness programs, self-compassion programs, and behavioral management programs. An open pilot trial was delivered to 10 informal caregivers of ADRD individuals |
Caregivers of persons living with dementia | 2025 |
| Reducing Suicide Risk Among Aging Caregivers of Persons with AD/ADRD: Adapting, Implementing, and Evaluating Dialectical Behavior Therapy Skills Training Interventions | Reducing Suicide Risk Among Aging Caregivers of Persons With AD/ADRD | Jonathan Singer, Texas Tech University | Dialectical behavior therapy skills training groups tailored to the unique experiences and needs of informal caregivers of persons with Alzheimer's Disease and related dementias to reduce suicide-related outcomes | Informal caregivers (Ages 50+) of persons with Alzheimer's disease and related dementias | 2026 |
| Supporting Dementia Caregivers During Medicare Home Health: Developing the DECLARE Needs Assessment Intervention | TBD | Julia Burgdorf, Visiting Nurse Service of New York | DECLARE, a self-assessment/web-based survey platform that asks caregivers about their needs and concerns, to improve home health care team communication with and in support of caregivers | Home health staff and Alzheimer’s disease and related dementias (AD/ADRD) caregivers | 2028 |
| The Living Memory Home: Reducing Grief and Improving Relationships Between Home-based Patients with ADRD and Their Family Caregivers | TBD | Holly Prigerson, Joan and Sanford I Weill Medical College of Cornell University | LMH-4-Dementia Care Pairs (LMH-4-DCP), a reminiscence-based intervention for family caregiver and person with dementia to address family caregivers' pre-loss grief and enhance relationship quality | Caregivers and persons with dementia | 2025 |
| Caregiving While Black-LIVE: Empowering Black Dementia Caregivers to Navigate Care | TBD | Fayron Epps, Emory University | Asynchronous/synchronous psychoeducation intervention that promotes caregiving self-efficacy in Black caregivers | Adult family caregivers (Ages 40-75) to persons with Alzheimer’s disease and related dementia | 2025 |
| Plans4Care: Personalized Dementia Care On-Demand | TBD | Sokha Koueth, Plans4care Inc. | Software system that provides caregivers of persons with Alzheimer's disease or Alzheimer's disease related dementia with personalized, evidence-based strategies on-demand to address self-identified care challenges | Caregivers of persons living with Alzheimer's disease or Alzheimer's disease related dementia from a care setting | 2024 |
| Recharge Behavioral Therapy for Caregivers of Individuals with Alzheimer's Disease | TBD | Bruno Kajiyama, Photozig, Inc. | Recharge behavioral therapy delivered through the recharge mobile app to help reduce depressive symptoms and alleviate stress of caregivers of individuals with Alzheimer’s disease | Adult family caregivers (Ages 18+) to individuals with Alzheimer’s disease | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Decisions About Cancer Screening in Alzheimer's Disease | Decisions About Cancer Screening in Alzheimer's Disease (DECAD) | Nicole Fowler, Indiana University-Purdue University Indianapolis | A mammography decision aid that will help caregivers of patients with Alzheimer's make decisions about stopping or continuing breast cancer screening | Dyads consisting of an older woman with Alzheimer's disease (Ages 75+) and a family caregiver (Ages undefined) | 2024 |
| A Video Intervention to Improve Decision Making in Early-Onset Dementia Caregivers | Care Planning for a Loved One With Dementia: Knowledge, Preparing for Decisions, and Emotions | Bradford Dickerson, Massachusetts General Hospital | Video-based decision aids (user manuals) to improve decision making skills for caregivers of persons with early-onset dementia | Caregivers (Ages 18+) of those with young-onset Alzheimer's disease and related dementias (onset age <65 years old) | 2024 |
| A Communication-based Intervention for Early Stage Dementia Patient-Caregiver Dyads to Increase Engagement in Advance Care Planning and Reduce Caregiver Burden | Developing a Communication Intervention for People with Memory Changes and Their Caregivers | Sara Czaja, Joan and Sanford I Weill Medical College of Cornell University | Communication-based intervention to improve preparedness for advance care planning (ACP) | Adults with Alzheimer's disease and related dementias and their caregivers | 2024 |
| Safety in Dementia: An Online Caregiver Intervention | "Safety in Dementia": An Online Caregiver Intervention | Marian Betz, University of Colorado Anschutz Medical Campus | RCT of the “Safety in Dementia” (SiD) online tool to address firearm access, thereby reducing injury risk, among informal caregivers of community-dwelling adults with dementia | Informal caregivers of community-dwelling adults with dementia | 2024 |
| Integration of Health Information Technology and Promotion of Personhood in Family-Centered Dementia Care | Integration of Health Information Technology and Promotion of Personhood in Family-Centered Dementia Care | Ellen Brown, Florida International University | Assistive alternative communication device for persons living with dementia to communicate care preferences to caregiver and provider | Dyads of caregivers and persons living with dementia | 2025 |
| Designing a Culturally Tailored Formal Care Decision-Making Intervention for African American Dementia Dyads and Families | DECIDE: Dyads and Families | Kalisha Johnson, Emory University | Tailored strategies to support formal care decision-making processes | African-American parent-adult daughter dyad | 2026 |
| Adapting Supported Decision Making to Promote Well-being and Improve Health Outcomes for Persons Living with Alzheimer's Disease and Alzheimer's Disease Related Dementias | TBD | Emily Largent, University of Pennsylvania | A toolkit to improve decision-making | Individuals living with Alzheimer's disease and related dementia (AD/ADRD), their care partners, and providers | 2027 |
| Enhancing Triadic Communication About Cognition for Older Adults with Alzheimer's Disease or Related Dementias Facing a Cancer Management Decision | TBD | Allison Magnuson, University of Rochester | COACH-Cog, an adapted tool to facilitate conversations about aging-related conditions, such as cognition, with older patients and their care partners | Dyads of people living with dementia and their care partners | 2027 |
| The Role of Visit Audio Recordings in Triadic Dementia Care | TBD | Paul Barr, Dartmouth College | HealthPAL, a visiting recording platform to improve tridiatic interpersonal communications | IIndividuals with Alzheimer's disease and related dementia (AD/ADRD), care partners, and providers | 2027 |
| Adapting and Testing the Care Partner Hospital Assessment Tool (CHAT) for Use in Dementia Care | Dementia Care Partner Hospital Assessment Tool | Beth Fields, University of Wisconsin - Madison | Care Partner Hospital Assessment Tool (CHAT): a novel approach designed to increase care partner preparedness for caregiving tasks during their family member or friends’ hospitalization | Patients living with Alzheimer's disease and related dementia (AD/ADRD) and their care partners, healthcare system administrators, and clinicians | 2027 |
| Negotiation Training to Optimize Caregiver Communication in Alzheimer's Disease | Negotiation Training for Caregiver Communication in AD | Lee Lindquist, Northwestern University | Negotiation and dispute resolution training program for caregivers of persons living with dementia | Adult family caregivers of persons living with dementia that provide at least 10 hours weekly support | 2025 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Nursing Home Pragmatic Clinical Trial of APPROACHES (Aligning Patient Preferences: A Role Offering Alzheimer's Patients, Caregivers, and Healthcare Providers Education and Support) | Aligning Patient Preferences: a Role Offering Alzheimer's Patients, Caregivers, and Healthcare Providers Education and Support (APPROACHES | Susan Hickman, Indiana University-Purdue University Indianapolis | APPROACHES, an Advance Care Planning (ACP) Specialist Program to improve care and reduce unwanted, burdensome hospitalizations through improved ACP procedures, standardized staff education on ACP, and systematic ACP facilitation delivered by nursing home staff | Adults with Alzheimer's disease and related dementias, their family caregivers, and nursing home providers | 2024 |
| Optimal Medication Management in Alzheimer's Disease and Dementia | Optimal Medication Management in Alzheimer's Disease and Dementia (Optimize) | Elizabeth Bayliss, Kaiser Foundation Hospitals - Washington | Pragmatic deprescribing intervention to improve medication management and improve overall health | Older adults with Alzheimer's disease and related dementias or mild cognitive impairment | 2024 |
| METRIcAL - Music & MEmory: A Pragmatic TRIal for Nursing Home Residents with Alzheimer's Disease | Music & MEmory: A Pragmatic TRial for Nursing Home Residents With ALzheimer's Disease (METRIcAL) - Part 1 | Vincent Mor, Brown University | MUSIC & MEMORY (M&M) Music Program, a personalized music program in which caregivers (nursing home staff, family, or others) provide people with dementia with music playlists tailored to their personal history of music preferences | Nursing home residents with moderate to severe dementia | 2024 |
| The Hospice Advanced Dementia Symptom Management and Quality of Life Trial (HAS-QOL) | The Hospice Advanced Dementia Symptom Management and Quality of Life Trial (HAS-QOL) | Abraham Brody, New York University | Dementia Symptom Management at Home Program Hospice Edition (Aliviado Dementia Care-Hospice Edition), a multi-modal quality assurance performance improvement (QAPI) program for improving the quality of care provided to persons with dementia and support to their informal caregivers through hospice | Hospice agencies | 2024 |
| Optimizing Mealtime (OPTIMAL): Development and Pilot Testing of a Person-Centered Mealtime Care Intervention for Nursing Home Residents with Alzheimer's Disease and Related Dementias (ADRD) | OPTIMAL in NH Residents With Dementia | Wen Liu, University of Iowa | Person-centered mealtime care intervention for nursing home residents with Alzheimer's disease and related dementias | Interventionalists and nursing home residents living with Alzheimer's disease and related dementias (Ages 55+) | 2024 |
| Using the Electronic Health Record to Identify and Promote Goals-of-Care Communication for Older Patients with Serious Illness | Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2) (PICSI-H) | Ruth Engelberg, University of Washington | Electronic health record (EHR)-based Clinician Jumpstart intervention to promote goals-of-care communication for older patients with serious illness | Older adults (Ages 65+; adults ages 65 - 79 must have 1+ chronic condition) | 2024 |
| Testing the Efficacy of FFC-AC-EIT in Patients with Alzheimer's Disease and Related Dementias | Implementation of Function Focused Care in Acute Care | Barbara Resnick, University of Maryland, Baltimore | Function Focused Care for Acute Care (FFC-AC-EIT), a care interaction intervention to increase physical activity and prevent functional decline during hospitalization | Older adults with Alzheimer's disease and related dementias (AD/ADRD) admitted to the hospital (Ages 55+) | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Can Value Champions Reduce Inappropriate Prescribing for People with Dementia? (Demo) | Can Value Champions Reduce Inappropriate Prescribing for People With Dementia? | Michael Parchman, Kaiser Permanente of Washington Health Research Institute | Intervention led by clinical value champions embedded within primary care settings to decrease the use of potentially inappropriate medications in patients living with dementia | Persons living with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Cognitive Stimulation Therapy for Mild to Moderate Dementia (Pilot) | Cognitive Stimulation Therapy for Dementia: A Two-Armed Pragmatic Trial | Michael Lepore, University of Maryland School of Nursing | Cognitive Stimulation Therapy (CST), an online group intervention to actively engage and stimulate cognitive processes of persons living with dementia to reduce depressive symptoms | Persons living with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Collaborative Care Coordination Program for Alzheimer’s Disease and Related Dementias (Co-CARE-AD) (Demo) | Collaborative Care Coordination Program for Alzheimer's Disease and Related Dementias (Co-CARE-AD) | Xiaojuan Li, Harvard Pilgrim Health Care, Inc. | Dementia Care Consultation (DCC) program, a collaborative care coordination program delivered by a care consultant to reduce patient healthcare utilization and improve caregiver knowledge and well-being | Dyads of persons living with dementia and their caregiver | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Deprescribing of Diabetes Treatment Regimens in Long Term Care Residents with ADRD (Pilot) | Deprescribing of Diabetes Regimens in Long Term Care Residents With Alzheimer's | Medha Munshi, Harvard Medical School | An educational intervention directed at Long Term Care Facility (LTCF) staff to deprescribe and reduce the number of high risk medications (HRMs) in long term care facility (LTCF) residents with diabetes and ADRD | Long-term care facility (LTCF) providers and LTCF residents with diabetes and Alzheimer's disease and related dementias (AD/ADRD) | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Implementation of a Telehealth Palliative Care Model for Persons with Dementia (Pilot) | Implementation of a Telehealth Palliative Care Model for Persons With Dementia (IMPACT) | Joan Carpenter, University of Maryland School of Nursing | Telehealth intervention called Palliative Care Consultation in Post-Acute Care (PCC-PAC) to meet the needs of persons living with dementia newly admitted to nursing homes | Persons living with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Patient Priorities Care for Hispanics with Dementia (Pilot) | Patient Priorities Care for Hispanics With Dementia (PPC-HD) | Aanand Naik, University of Texas Health Science Center at Houston | Patient Priorities Care (PCC), an EHR-based intervention to improve care decision strategies and align with patient priorities, for older adults with multiple chronic conditions | Hispanic people living with dementia and chronic conditions | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Pilot Pragmatic Clinical Trial to Embed Tele-Savvy into Health Care Systems (Pilot) | Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems | Richard Fortinsky, University of Connecticut Health Center | Tele-Savvy, an online program to improve caregiver mastery | Family members/informal caregivers of people living with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Testing Critical Components for a Trial of Advance Care Planning in Primary Care for Dementia (Pilot) | Advance Care Planning (ACP) in Primary Care for Dementia (ADVANCE-PC) | Annette Totten, Oregon Health and Science University | ADVANCE-PC delivered using remote technology (ECHO), a communications and implementation support intervention to provide training and technical assistance tailored to the needs of primary care clinicians and clinics | Persons living with dementia, clinicians, and staff | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Virtual Training for Latino Caregivers to Manage Symptoms of Dementia (Pilot) | Virtual Training for Latino Caregivers to Manage Symptoms of Dementia | Magaly Ramirez, University of Washington | STAR-VTF is a program that teaches caregivers skills to reduce behavioral and psychological symptoms of dementia | Caregivers of persons living with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Implementation of MIND at Home Program in Primary Care for Patients Living with Dementia (Pilot) | Implementation of MIND at Home Into Primary Care for People Living With Dementia | Elizabeth Ciemins, American Medical Group Association | MIND at Home is a dementia care coordination model that includes coordination between persons living with dementia, their care partner, a memory care coordinator and their provider | Dyads of caregivers and individuals with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Mindfulness-Based Dementia Care Partner Program to Reduce Depressive Symptoms (Pilot) | Mindfulness-based Dementia Care Partner Program to Reduce Depressive Symptoms | Leah Hanson, HealthPartners Institute | The Mindfulness-Based Dementia Care (MBDC) is a program for care partners of persons living with dementia to incorporate mindfulness practices into day-to-day life to help cope with the challenges and stresses of dementia care | Care partners of persons living with dementia | 2024 |
| Improving Post-Diagnosis Dementia Care in Primary Care | TBD | Halima Amjad, Johns Hopkins Bayview Medical Center | Pragmatic intervention to facilitate high quality, comprehensive post-diagnosis care and improve quality of care and patient outcomes | Persons living with dementia, in traditional primary care settings | 2025 |
| Impact of a Novel Socially Assistive Robotic Architecture on Engaging Older Adults with Mild Cognitive Impairment, Alzheimer's Disease, and Related Dementia in Long Term Care Settings | Use of Socially Assistive Robots for Long Term Care Older Adults With Cognitive Impairment and Apathy | Nilanjan Sarkar, Vanderbilt University | Socially assistive robot to interact with long-term care setting residents with either dementia or mild cognitive impairment | Person living with dementia or mild cognitive impairment in assisted living or nursing home facilities (Ages 70+) | 2025 |
| Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) | Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) | Miguel Vazquez, University of Texas, Southwestern Medical Center | Pragmatic trial of intensive blood pressure management | Older adults (Ages 70+) | 2025 |
| Screening for Cognitive Impairment Following Critical Illness: Designing and Testing an Implementation Program to Support High Risk Older Adults | TBD | Jessica Palakshappa, Wake Forest University | Cognitive screening program for incident mild cognitive impairment or Alzheimer's disease and related dementias | Older adults with critical illness | 2026 |
| Enhancing Shared Decision-making to Prompt and Guide Individualized Care for People with Alzheimer's Disease and Diabetes | Enhancing Shared Decision-making to Guide Care for People With Dementia and Diabetes | April Savoy, Indiana University-Purdue University Indianapolis | Shared Decision-Making Tool: new internet based interactive information visualizations designed to facilitate shared decision-making and recognize certain needs; Continuous Glucose Monitoring: a wearable device that continuously monitors glucose levels in near real-time | Individuals with Dementia and Diabetes and their caregivers | 2027 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: A Patient-facing Tool to Reduce Opioid-Psychotropic Polypharmacy in PLWD from investigator (Pilot) | A Patient-facing Tool To Reduce Opioid-Psychotropic Polypharmacy in People Living With Dementia (PLWD) | Donovan Maust, University of Michigan | The intervention, EMPOWER, is an educational brochure focused on the risks associated with psychotropic and opioid polypharmacy that will be sent to participant via mail to "nudge”/encourage them to have discussions with the prescribing clinicians about the inappropriateness of the regimen to lower polypharmacy exposure for persons living with dementia | Persons living with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Deprescribing to Reduce Injurious Falls Among Older Adults With Dementia (STOP-FALLS-D) (Pilot) | Deprescribing to Reduce Injurious Falls Among Older Adults With Dementia (STOP-FALLS-D) | Elizabeth Phelan, University of Washington | STOP-FALLS-D is an educational intervention to inform and nudge patients, their care partner(s), and their PCPs to work together to reduce use of CNS-active medications and prevent adverse outcomes (falls and injuries) associated with their use | Persons living with dementia, their care partners, and their primary care providers (PCPs) | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Embedded Clinical Trial of Patient Priorities Care Among Persons Living with MCI and Dementia (Pilot) | Perspectives on Embedded Patient Priorities Care (PEP Talks) | Jennifer Carnahan, Indiana University Health | Patient Priorities Care (PPC), is an evidence-based program to identify the goals and values of patients and care partners by 1) the clinician contacting the patient and care partner for a discussion of their priorities and 2) integration of priorities into the patient’s care plan | Patients with mild cognitive impairment or dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Improving How People Living with Dementia Are Selected for Care Coordination (Demo) | Improving How People Living with Dementia Are Selected for Care Coordination | Lisa Kern, Joan and Sanford I Weill Medical College of Cornell University | Intervention to identify and assign care coordinators to persons living with dementia based on their care partners’ self-reported difficulty with care coordination as compared to the usual approach of assigning care coordinators after hospital discharge | Persons living with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Integration of Machine Learning and Clinical Decision Support to Prevent Postoperative Delirium in Patients with Cognitive Impairment (Demo) | Integration of Machine Learning and Clinical Decision Support to Prevent Postoperative Delirium in Patients with Cognitive Impairment (Demo) | Ira Hofer, Icahn School of Medicine at Mount Sinai | CDS prompts, a series of prompts following the notification that a patient is at increased risk of postoperative delirium (POD) to promote best clinical practices for the prevention of POD | Attending physicians and their adult patients with a history of cognitive impairment who will be undergoing surgery | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Reducing Inappropriate Medication Use for BPSD and Improving Health Outcomes in PLWD from investigator (Pilot) | Reducing Inappropriate Medication Use for BPSD and Improving Health Outcomes in PLWD from investigator | Helen Kales, University of California Davis | Describe, Investigate, Create, Evaluate (DICE) is an intervention to manage behavioral and psychological symptoms of dementia (BPSD). DICE includes a 6-hour online modular training, manual, and additional training as needed coaching from a DICE trainer that will be completed by clinic social workers (called Onsite DICE Coordinators or ODCs). | Persons living with dementia and their care partner dyads | 2024 |
| The Care Ecosystem Response to COVID-19: Accelerating Research on Dementia Care that Meets the Needs of Caregivers and Persons with Dementia during COVID-19 | TBD | Katherine Possin, University of California San Francisco | The Care Ecosystem, a team-based care model that can lead to quality improvements for family caregivers and formal care providers | Family caregivers and formal care providers | 2025 |
| Developing and Testing a Population Health Approach to Deprescribing and Optimizing Medications in Older Adults | TBD | Michelle Keller, Cedars-Sinai Medical Center | Pharmacist-led deprescribing intervention aimed at reducing inappropriate medications | Patients with with 5 medications prescribed and a face-to-face primary care encounter in the last year (Ages 65+) | 2027 |
| Developing, Implementing, and Evaluating a Caregiver and Elder Abuse Screening, Risk Assessment and Treatment to Improve Outcomes for Older and Vulnerable Adults with MCI/ADRD | TBD | Monique Pappadis, University of Texas Medical Branch | Caregiver and Patient Abuse assessment For Older and Vulnerable populations (CAPA-OV), a screening and intervention tool for use in primary care settings to screen for elder abuse among older and vulnerable adults with mild cognitive impairment or Alzheimer's disease and related dementias (AD/ADRD), as well as the inclusion of a risk assessment for accompanying caregivers | Persons living with dementia (Ages 65+), their caregivers, and healthcare providers | 2024 |
| The Effect of Smart Ambient Bright Light for Nursing Home Residents with Alzheimer's Disease and Related Dementias | Smart Lighting for Nursing Home Residents With Dementia | Ying-Ling Jao, Pennsylvania State University |
The intervention is a smart ambient bright light (SABL) intervention which includes tunable LED lights, photosensors, and controllers |
Nursing home residents with Alzheimer's disease and related dementia (AD/ADRD) (Ages 55+) | 2024 |
| Making Connections Thru Music: A Group Music Therapy-Based Intervention for Persons with Dementia | TBD | Gregg Gorzelle, Hopeful Aging LLC | Making Connections Thru Music (MCTM) sessions, an evidence-based music and discussion intervention to improve engagement, enhance quality of life, and reduce behavioral expressions in persons with dementia | Caregiving volunteers and resident living staff for persons living with dementia | 2025 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Partnering with Providers to Understand the Individualized Positive Psychosocial Intervention Outcomes of Interest for PLWD (Pilot) | Testing the Feasibility of the Individualized Positive Psychosocial Intervention (IPPI) | Katherine Abbott, Brown University | A Individualized Positive Psychosocial Intervention (IPPI) program that tailors activities to resident preferences and provides people living with dementia with preference-based, person-centered care to improve their mood and reduce communication of distress. | Persons Living With Dementia residing in nursing homes | 2024 |
| VoiceLove: An App-Based COMmunication Tool Designed to Address DeliriUm and Improve Family ENgagement and PatIent/Family SatisfaCtion in CriticAlly Ill PaTiEnts (COMMUNICATE) | TBD | E. Wesley Ely, Voicelove LLC | VoiceLove is a HIPAA-compliant mobile application that enables expanded family engagement for patients in the Intensive Care Unit (ICU) | Clinicians, patients, and family members within medical, surgical, and coronary Intensive Care Units (ICU) | 2024 |
| Natives Engaged in Alzheimer's Research: Cognition After OSA Treatment Among Native American People | TBD | Denise Dillard, Washington State University | Positive airway pressure therapy, a behavioral intervention for obstructive sleep apnea, to improve sleep quality, cognitive function, and vascular risk factors for Alzheimer's disease and related dementias | American Indians from Strong Heart Study communities (Ages 55+) | 2026 |
| A Pragmatic Crossover Trial to Test the Effectiveness of a Novel Lighting System to Reduce Nighttime Falls in Persons with Alzheimer’s Disease and Related Dementias | The Nightlight Falls Prevention Study | Sheryl Zimmerman, University of North Carolina at Chapel Hill | A lighting intervention to reduce nighttime falls | Individuals with Alzheimer's disease and related dementia | 2027 |
| Enhancing Sleep Quality for Nursing Home Residents with Dementia: Pragmatic Trial | Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase ( 40Winks ) | A. Lynn Snow, University of Alabama | Improve clinical outcomes for nursing home residents with Alzheimer's disease or related dementias by testing an evidence-based intervention to improve these residents' sleep | Individuals with Alzheimer's disease or related dementia (Ages 50+) | 2027 |
| mGlide-Care: A mHealth Partnership with Care Givers to Improve HTN Management in Patients with Cognitive Impairment | mGlide-Care: A mHealth Partnership with Care Givers to Improve HTN Management in Patients with Cognitive Impairment | Kamakshi Lakshminarayan, University of Minnesota Twin Cities | An intervention (mGlide-Care) to address uncontrolled hypertension in people with mild cognitive impairment and early stage Alzheimer's disease and related dementia (AD/ADRD) | Participants with uncontrolled hypertension and early stage Alzheimer's disease and related dementia (AD/ADRD) or mild cognitive impairment (Ages 60 - 85) | 2028 |
| METRIcAL - Music & MEmory: A Pragmatic TRIal for Nursing Home Residents with ALzheimers Disease | Music & MEmory: A Pragmatic TRial for Nursing Home Residents With ALzheimer's Disease (METRIcAL) - Part 2 | Vincent Mor, Brown University | MUSIC & MEMORY (M&M) Music Program, music is preloaded on personalized music devices to increase nursing use of the music with residents | Nursing home residents with moderate to severe dementia | 2024 |
| U.S. Deprescribing Research Network: PPC Deprescribing | PPC Deprescribing | Holly Holmes and Aanand Naik, University of Texas Health Science Center at Houston | Patient Priorities Care (PPC), a three-step care plan regarding the implementation of priorities identification and alignment of deprescribing practices as part of the routine care of adults living with dementia | Adults with dementia (ages 65+) and their caregivers | 2024 |
| ED-LEAD: Emergency Departments LEading the transformation of Alzheimers and Dementia care | ED-LEAD: Emergency Departments LEading the transformation of Alzheimers and Dementia care | Joshua Chodosh, New York University School of Medicine | Emergency and post-emergency care through patient-care partner focused interventions: 1) Emergency Care Redesign; 2) Nurse-led Telephonic Care; and 3) Community Paramedic-led Transitions Intervention | Persons living with dementia who visit the emergency department (Ages 66+) | 2028 |
| Testing the Pain-CPG-EIT | Testing the Pain Clinical Practice Guideline | Barbara Resnick, University of Maryland, Baltimore | The study will evaluate the efficacy and treatment fidelity of an intervention to improve assessment, diagnosis and management of pain (Pain Management Clinical Practice Guideline, PAIN-CPG-EIT) among nursing home residents living with dementia | Nursing home residents living with dementia (Ages 65+) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Meaningful Activity Intervention for Individuals with Early-Stage Dementia: Involving the End User in Intervention Design | User-Led Meaningful Activity and Early-Stage Dementia | Natalie Regier, Johns Hopkins Bayview Medical Center | Service user-led meaningful activity intervention to treat mild dementia | People that are mild or early stages of dementia (Ages 60+) | 2024 |
| A Randomized Controlled Trial of Visual Cues, Signage, and Spaced-Retrieval Education within Long Term Care Communities to Assist with Wayfinding | Effects of Visual Cues and Education for People Who Live Within Long Term Care Communities to Assist in Wayfinding | Rebecca Davis, Grand Valley State University | Assistive cues (salient cues) plus spaced retrieval education to help older adults who live in senior communities remember the presence and function of the environmental wayfinding cues | Residents from 12 senior assisted-living facilities (Ages 62+) | 2024 |
| MEMORI Corps: A Novel Activity-based Companion Care Program to Benefit Community-Living Persons with Dementia, their Families, and Senior Volunteers | MEMORI Corps: Activity-based Companion Care for Dementia (MEMORI Corps) | Quincy Samus, Johns Hopkins Bayview Medical Center | Activity-based home healthcare to treat people with dementia | People with dementia (Ages 55+) and caregivers (Ages 18+) | 2024 |
| Improving Everyday Task Performance through Repeated Practice in Virtual Reality | Improving Everyday Task Performance Through Repeated Practice in Virtual Reality. (VKI) | Tania Giovannetti, Temple University | Virtual reality training intervention for persons with Alzheimer's Disease to improve performance of everyday tasks | Older adults with mild to moderate Alzheimer's disease (Ages 65+); Informants with knowledge of person with Alzheimer's disease's level of function | 2024 |
| Care4AD: A Comprehensive Care Coordination and Management Platform for Alzheimer's Disease and Related Dementias | Care Coordination System for People With Dementia | Vaziri Ashkan, BioSensics | Care4AD, a comprehensive care platform to improve care for people with Alzheimer's disease | Adults with mild to moderate Alzheimer's disease (Ages 56+) | 2024 |
| Impact of Novel Rehabilitative Approaches for Dysphagia in Patients with Alzheimer's Disease and Related Dementias | Interventions for Patients With Alzheimer's Disease and Dysphagia | Nicole Rogus-Pulia, University of Wisconsin - Madison | Dysphagia rehabilitative interventions (lingual strengthening and saliva substitute use) to improve swallowing-related outcomes | Older adults with diagnosis of dementia, cognitive impairment, or memory loss (Ages 55 - 90) | 2024 |
| Decision Making Among Older Adults: the AUTO study | Advancing Understanding of Transportation Options (AUTO) | Marian Betz, University of Colorado Anschutz Medical Campus | Web-based driving decision aid (DDA), an online tool that guides an individual to optimize decision-making | Older drivers without severe cognitive impairment (Ages 70+) and family members | 2024 |
| A Dyadic Approach for a Remote Physical Activity Intervention in Adults with Alzheimer’s Disease and their Caregivers | A Dyadic Approach for a Remote Physical Activity Intervention in Adults With AD and Their Caregivers | Lauren Ptomey, University of Kansas Medical Center | Moderate physical activity intervention for adults with Alzheimer’s Disease and their Caregivers to improve mobility | Adults with mild moderate Alzheimer's disease and their caregivers (Ages 55+) | 2024 |
| Developing a PRogram to Educate and Sensitize Caregivers to Reduce the Inappropriate Prescription Burden in Elderly with Alzheimer's Disease Study (D-PRESCRIBE-AD) | A Program to Reduce Inappropriate Medications Among Older Adults With Alzheimer's Disease (D-PRESCRIBE-AD) | Jerry Gurwitz, University of Massachusetts Medical School | Patient/caregiver-centered, multifaceted educational intervention on inappropriate prescribing | Older adults with Alzheimer's disease and related dementias (AD/ADRD) | 2025 |
| Using Design Thinking Approaches to Tailor a Dyadic Behavioral Sleep Intervention for Persons Living with Dementia and Their Caregivers | TBD | Glenna Brewster Glasglow, Emory University | T-Dyadic Sleep, a cognitive behavioral therapy for insomnia (CBTI) intervention to examine acceptability and feasibility as well as preliminary efficacy on objective and subjective sleep outcomes | Persons living with mild cognitive impairment or early-stage dementia and their caregivers | 2026 |
| Music-based Intervention for Insomnia in Persons Living with Dementia and their Caregivers | TBD | Darina V. Petrovsky, Rutgers Biomedical And Health Sciences | Tailored music-based mobile application aimed at improving insomnia symptoms in persons living with dementia | Underrepresented community-dwelling persons living with dementia and their caregivers | 2026 |
| A Dyadic Approach to Improve Sleep and Well-being Among Persons with Alzheimer's Disease and Their Caregivers | A Dyadic Sleep Health Approach for Persons With Alzheimer's Disease and Caregivers | Yeonsu Song, University of California Los Angeles | Dyadic sleep intervention to improve subjective and objective sleep quality | Dyads of people living with dementia and their care partners | 2027 |
| Addressing Hearing Loss as a Common Unmet Contributor to Neuropsychiatric Symptoms | TBD | Esther Oh, Johns Hopkins Bayview Medical Center | A hearing care intervention to treating neuropsychiatric symptoms | Individuals living with Alzheimer's disease and related dementia (AD/ADRD) | 2027 |
| Improving Person-Environment Fit of Community-Residing Older Adults with Dementia Through Assessment and Individualized Intervention | TBD | Elizabeth Rhodus, University of Kentucky | Harmony at HOME will provide caregiver training for assessment of the environment as an antecedent to behaviors of the person with Alzheimer's disease and related dementias & implementation of environmental cueing as a tool to create a supportive environment for functional behaviors and activity participation | Persons living with dementia and their care partners | 2027 |
| Randomized Clinical Trial of a Brief, Anxiety Intervention for Mild Cognitive Impairment/mild Alzheimer’s Disease and their Care Providers | Treatment of Stress and Anxiety in MCI/Mild ADRD | Norman Schmidt, Florida State University | Cognitive anxiety sensitivity treatment (CAST): a brief, fully computerized CBT-based intervention in people living with mild cognitive impairment | Dyads consisting of persons with mild cognitive impairment or mild Alzheimer's disease and related dementias (AD/ADRD) and their care partners | 2027 |
| Home Alone: Developing a Home-Based Intervention for People with Cognitive Impairment Who Live Alone | Home Alone | Joseph Gaugler, University of Minnesota Twin Cities | Home Alone combines behavioral activation (BA) with other evidence-based intervention approaches (i.e., Tailored Activity Program/TAP; Skills2Care®) that target the environment in order to tailor activity that is fulfilling and meaningful to persons with cognitive impairment | Persons with cognitive impairment who live alone | 2024 |
| Development of a Reminiscence Therapy Online Platform with Machine Learning to Increase Engagement with People Living with Dementia and Their Care Partners | LifeBio Memory Digital Reminiscence Platform | Lisbeth Sanders, LifeBio Inc | LifeBio Memory, an online platform that stores stories, videos, and photos and uses information to make personalized reminiscence therapy exercises | Adult staff (Ages 18+) in assisted living facility with dementia care residents in assisted living care setting (Ages 55+) | 2024 |
| eAlign: A Patient Portal-based Intervention to Align Medications with What Matters Most | TBD | Ariel Green, Johns Hopkins Bayview Medical Center | eALIGN, a patient portal intervention to align medication decisions with persons living with Alzheimer's disease and related dementias (AD/ADRD) and care partners' goals, provide care partner training in the use of nonpharmacologic methods to address behavioral and psychological symptoms of dementia, and reduce polypharmacy and potentially inappropriate medication use | Older adults with diagnosis of Alzheimer's disease and related dementia who receive 5 or more chronic daily medications (Ages 65+) | 2027 |
| Promoting Independence with Compensatory Cognitive Rehabilitation: A Pilot Clinical Trial for Early-Stage Alzheimer's Disease | Promoting Independence With Compensatory Cognitive Rehabilitation | Alyssa Lanzi, University of Delaware | A behavioral treatment, Structured External Memory Aid Treatment (SEMAT), to promote independent living skills | Adults with mild cognitive impairment (Ages 65 - 85) | 2026 |
| U.S. Deprescribing Research Network: Adapting the Shed-MEDS Deprescribing Intervention to Dementia Care in Assisted Living | Adapting the Shed-MEDS Deprescribing Intervention to Dementia Care in Assisted Living | Jennifer Kim, Vanderbilt University | A patient/ surrogate-centered deprescribing intervention adapted for dementia (Shed-MEDS) to reduce exposure to unnecessary or potentially harmful medications among residents with dementia living in an assisted living facility | Residents of an assisted living facility with dementia who are taking 5+ medications or 1 potentially inappropriate medication | 2024 |
| A Stakeholder Derived Intervention to Enhance Technology Engagement and Reduce the Emotional Divide in Distance Caregiving of Older Adults with Cognitive Impairment | TBD | Alyssa Weakley, University of California Davis | Interactive-Care (I-Care), remote caregiver platform to improve everyday functioning and independence of care receivers, remote caregiver involvement, and the emotional bond between the dyad | Mild Alzheimer's disease and related dementia / cognitively impaired care receiver and remote caregivers | 2028 |
| Developing a Nonpharmacological Pain Intervention for Community Dwelling Older Adults with Dementia | TBD | Annalisa Na, Drexel University | A program where participants will start each session with pain, vital signs, and environmental assessments; then receive an individualized home-based exercise program | People living with mild to very mild dementia with osteoarthritis (Ages 65+) and their caregiver | 2027 |
| A Social Engaging Restorative Virtual Environment (SERVE) Volunteer Intervention to Support Social Engagement and Well-being in Older Adults with Cognitive Impairment | TBD | Saleh Kalantari, Cornell University | A VR-based intervention to improve the wellbeing and quality of life of older adults with mild cognitive impairment | Older adults with mild cognitive impairment and non-impaired older adult volunteers | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Improving Outcomes for Family Caregivers and Older Adults with Complex Conditions: The Adult Day Service Plus Program | Improving Outcome for Family Caregivers of Older Adults With Complex Conditions: The Adult Day Plus (ADS Plus) Program (ADS Plus) | Laura Gitlin, Johns Hopkins Bayview Medical Center | Adult day service (ADS) Plus, including care management, referral/linkage, education about dementia, situational counseling, emotional support, stress reduction techniques, and skills to manage behavioral symptoms | Caregivers initially enrolling their relative in one of the Adult Day Service sites (Ages 21+) | 2024 |
| The Care Ecosystem: Navigating Patients and Caregivers Through Stages of Dementia Care | Care Ecosystem: Navigating Patients and Families Through Stages of Care, Extension Trial | Katherine Possin, University of California San Francisco | Navigated Care, a comprehensive longitudinal continuing care program that supports model care for persons with dementia and their family caregivers | Persons with dementia (Ages 45+) and caregiver dyads | 2023 |
| Training the Long-Term Services and Supports Dementia Care Workforce in Provision of Care to Sexual and Gender Minority Residents | MN Inclusive LTSS for LGBTQ Seniors (MILLS) | B.R. Simon Rosser, University of Minnesota Twin Cities |
|
Long-term services and support staff (Ages 18+), Sexual and Gender Minority (SGM) residents, and SGM resident caregivers | 2026 |
| Improving Information Sharing Between Family Caregivers and Home Care Aides Caring for Persons Living with ADRD | TBD | Chanee Fabius, Johns Hopkins Bayview Medical Center | A feasibility test of a home care role and preference guide designed to improve information sharing between family caregivers and home care aides of persons living with Alzheimer's disease and related dementias (AD/ADRD) receiving Medicaid Home and Community-Based Services in Maryland | Family caregivers and home care aides of older adults living with Alzheimer's disease and related dementia (AD/ADRD) | 2027 |
| Improving Alzheimer's Disease and Related Dementias Care in Rural Areas | TBD | Patricia Prusaczyk, Washington University in St. Louis | A communication and care coordination tool for providers of patients with Alzheimer's disease and related dementias | Providers of care for individuals living with Alzheimer's disease and related dementias | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Indiana Palliative Excellence in Alzheimer Care Efforts-RCT | Indiana Palliative Excellence in Alzheimer's Care Efforts (IN-PEACE) | Greg Sachs, Indiana University-Purdue University Indianapolis | Palliative care to improve the care of community dwelling patients with dementia and their family caregivers through an innovative model of supportive care that combines an existing, evidence-based intervention for dementia care with an innovative intervention | People with moderate to severe stage dementia (Ages 65+) | 2024 |
| Transforming Residential Palliative Care for Persons with Dementia Through Behavioral Economics and Data Science: Promoting Advance Care Planning Using a Prognosis and Outcome Information Sheet Among Persons with Advanced Dementia in Long-term Services and Support Facilities (Pilot) | Pilot Study of an Advance Care Planning Intervention Among Persons With Dementia | Donald Sullivan, Oregon Health and Science University | Education information sheet for the promotion of advanced care planning (ACP) among family members of persons with advanced dementia in long-term services and support facilities | Clinicians and family members of persons with advanced dementia in long-term services and support facilities | 2024 |
| Transforming Residential Palliative Care for Persons with Dementia Through Behavioral Economics and Data Science: Systematic Identification of NH Residents with 6-month Mortality Risk for Hospice Informational Referral (Pilot) | TBD | Laura Hanson, University of North Carolina at Chapel Hill | A machine-learning mortality prediction model to identify nursing residents with late-stage Alzheimer's disease and related dementias appropriate for hospice informational referrals to reduce goal-discordant hospital transfers | Nursing home residents with late-stage Alzheimer's disease and related dementia | 2024 |
| Enhanced Dementia Instruction and Tool in Home Hospice Care (EDITH-HC) | Pilot Testing Dementia-Enhanced Training and Tool for Home Hospice Clinicians (EDITH-HC) | Elizabeth Luth, Rutgers Biomedical And Health Sciences | Training program and tool to improve clinicians' knowledge of dementia-related challenges in home hospice care, reduce family caregiver burden, and reduce hospice disenrollment | Nurses or social workers who provides home hospice to persons living with dementia and family caregivers | 2024 |
| PCplanner: Operationalizing Needs-focused Palliative Care for Older Adults in Intensive | A Needs-focused Palliative Care Intervention for Older Adults in ICUs (PCplanner) | Christopher Cox, Duke University | PCplanner-augmented care and PCplanner mobile, augmented collaborative palliative care that will allow patients and their family members to report their needs in a platform viewable by ICU physicians to 1) reduce family caregivers' unmet needs and psychological distress, 2) increase the frequency of goal concordant treatment among older adult patients, and 3) reduce hospital length of stay | Older adults (Ages 65+) managed in an ICU and their family members (Ages 18+), and physicians and nurses (Ages 18+) from academic and community settings | 2024 |
| Palliative Care Needs and Outcomes for Dementia Patients | Supportive Care for Cognitively Impaired Patients and Families | Vyjeyanthi S. Periyakoil, Stanford University | Nurse-led early palliative care intervention (EPC) involving conducting systematic assessment and providing coaching to patients to improve care and well-being | Community-dwelling Stanford ADRC participants (Ages 60 - 100) | 2024 |
| Palliative Care for Persons with Late-stage Alzheimer's and Related Dementias and their Caregivers: A Randomized Clinical Trial | Palliative Care for Persons With Late-stage Alzheimer's and Related Dementias and Their Caregivers (ADRD-PC) | Laura Hanson, University of North Carolina at Chapel Hill | Dementia-specific palliative care intervention involving caregiver education and transitional care | Dyads of hospitalized patients with late stage Alzheimer's disease and related dementias (AD/ADRD) and their family caregivers | 2025 |
| UPLIFT-AD (Utilizing Palliative Leaders in Facilities to Transform Care for Alzheimer's Disease) Intervention | Utilizing Palliative Leaders In Facilities to Transform Care for Alzheimer's Disease (UPLIFT-AD) | Kathleen Unroe, Indiana University-Purdue University Indianapolis | Palliative care intervention utilizing palliative care champions to consult and help surrogate decision makers | Surrogate decision makers for persons living with dementia in nursing homes | 2025 |
| LEADing End-of-Life Dementia Care Conversations | LEADing Dementia End-of-Life Planning Conversations (LEAD) | Kara Dassel, University of Utah | Tool to help persons with preclinical awareness of Alzheimer's disease and related dementia risk and those with early-stage cognitive impairment to begin advance care planning conversations with a care partner | Community-dwelling pairs consisting of persons in the preclinical or early stage of Alzheimer's disease and related dementia (AD/ADRD) and their care partner | 2027 |
| Palliative Care at Home for Patients With Dementia | Palliative Care at Home for Patients with Dementia | Nathan Goldstein, Icahn School of Medicine at Mount Sinai | A new novel home-based palliative care intervention for patients with advanced AD/ADRD and their caregivers. Dyads will be cared for by a pyramid of palliative care and dementia care trained providers who will continue to work with the patient / caregiver through face-to-face visits, video visits, and (at least) weekly phone calls for 12 months | Older adults (ages 65+) with advanced dementia, based on Global Deterioration Score (GDS) >6 who are impairment in at least one activity of daily living (ADL) and their family caregiver | 2027 |
| A Novel Intervention to Improve Care for Older Sexual and Gender Minority (SGM) Adults with Serious Illness and Especially Those with Alzheimer's and Related Dementias (ADRD) | TBD | Carey Candrian, University of Colorado Anschutz Medical Campus | 1) Stakeholder-based behavioral intervention: trains hospice interdisciplinary staff in person-centered communication to promote authentic end-of-life care for sexual and gender minority patients (SGM) patients; and 2) Communication training intervention: teaching hospice interdisciplinary staff to sensitively collect and incorporate sexual orientation and gender identity (SOGI) data to more effectively communicate to accomplish assessment and person-centered care when providing end of life | Hospice interdisciplinary team (IDT) staff, sexual and gender minority (SGM) former/current patients, and SGM older adults current/former caregivers for people living with Alzheimer's disease and related dementia (AD/ADRD) | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Adapting an Evidence-Based Program that Improves Oral Hygiene and Health for Assisted Living Residents with Dementia | Oral Hygiene in Assisted Living | Sheryl Zimmerman, University of North Carolina at Chapel Hill | A program to provide daily mouth care to reduce bacteria in the mouth that can lead to aspiration pneumonia for assisted living residents | Residents with dementia, care staff, and dental hygienists (Ages 18+) | 2024 |
| Nursing Home Prevention of Injury in Dementia (NH PRIDE) | Nursing Home Prevention of Injury in Dementia (NH PRIDE) | Sarah Berry, Hebrew SeniorLife / Hebrew Rehabilitation Center | Centralized Injury Liaison Service (ISL) to decrease injurious falls in nursing home residents | Nursing home residents at high risk for injurious falls, and nursing home staff at participating facilities | 2024 |
| Changing Talk Online Training (CHATO): A National Trial to Reduce Behavioral Symptoms in Long Term Care Residents with Alzheimer's Disease and Other Dementias | Changing Talk Online Training (CHATO) National Trial | Kristine N. Williams, University of Kansas Medical Center | Elderspeak and communication training to reduce behavioral symptoms in long term care settings | Nursing home staff | 2026 |
| Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce | TBD | Sheryl Zimmerman, University of North Carolina at Chapel Hill | Two training arms (essentiALZ alone and essentiALZ + ECHO) in terms of adoption, reach, and reaction. The trial will determine effectiveness of two training arms in relation to each other and to a control arm | Staff at Assisted Living facilities | 2027 |
| Improving Health Equity in Long-term Care Residents with Dementia: The Role of Race and Ethnicity in Resident-to-Resident Aggression | TBD | E-Shien Chang, Joan and Sanford I Weill Medical College of Cornell University | A new staff education module aimed to prevent and mitigate race/ethnicity-related resident-to-resident aggression in long-term care facilities | Nursing home healthcare providers (Ages 18+) | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Commercializing In-Home Supportive Technology for Dementia Caregivers | In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Spanish Language Homes | Gene Wang, People Power Company | People Power Caregiver is a newly developed hardware and software system that is designed to create a safer and more supportive home environment for caregivers and persons with dementia and mild cognitive impairment; People Power Caregiver combines modern Internet-of-Things and artificial intelligence technologies | Dyads of caregivers and individuals with dementia or mild cognitive impairment who live in a Spanish language home. Caregivers must have an iPhone or Android phone. | 2024 |
| Commercializing In-Home Supportive Technology for Dementia Caregivers | In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Rural Homes | Gene Wang, People Power Company | People Power Caregiver is a newly developed hardware and software system that is designed to create a safer and more supportive home environment for caregivers and persons with dementia and mild cognitive impairment; People Power Caregiver combines modern Internet-of-Things and artificial intelligence technologies | Dyads of caregivers and individuals with dementia or mild cognitive impairment who live in a rural home. Caregivers must have an iPhone or Android phone. | 2024 |
| Commercializing In-Home Supportive Technology for Dementia Caregivers | In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Wearables | Gene Wang, People Power Company | People Power Caregiver is a newly developed hardware and software system that is designed to create a safer and more supportive home environment for caregivers and persons with dementia and mild cognitive impairment; People Power Caregiver combines modern Internet-of-Things and artificial intelligence technologies | Dyads of caregivers and individuals with dementia or mild cognitive impairment in homes with Apple Watch. Caregivers must have an iPhone or Android phone. | 2024 |
| Robot-Assisted Cognitive Training for Socially Isolated Older Adults with Mild Cognitive Impairment | Robot-Assisted Cognitive Training for Socially Isolated Older Adults with Mild Cognitive Impairment (MCI) | Jenay Beer, Applied Universal Dynamics, Corp. | Socially-assistive robot to deliver cognitive training in the form of a music (piano) learning intervention | Older adults with mild cognitive impairment (Ages 65+) | 2024 |
| Social Assistive Robot Interface for People with Alzheimer's and Other Dementias to Aid in Care Management | SimpleC Wellness Platform With Social Robot Interaction (Long-term) | Daniel Hedin, Advanced Medical Electronics Corp. | Socially-Assistive Robot (SAR) to engage persons living with dementia in a detailed natural language conversation as psychosocial support | Persons living with dementia and their caregivers who live (or work) in an Assisted Living Facility. | 2023 |
| A Mobile Informatics Solution to Aid in Memory | A Mobile Informatics Solution to Aid in Memory | Gary Havey, Advanced Medical Electronics Corp. | Smartwatch Reminder (SR) system, to automatically transmit pictures and relevant information, such as name or relationship, to a smartwatch worn by the person with memory concerns when family or friends visit | Dyads of persons with memory concerns (Ages 30 - 70) and their care partners (Ages 21+) | 2024 |
| Using Gamification, Predictive Analytics, Artificial Intelligence, and Alexa Voice to Optimize User Experience for Individuals Living with AD/ADRD and Their Caregivers | Efficacy of Gamification in Enhancing User Engagement | Matthew Golden, MapHabit, Inc. | MapHabitTM system, an assistive technology app that helps accomplish activities of daily living, maintain independence, and improves overall quality of life for users | Older adults with Alzheimer's disease and related dementias (AD/ADRD) | 2024 |
| ORCASTRAIT Oregon Roybal Center for Care Support Translational Research Advantaged by Integrating Technology: Optimizing Dementia Caregivers' Biological Clock through Lifestyle Change (Pilot) | Self-Care for Dementia Caregivers: User-Centered Design | Sarah Stahl, University of Pittsburgh | iCARE is a multicomponent intervention that uses mobile technology and motivational health coaching to optimize behaviors that keep the body’s biological clock in sync: sleep, exercise, and social activities | Caregivers of persons living with dementia | 2024 |
| ORCASTRAIT Oregon Roybal Center for Care Support Translational Research Advantaged by Integrating Technology: Protecting Alzheimer Caregivers using Technology through StayingSharp (PROACTS) (Pilot) | Protecting Alzheimer's Caregivers Using Technology Through Staying Sharp (PROACTS) | Chao-Yi Wu, Oregon Health and Science University | Staying Sharp, an online multi-component health intervention to promote a healthier lifestyle and improved skills for coping with the stress involved in dementia caregiving | Caregivers of persons with Alzheimer's disease and related dementias (AD/ADRD) | 2024 |
| Motor Learning of Fall Resistant Skills from Laboratory-Induced Falling Among People with Alzheimer's Disease | Perturbation Training Reduces Falls in People With AD (STAD) | Feng Yang, Georgia State University | Perturbation training, a motor learning intervention to prevent falls | Older adults with mild Alzheimer's disease | 2024 |
| ORCASTRAIT Oregon Roybal Center for Care Support Translational Research Advantaged by Integrating Technology: Neighborhood-based Physical and Social Activity for Older Black Caregivers and People Living With Dementia (SHARP-CG) (Pilot) | Neighborhood-based Physical and Social Activity for Older Black Caregivers and People Living With Dementia (SHARP-CG) | Raina Croff, Oregon Health and Science University | The SHARP Android application preloaded with 72 GPS-linked routes, each route with three “Memory Markers” (historical localized images with two associated questions) designed to prompt conversational reminiscence about local Black history, culture, and life experiences while walking | Triads of 1) primary caregiver, 2) caregiver support person, and 3) African American person with early-stage dementia | 2024 |
| Reducing Loneliness of Older Adults in Long Term Care Facilities through Collaborative Augmented Reality | TBD | Nilanjan Sarkar, Vanderbilt University | HMD-AR, a collaborative head mounted display augmented reality to maximize social connection and engagement | Older adults residing in LTC facilities, family members of the older adults, and formal staff caregivers employed in the Department of Recreational Activities | 2024 |
| Effectiveness and Adoption of a Smart Home-based Social Assistive Robot for Care of Individuals with Alzheimer's Disease | TBD | Sajay Arthanat, University of New Hampshire | Mobile Assistive Robot with Smart Sensing (MARSS) is a smart home-based social assistive robot with multi modal care protocols which combines best practices and existing research on home automation, human-robot interaction, and Alzheimer's disease care giving | Individuals with Alzheimer’s diseases and caregiver dyads | 2027 |
| Using Rendever to Improve the Quality of Life of Older Adults with Cognitive Impairments in Senior Living Communities and Their Family Members Who Live at a Distance | Technology and Family Thriving Study (Thrive) | Kyle Rand, Rendever | Rendever virtual reality (VR) platform designed to improve quality of life of residents with Alzheimer's disease and related dementias in senior living communities and their adult children who live at a distance | Dyads of residents with Alzheimer's disease and related dementias in senior living communities and their adult children | 2024 |
| Telehealth-Enhanced Patient-oriented Recovery Trajectory After Intensive Care | Telehealth-enhanced Patient-oriented Recovery Trajectory After Intensive Care (TelePORT) | Leanne Boehm, Vanderbilt University | Collaborative telemedicine-delivered ICU-Recovery Clinic intervention to identify and improve long-term cognitive impairment, physical and mental health dysfunction, social integration, and self-management behaviors for older critically ill adults | Older adults treated in a medical or surgical ICU for acute respiratory failure and/or septic shock and at high risk for developing Post-Intensive Care Syndrome (Ages 45+) | 2028 |
| A Light Exposure Tracker Designed to Improve the Circadian Entrainment for Alzheimer Disease Patients - Aim 2 | TBD | Erik Page, Blue Iris Labs, Inc. | Speck Sr., an active lighting intervention designed to add morning light and reduce evening light to optimize light exposure and support circadian entrainment | Healthy adults and adults living at home with mild cognitive impairment or early stage Alzheimer's disease and related dementias | 2024 |
| A Light Exposure Tracker Designed to Improve the Circadian Entrainment for Alzheimer Disease Patients - Aim 1 | TBD | Erik Page, Blue Iris Labs, Inc. | Speck Sr., an active lighting intervention designed to add morning light and reduce evening light to optimize light exposure and support circadian entrainment | Healthy older adults | 2024 |
| Over-The-Counter Hearing Aid Treatment for Adults with Cognitive Decline Due to Alzheimer's Disease and Related Dementias | TBD | Pamela Souza, Northwestern University | Hearing or communication intervention to improve cognition and overall communication ability | Adults with mild hearing loss and early-stage Alzheimer's disease, related dementia, or mild cognitive impairment (Ages 60+) | 2025 |
| Smartphone-based Solutions for Prospective Memory in Mild Cognitive Impairment and Dementia | TBD | Michael Scullin, Baylor University | Prospective memory training for persons with mild cognitive impairment or mild dementia using smart-phone based strategies | People with mild cognitive impairment or mild dementia from underserved or digitally disadvantaged populations and their study partners | 2028 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Accessible Hearing Care for Reduction of Disruptive Behaviors and Caregiver Burden in Dementia | HEARS-SLP: Providing SLP-Delivered Hearing Health Care to Individuals With Cognitive Impairment | Carrie Nieman, Johns Hopkins Bayview Medical Center | Communication intervention delivered at home (counseling program combined with a low-cost, over-the-counter amplification device) to optimize hearing and communication for older adults with Alzheimer's disease and related dementia | Older adults with dementia and their caregivers (Ages 18+) | 2024 |
| Promoting Seniors Health with Home Care Aides: A Randomized Controlled Trial | Promoting Seniors' Health With Home Care Aides | Naoko Muramatsu, University of Illinois at Chicago | Healthy Moves for Aging Well (Healthy Moves), a safe physical activity program delivered by home care aides, which consists of a brief motivational enhancement and three movements to be performed in a seated position | Pairs of of eligible patients and their home care aides | 2024 |
| Pragmatic Trial of the Effectiveness and Cost-Effectiveness of Dementia Care | D-CARE - The Dementia Care Study: A Pragmatic Clinical Trial of Health System-Based Versus Community-Based Dementia Care (D-CARE) | David Reuben, University of California Los Angeles | Pragmatic intervention to compare clinical effectiveness and cost-effectiveness of community-based dementia care and health system-based care | Dyads of persons with dementia and their primary caregivers (Ages 18+) | 2024 |
| PLAN: Dementia Literacy Education and Navigation for Korean Elders with Probable Dementia and their Caregivers | PLAN: Dementia Literacy Education and Navigation for Korean Elders With Probable Dementia and Their Caregivers (PLAN) | Hae-Ra Han, Johns Hopkins Bayview Medical Center | PLAN, a dementia literacy training used to train community health workers to improve caregiver's dementia literacy, self-efficacy in dementia care and service use, social support, depression, and quality of life | Community health workers and dyads of individuals with probable dementia (Ages 65+) and their caregiver (Ages 18+) | 2024 |
| Behavioral Change Following Culturally-Informed Biomarker Disclosure in Alzheimer’s Disease | Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure (SHARED III) | Annalise Rahman-Filipiak, University of Michigan | Diagnostic Disclosure Protocol, where participants receive information about current cognitive performance to assess long-term behavior, safety, and efficacy in patients with amnestic Mild Cognitive Impairment (aMCI) following biomarker disclosure | Adults diagnosed with amnestic mild cognitive impairment within the past 12 months (Ages 50+) | 2026 |
| Primary Care Based Collaborative Approach to Care Management for Older Adults with Dementia | TBD | Stephanie Nothelle, Johns Hopkins Bayview Medical Center | Develop and implement a practical primary care based intervention to facilitate collaboration across care management programs | Older adults with Alzheimer's disease and related dementia (AD/ADRD) | 2026 |
| Natives Engaged in Alzheimer's Research: Indians Transforming Alzheimer's Care Training (INTACT) | TBD | Patrik Johansson, Washington State University | INTACT, a clinic-level intervention to improve Alzheimer's disease and related dementias diagnosis and quality of care for American Indian and Alaska Natives | Rural clinics serving American Indian and Alaska Natives | 2026 |
| Multi-Stakeholder Engagement for Interdisciplinary Telehealth in Lewy Body Dementia | Telehealth in Lewy Body Dementia | Bhavana Patel, University of Florida | Telemedicine model of Lewy Body Dementia interdisciplinary care | Individuals living with Lewy Body Dementia and their caregivers | 2026 |
| A Novel Platform to Facilitate Provider Adoption of Cognitive Care Planning | TBD | Bin Huang, Braincheck, Inc. | BC-Care (BrainCheck), a cognitive care planning tool that integrates patient, provider, and caregiver input to generate personalized Alzheimer's disease and related dementias (AD/ADRD) recommendations and follow-up care to be implemented during an AD/ADRD's patient's medical visit | Adults with an existing diagnosis of mild to moderate dementia (Ages 65+), their caregiver, and their health care provider | 2024 |
| Effect of Acetylcholinesterase Inhibitors on Bone Metabolism and Fracture Risk Factors Among Older Adults with Mild to Moderate Alzheimer's Disease | Effect of Acetylcholinesterase Inhibitors on Bone Metabolism | Richard Lee, Duke University | Donepezil, an acetylcholinesterase inhibitor, compared to placebo to measure the effect on fracture risk factors including bone mineral density (BMD), bone turnover markers, and bone quality | Older adults with biomarker-diagnosed Alzheimer’s disease and related dementias at the Duke Memory Disorders Clinic | 2025 |
| A Pilot of Memory Support System for Older Chinese Americans with Mild Cognitive Impairment | TBD | Clara Li, Icahn School of Medicine at Mount Sinai | Chinese adapted memory support system that uses a day planner and note-taking system as a support tool to train individuals with mild cognitive impairment to perform their instrumental of activities of daily living independently | Chinese American older adults (Ages 65+) and their care partners who are primarily Mandarin and Cantonese-speaking | 2025 |
Section 5: Diagnostic Tools, Assessments, & Imaging Studies
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Digital Detection of Dementia Florida Replication Site Pragmatic Cluster-Randomized Controlled Comparative Effectiveness Trial (D3) | Digital Detection of Dementia (D Cubed) Studies (Dcubed) | Malaz Boustani, Indiana University-Purdue University Indianapolis | The Passive Digital Marker (PDM), a Machine Learning (ML) algorithm, and the Quick Dementia Rating Scale (QDRS), a patient reported outcome (PRO) tool, to detect cognitive impairment and improve the annual rate of new documented Alzheimer's disease and related dementias (AD/ADRD) diagnosis in primary care practices | Eligible primary care clinics within the UMiami Health system and adults with at least one visit to a primary care physician within the past year (Ages 65+) | 2025 |
| Digital Detection of Dementia Pragmatic Cluster-Randomized Controlled Comparative Effectiveness Trial (D2) | Digital Detection of Dementia (D Cubed) Studies (Dcubed) | Malaz Boustani, Indiana University-Purdue University Indianapolis | The Passive Digital Marker (PDM), a Machine Learning (ML) algorithm, and the Quick Dementia Rating Scale (QDRS), a patient reported outcome (PRO) tool, to detect cognitive impairment and improve the annual rate of new documented Alzheimer's disease and related dementias (AD/ADRD) diagnosis in primary care practices | Eligible primary care clinics within the Eskenazi Health system and adults with at least one visit to a primary care physician within the past year (Ages 65+) | 2025 |
| Biomarker Predictors of Memantine Sensitivity in patients with Alzheimer's Disease | Biomarker Predictors of Memantine Sensitivity in Patients With Alzheimer's Disease | Neal Swerdlow, University of California San Diego | Identify sensitivity levels of memantine, an NMDA receptor antagonist approved for treatment of moderate-to-severe Alzheimer's disease | Older adults with Alzheimer's disease | 2024 |
| Development of an Ophthalmic Diagnostic Probe for Cerebral Amyloid Angiopathy in Patients | TBD | Stella Sarraf, Amydis Diagnostics Inc. | Ophthalmic diagnostic probe to detect cerebral amyloid angiopathy (vascular disease) | Healthy adults and Cerebral Amyloid Angiopathy adult patients | 2024 |
| Emergency General Surgery Delirium Recovery Model: A Collaborative Care Intervention | Delirium and Neuropsychological Recovery Among Emergency General Surgery Survivors | Ben Zarzaur, University of Wisconsin - Madison | Emergency General Surgery Delirium Recovery Program, a care collaborative program to cognitive, functional and psychological recovery after episode(s) of delirium | Surgery patients who suffer at least one episode of delirium in the post-operative period (Ages 65+) | 2027 |
| Evaluating Cognitive Impairment as a Moderator of Locomotor Learning in Older Adults Post-stroke | Cognition and Motor Learning Post-stroke | Kristan Leech, University of Southern California | Biomechanical analyses, neuropsychological assessments, and brain imaging techniques to examine the structural integrity of the dorsolateral prefrontal cortex in explicit locomotor learning and inform the development of a gait rehabilitation intervention for older adults post-stroke | Older adults with post-stroke cognitive impairment | 2026 |
| Identifying and Supporting Patients with Undiagnosed Dementia Using the EHR Risk of Alzheimer's and Dementia Assessment Rule (eRADAR): A Pilot Clinical Trial | The Brain Health Study: A Pragmatic, Patient-Centered Trial | Sacha Dublin, Kaiser Foundation Hospitals - Washington | EHR dementia screening tool to follow up with high risk patients with potential undiagnosed dementia | Older adults enrolled in Kaiser Washington or UCSF care within the past 2 years with no prior diagnosis of dementia (Ages 65+) | 2024 |
| Integrating Home-based Video Teleneuropsychology into Clinical Practice: Typical Versus Atypical Alzheimer's Disease | VIdeo Telehealth in Alzheimer's: NeuroPsychology (VITAL-NP) (VITAL-NP) | Brianne Bettcher, University of Colorado Anschutz Medical Campus | Home-based video Tele-neuropsychological assessment (TeleNP) versus a face-to-face (FF) neuropsychological assessment in older adults with suspected Alzheimer's disease or related dementias for the delivery of neuropsychological evaluations | Care recipient (Ages 60 - 89) who are undergoing evaluation for possible Alzheimer's disease and whose severity ranges from mild cognitive impairment to mild dementia and their care partner | 2024 |
| Locus-coeruleus Function in Normal Elderly and AD Risk (LEAD) | Locus-coeruleus Function in Normal Elderly and AD Risk (LEAD) | Ricardo Osorio, New York University School of Medicine | Locus coeruleus (LC) targeted imaging coupled with other biomarker testing to determine whether LC dysfunction can be measured in preclinical Alzheimer's disease stages | Cognitively normal older adults (Ages 60 - 75) | 2024 |
| Low-cost Detection of Dementia Using Electronic Health Records Data: Validation and Testing of the eRADAR Algorithm in a Pragmatic, Patient-centered Trial | The Brain Health Study: A Pragmatic, Patient-Centered Trial | Sascha Dublin, Kaiser Foundation Hospitals - Washington | Electronic health record (EHR) dementia screening tool to detect cognitive impairment | Older adults enrolled in Kaiser Washington or UCSF care within the past two years with no prior diagnosis of dementia (Ages 65+) | 2026 |
| Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History (PATH) | Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History (PATH) | Christian Lobue, University of Texas Southwestern Medical Center | Mechanistic study using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools | Individuals with amnestic mild cognitive impairment with and without a history of mild traumatic brain injury (TBI) | 2027 |
| Quantitative Imaging of Brain Glymphatic Function in Humans | Quantitative Imaging of Brain Glymphatic Function in Humans | Manus Donahue, Vanderbilt University Medical Center | MRI and PET imaging to evaluate levels of beta-amyloid burden and assess lymphatic drainage function | Older adults with Parkinson's disease (Ages 55 - 80) | 2025 |
| ToolBox Detect: Low Cost Detection of Cognitive Decline in Primary Care Settings | ToolBox Detect: Low Cost Detection of Cognitive Decline in Primary Care Settings | Cindy Nowinski, Northwestern University | Cognitive assessment toolbox to detect cognitive decline in Medicare Annual Wellness visits. | Older Adults/Patients (Ages 65+) | 2025 |
| Using Routine Care Electronic Medical Record Data and Artificial Intelligence to Develop a Passive Digital Marker to Predict Postoperative Delirium | TBD | Sanjay Mohanty, Indiana University-Purdue University Indianapolis | Test a clinical decision support tool incorporating a Passive Digital Marker (PDM) that predicts postoperative delirium based on EHR data and machine learning techniques for feasibility, acceptability, and effect size | Patients scheduled for elective major abdominal surgery requiring inpatient stay of more than 24 hours (Ages 50+) | 2027 |
| Using the PROMIS Cognition Item Bank for Early Detection of Cognitive Decline in Primary Care | Maria Edelen, RAND Corporation | Electronic health record (EHR) dementia screening tool, implemented in clinical practice to increase early detection of cognitive impairment | Providers of patients (Ages 65+) | 2024 | |
| A Cognitive Risk Calculator and Screening tool for Primary Care Settings | TBD | Darlene Floden, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University | Cognitive screening tools (EHR-based Cognitive Risk Calculator and iPad-based Brief Assessment of Cognitive Health) used in primary care settings to detect dementia | Providers caring for patients (Ages 60+) | 2025 |
| A Technology-Driven Intervention to Improve Early Detection and Management of Cognitive Impairment | Leah Hanson, HealthPartners Institute | Electronic health record (EHR) cognitive impairment clinical decision support tool to improve early detection and management of cognitive impairment | Patients with elevated dementia risk | 2025 | |
| First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Healthy and Alzheimer's Diseased Brain | First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia | David Wilson, University of California San Francisco | A novel PET imaging tracer, RP-115, to evaluate changes in astrocytes in healthy versus cognitively impaired Alzheimer's disease patients by quantitative PET imaging of the excitatory amino acid transporter 2 (EAAT2; an astrocytic glutamate transporter) | Individuals with Alzheimer's disease and healthy older adults | 2026 |
|
Napping, Sleep, Cognitive Decline and Risk of Alzheimers Disease |
Napping, Sleep, Cognitive Decline and Risk of Alzheimer's Disease |
Yue Leng, University of California San Francisco | Cognitive behavioral therapy for insomnia (CBT=I), which incorporates cognitive, behavioral and educational components to improve cognitive outcomes | Older adults with mild cognitive impariment or mild Alzheimer's disease (Ages 65+) | 2024 |
| READI-SET-GO: Researching Efficient Approaches to Delirium Identification - Sustaining Effective Translation to create Gero-friendly Organizations | Researching Efficient Approaches to Delirium Identification-Sustaining Effective Translation (READI-SET-GO) | Donna Fick, Pennsylvania State University | Daily nurse-led delirium screening using the Ultra-brief Confusion Assessment Method in routine care among all hospitalized older adults to inform best practices for delirium identification, including in vulnerable individuals such as those with Alzheimer’s disease and related dementias | Adults, including a subgroup of participants with Alzheimer’s disease and Alzheimer’s related dementia, with an expected hospital length of stay of 3 or more days (Ages 70+) | 2028 |
| Cognitive Screening Made Easy for Primary Care Providers | TBD | Robin Hilsabeck, University of Texas at Austin | Cognitive screening tool (RACS app) for primary care providers to conduct cognitive screenings on a regular basis | Cognitively normal and cognitively impaired adults (Ages 60+) | 2026 |
| Novel Methods for Clinical Trials in Dementia and Cognitive Decline | TBD | Donald Royall, University of Texas Health Science Center at San Antonio | Donepezil, a cholinesterase inhibitor, to measure the impact on the latent dementia severity metric, and Adipokines, inflammatory proteins, to test the the effects of donepezil on the latent dementia severity metric. | People with Alzheimer's disease or mild cognitive impairment (Ages 65 – 100) | 2028 |
| Leveraging Electronic Health Records for Reducing Dementia Screening Disparities in Diverse Communities | TBD | Narges Razavian, New York University School of Medicine | Electronic health records/artificial intelligent predictive model used to improve Alzheimer’s disease and related dementias screening rates and early diagnosis and healthcare metrics related to cognitive health | Primary care providers and patients at high risk for mild cognitive impairment or Alzheimer’s disease and related dementias | 2028 |
Section 6: Treatments for Neuropsychiatric Symptoms
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Randomized Controlled Trial of Electroconvulsive Therapy Plus Usual Care Versus Simulated-ECT plus Usual Care for the Acute Management of Severe Agitation in Alzheimer's Dementia (ECT-AD) | Electroconvulsive Therapy (ECT) for Agitation in Alzheimer's Dementia (AD) | Brent Forester, McLean Hospital | Electroconvulsive Therapy to treat severe agitation in moderate to severe stage Alzheimer's disease | People with moderate to severe stage Alzheimer's disease (Ages 55+) | 2024 |
| Methodology Issues in a Tailored Light Treatment for Persons with Dementia | Methodology Issues in a Tailored Light Treatment for Persons with Dementia | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Light treatment designed to promote better sleep, cognition, mood and behavior in people living with Alzheimer's disease or related dementias | Individuals with Alzheimer's disease or related dementias and sleep problems (Ages 65+) | 2025 |
| Problem Adaption Therapy for Mild Cognitive Impairment with Depression | Problem Adaptation Therapy for Mild Cognitive Impairment and Depression (PATH-MCI) | Dimitris Kiosses, Joan and Sanford I Weill Medical College of Cornell University | Problem Adaptation Therapy (PATH), a novel psychosocial intervention designed to reduce depression and disability in older adults with major depression | People with Mild Cognitive Impairment and depression (Ages 60+) | 2024 |
| Circuit-specific Neuromodulation for the Treatment of Apathy in Alzheimer's Disease | TMS as a Treatment for Apathy in Alzheimer's Disease | Mark Eldaief, Massachusetts General Hospital | Repetitive Transcranial Magnetic Stimulation (rTMS) to modulate cortico-striatal circuits in neurodegenerative patients with apathy | Alzheimer's disease participants with apathy (Ages 50 - 80) | 2024 |
| Development of Memesto, A Wearable Repetitive Message and Music Therapy Device that Senses and Reduces Agitation in Persons with AD/ADRD | Memesto Wearable Device for Persons With Dementia | Jeffery Banker, Edgewater Safety Systems LLC | Wearable therapy device that automatically senses rising agitation and alerts caregivers, while deploying calming voice and music therapy to help avoid crisis level behavior | Adults with dementia diagnosis | 2023 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Escitalopram for Agitation in Alzheimer's Disease | Escitalopram for Agitation in Alzheimer's Disease (S-CitAD) | Constantine Lyketsos, Johns Hopkins Bayview Medical Center | Escitalopram, a small molecule selective serotonin reuptake inhibitor (SSRIs) antidepressant to treat agitation in Alzheimer's disease | People with Alzheimer's disease and agitation | 2024 |
| Lifes end Benefits of CannaBidol and TetrahYdrocannabinol (LiBBY) Trial | Life's End Benefits of Cannabidiol and Tetrahydrocannabinol (LiBBY) | Jacobo Mintzer, Medical University of South Carolina | Cannabidol and Tetrahydrocannabinol, Cannabis chemotypes, to improve quality of life in adults with Alzheimer's disease | Adults with Alzheimer's disease | 2024 |
| Pilot Trial of Dronabinol Adjunctive Treatment of Agitation in Alzheimer's Disease | Trial of Dronabinol Adjunctive Treatment of Agitation in Alzheimer's Disease (AD) (THC-AD) | Paul Rosenberg; Brent Forester, Johns Hopkins University; McLean Hospital | Dronabinol, a synthetic form of THC and partial agonist of CB1/2 endocannabinoid receptors to treat severe agitation in Alzheimer's disease | People with Alzheimer's disease and agitation (Ages 60-90) | 2024 |