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Ongoing Alzheimers and Related Clinical Trials and Studies

Page last updated: November 28, 2018

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Table 1: Early-stage Clinical Drug Development (Phase I and Phase II Clinical Trials)

Grant Number
Trial Name
Principal Investigator/ Institution
Intervention
Population
Anticipated Completion Date
Amyloid
R01 AG049702
Phase I Clinical Studies with the gamma-secretase Modulator, NGP 555, to Establish Safety, Pharmacokinetics, and Biomarker Efficacy Maria Kounnas and William Comer, Neurogenetics, Inc. NGP 555 Cognitively healthy older adults, People with Alzheimer's disease
2019
RF1 AG051593
Phase 1 safety trial for CT1812, a novel small molecule therapeutic targeting a synaptic receptor for Abela oligomers Susan Catalano, Cognition Therapeutics, Inc. CT1812 Healthy volunteers
2019
RF1 AG054176
Phase 1b first in patient safety trial for CT1812, a novel Alzheimer's synaptic protection therapeutic Susan Catalano, Cognition Therapeutics, Inc. CT1812 People with Alzheimer's disease
2019
R01 AG041502
Citalopram Decreases CSF Aβ: A Randomized Dose Finding Trial Yvette Sheline, Washington University Citalopram Healthy older adults Ages 65 - 80
2019
R01 AG047922
Active Immunotherapy for Cognitive Decline in Adults with Down Syndrome Michael Rafii, University of California, San Diego ACI-24 Down syndrome adults age 35-55
2020
R44 AG056166
IND, FIH study and 3-month tox for PTI-125, a novel therapeutic for Alzheimer's disease Lindsay H. Burns, Pain Therapeutics, Inc. PTI-125 Healthy volunteers
2019
RF1 AG057553
A Pilot Synaptic Vesicle Glycoprotein 2A (SV2A) PET Study to Evaluate the Effect of CT1812 Treatment on Synaptic Density in Subjects with Mild to Moderate Alzheimer's Disease Susan Catalano, Cognition Therapeutics, Inc. CT1812 People with Alzheimer's disease
2020
RF1 AG057780
A Pilot CSF Catheter Study to Evaluate the Effect of CT1812 Treatment on Aβ Oligomer Clearance into CSF in Subjects with Mild to Moderate Alzheimerʼs Disease Susan Catalano, Cognition Therapeutics, Inc. CT1812 People with Alzheimer's disease
2020
ApoE, Lipids, and Lipoprotein Receptors
R01 AG054434
The delivery of essential fatty acids to the Brain in Alzheimer's disease Yassine, Hussein, University of Southern California Docosahexaenoic acid (DHA) Healthy adult carriers and non-carriers of APOE ε4
2022
Neurotransmitter Receptors
R01 AG048349
Phase IIb Trial for Slowing Progression in Mild Cognitive Impairment Michela Gallagher and Marilyn Albert, Johns Hopkins University Levetiracetan (LEV) People with Mild Cognitive Impairment
2021
R01 AG047992
Long Term Nicotine Treatment of Mild Cognitive Impairment Paul Newhouse, Vanderbilt University; Paul Aisen, Alzheimer's Therapeutic Research Institute Nicotine People with Mild Cognitive Impairment
2021
R21 AG056882
Network-Level Mechanisms for Preclinical Alzheimer's Disease Development Shi-Jiang Li, Medical College of Wisconsin Levetiracetan (LEV) Healthy adults, carriers of APOE ε4
2020
Metabolism and Bioenergetics
RF1 AG041845
Therapeutic Effect of Intranasal Insulin on Cognition, Function and AD Biomarkers Suzanne Craft, University of Washington Intranasal Insulin People with Mild Cognitive Impairment or mild Alzheimer's disease, Ages 55 – 85
2018
R44 AG049510
Clinical Evaluation of T3D-959 as a Potential Disease Remedial therapeutic for the Treatment of Alzheimer's Disease John Didsbury, T3D Therapeutics; Suzanne De la Monte, Rhode Island Hospital T3D-959 People with Alzheimer's disease
2018
R01 AG043679
Benfotiamine in Alzheimer's Disease: A pilot study Gary Gibson, Burke Medical Research Institute Benfotiamine People with Mild Cognitive Impairment or Alzheimer's disease
2020
R44 AG054243
BPN14770 Safety and Cognitive Effect in Young and Elderly Subjects Mark Gurney, Tetra Discovery Partners, Inc. BPN14770 Healthy volunteers
2018
Vasculature
R01 AG042127
Hypertension, angiotensin receptor blockers, and cognition: effects and mechanisms Ihab Hajjar, Emory University Candesartan Hypertensive adults age 60+ with Mild Cognitive Impairment
2019
R01 AG049752
A biomarker-driven trial of angiotensin receptor blockers for prodromal Alzheimer Ihab Hajjar, Emory University Candesartan Non-hypertensive adults age 40+ with Mild Cognitive Impairment
2022
K01 AG054731
NAD+ therapy for improving memory & cerebrovascular function in patients with MCI Christopher Martens, University of Colorado Nicotinamide Riboside (NR) People with amnestic Mild Cognitive Impairment Ages 60-90
2023
Growth Factors and Hormones
R01 AG051596
A double-blinded, randomized, controlled phase 2a safety, proof-of-concept and exploratory end point trial of the drug LM11A-31 in patients with mild to moderate Alzheimer's disease. Manfred Windisch, PharmatropiX-NeuroScios, Inc. LM11A-31 People with Alzheimer's disease
2022
Multi-target
UF1 AG046148
Allopregnanolone Regenerative Therapeutic for MCI/AD: Dose Finding Phase I Roberta Diaz Brinton, University Southern California Allopregnanolone People with Mild Cognitive Impairment or mild Alzheimer's disease
2019
R01 AG042419
Modulation of microRNA Pathways by Gemfibrozil in predementia Alzheimer's Disease Gregory Jicha, University of Kentucky Gemfibrozil People with Mild Cognitive Impairment
2019
U19 AG010483
Discover Study (CSF Sampling: Safety, Tolerability, PK and PD of Posiphen) Martin Farlow, Indiana University; Douglas Galasko, University of California, San Diego Posiphen People with amnestic Mild Cognitive Impairment or mild Alzheimer's disease
2019
R01 AG055389
Evaluation of Brain and Cognitive Changes in Older Adults with MCI Taking Lithium to Prevent Alzheimer Type Dementia Ariel Gildengers, University of Pittsburgh Medical Center Lithium People with Mild Cognitive Impairment Age 60+
2023
R01 AG051618
Phase II RCT of High-dose Vitamin D Supplements in Older Adults without Dementia John Olichney, University of California, Davis Vitamin D People with Mild Cognitive Impairment or mild Alzheimer's disease
2023
R01 AG055422
Anti-Viral therapy in Alzheimer's disease Davangere Devanand, Columbia University Valacyclovir People with mild Alzheimer's disease
2023
Oxidative Stress
R44 AG055184
2-Hydroxybenzylamine for the prevention of Alzheimer's disease: Initial Evaluation in Humans John Rathmacher, Metabolic Technologies, Inc. 2-hydroxybenzylamine Healthy volunteers
2019
R01 AG054131
Age- Related Mild Cognitive Impairment and novel protective role of Glutathione: implications for Alzheimer's Disease Sekhar Viswanath Viswanath, Baylor College of Medicine Glutathione Adults (aged 65-80) with MCI
2023
Other
R01 AG041795
Olfactory deficits and donepezil treatment in cognitively impaired elderly Davangere Devanand, Columbia University Donepezil People with Mild Cognitive Impairment or Alzheimer's disease
2019

Note: For more information on new and currently recruiting trials, visit NIA's clinical trials finder or ClinicalTrials.gov.

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Table 2: Late-stage Clinical Drug Development (Phase II/III and Phase III Clinical Trials)

Grant Number
Trial Name
Principal Investigator/ Institution
Intervention
Population
Anticipated Completion Date
Amyloid
U19 AG010483
A4 Trial Anti-Amyloid treatment in Asymptomatic Alzheimer's Disease Reisa Sperling, Brigham and Women's Hospital Solanezumab Cognitively healthy older adults who are amyloid positive on brain imaging
2019
UF1 AG046150
Generation Study: Alzheimer's Prevention Initiative Apolipoprotein E4 Trial Eric Reiman and Pierre Tariot, Banner CAD106, CNP520 Cognitively healthy individuals with two copies of the APOEε4 gene
2020
R01 AG046179
Dominantly Inherited Alzheimer's Network Trials Unit – Adaptive Prevention Trial Randall Bateman, Washington University Gantenerumab, Solanezumab Cognitively healthy or mildly impaired adults who are Alzheimer's disease genetic mutation carriers
2022
R01 AG054029
The A3 Study: Ante-Amyloid Prevention of Alzheimer's disease Reisa Sperling, Brigham and Women's Hospital; Paul Aisen, Alzheimer's Therapeutic Research Institute; Keith Johnson, Massachusetts General Hospital TBD BACE inhibitor Cognitively healthy older adults with "non-elevated" amyloid levels on screening PET ages 60–75. Adults 60 – 65 must also carry at least one APOE ε4 allele
2023
R01 AG055444
Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Colombia Trial Eric Reiman and Pierre Tariot, Banner Health; Francisco Lopera, Universidad De Antioquia Crenezumab Cognitively healthy adults who are Alzheimer's disease genetic mutation carriers Age 30+
2023
Vasculature
268200900047C-0-0-1
SPRINT-MIND (Systolic Blood Pressure Intervention Trial-MIND) David Reboussin and Jeff Williamson, Wake Forest University Blood pressure lowering to <140 mmHg versus <120 mmHg Adults age 55+ with systolic blood pressure of 130 mmHg or higher, history of cardiovascular disease, high risk for heart disease
2019

Note: For more information on new and currently recruiting trials, visit NIA's clinical trials finder or ClinicalTrials.gov.

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Table 3: Non-Pharmacological Interventions

Grant Number
Trial Name
Principal Investigator/ Institution
Intervention
Population
Anticipated Completion Date
Exercise
R21 AG040310
The Effect of Physical Activity on Cognition Relative to APOE Genotype Jennifer Etnier, University of North Carolina at Greensboro Aerobic exercise and strength training Healthy adults with family history of Alzheimer's disease
2018
R01 AG043392
Aerobic Exercise in Alzheimer's Disease: Cognition and Hippocampal Volume Effects Fang Yu, University of Minnesota Aerobic exercise training People with Alzheimer's disease
2019
R01 AG043962
Effect of Aerobic Exercise on Alzheimer's Pathophysiology in Preclinical AD Jeffrey Burns, University of Kansas Aerobic exercise training Cognitively healthy older adults who are amyloid positive on brain imaging
2019
R01 AG045058
Genes, Exercise, Neurocognitive and Neurodegeneration: Community–Based Approach Thomas Obisesan, Howard University Aerobic exercise training People with Mild Cognitive Impairment
2020
R01 AG046928
Effects of Physical Activity on Brain Function and Network Connectivity in MCI Judy Pa, University of California at San Francisco Aerobic exercise training People with Mild Cognitive Impairment
2021
U19 AG010483 (7833)
EXERT (Exercise MCI Trial) Laura Baker, Wake Forest University; Carl Cotman, University of California at Irvine Aerobic exercise training People with Mild Cognitive Impairment
2022
R01 AG057552
Exercise for Brain Health with Increased Genetic Risk for Alzheimer's Disease Jerome Carson Smith, University of Maryland Exercise training Physically inactive adults ages 60 to 80
2023
K23 AG049906
A Novel Mobile Health Exercise Intervention in Aging: Brain Perfusion and Cognition Zvinka Zlatar, UC San Diego Walking Healthy adults ages 65-75
2021
R01 AG043452
Enhancing function in later life: Exercise and functional network connectivity Angela Bryan, University of Colorado, Boulder Continuous and interval exercise training Sedentary adults ages 25 and older
2019
R01 AG055500
Exercise to improve hippocampal connectivity and learning in older adults Michelle Voss, University of Iowa Fitness training Sedentary adults ages 55 to 80
2021
R01 AG054427
Mindfulness Training for Mitigating Age-Related Cognitive Decline in the Elderly Prakash, Ruchika, Ohio State University Mindfulness training Adults aged 65-85
2022
R21 AG049968
The entorhinal cortex and aerobic exercise in aging Karin Schon, Boston University Aerobic exercise Sedentary adults aged 60-80
2019
R01 AG053952
Investigating Gains in Neurocognition in an Intervention Trial of Exercise Kirk Erickson, University of Pittsburgh; Jeffrey Burns, University of Kansas; Edward McAuley, University of Illinois – Urbana-Champaign; Arthur Kramer, Northeastern University Walking Sedentary adults 65 to 80
2021
Diet
R01 AG052583
MIND Diet Intervention to Prevent Alzheimer's Disease Martha Clare Morris, Rush University Combination Mediterranean and DASH (Dietary Approaches to Stop Hypertension) diet Cognitively healthy older adults age 65+
2022
R01 AG055122
Modified Ketogenic Diet Effects on Alzheimer's Disease Biomarkers and Cognition in Mild Cognitive Impairment Suzanne Craft, Wake Forest University Ketogenic diet People with amnestic Mild Cognitive Impairment Age 55-85
2023
R01 AG050657
Cocoa Supplement and Multivitamin Outcomes Study in the Mind (COSMOS-Mind) Laura Baker, Wake Forest University Health Sciences, Brigham and Women's Health Daily use of cocoa flavanols with or without a multivitamin 65 years and older
2021
R01 AG043398
Omega 3 Pufas for the Vascular Component of Age-Related Cognitive Decline Lynne Shinto, Oregon Health & Science University Omega 3 polyunsaturated fatty acids (pufas) 80 years and older
2018
R01 AG055527
Multicultural Healthy Diet to Reduce Cognitive Decline & Alzheimer Disease Risk Yasmin Mossavar-Rahmani, Albert Einstein College of Medicine Multicultural Healthy Diet 40 to 65 years
2022
Cognitive Training
R01 AG045163
Cognitive training and practice effects in MCI Kevin Duff, University of Utah Computerized cognitive training People with Mild Cognitive Impairment
2020
R01 AG045154
Processing Speed Training to Preserve Driving and Functional Competencies in MCI Virginia Bradley, University of Alabama at Birmingham Computerized processing speed training People with Mild Cognitive Impairment
2020
R44 AG047722
Plasticity-based Adaptive Cognitive Remediation for Alzheimer's Disease Phase II Lee, Hyun Kyu, Plasticity, Inc Computerized cognitive training Cognitively healthy older adults age 65+
2021
R01 AG051628
Conversational engagement to delay onset Alzheimer's Disease: Phase II Hiroko Dodge, Oregon Health & Science University Conversation based social interaction Cognitively healthy older adults age 80+
2022
K25 AG050759
The influence of multi-domain cognitive training on large scale structural and functional brain networks in MCI Seyed Hosseini, Stanford University Computerized cognitive training People with Mild Cognitive Impairment
2022
R01 AG052440
Cognitive training and neuroplasticity in mild cognitive impairment Davangere P. Devanand, Columbia University Computerized cognitive training People with Mild Cognitive Impairment
2023
R21 AG053161
Using Smartphone Personal Assistant Technology to Improve Prospective Memory in Alzheimer's Disease Michael Scullin, Baylor University Smartphone People with mild Alzheimer's disease
2020
R01 AG055425
Communication Bridge: A person-centered Internet-based intervention for individuals with primary progressive aphasia Emily Rogalski, Northwestern University Personalized speech-language therapy intervention Individuals with Mild Primary Progressive Aphasia
2023
R01 AG056428
Interventions to Attenuate Cognitive Decline EDWARDS, JERRI, University of South Florida Intense piano training 200 participants at least 60 years of age
2020
R21 AG056145
Videogame-based environmental enrichment training for altercations in hippocampal function and memory in middle-aged adults STARK, CRAIG E, UC Irvine Minecraft Complexity (↑complexity/↓spatial), Minecraft Spatial (↓complexity/↑spatial) 105 naive video gaming, healthy volunteers (35 per group), aged 40-49
2019
R01 AG049424
Enhancing Cognitive Control in Older Adults with Complementary Interventions GAZZALEY, ADAM H, UCSF Externally-oriented attention training (AT) and internally oriented meditation training (MT) 225 older adults (local)1650 older adults (national) 50 younger adults (local)
2020
R01 AG052439
MIND Food and Speed of Processing Training in Older Adults with Low Education, The MINDSpeed Alzheimers Disease Prevention Pilot Trial CLARK, DANIEL O., Indiana University High polyphenol (MIND) foods combined with speed of processing cognitive training 180 older adults (60+)
2022
R43 AG058287
Developing and testing a neurotherapeutic treatment to improve spatiotemporal cognition in seniors ARONSON, THEODORE, COGNIVIVE, INC. BrainPixel 10 healthy seniors aged 65-85
2018
R21 AG054810
Applying Person-Centered Approach to Enhance Cognitive Training in Assisted Living Facility Residents with Mild Cognitive Impairment LIN, FENG VANKEE, University of Rochester School of Nursing Computerized cognitive interventions (CCIs) 50 MCI residents from Assisted Living facilities, aged ≥65
2019
Combination Therapy
R01 AG045157
Cognitive and Aerobic Resilience for the Brain Frederick Unverzagt, Indiana University Aerobic exercise training, Cognitive training People with Mild Cognitive Impairment
2020
R15 AG042109
Preventing or ameliorating Alzheimer's and related dementias: An interactive Physical and Cognitive Exercise System (iPACES™) for Mild Cognitive Impairment(MCI)/Neurocognitive Disorder (mNCD) Cay Anderson-Hanley, Union College Interactive physical and mental exercise (cybercycling) People with Mild Cognitive Impairment
2021
R41 AG053120
Memory Lane: A neuro-exergame to mitigate cognitive decline in later life Emilie Saulnier, 1st Playable Productions; Cay Anderson-Hanley, Union College Interactive physical and mental exercise (cybercycling) Healthy older adults
2022
R01 AG049749
Exercise and Intensive Vascular Risk Reduction in Preventing Dementia Rong Zhang, UT Southwestern Medical Center; Ellen Binder, Washington University; Jeffrey Burns, University of Kansas Medical Center; Munro Cullum, UT Southwestern Medical Center; Jeffrey Keller, Pennington Biomedical Research Center; Diana Kerwin, Texas Health Presbyterian Hospital Dallas Aerobic exercise and Atorvastatin Cognitively healthy older adults age 65+
2022
R01 AG055469
Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training in MCI (The ACT Trial) Fang Yu, University of Minnesota Aerobic Exercise and Cognitive Training People with Mild Cognitive Impairment Age 65-74
2023
R01 AG057508
Multidomain Alzheimer's Risk Reduction Study (MARRS) Pilot Kristine Yaffe, University of California, San Francisco; Eric Larson, Group Health Research Institute Multi-domain Alzheimer's risk reduction Individuals with subjective cognitive complaints Age ≥70
2022
R01 AG054077
Augmenting Cognitive Training in Older Adults - The ACT Grant Adam Woods, University of Florida Neurostimulation (tDCS) and cognitive training Adults aged 65 to 89 with age related cog. decline
2022
Other
R21 AG054876
Treatment of mild cognitive impairment with transcutaneous vagal nerve stimulation John Williamson, University of Florida Transcutaneous vagal nerve stimulation (tVNS) People with amnestic MCI
2020
R01 AG051545
Hyperbaric oxygen therapy for cognition in diabetic elderly at high dementia risk Michal Schnaider Beeri, Icahn School of Medicine at Mount Sinai; Mary Sano, Icahn School of Medicine at Mount Sinai Hyperbaric oxygen therapy People with Mild Cognitive Impairment
2022
R01 AG054435
Changing the Trajectory of Mild Cognitive Impairment with CPAP Treatment of Obstructive Sleep Apnea Nalaka Gooneratne/University of Pennsylvania Continuous positive airway pressure (CPAP) People with obstructive sleep apnea and amnestic Mild Cognitive Impairment Age 55-75
2022
R01 AG054130
INtervention for Cognitive Reserve Enhancement in Delaying the Onset of Alzheimer's Symptomatic Expression: The INCREASE study Daniela Moga, University of Kentucky; Gregory Jicha, University of Kentucky Medication management Non-demented older adults age 65+
2022
R01 AG055526
Noninvasive Cortical Stimulation to Improve Memory in Mild Cognitive Impairment Joy Taylor, Stanford Repetitive Transcranial Magnetic Stimulation (rTMS) People with Mild Cognitive Impairment Age 55+
2023
R01 AG056102
Web-enabled social interaction to delay cognitive decline among seniors with MCI: Phase I Hiroko Dodge, Oregon Health & Science University Conversation based social interaction People with Mild Cognitive Impairment
2023
K23 AG058809
Meaningful Activity Intervention for Individuals With Early-Stage Dementia: Involving the End User in Intervention Design Natalie Regier, Johns Hopkins University Service user-led meaningful activity intervention People that are mild or in the early stages of dementia Age ≥60
2024
R21 AG052820
Investigating dementia worry and its impact on older adults MAXFIELD, MOLLY, UNIVERSITY OF COLORADO AT COLORADO SPGS Optimistic empirically supported information on both how dementia risk can be minimized and how planning can minimize its negative effects on self and others 48 middle-aged and older adults
2019
K23 AG055668
A Dyadic Sleep Intervention for Alzheimers Disease Patients and Their Caregivers SONG, YEONSU, UCLA Behavioral sleep intervention program 40 AD patient-caregiver dyads
2022
K99 AG056598
Napping, Sleep, Cognitive Decline and Risk of Alzheimers Disease LENG, YUE, UCSF Bright light therapy (BLT) and cognitive behavioral therapy for insomnia (CBT-i) 40 older adults (aged 65 and above) with MCI or mild Alzheimer's disease
2019
R44 AG057364
Automated Social Interactive Interface to Monitor and Update Intervention Plans for People with MCI, Alzheimers and Other Dementias HAVEY, GARY D, Advanced Medical Electronics Corp. Social interactive interface (SII) + SimpleC platform 60 individuals with dementia and their caregivers
2018
R41 AG056230
My MESSAGE: Improving Wayfinding and Reducing Challenging Behaviors in Persons with Dementia Through the Use of RFID Technology ZEISEL, JOHN, Hearthstone Alzheimer Care My MESSAGE System 24 persons with dementia, aged 65+
2018
R21 AG050898
Cognitive Enhancement Through Transcranial Laser Therapy Andrena Haley, The University of Texas at Austin Low Level Light/Laser Therapy (LLLT) 30 men and 30 postmenopausal women, aged 45-65
2018
R01 AG055426
Aging, Cognition, and Hearing Evaluation in Elders (ACHIEVE) Randomized Trial Frank Lin, Josef Coresh, Johns Hopkins University Hearing aid placement 70 to 84 years
2022

Note: For more information on new and currently recruiting trials, visit NIA's clinical trials finder or ClinicalTrials.gov.

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Table 4: Clinical Therapy Development for the Neuropsychiatric Symptoms of AD/ADRD

Grant Number
Trial Name
Principal Investigator/ Institution
Intervention
Population
Anticipated Completion Date
Pharmacological
R01 AG047146
Treatment of psychosis and agitation in Alzheimer's disease Davangere Devanand, Columbia University Lithium People with Alzheimer's disease and agitation/aggression
2020
R01 AG046543
Apathy in Alzheimer's Disease Methylphenidate Trial II (ADMET II) Jacobo Mintzer, Krista Lanctot, Nathan Herrmann, Paul Rosenberg, Roberta Scherer, Medical University of South Carolina Methylphenidate People with Alzheimer's disease and apathy
2020
R01 AG052510
Escitalopram for Agitation in Alzheimer's Disease Constantine Lyketsos, Johns Hopkins University; Anton Porsteinsson, University of Rochester Escitalopram People with Alzheimer's disease and agitation
2022
R01 AG050515
Pilot Trial of Dronabinol Adjunctive Treatment of Agitation in Alzheimer's Disease Paul Rosenberg, Johns Hopkins University; Brent Forester, McLean Hospital Dronabinol People with Alzheimer's disease and agitation
2022
U19 AG010483
PEACE-AD (Prazosin for Agitation In Alzheimer's Disease) Elaine Peskind and Murray Raskind, University of Washington Prazosin People with Alzheimer's disease and severe agitation
2021
Non-Pharmacological
R01 AG041781
Reducing Agitation in Dementia Patients at Home: The Customized Activity Trail Laura Gitlin, Johns Hopkins University Patient customized activity People with dementia and a family caregiver
2019
R01 AG050514
Problem Adaption Therapy for Mild Cognitive Impairment with Depression Dimitris Kiosses, Cornell University; Paul Rosenberg, Johns Hopkins University Psychosocial therapy People with Mild Cognitive Impairment and depression
2022

Note: For more information on new and currently recruiting trials, visit NIA's clinical trials finder or ClinicalTrials.gov.

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Table 5: Care Interventions

Grant Number
Trial Name
Principal Investigator/ Institution
Intervention
Population
Anticipated Completion Date
R01 AG046274
MIND: An RCT of care coordination for community-living persons with dementia Quincy Samus, Johns Hopkins University Home based care coordination People with Alzheimer's disease and family caregiver
2020
R01 AG056610
A Multi-Site Cluster RCT of the Dementia Symptom Management At Home Program Abraham Aizer Brody, New York University Home healthcare People with dementia
2023
R01 AG046217
Function and Behavior Focused Care for Nursing Home Residents with Dementia Elizabeth Galik, University of Maryland Caregiver training People with dementia and a paid caregiver
2019
R21 AG052140
Triggered Palliative Care for Advanced Dementia: A Pilot Study Laura C. Hanson, University of North Carolina Palliative care People with advanced dementia
2019
R01 AG040220
Indiana University Dementia Screening Trial: The IU CHOICE Study Malaz Boustani, Indiana University Dementia Screening and collaborative care People age 75 and older attending urban primary care
2019
R44AG049579
HOME 4 CARE--the Hearthstone Optimized Multimedia Environment for Care-planning, Activities, Recreation, and Education GORZELLE, GREGG, Hearthstone Alzheimer Care, LTD Home 4 CARE (the Hearthstone Optimized Multimedia Environment for Care-Planning, Activities, Recreation, and Education) 48 home health clients, 24 assisted living residents, 48 home health aides, 12 assisted living resident assistants, 8 home health case managers, and 4 assisted living managers
2019
R01AG044504
Translation of COPE for Publicly-Funded Home Care Clients and their Families FORTINSKY, RICHARD H, University of Connecticut Care of Persons with Dementia in their Environments (COPE) 290 dyads of clients with dementia and their CGs in a combined Medicaid waiver and state revenue-funded home care program
2019
R01AG049692
Improving Outcomes for Family Caregivers and Older Adults with Complex Conditions: The Adult Day Service Plus Program GITLIN, LAURA N, Johns Hopkins University Adult day service (ADS) Plus 300 caregivers initially enrolling their relative in one of the 30 ADS sites
2021
R01AG043440
An RCT of an Educational Video to Improve Nursing Home Care in End-Stage Dementia MITCHELL, SUSAN L (contact); VOLANDES, ANGELO, Hebrew Rehabilitation Center Advance care planning 360 nursing home residents in 20 matched nursing homes
2018
R01AG056715
The Care Ecosystem: Navigating patients and caregivers through stages of dementia care POSSIN, KATHERINE LAUREL, UCSF Care Ecosystem 1050 person with dementia and caregiver dyads
2023
R21AG057451
METRIcAL - Music & MEmory: A Pragmatic TRIal for Nursing Home Residents with ALzheimers Disease MOR, VINCENT, Brown University MUSIC & MEMORY (M&M) Music Program 66 Nursing Home facilities
2018
R21AG057463
A Nursing Home Pragmatic Clinical Trial of APPROACHES (Aligning Patient Preferences: A Role Offering Alzheimer's patient, Caregivers, and Healthcare Providers Education and Support) HICKMAN, SUSAN, Indiana University APPROACHES Trial 206 urban and rural Nursing Home facilities
2019
R43AG059443
LEAD IT! An App to Enable Persons with Early Stage Dementia to Lead Group Activities for Their Peers SKRAJNER, MICHAEL JOHN, Hearthstone Alzheimer Care, LTD LEAD IT! (tablet-based app) 24 persons with dementia (i.e., 20 player-participants and 4 resident leaders)
2018
R44AG044019
Online Training & Certification for Competency in Dementia Friendly Hospital Care HOBDAY, JOHN V (contact); MITTELMAN, MARY SHERMAN, HealthCare Interactive, Inc. Hospital Training and Certification Technology (HTCT) 12 hospitals (at least 33 participants per site)
2019
R01AG057389
Resident-to-Resident Elder Mistreatment Intervention for Dementia Care in Assisted Living TERESI, JEANNE A (contact); LACHS, MARK STEVEN; PILLEMER, KARL A, Cornell University Training of nursing, social work, administrative and other staff on R-REM 6 assisted living residence (ALRs) facilities
2022
R01AG054079
Testing Tele-Savvy, an On-line Psychoeducation Program for Informal Alzheimers Caregivers HEPBURN, KEN W (contact); GRIFFITHS, PATRICIA C, Emory University Tele-Savvy 216 informal caregivers (family/friends) of persons living with Alzheimer's
2020
R01AG043485
Community-based End-of-life Intervention for African American Dementia Caregivers BONNER, GLORIA J, University of Illinois at Chicago Education Activation (EduAct) intervention 304 AA healthcare proxies (HCPs) for persons with dementia
2019
R43AG059442
Decide, Discover, and Do: An Intervention for Community-Dwelling Older Adults with Alzheimers and Other Dementias GORZELLE, GREGG, Hearthstone Alzheimer Care, LTD Decide, Discover, and Do (D3)! - software application (interactive, video-based series of education courses and activities) Phase 1: 20 participants (10 persons with dementia/family caregivers dyads) PWD = 55+; Phase 2: 50 dyads [N=100]
2018
R01AG048931
The Residential Care Transition Module GAUGLER, JOSEPH E., University of Minnesota Residential Care Transition Module (RCTM) 240 family caregivers who have recently admitted a relative to residential long-term care program
2021
R01AG049764
Cognitive training to protect immune systems of older caregivers HEFFNER, KATHI L University of Rochester Computerized cognitive training 180 older caregivers of a family member with Alzheimer's Disease (AD) or AD-related dementia (ADRD)
2020
R21AG054119
Web-based Behavioral Activation for Alzheimers Caregivers MAUSBACH, BRENT T, UCSD Web-Based Behavioral Activation (wBA) 44 dementia caregivers
2019
R01AG052495
Mindfulness based stress reduction for family caregivers of dementia patients MOYNIHAN, JAN A, University of Rochester Mindfulness Based Stress Reduction (MBSR) 240 women and men, aged 60 and older, who currently live with and are the primary caregivers for a community dwelling dementia patient
2021
R01AG056424
Mindfulness Meditation and Insomnia in Alzheimer Disease Caregivers: Inflammatory and Biological Aging Mechanisms IRWIN, MICHAEL R, UCLA Mindful Awareness Practices for Insomnia (MAP-I) 150 AD spousal caregivers
2022
R43AG058277
Mindfulness-based Cognitive Coping Mobile App Intervention for caregivers of individuals with Alzheimer's Disease KAJIYAMA, BRUNO, Photozig, Inc. Mindfulness-based Cognitive Coping (MCC) Mobile App 25 dementia caregivers
2018
R43AG059327
A mobile self-compassion intervention for Hispanic Dementia Caregivers KAJIYAMA, BRUNO, Photozig, Inc. Self-Compassion Coping intervention for dementia caregivers (SCC) - mobile application 25 Hispanic/Latino caregivers 18+ years of age
2019
R01AG054009
A non-pharmacological intervention for patients with Alzheimer s disease and family caregivers CZAJA, SARA J, University of Miami Dyadic cognitive/functional training intervention 240 dyads of individuals with mild AD and their CGs
2022
RF1AG015301
Alzheimer Caregiver Coping: Mental and Physical Health GRANT, IGOR (contact); MAUSBACH, BRENT T, University of California San Diego Behavioral Activation (BA) 200 spousal CG (>55 years old) providing care at home
2019
R21AG054143
Hip Fracture Caregiver Intervention Function Focused Care Hip Care at Home GRUBER-BALDINI, ANN L, University of Maryland Function Focused Care for the Cognitively Impaired: Hip Care at Home (FFC-HC) 20 hip fracture patients with ADRD and their informal caregivers
2019
R44AG053936
Tools for Coordination Among Caregivers of Patients with Alzheimers Disease and Other Dementias HAVEY, GARY D, Advanced Medical Electronics Corp. SimpleC Companion 30 individuals with dementia (10 each with mild, moderate, or severe) and their caregivers
2019
R21AG054262
Adapting and testing an Alzheimer's family caregiver intervention in Vietnam HINTON, WALTER LADSON (contact); NGUYEN, HUONG, UC Davis Vietnamese version of REACH-VA 30 dyads of patients diagnosed with dementia and their family caregivers
2019
R21AG051970
Mindfulness and guided imagery for depressed family caregivers of patients with Alzheimer's disease and related dementias: clinical outcomes and neural mechanisms JAIN, FELIPE A, UCSF Central Meditation and Imagery Therapy for Caregivers (CMIT) 50 depressed caregivers of family members with Alzheimer's disease and related dementias
2018
R43AG051303
Caregiver training app to maintain independence in persons with Alzheimers JAKOBS, THOMAS, InvoTek, Inc. Levels of Assistance (LoA) caregiving app 10 family caregiver/elder with dementia dyads
2018
K01AG052646
A Culturally-Relevant Approach to Reducing Dementia Caregiver Stress in an Underserved Population MEYER, OANH L, UC Davis Culturally-relevant, multicomponent intervention addressing dementia with a novel piece addressing cultural and inter-personal support in families 24 caregiver and secondary caregiver dyads
2020
R01AG054536
Old SCHOOL Hip Hop: A randomized controlled trial to improve dementia knowledge NOBLE, JAMES MCCALLUM, Columbia University "Old SCHOOL Hip Hop" (Seniors Can Have Optimal aging and Ongoing Longevity, OSHH) Twenty schools (with 3000 total students)
2022
R01AG055424
Decisions about Cancer Screening in Alzheimers Disease FOWLER, NICOLE R, Indiana University Mammography decision aid 426 dyads consisting of an older woman with AD and a family caregiver
2022
R01AG045043
Improving advance care planning for seniors at risk for Alzheimers disease and related dementias and their caregivers SUDORE, REBECCA L, Northern California Institute for Research and Education PREPARE 24 cognitively impaired 55+ adults and 24 caregivers
2019
R01AG057714
Preparation for End of Life Decision Making in Mild Alzheimers Disease SONG, MI-KYUNG, Emory University SPIRIT (Sharing Patient's Illness Representation to Increase Trust 120 patient-surrogate dyads
2022
R01 AG055488
Older Adults Living with Alzheimers Disease and their Caregivers: Testing an Evidence-Based Intervention for Underserved Populations FREDRIKSEN-GOLDSEN, KAREN ILENE (contact); TERI, LINDA, University of Washington Enhanced Reducing Disabilities in Alzheimer's Disease (RDAD) 225 dyads of care recipients with AD/RD and their caregivers
2022
R44 AG046944
Accurate WiFi-Based Localization of Dementia Patients For Caregiver Support SHEIKH, SUNEEL ISMAIL, ASTER Labs, Inc. Activlink Study 2a: dementia patients residing in skilled or memory care facilities; Study 2b: 80 independently dwelling mild dementia patients
2019

 

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Table 6: Delirium/Post-Operative Cognitive Decline

Grant Number
Trial Name
Principal Investigator/ Institution
Intervention
Population
Anticipated Completion Date
R01 AG053582
Pathophysiology of postoperative delirium and the use of biomimetic sleep as a treatment strategy in the CSICU Oluwaseun Johnson-Akeju, Massachusetts General Hospital Preemptive biomimetic sleep induction in reducing the incidence of delirium >=60 yrs old scheduled for cardiac surgical procedure
2021
1R42 AG059451
Novel Arm Restraint for Critically Ill Patients to Reduce Immobility, Sedation, Agitation and Cognitive Impairment Stapleton, Renee Needham, Dale Murray, HEALTHY DESIGN, LTD. CO. Novel Arm Restraints Adults 65 or older who are critically ill
2021
R01 AG055391
Decreasing Alzheimers Disease and Related Dementias after Delirium-Exercise and Cognitive Training (DDD-ECT) Babar Khan, Indiana University Physical Activity and Brain HQ training Adults 65 or older with history of delirum
2023

 

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