NIA-Funded Active Alzheimer’s and Related Dementias Clinical Trials and Studies
The National Institute on Aging (NIA) is currently supporting 459 active clinical trials on Alzheimer’s disease and related dementias (AD/ADRD). These trials reflect diverse drug and mechanistic targets, as well as diversity in the stages of AD/ADRD they address. NIA’s active trials include: Clinical Drug Development – Phase I and II (59), Clinical Drug Development – Phase II/III and Phase III (7), Non-drug (152), Dementia Care and Caregiver (210), Diagnostic Tools, Assessments, & Imaging Studies (22), and Treatments for Neuropsychiatric Symptoms (9). Please see the tables below for more details about these trials.*
Please note: The data in the graphics are from September 2022.
On this page:
- Section 1: Clinical Drug Development – Phase I and II (59 trials)
- Section 2: Clinical Drug Development – Phase II/III and Phase III (7 trials)
- Section 3: Non-drug (152 trials)
- Section 4: Dementia Care and Caregiver (210 trials)
- Section 5: Diagnostic Tools, Assessments, & Imaging Studies (22 trials)
- Section 6: Treatment for Neuropsychiatric Symptoms (9 trials)
*The data in the tables below are from September 2022
Section 1: Clinical Drug Development – Phase I and II
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Clinical Trials to Prevent Alzheimer's Disease in Down Syndrome | Trial-Ready Cohort-Down Syndrome (TRC-DS) (TRC-DS) | Michael S. Rafii, University of Southern California | Anti-Aβ immunotherapy to remove amyloid plaques | Non-demented adults with down syndrome (Ages 35 - 55) | 2025 |
| A Pilot Electroencephalography (EEG) Study to Evaluate the Effect of CT1812 Treatment on Synaptic Activity in Subjects with Mild to Moderate Alzheimer's Disease | Pilot Clinical Study of CT1812 in Mild to Moderate Alzheimer's Disease Using EEG | Susan Catalano, Cognition Therapeutics Inc | CT1812, a small molecule sigma2 receptor antagonist that displaces Aβ oligomers bound to neuronal receptors at synapses | Mild to moderate AD patients (Ages 50 - 80) | 2023 |
| A Single Ascending Dose, Multiple Ascending Dose Phase I Study of the GSM 776890 in Healthy Normal Subjects | TBD | Steven Lee Wagner, University Of California, San Diego | Gamma secretase modulator (GSM)776890, an Allosteric modulator of APP processing | Healthy adult participants | 2023 |
| COG0202, A Randomized Double Blind, Placebo Controlled, Parallel Group Trial to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease over 18 Months | TBD | Susan Catalano, Cognition Therapeutics Inc | CT1812, a small molecule sigma2 receptor antagonist that displaces Aβ oligomers bound to neuronal receptors at synapses | Older adults with early AD, late mild cognitive impairment, and mild AD dementia | 2025 |
| A Seamless Phase 2A-B Randomized Double Blind Placebo Controlled Trial to Evaluate the Efficacy and Safety of PQ 912 in Patients with Early Alzheimer's Disease | A Trial to Evaluate the Efficacy and Safety of PQ912 in Patients With Early AD | Howard Feldman, University of California San Diego | PQ 912, a small molecule glutaminyl cyclase (QC) inhibitor to treat both amyloidopathy and neuroinflammation | Adults with MCI or mild probable AD (Ages 50 - 89) | 2023 |
| Human AME study of CT1812, a Small Molecule in Phase 2 Clinical Trials for the Treatment of Alzheimer's Disease | Study to Assess the Absorption, Metabolism, Excretion, and Mass Balance of CT1812 in Healthy Adult Male Subjects (COG0108) | Susan Catalano, Cognition Therapeutics Inc | CT1812, a small molecule sigma2 receptor antagonist that displaces Aβ oligomers bound to neuronal receptors at synapses | Healthy male volunteers (Ages 30 - 65) | 2023 |
| A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2 Study to Evaluate the Safety and Efficacy of CT1812 in Subjects with Dementia with Lewy Bodies | Study to Evaluate the Safety, Tolerability and Efficacy of CT1812 in Subjects With Mild to Moderate Dementia With Lewy Bodies (COG1201) | Susan Catalano, Cognition Therapeutics Inc | CT1812, a small molecule sigma2 receptor antagonist that displaces Aβ oligomers bound to neuronal receptors at synapses | Individuals with mild to moderate Lewy Body Dementia | 2024 |
| Safety, Tolerability, Immunogenicity of First-in-Human Aβ DNA Vaccine, AV-1959D Phase 1 Trials in Early-Stage AD Subjects: Based on IND18953 Cleared by FDA. | TBD | Michael Agadjanyan, Institute for Molecular Medicine | AV-1959D, a DNA based vaccine targeting amyloid beta to reduce amyloid plaque | Early AD participants (Ages 60 - 85) | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Evaluating the Disease-Modifying Potential of a Sleep Intervention for Alzheimer's Disease Outcomes | Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging | Natalie Denburg, University of Iowa | Melatonin, a hormone that regulates sleep, to improve cognition in older adults | Older adults (Ages 60 - 75) | 2024 |
| RCT Targeting Cognition in Early Alzheimer's Disease by Improving Sleep with Trazodone (Rest) | Targeting Cognition in Early Alzheimer's Disease by Improving Sleep with Trazodone (REST) | Barry Greenberg, Johns Hopkins University | Trazadone, an antidepressant to treat sleep disturbance and improve cognitive outcomes | Individuals with prodromal AD/amnestic Mild Cognitive Impairment and sleep complaints | 2026 |
| The benefits of nicotinamide riboside upon cognition and sleep in older veterans | The benefits of nicotinamide riboside upon cognition and sleep | Carleara Weiss, State University of New York at Buffalo | Nicotinamide riboside (NR) supplementation to enhance cognition by improving objective sleep duration and sleep quality in older persons | Older adults (65-85) with poor sleep quality (Pittsburgh Sleep Quality Index (PSQI) global score >5) | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Clinical Trial of AAV2-BDNF Gene Therapy in Alzheimer's Disease | A Clinical Trial of AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment | Mark Tuszynski, University of California, San Diego | Brain Derived Neurotrophic Factor (BDNF) Gene Therapy to potentially slow or even reverse cognitive decline in Alzheimer’s disease | Adults with early AD and/or Mild Cognitive Impairment | 2026 |
| The LUCINDA Trial | The LUCINDA Trial: LUpron Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's (LUCINDA) | Tracy Butler; James Galvin; Craig Atwood, New York University School of Medicine; Florida Atlantic University; University of Wisconsin | Lupron, a small molecule gonadotropin-releasing hormone (GnRH) receptor agonist to slow cognitive decline in women with mild to moderate AD | Women with mild-moderate Alzheimer's Disease who are also taking AChEl (Ages 65 - 90) | 2024 |
| Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics | Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics (NoMEN Study) | Lyndsey DuBose, University of Colorado Denver | GnRH antagonist, a gonadotropin-releasing hormone antagonist | Premenopausal women with lower E2 | 2023 |
| PhytoSERM for Menopausal Hot Flashes and Sustained Brain Health | TBD | John Rinehart, Neutherapeutics, Llc | PhytoSERM (a selective estrogen receptor beta (ERß) modulator; a rationally designed formulation of three phytoestrogens, genistein, daidzein, and S-equol) | Peri- and post-menopausal women (45-60 years old) | 2024 |
| PhytoSERM Efficacy to Prevent Menopause Associated Decline in Brain Metabolism and Cognition: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Clinical Trial | TBD | Roberta Brinton, University of Arizona | PhytoSERM, a selective estrogen receptor beta (ERß) modulator to improve brain metabolism and cognitive function | Peri- and postmenopausal women (Ages 45 - 60) | 2027 |
| Arterial Stiffness, Cognition, and Equol (ACE) | TBD | Akira Sekikawa, University of Pittsburgh at Pittsburgh | Equol supplementation as an intervention to improve cognitive decline by targeting arterial stiffness and white matter lesions in the brain | Older adults aged 65+ | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Phase 1 Clinical Trial of CMS121, a Novel Therapeutic Candidate for Alzheimer's Disease | Safety, Tolerability and Pharmacokinetics of CMS121, a Drug Candidate for Alzheimer's Disease, in Healthy Subjects (CMS121) | William Raschke, Virogenics, Inc. | CMS121, a small molecule therapy to reduce neuroinflammation | Healthy adult volunteers | 2023 |
| First-in-Human (Phase 1) Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of IBC-Ab002 in Persons with Early Alzheimer's Disease (AD) | A First in Human Study of IBC-Ab002 in Persons With Early Alzheimer's Disease (AD) | Eti Yoles, Immunobrain Checkpoint Inc. | IBC-Ab002, an antibody therapy targeting the peripheral immune system | Individuals with early AD (Ages 50 - 75) | 2024 |
| Development of a Stress Kinase Inhibitor Therapeutic Candidate for Alzheimer's Disease and Related Dementia | MW150 Stress Kinase Inhibitor in Mild to Moderate Alzheimer's Disease (SKI-AD) | Wayne Anderson, Neurokine Therapeutics, LLC | MW150, a small molecule inhibitor of p38alphaMAPK serine/threonine protein kinase to reduce neuroinflammation and improve synaptic function. | Mild to Moderate Alzheimer's Disease (Ages 50 - 85) | 2024 |
| GM-CSF Sargramostim Treatment to Improve Cognition in Down Syndrome | TBD | Huntington Potter, University of Colorado Denver | Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Sargrammostim, an immune system modulator to improve cognition | Young adults with Down Syndrome | 2023 |
| Assessment of Lenalidomide to Treat Alzheimer's Disease | MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI Patients (MCLENA-1) | Marwan Sabbagh; Boris Decourt, Cleveland Clinic; Arizona State University | Lenalidomide, a small molecule Anti-inflammatory immunomodulator to reduce neuroinflammation and slow or prevent AD | Adults with amnestic Mild Cognitive Impairment (Ages ≥50) | 2024 |
| Phase II Trial of GM-CSF sargramostim in Alzheimer's Disease | Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease (SESAD) | Huntington Potter, University Of Colorado Denver | Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Sargrammostim, an immune system modulator to improve cognition | Older adults with mild-to-moderate AD | 2024 |
| BEACH: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage Phase 2a Trial | Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH) (BEACH) | Daniel Hanley and Linda Van Eldik, Johns Hopkins University | MW189, a small molecule that selectively suppresses injury- and disease-induced neuro- inflammation | Participants with spontaneous, non-traumatic, Intracranaial Hemorrhage | 2025 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Effects of Orally Administered Nicotinamide Riboside on Bioenergetic Metabolism, Oxidative Stress and Cognition in Mild Cognitive Impairment and Mild Alzheimer's Dementia | Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia | Fei Du, McLean Hospital | Nicotinamide riboside (NR), an orally bioavailable precursor of NAD+, to enhance mitochondrial function, and improve cognition | Adults with mild cognitive impairment and mild Alzheimer’s disease (Ages 55-89) | 2025 |
| Phase 2 Randomized, Double-Blind, Placebo-Controlled Clinical Trial of T3D-959 in Mild to Moderate Alzheimer's Disease Subjects | Clinical Study Evaluating Efficacy and Safety of T3D-959 in Mild-to-moderate AD Subjects | John Didsbury, T3D Therapeutics | T3D-959, a small molecule PPARγ and PPARδ agonist to improve cognition in AD | Adults with mild to severe Alzheimer's disease (Ages 50-90) | 2023 |
| Phase II Randomized Controlled Trial of Benfotiamine in Early Alzheimer's Disease | TBD | Gary Gibson, Winifred Masterson Burke Medical Research Institute | Benfotiamine, a small molecule thiamine derivative to improve cognition and overall global function | Inidividuals with early AD, including mild cognitive impairment (MCI) and mild dementia with plasma evidence of amyloid positivity | 2027 |
| NAD+ Therapy for Improving Memory & Cerebrovascular Function in Patients with Mild Cognitive Impairment | NAD Therapy for Improving Memory and Brain Blood Flow in Older Adults with Mild Cognitive Impairment |
Christopher Martens, University of Colorado |
Nicotinamide Riboside, a precursor molecule of Nicotinamide adenine dinucleotide (NAD+) to improve cerebrovascular function and improve memory in patients with MCI | People with amnestic mild cognitive impairment (Ages 60-90) | 2023 |
| Effects of NAD restoration on neurovascular coupling in community dwelling older adults | The Effect of NAD Supplementation on Brain Vascular Health in Aging | Andriy Yabluchanskiy, University of Oklahoma | Nicotinamide Adenine Dinucleotide (NAD) supplementation to improve brain health and memory | Older adults (60-85 years of age) | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Senolytics to Improve Cognition and Mobility in Older Adults at Risk of Alzheimer’s Disease | Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease (STAMINA) | Lewis Lipsitz, Hebrew Rehabilitation Center for Aged | Quercetin and Dasatinib, a senolytic combination, to improve brain blood flow | Older adults with slow gate speed and Mild Cognitive Impairment (Ages 70 - 90) | 2023 |
| A Proof of Concept Trial of a Sirtuin-NAD+ Activator in Alzheimer's Disease | Sirtuin-NAD Activator in Alzheimer's Disease | Shalender Bhasin, Brigham and Women's Hospital | β nicotinamide mononucleotide (βNMN): An NAD+ precursor to slow AD progression and improve cognition | Mild AD dementia participants | 2024 |
| Repurposing Siponimod for Alzheimer's Disease | TBD | Marwan Sabbagh, Cleveland Clinic Lerner COM-CWRU | Siponimod, an immunomodulatory small molecule used to treat multiple sclerosis and serves as a neuroprotective | Individuals with early AD (Ages 60 - 85) | 2026 |
| Evaluation of Brain and Cognitive Changes in Older Adults with MCI Taking Lithium to Prevent Alzheimer Type Dementia | Lithium As a Treatment to Prevent Impairment of Cognition in Elders (LATTICE) | Ariel Gildengers, University of Pittsburgh Medical Center | Lithium, a GSK3α and GSK3β inhibitor to prevent or slow cognitive decline in older adults with MCI | People with mild cognitive impairment Age (Ages ≥60) | 2023 |
| Depression treatment and Aβ dynamics: A Study of Alzheimer’s disease Risk | Aβ Dynamics in LLMD | Nunzio Pomara, New York University School of Medicine | Escitalopram Oxalate, a SSRI antidepressant to examine effects of AD biomarkers | Older cognitively unimpaired adults with Major Depressive Disorder (Ages 60+) | 2026 |
| Citalopram as a Posterior Cortical Protective Therapy in Parkinson Disease | Citalopram as a Posterior Cortical Protective Therapy in Parkinson Disease | Vikas Kotagal, University of Michigan | Citalopram, a selective serotonin-reuptake inhibitor to test effect on amyloid-beta levels in the visuospatial cortex and visuospatial cognitive abilities in patients with Parkinson’s disease (PD) | Older adults with PD diagnosis and no active depression (Ages 65+) | 2025 |
| Allopregnanolone as Regenerative Therapeutic for Alzheimer's: Phase 2 Clinical Trial | Allopregnanolone Regenerative Therapeutic for Mild Alzheimer's Disease (REGEN-BRAIN©) | Roberta Diaz Brinton; Kathleen E. Rodgers; Lon S. Schneider, University of Arizona; University of Southern California | Allopregnanolone, a small molecule that stimulates anti-inflammatory mechanisms and mitochondrial function to regenerate neurons and restore cognition in AD | Adults who are APOEe4 positive and diagnosed with mild AD (Ages ≥55) | 2025 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A randomized, placebo-controlled, double-blind study to evaluate safety and efficacy of NDX-1017 treatment in Alzheimer's dementia patients | Open Label Study of ATH-1017 for Treatment of Mild to Moderate Alzheimer's Disease | Hans Moebius, Athira Pharma, Inc. | ATH-1017, a new investigational drug, designed to boost regenerative pathways in brain cells to improve brain health and function | Individuals with mild-to-moderate Alzheimer’s disease (Ages 55-85) | 2023 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Age-Related Mild Cognitive Impairment and Novel Protective Role of Glutathione: Implications for Alzheimer's Disease | Glutathione in Mild Cognitive Impairment | Sekhar Rajagopal Viswanath, Baylor College of Medicine | Glutathione supplementation to improve cognition in AD | Adults with MCI (Ages 65 - 80) | 2023 |
| Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease | Glutathione and Alzheimer's Disease | Rajagopal Viswanath Sekhar, Baylor College of Medicine | Glutathione supplementation to improve cognition in AD | Mild cognitive impairment (MCI) and mild Alzheimer’s disease (mild-AD) subjects (Ages 55 - 85) | 2025 |
| Veri-T: A phase 1 Placebo-Controlled Trial of Verdiperstat in Semantic Variant Primary Progressive Aphasia Due to Underlying FTLD-TDP | Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology (Veri-T-001) | Peter Ljubenkov, University of California, San Francisco | Verdiperistat, a microglial myeloperoxidase inhibitor that modulates proinflammatory microglia | Participants with Semantic variant primary progressive aphasia (Ages 18 - 80) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| The Delivery of Essential Fatty Acids to the Brain in Alzheimer's Disease | DHA Brain Delivery Trial (PreventE4) | Hussein Yassine, University of Southern California | Docosahexaenoic acid (DHA) supplementation, a dietary lipid to improve cognition in AD | Healthy adult carriers and non-carriers of APOE ε4 (Ages 60 - 80) | 2023 |
| Long Term Nicotine Treatment of Mild Cognitive Impairment | Memory Improvement Through Nicotine Dosing (MIND) Study (MIND) | Paul Newhouse; Paul Aisen, Vanderbilt University; Alzheimer's Therapeutic Research Institute | Nicotine to improve cognition in AD | People with Mild Cognitive Impairment (Ages ≥55) | 2023 |
| Cognitive, Urinary, and Functional Trajectories of Older Women Using Pharmacologic Treatment Strategies for Urgency Incontinence | Treating Incontinence for Underlying Mental and Physical Health (TRIUMPH) | Alison Huang, University of California, San Francisco | Tolterodine and Mirabegron, anticholinergic bladder medications | Older women with urinary incontinence and without pre-existing dementia | 2027 |
| A Phase 1b Multiple Ascending Dose Study of the Safety and Tolerability of BMS-984923 in Alzheimer's Disease | TBD | Adam Peter Mecca, Yale University | BMS-984923, blocks aberrant Amyloid beta activation of mGluR5 | Adults with early AD (Ages 50 - 80) | 2024 |
| Health of the Cholinergic System and Risk for Alzheimer's Disease in Postmenopausal Women | Cholinergic Health After Menopause (CHAMP) | Julie A. Dumas, University of Vermont & St Agric College | Mecamylamine, a cholinergic antagonist, to study the relations between the cholinergic system's functional integrity, cognition, and known AD biomarkers | Postmenopausal women (Ages 50 - 70) | 2024 |
| Pathophysiology of Postoperative Delirium and the Use of Biomimetic Sleep as a Treatment Strategy in the CSICU | Maximizing trEatment of Neurological Dysfunction Using INtravenous Guanfacine Study (MENDING) | Oluwaseun Johnson-Akeju, Massachusetts General Hospital | Guanfacine, an alpha-2 agonist and FDA-approved medication for hypertension and ADHD, to reduce the incidence of delirium in hospitalized COVID-19 patients | Hospitalized COVID-19 patients | 2023 |
| Preclinical and early clinical development of a GABA-A a5 PAM | TBD | Sharon Rosenzweig-Lipson, AgeneBio, Inc. | BPN-27473, a potent, selective, and orally active GABA-A a5 Positive Allosteric Modulator (PAM) for the treatment of MCI due to AD | Healthy Older Adults | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| (-)-Phenserine Inhibition Of Neuronal Death In Alzheimer’s Disease And Developing Brain-Labeled Plasma Exosomes Assays As Biomarkers For A Phenserine Phase 1B Ascending Dose Trial | TBD | Lon S. Schneider, University of Southern California | (-)-PHENSERINE, a small molecule that inhibits neuronal pre-programmed cell death, to prevent neuronal dysfunction and death | Adults with probable AD (Ages 70 - 82) | 2024 |
| Treating Hyperexcitability in Alzheimer’s Disease with Levetiracetam to Improve Brain Function and Cognition | Treating Hyperexcitability in AD With Levetiracetam | Mouhsin Shafi, Harvard | Levetiracetam, a small molecule synaptic vesicle protein (SV2A) modulator, to improve cognition in AD | Adults with probable AD (Ages 50 - 90) | 2023 |
| A Randomized, Double blind, Placebo-controlled Study to Evaluate the Impact of Nilotinib Treatment on Safety, Tolerability, Pharmacokinetics and Biomarkers in Dementia with Lewy Bodies (DLB) | Impact of Nilotinib on Safety, Tolerability, Pharmacokinetics and Biomarkers in Dementia With Lewy Bodies | Charbel Moussa, Georgetown University | Nilotinib, a small molecule inhibitor of Abelson kinase to facilitate degradation of neurotoxic proteins and promote survival of neurons | Adults with clinical diagnosis of LBD with both dementia and Parkinsonism (Ages 25 - 90) | 2023 |
| Long-term Therapeutic Effects of Synthetic Bryostatin-1 in Advanced AD Without Memantine | Bryostatin Treatment of Moderately Severe Alzheimer's Disease | Miao-Kun Sun, Neurotrope Bioscience Inc | Bryostatin-1 , a small molecule activator of PKCε in the hippocampus to restore synaptic function and improve cognition in advanced AD | Adults with advanced AD (Ages 55 - 85) | 2023 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| First in Human Study of a Tau Self-Association Small Molecule Inhibitor in Healthy Volunteers | TBD | William Erhardt, Oligomerix, Inc | Tau self-association inhibitor (OLX-07010) | Healthy adults (18-50 years) and Healthy older adults (51-75 years) | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid and Tau in Older Adults (IPAT-study) | Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study) (IPAT) | Rong Zhang, University of Texas Southwestern Medical Center | Intensive lowering of systolic blood pressure (SBP) | Older adults age 60 to 80 years who have hypertension (SBP=130 mmHg), family history of dementia, and/or subjective memory complaints | 2027 |
| Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging (SMArT–HS) | Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging (SMArT-HS) | Gregory A. Jicha; Peter Nelson, University of Kentucky | Nicorandil, a small molecule agonist for sulfonyl urea receptor 2 protein (SUR2), to improve cognition and hippocampal pathology | Adults with probable Hippocampal sclerosis (HS)-aging (Ages ≥ 75) | 2024 |
| PRagmatic EValuation of evENTs And Benefits of Lipid-Lowering in oldEr Adults (PREVENTABLE) | Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults (PREVENTABLE) | Karen Alexander, Duke University | Atorvastatin, a statin to reduce death, dementia, and persistent disability | Community-dwelling adults without clinically evident cardiovascular disease, significant disability, or dementia (Ages 75+) | 2027 |
| Hypertension, Intracranial Pulsatility and Brain A-beta Accumulation in Older Adults | Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial) (HIPAC) | Rong Zhang, UT Southwestern Medical Center | Amlodipine (calcium channel blocker), Losartan (angiotensin II receptor blocker), and other antihypertensive drugs to reduce systolic blood pressure and alter brain function | Older adults with hypertension (Ages 55 - 79) | 2023 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Phase II RCT of High-dose Vitamin D Supplements in Older Adults Without Dementia | High-dose Vitamin D Supplements in Older Adults | John Olichney, University of California, Davis | Vitamin D supplements, to improve cognitive outcomes in elderly groups at risk for dementia | People with mild cognitive impairment or mild Alzheimer’s disease (Ages 65 - 90) | 2024 |
| Anti-Viral therapy in Alzheimer's disease | Anti-viral Therapy in Alzheimer's Disease | Davangere Devanand, Columbia University | Valacyclovir, an Antiviral (Herpes Simplex Virus drug) to examine if HSV contributes to the pathology of AD and whether antiviral treatment can improve cognition | People with mild Alzheimer's disease | 2023 |
| The Use of Deferiprone to Improve Subarachnoid Hemorrhage Cognitive Outcome: U-DISCO | Deferiprone for Ruptured Brain Aneurysm | David M Hasan, University of Iowa | Deferiprone to improve cognitive outcomes | Adults with aneurysmal subarachnoid hemorrhage at risk for cognitive decline (Ages 18 - 70) | 2025 |
Section 2: Clinical Drug Development – Phase II/III and Phase III
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| The A3 Study: Ante-Amyloid Prevention of Alzheimer's Disease | AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid | Reisa Sperling, Brigham And Women's Hospital | BAN2401 , anti-amyloidβ antibody to prevent cognitive decline in AD by preventing amyloid accumulation | Cognitively healthy older adults with "intermediate" amyloid levels on screening PET. (Ages 55 - 80, Adults 55 – 64 must also carry at least one APOE ε4 allele) | 2024 |
| Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) Open-Label Extension Study | Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss (A4) | Reisa Sperling, Brigham And Women's Hospital | Solanezumab, an anti-amyloidβ antibody to prevent cognitive decline associated with early AD pathology | Cognitively healthy older adults who are amyloid positive on brain imaging (Ages ≥65) | 2024 |
| Combination Anti-amyloid Therapy for Preclinical Alzheimer's Disease (A-45) | AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid | Paul Aisen, University of Southern California | BAN2401, anti-amyloidβ antibody to slow or prevent cognitive decline in cognitively normal preclinical AD participants | Cognitively healthy older adults with "elevated" amyloid levels on screening PET. (Ages 55 - 80). Adults 55 - 64 must have an additional risk factor. | 2025 |
| Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study | An Efficacy and Safety Study of ALZ-801 in APOE4/4 Early AD Subjects (APOLLOE4) | Susan Abushakra, Alzheon, Inc. | ALZ-801 (tramiprosate pro-drug), an inhibitor of Aβ oligomer formation | Individuals with APOE4/4 and early AD diagnosis | 2025 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Metformin in Alzheimer's Dementia Prevention | Metformin in Alzheimer's Dementia Prevention (MAP) | Jose Alejandro Luchsinger, Columbia University Health Sciences | Metformin, a medication with proven efficacy in decreasing hyperinsulinemia and preventing diabetes, repurposed for the prevention of Alzheimer’s dementia | Adults with amnestic mild cognitive impairment (Ages 55 - 90) | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Phase 3 Pivotal Trial of AGB101 to Slow Progression in MCI due to Alzheimer's Disease | Study of AGB101 in Mild Cognitive Impairment Due to Alzheimer's Disease (Hope4MCI) | Richard Charles Mohs, Agenebio, Inc. | AGB101 (levetiracetam), a small molecule synaptic vesicle protein (SV2A) modulator, to slow progression of amnestic MCI due to AD | Adults with amnestic Mild Cognitive Impairment (Ages 55 - 85) | 2023 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| DIAN-TU: Tau Next Generation Prevention Trial | Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. (DIAN-TU) | Randall Bateman, Washington University | Anti-tau therapy to prevent AD | Cognitively healthy or mildly impaired adults who are Alzheimer's disease genetic mutation carriers | 2025 |
Section 3: Non-drug
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Losing specificity: The role of the locus coeruleus in age-related distractibility | The Role of the Locus Coeruleus in Age-related Distractibility | Tae-Ho Lee, Virginia Polytechnic Institute and State University | For aim 3, they will administer two weeks of either 1) multi-modal adaptive attention training or 2) practice on a training version of the criterion attention task, to facilitate neural plasticity in the brain, and will then examine how this may modulate locus coeruleus (LC)-salience network (SN) connectivity and mitigate distractibility | 100 healthy participants aged 55–75 from both the Roanoke and Blacksburg metropolitan area in Virginia | 2027 |
| Developing a Mobile App-Based Intervention to Promote Cognitive Health in Older Chinese Americans | Cognitive Training RCT for Older Chinese Americans | Hanzhang Xu, Duke University | A mobile app-based cognitive training (aka mHealth) intervention that is culturally and linguistically relevant to older Chinese Americans to, ultimately, enhance cognitive function in the population. Includes dementia knowledge education, culturally-appropriate app content, cognitive training activities, and training reminders. | Older Chinese Americans without cognitive impairment and adult children of older Chinese Americans | 2024 |
| Mindfulness Matters: The Impact of Mindfulness Based Stress Reduction on Post-Stroke Cognition | Mindfulness Based Stress Reduction and Post-Stroke Cognition | Elisabeth Breese Marsh, Johns Hopkins University | Mindfulness training to reduce post-stroke cognitive impairment | Adults presenting with neurological symptoms due to acute ischemic stroke (symptom onset within the week prior to admission) and evidence on brain MRI of acute ischemic stroke (imaging negative strokes and TIAs will be excluded) (Ages ≥18 years) | 2023 |
| Better Memory with Literacy Acquisition Later in Life: A Randomized Controlled Trial | Better Memory with Literacy Acquisition Later in Life: A Randomized Controlled Trial | Lea Tenenholz Grinberg, University Of California, San Francisco | Education program to improve episodic memory and enhance hippocampal connectivity | Illiterate adults of any gender, with availability to participate in literacy training for at least 6 months (Ages 40 - 89) | 2023 |
| Understanding Individual Differences in Working Memory Training and Transfer in Older Adults at Risk of Alzheimer's Disease and Related Dementias | Understanding Individual Differences in Working Memory Training and Transfer in Older Adults | Aaron Seitz, University of California Riverside | Cognitive training program focused on working memory systems and the role of inhibitory control, to promote health and general cognition | Older adults at risk for AD/ADRD | 2024 |
| Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) | Improving Neurological Health in Aging Via Neuroplasticity-based Computerized Exercise (INHANCE) | Thomas Vanvleet; Mouna Attarha, Posit Science Corporation | INHANCE, a computerized cognitive training program based on neuroplasticity principles to reduce long-term risk of dementia | Healthy older adults (Ages 65+) | 2023 |
| Planning an Adaptive Clinical Trial of Cognitive Training to Improve Function and Delay Dementia | The Active Mind Trial | Jerri Edwards, University of South Florida | Combination of cognitive training exercises to modify the functional trajectories of adults with MCI | Adults (Ages 65 - 89) | 2027 |
| Elucidating the Necessary Components and Mechanisms of Cognitive Training | Elucidating the Necessary Active Components of Training (ENACT) | Lesley A Ross, Clemson University | Bottom-up driven process-based training (BUD) and top-down driven training (TDD), two types of strategy-based cognitive training to improve cognition | Adults (Ages 45-90) | 2023 |
| Cognitive Training and Neuroplasticity in Mild Cognitive Impairment | Cognitive Training and Neuroplasticity in Mild Cognitive Impairment (CogTraining) | Davangere P. Devanand, Columbia University | Computerized cognitive training to improve cognitive performance | People with Mild Cognitive Impairment (Ages 55 - 95) | 2023 |
| Communication Bridge: A Person-Centered Internet-based Intervention for Individuals with Primary Progressive Aphasia | Communication Bridge: A Person-centered Internet-based Intervention for Individuals With Primary Progressive Aphasia | Emily Rogalski, Northwestern University | Personalized speech-language therapy intervention | Individuals with Mild Primary Progressive Aphasia (Ages ≥30) | 2023 |
| Patient-Centered Serious Games for Remote Cognitive Training in Older Adults with Mild Cognitive Impairment | Serious Game-based Interventions in Patients With Mild Cognitive Impairment Outside the Clinic | Sunghoon Lee and Jean Daneault, University of Massachusetts Amherst and Rutgeres University | Serious games (Neuro-World), to stimulate working memory and improve cognition | Older adults with Mild Cognitive Impairment | 2023 |
| Feasibility of the Memory and Attention Adaptation Training-Geriatrics Intervention in Older Cancer Survivors with Mild Cognitive Impairment | Feasibility of the Memory and Attention Adaptation-Training Geriatrics Intervention in Older Cancer Survivors With Mild Cognitive Impairment | Allison Magnuson, University of Rochester | Memory and Attention Adaptation Training-Geriatrics (MAAT-G), a cognitive behavioral therapy-based intervention comprised of a series of videoconferencing workshops | Older cancer survivors with Mild Cognitive Impairment (Ages 65+) | 2024 |
| The Adherence Promotion with Person-centered Technology (APPT) Project: Promoting Adherence to Enhance the Early Detection and Treatment of Cognitive Decline | Smart Reminders to Promote Home-based Cognitive Training | Walter Richard Boot, Florida State University | Mobile platform-based support system intervention to improve adherence to home-based cognitive assessment | Non-cognitively impaired adults (Ages 65+) | 2024 |
| Prospective Memory Impairment in Parkinson Disease-related Cognitive Decline: Intervention and Mechanisms | Everyday Memory Impairment in PD-related Cognitive Decline (PMT2) | Erin Foster, Washington University at Saint Louis | Memory encoding strategies to improve prospective memory | Adults who meet criteria for typical idiopathic PD (Ages 50+) | 2025 |
| Early Cognitive Training and Rehabilitation to Prevent Cognitive Decline in Older Hospitalized Adults with Delirium | Early Cognitive Intervention in Delirium | Jin Ho Han, Vanderbilt University Medical Center | Cognitive training rehabilitation program for individuals with delirium to improve working memory | Older delirious patients with and without ADRD | 2025 |
| Transferring Speed of Processing Gains to Everyday Cognitive Tasks After Stroke | Transferring Speed of Processing Gains to Everyday Cognitive Tasks After Stroke | Edward Taub, University of Alabama at Birmingham | Web-based computer game that trains cognitive processing speed to improve everday activities | Stroke Patients | 2025 |
| Promoting Independence with Compensatory Cognitive Rehabilitation: A Pilot Clinical Trial for Early-Stage Alzheimer's Disease | Promoting Independence With Compensatory Cognitive Rehabilitation | Alyssa Marie Lanzi, University of Delaware | A behavioral treatment (Structured External Memory Aid Treatment (SEMAT) to promote independent living skills | Adults with MCI (Ages 65 - 85) | 2026 |
| Cognitive Training to Reduce Incidence of Cognitive Impairment in Older Adults | Preventing Alzheimer's Disease with Cognitive Training | Jerri Edwards, University of South Florida | Speed of processing training intervention to reduce incidence of MCI or dementia | Older adults who are cognitively normal | 2026 |
| Modulation of Hippocampal Circuitry and Memory Function with Focused Ultrasound in Amnestic MCI | Modulation of Hippocampal Circuitry and Memory Function With Focused Ultrasound in Amnestic MCI (LIFUP-MCI) | Susan Bookheime, University of California Los Angeles | Low intensity focused ultrasound pulsation (LIFUP) to improve learning and memory | Adults (Ages ≥ 75) | 2026 |
| Use of the KF Modified Story Memory Technique to Improve New Learning and Memory in Individuals with Mild Cognitive Impairment | Improve New Learning and Memory in Individuals With Mild Cognitive Impairment | Nancy Chiaravalloti, Kessler Foundation, Inc. | A modified story memory technique (KF-mSMT), a structured cognitive rehabilitation (CR) treatment composed of the application of imagery and context to facilitate learning | Older adults (age 60+) with MCI and no evidence of dementia | 2027 |
| Web-based technology and cognitive training: Improving executive control in cognitively healthy older adults | Using Teleneuropsychology to Optimize Cognition in Healthy Aging: The Web-based Breakfast Game | Sharon Sanz Simon, Columbia University | The intervention includes a web-based cognitive training of Executive Control (EC) using an ecological Emphasis Change (EmCh) approach with a task named the Breakfast Game (B-Game). Participants (N=120) will be randomly allocated in three groups (40 participant in each group): G1) participants will play the game under EmCh instructions; G2) participants will play the game without EmCh (i.e., active control); and G3) participants will not perform any intervention (i.e., passive control). The G3 purpose is to control practice effects of the neuropsychological tests that will be repeated at pre, post and three-month follow-up. | Cognitively healthy older adult participants between the ages of 60 and 75 years | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training in MCI (The ACT Trial) | The ACT Trial: Effects of Combined Aerobic Exercise and Cognitive Training in MCI | Fang Yu, University of Minnesota | Aerobic exercise (cycling) and a specific type of cognitive training (speed of processing training) intervention to improve reasoning and memory, as well as to improve brain structure and function | People with Mild Cognitive Impairment (Ages 65 - 74) | 2024 |
| MIND Food and Speed of Processing Training in Older Adults with Low Education, The MINDSpeed Alzheimer's Disease Prevention Pilot Trial | MINDSpeed Food and Brain Training RCT (MINDSpeed) | Daniel O. Clark, Indiana University | Nutrition intervention (with foods high in polyphenols) combined with cognitive training exercises to test impact on cognitive performance | Older adults (60+) | 2023 |
| Augmenting Cognitive Training in Older Adults - The ACT Grant | Augmenting Cognitive Training in Older Adults (ACT) | Adam Woods, University of Florida | Neurostimulation (tDCS) combined with cognitive training program to slow cognitive decline | Adults with age-related cog. Decline (Ages 65 - 89) | 2023 |
| Decreasing Alzheimer's Disease and Related Dementias after Delirium-Exercise and Cognitive Training (DDD-ECT) | Improving the Recovery and Outcome Every Day After the ICU (IMPROVE) | Babar Khan, Indiana University | Physical and cognitive exercise programs to improve cognitive functioning of older adults who experience an episode of delirium while hospitalized in an intensive care unit | Adults with history of delirium (Ages 65+) | 2023 |
| Influence of Strategy Training on Disability for Older Adults with Mild Cognitive Impairment | Facilitating Optimal Routines in Aging (ForAging) | Juleen Rodakowski, University of Pittsburgh | Strategy Training to slow the emergence of disability and decline in cognition | People with Mild Cognitive Impairment (Ages ≥60) | 2023 |
| Digital Multidomain Lifestyle Intervention to Address Cognitive Health and Modifiable Risk Factors for Alzheimer's Disease | Reducing Dementia Risk With Digital Health Coaching (DC-MARVEL) | Jordan Glenn, Neurotrack Technologies Inc | MindMate + Health Coaching, a digital intervention consisting of the MindMate cognitive health app (digital multi-domain lifestyle intervention designed to address modifiable risk factors for dementia) and Neurotrack's personalized health coaching platform | At-risk adults (Ages 45 - 64) | 2023 |
| TeleExergame: An Interactive Tele-Rehabilitation Platform for Improving Motor Function in Older Adults with Cognitive Deficit | Remote Game-based Exercise Program for Cognitive and Motor Function Improvement | Ashkan Vaziri, Biosensics, LLC | A tele-exercise system that allows a qualified therapist to remotely supervise and interact with the patient during goal-oriented game-like and low risk exercise tasks that have been designed to improve balance and cognition | Individuals with Mild Cognitive Impairment and/or mild dementia | 2024 |
| Neuro-exergaming for the Prevention and Remediation of Decline Due to Alzheimer's Disease and Related Dementias: A Clinical Trial of the Interactive Physical and Cognitive Exercise System (iPACES v3) | The Interactive Physical and Cognitive Exercise System (v3) for Mild Cognitive Impairment (MCI) (iPACES) | Cay Anderson-Hanley; John P. Arciero; Paul J. Arciero; Mina Dunnam; David Arthur Merrill; Stella E. Panos; Emilie Saulnier, IPACES, LLC | iPACES v3, a physical and cognitive exercise system that can be used at home | People with Mild Cognitive Impairment or subjective cognitive complaints (Ages ≥50) | 2023 |
| Targeted Physical and Cognitive Activity in a VR Environment in Older Adults at Risk for Alzheimer's Disease | TBD | Judy Pa, University of Southern California | Physical and cognitive activity program in a virtual reality environment to improve cognition | People with early Mild Cognitive Impairment (Ages 55 - 80) | 2025 |
| Effectiveness of Implementing an Intensive Blood Pressure Reduction Intervention on Cognitive Decline in Low-income and Minority Hypertensive Patients | Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control in Minimize Cognitive Decline (IMPACTS-MIND) | Katherine Mills, Tulane University of Louisiana | Multifaceted intensive blood pressure intervention | Racial minority and low-income hypertensive patients | 2025 |
| Remote Monitoring and Virtual Collaborative Care for Hypertension Control to Prevent Cognitive Decline | Remote Monitoring and Virtual Collaborative Care For Hypertension Control to Prevent Cognitive Decline Phase II (vCCC 2) | Jeffrey Burns, University of Kansas Medical Center | Remote blood pressure monitoring and management through a virtual Collaborative Care Clinic (vCCC) | Older adults with hypertension | 2025 |
| Neuromechanisms of Falls in Older Adults with MCI: Targeting Assessment and Training of Reactive Balance Control | Dual Task Perturbation Training for OAwMCI | Tanvi Bhatt, University of Illinois at Chicago | A novel four-week perturbation-based cognitive-motor intervention for improving reactive balance control and cognition | Older adults with MOCA less than 26 out of 30 will be classified as mild cognitive impairment and those above 26 out of 30 as cognitively intact older adults (Ages 55+) | 2026 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Novel Food-based Approach for Prevention of Age-associated Cognitive Decline in Older Adults with Obesity | TBD | Susan Roberts and Maria Franceschini, Tufts University and Harvard University | Nutrition-based intervention to improve cognitive and brain functioning | Older adults who are overweight/ obese | 2023 |
| Modified Ketogenic Diet Effects on Alzheimer's Disease Biomarkers and Cognition in Mild Cognitive Impairment | Brain Energy for Amyloid Transformation in Alzheimer's Disease Study (BEAT-AD) | Suzanne Craft, Wake Forest University | Ketogenic diet to improve cognitive symptoms and pathology in Mild Cognitive Impairment | People with amnestic Mild Cognitive Impairment (Ages 55 - 85) | 2023 |
| Multicultural Healthy Diet to Reduce Cognitive Decline & Alzheimer's Disease Risk | Multicultural Healthy Diet to Reduce Cognitive Decline (MHD) | Yasmin Mossavar-Rahmani, Albert Einstein College of Medicine | An anti-inflammatory, multicultural health diet (MHD) to improve cognitive function in a culturally diverse population of adults | Adults (Ages 40 - 65) | 2023 |
| Dietary Modulation Of Neuroinflammation In Age-Related Memory Disorders | Dietary Modulation of Neuroinflammation in Age-Related Memory Disorders | Richard Sloan, New York State Psychiatric Institute | Cocoa-flavanol supplement to reduce systemic inflammation, improve cerebral blood volume to the hippocampus, and improve cognition | Adults (Ages 50 - 69) | 2023 |
| Enhanced Mediterranean Diet For Alzheimer's Disease Prevention | Nutrition Interventions for Cognitive Enhancement (NICE) | Debra Sullivan, University of Kansas Medical Center | To investigate the effects of a Mediterranean diet (MedD) that is enhanced with extra virgin olive oil (EVOO), almonds, and omega-3 supplements (Med+O) on cognition, brain volume, cerebral antioxidant status, and cardiometabolic biomarkers in adults without cognitive impairment. | Adults (Ages 65+) | 2023 |
| Validation and Mechanistic Interrogation of Metabolism Targeting for AD | Therapeutic Diets in Alzheimer's Disease (TDAD) | Russell Swerdlow, University of Kansas Medical Center | Ketogenic diet (KD) to test whether manipulating brain energy metabolism through the KD will benefit AD participants | People with Alzheimer's disease Ages 50 - 90) | 2024 |
| Brain Healthy Soul Food Diet Intervention Among Older African Americans | Brain Healthy Soul Food Diet Intervention Among Older African Americans (MIND+SOUL Diet) | Ashley Shaw, University of Kansas Medical Center | Culturally adapted, brain-healthy diet | Older African Americans (Ages 55+) | 2025 |
| MIND Diet and Dementia Prevention in Ischemic Stroke Patients | Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients | Neelum T Aggarwal, Rush University Medical Center | Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND), to test impact on cognition and brain biomarkers related to dementia in patients who are recovering from acute ischemic stroke | Individuals who have suffered acute stroke (Ages 60 - 80) | 2026 |
| APOE Genotype Effects on Triglycerides and Blood Flow in the Human Brain | Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain | Angela Hanson, University of Washington | High fat drink (heavy dairy cream) | Older adults with and without APOE E4 (Ages 55+) | 2025 |
| Caffeine and Postoperative Neurocognitive Recovery | The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study | Phillip Vlisides, University of Michigan | Test the effects of caffeine on neurocognitive and clinical recovery after major surgery | Adult surgical patients (greater than or equal to 70 years old) presenting for major non-cardiac, non-intracranial, non-major vascular surgery | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Effects of Physical Activity on Brain Function and Network Connectivity in MCI | Lifestyle Enriching Activities for Research in Neuroscience Intervention Trial: LEARNit Study | Arthur Toga, University of Southern California | Home-based moderate-aerobic walking program | Older adults without dementia (Ages 55 - 80) | 2023 |
| Investigating Gains in Neurocognition in an Intervention Trial of Exercise | Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE) | Kirk Erickson; Jeffrey Burns; Edward Mcauley; Arthur Kramer, University of Pittsburgh; University of Kansas; University of Illinois Urbana-Champaign; Northeastern University | Exercise program to decrease cognitive decline associated with aging | Sedentary adults (Ages 65 - 80) | 2023 |
| Mechanisms of Adherence to Light Intensity Physical Activity to Prevent Alzheimer's Disease and Related Dementias | TBD | Jonathan Hakun, Penn State Health Milton S. Hershey Medical Center |
Intervention: Adaptive Step Goals with Interim Goal Setting Participants will be randomized into one of two arms of this intervention: Control Arm: receives adaptive daily step goals and Self-monitoring Treatment Arm: receives daily step goals , Self-monitoring and Interim goal setting (every 2-3 hours throughout each day), on study smart phone, to promote increased goal maintenance. |
Middle-aged adults with increased risk for ADRD (adults with obesity) | 2023 |
| A Mobile Tai Chi Platform for Fall Prevention in Older Adults | A Mobile Tai Chi Platform for Fall Prevention in Older Adults - Phase II | Paolo Bonato, Biosensics, LLC | Tai Chi intervention, to assess the impact of the multimodal exercise on combined physical and cognitive function | Older adults with mild cognitive impairment (Ages 65-86) | 2023 |
| Exercise to Improve Hippocampal Connectivity and Learning in Older Adults | Exercise Effects on Brain Health and Learning From Minutes to Months (EXTEND) | Michelle Voss, University of Iowa | Exercise program to improve learning and increase functional hippocampal-cortical communication that otherwise declines with aging | Sedentary Adults (Ages 55 - 80) | 2023 |
| Exercise for Brain Health with Increased Genetic Risk for Alzheimer's Disease | Exercise for Brain Health in the Fight Against Alzheimer's Disease | Jerome Carson Smith, University of Maryland | Exercise and flexibility training programs to improve quality of life and physical function | Physically inactive adults (Ages 60 - 80) | 2023 |
| Mechanical Integrity of Memory Systems in Mild Cognitive Impairment | Aging Brain Structure and Memory in Response to Exercise | Curtis Johnson, University of Delaware | To study how the mechanical integrity of the brain-measured by determining viscoelastic properties through magnetic resonance elastography (MRE), changes during aging, in both normal and cognitively impaired individuals, and in response to 3 months of exercise therapy | Healthy participants and participants with amnestic Mild Cognitive Impairment (Ages 65+) | 2023 |
| The Effect of Physical Activity on Cognition Relative to APOE Genotype (PAAD-II) | The Effect of Physical Activity on Cognition Relative to APOE Genotype (PAAD-2) | Jennifer Etnier, University of North Carolina Greensboro | Physical Activity program intervention to delay the onset of AD | Adults with a family history of Alzheimer's disease (Ages 40 - 65) | 2023 |
| Rhythm Experience and Africana Culture Trial | Rhythm Experience and Africana Culture Trial (REACT) | Kirk Erickson, University of Pittsburgh | To investigate whether African Dance improves cognitive, neurological, physical, psychosocial, and mood outcomes in 60- to 80-year-old African Americans | African Americans (Ages 60 - 80) | 2023 |
| Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE) | Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE) | Robert Newton; Owen Carmichael, Pennington Biomedical Research Center | Aerobic exercise & strength training programs to promote cognitive function in older African American adults | African Americans (Ages 65-85) | 2024 |
| FitMi AD: A Safe and Motivating Computer-guided Exercise System for Individuals with MCI or Mild Dementia Due to Alzheimer's Disease | FitMi AD Home Therapy for Individuals With MCI or Mild Dementia Due to Alzheimer's Disease | Daniel Zondervan, Flint Rehabilitation Devices | FitMi AD system, a wireless, sensorized at-home exercise device | Individuals with MCI or mild dementia | 2023 |
| Goal Setting to Promote Physical Activity Adherence in Midlife to Reduce Risk of Alzheimer's Disease and Related-Dementias: A Randomized Mechanistic Proof-of-Concept Trial | TBD | Molly Maxfield, Arizona State University | Intervention: Physical Activity (PA) Goal Setting Techniques Both phases of the study involve the following Arms: 1.No stated PA goals (Control group):will receive Physical Activity(PA) planning intervention that has no explicitly stated PA goals. 2. Static weekly PA goal of 150 minutes/week: will receive PA action planning intervention and a static weekly PA goal of 150 minutes/week of moderate-intensity activity 3. Self-selected weekly PA goal: be assigned a PA action planning intervention and will self-select their own moderate-intensity PA goal each week. 4. Incremental weekly PA goal increase: will receive a physical activity action planning intervention and be assigned a weekly PA goal that is 20% greater than the level of moderate-intensity PA performed the previous week. | Adults aged 45 to 65 years with BMI of 30 kg/m2 or greater | 2024 |
| Brain Health Together: A Live-streaming Group-based Digital Progam | TBD | Cynthia Benjamin, RH Studio 2 OpCo 22, Inc. | Brain Health Together, a 12-week, group-based, live streaming, digital program focused on addressing physical activity and social isolation to improve cognitive function | People living with Mild Cognitive Impairment (MCI) | 2023 |
| Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older Adults | Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment | Fuzhong Li, Oregon Research Institute | Tai Ji Quan (martial arts practice) intervention to slow cognitive decline in older adults with MCI | People with Amnestic Mild Cognitive Impairment (Ages ≥65) | 2024 |
| Partnered Rhythmic Rehabilitation for Enhanced Motor-Cognition in Prodromal Alzheimer's Disease | Partnered Rhythmic Rehabilitation in Prodromal Alzheimer's Disease | Madeleine E. Hackney, Emory University | Partnered Rhythmic Rehabilitation, an intervention that simultaneously targets cardiovascular, social and motor-cognitive domains, to improve motor-cognitive function, and neuronal, vascular and inflammatory intermediaries | Adults with prodromal Alzheimer's disease (Ages 50 - 80) | 2024 |
| The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults with Down Syndrome | The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome | Lauren Taylor Ptomey, University of Kansas Medical Center Research Institute | Moderate-to-vigorous physical activity in adults with down syndrome to prevent AD | Adults with down syndrome (Ages ≥ 18) | 2024 |
| Modulation Effects of Baduanjin Mind-body Exercise on Subjective Cognitive Decline | Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline (BDJ) | Jian Kong, Massachusetts General Hospital | Baduanjin (BDJ), a mind-body exercise to reduce cognitive decline | Adults (Ages 50 - 80) | 2024 |
| A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos | A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos | Gloria Adriana Perez, University of Pennsylvania | "Tiempo Juntos para la Salud," a multilevel intervention for Latinos with MCI including empowerment education for behavior change and individual motivation, building support network, and promoting community resources for safe walking to reduce inactivity, a factor for AD/ADRD | Spanish language dominant Latinos with MCI (Ages 55+) | 2024 |
| Cognitive and Physical Exercise to Improve Outcomes After Surgery in the Elderly | Cognitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study (COPEiOS) | Christopher Hughes, Vanderbilt University Medical Center | A comprehensive cognitive and physical training program compared to active control to improve outcomes after surgery in the elderly | Patients ≥60 years old undergoing elective major non-cardiac surgery with expected hospitalization ≥3 days | 2025 |
| Acute exercise and the cerebral metabolic response in aging and Alzheimer's Disease | Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease (AEROBIC) | Jill Kathleen Morris, University of Kansas | Exercise intervention to characterize the brain metabolic response to different exercise intensity levels and measure changes in cognition | People with Alzheimer's Disease (Ages ≥60) | 2025 |
| Yoga, Aerobic and Stretching Exercise Effects on Neurocognitive Performance: A Randomized Controlled Trial | Yoga, Aerobic and Stretching Exercise Effects on Neurocognition | Neha Gothe, University of Illinois | Yoga training and aerobic exercise programs to test effects on cognitive functions, neural activity and structure, and physiological parameters | Adults with normal cognition (Ages 55 - 79) | 2025 |
| CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimer's Disease | CYCLE-AD (CYcling to Cease or Limit the Effects of Alzheimer's Disease) (CYCLE AD) | Stephen M. Rao; Jay Alberts, Cleveland Clinic Lerner Com-CWRU | Indoor Cycling (high intensity; 60-90% of heart rate reserve) to slow or delay disease onset | Healthy elders at genetic risk for AD; APOE ε4 carriers (Ages 65-80) | 2025 |
| Determinants of Individual Differences in the Efficacy of Aerobic Exercise to Improve Brain Health and Reduce Alzheimer Disease Risk in Older African Americans | Exercise to Improve Brain Health in Older African Americans | Mark Gluck, Rutgers University Newark | Cardio Dance Fitness (CDF) intervention, and a Strength, Flexibility, & Balance intervention | Sedentary older African Americans (60+ years of age) | 2027 |
| Natives Engaged in Alzheimer's Research: IKE Kupuna (Elder Wisdom) Project | Natives Engaged in Alzheimer's Research - 'Ike Kupuna (NEAR) | Buchwald, Galvin, Kauwe, Washington State Universtiy | A tailored Hula dance program to prevent or slow cognitive decline | Older Native Hawaiians Pacific Islanders with uncontrolled hypertension (Ages 55+) | 2026 |
| Reducing African Americans Alzheimer's Disease Risk Through Exercise-MCI Cohort (RAATE-MCI) | Reducing African American's Alzheimer's Risk Through Exercise-Mild Cognitive Impairment (RAATE-MCI) (RAATE-MCI) | Robert Lee Newton, LSU Pennington Biomedical Research Center | Exercise intervention to reduce risk in African Americans with Mild Cognitive Impairment | African Americans with MCI (Ages 65 - 85) | 2026 |
| Differential Effects of Exercise Modality on Cognition and Brain in Older Adults | Combined Exercise Trial (COMET) | Eric Dennis Vidoni, University of Kansas Medical Center | Aerobic and resistance exercise programs, to test combined and independent effects on cognitive, neural, and physical function | Healthy individuals (Ages 65 - 80) | 2026 |
| Establishing the optimal frequency of dance movement for neurocognitive and physical outcomes in people at risk of Alzheimer's disease | Optimal Frequency of Dance in People at Risk for Alzheimer's Disease (IGROOVE) | Christina Hugenschmidt, Wake Forest University Health Sciences | Dance movement and music appreciation classes to improve cardiorespiratory fitness and cognition | Adults ( ≥65 years) at risk for AD due to subjective cognitive decline | 2027 |
| Influence of exercise training and intensity on cerebral blood flow regulation and cognitive function in mid-life adults with cardiovascular disease | Cardiac Rehab and Cerebral Blood Flow Study | Jenna-Lee Taylor, Mayo Clinic Rochester | Exercise intervention, comparing effects of High Intensity Interval Training (HIIT) vs. Medium Intensity Continuous Training (MICT) on cognitive function | Mid-life adults with cardiovascular disease | 2024 |
| Development of a Personalized Intervention to Motivate Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease | Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease | Laura Korthauer, Rhode Island Hospital | A 24-session healthy living education program, with enhanced content about health beliefs and mechanisms of behavior change | Cognitively healthy/normal adults aged 45-69 years, with at least two AD risk factors. | 2024 |
| Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity (EXEC-study) | TBD | Ulf Bronas, University of Illinois at Chicago | Home-based walking program to improve cognitive function in patients with co-morbid chronic kidney disease and MCI | Older adults with mild cognitive impairment and chronic kidney disease | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Impact of Music Improvisation Training on Brain Function and Cognition among Older Adults | TBD | Julene K. Johnson, University of California, San Francisco | Music improvisation intervention to promote improvements in self-regulation and facilitate late-life engagement in cognitively challenging activities | Neurologically healthy older and younger adults | 2023 |
| Multimodal Musical Stimulation for Healthy Neurocognitive Aging | TBD | Psyche Loui, Northeastern University | Gamma frequency stimulation is administered via lights, and tuned to user-defined music. Participants receive the intervention by listening to music while watching lights. Sham control involves the same procedures but without gamma stimulation. | Neurologically healthy older and younger adults | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Noninvasive Cortical Stimulation to Improve Memory in Mild Cognitive Impairment | Noninvasive Brain Stimulation for Mild Cognitive Impairment | Joy Taylor, Stanford | Repetitive Transcranial Magnetic Stimulation (rTMS) to improve memory in participants with Mild Cognitive Impairment | People with Mild Cognitive Impairment (Ages ≥55) | 2023 |
| Adaptive Neuromodulation of Working Memory Networks in Aging and Dementia | Neuromodulation of Memory in Aging (TMS-AD) | Simon Davis, Duke University | Closed-loop transcranial magnetic stimulation (TMS) | Healthy older adults and individuals with MCI (60-75 years of age) | 2027 |
| Gamma-Music Based Intervention for Mild Alzheimer's Disease | TBD | Psyche Loui, Northeastern University | Non-invasive gamma-frequency (40 Hz) light-flickering and auditory tone-stimulation | Participants with mild Alzheimer’s Disease (55-90 years of age) | 2027 |
| Individualized Closed-Loop Neuromodulation Therapy for Alzheimer's Disease | TBD | Joan Camprodon, Massachusetts General Hospital | Closed-loop transcranial Alternating Current Stimulation (tACS) at 40 Hz | Participants with AD (50-80 years of age) | 2024 |
| Cholinergic Functions and Modulation of the Cingulo-opercular Alertness Network in LBD | Stimulation of Cingulao-opercular Alertness Network (SCAN) | Nicolaas Ida Bohnen; Benjamin Michael Hampstead, University of Michigan at Ann Arbor | Transcranial direct current neurostimulation (tDCS) to test whether tDCS to these brain regions may be relevant to manage future fluctuations in alertness in people with Lewy body dementias. | Adults with Lewy Body Dementia | 2023 |
| Treating Mild Cognitive Impairment with Transcranial Direct Current Stimulation | Stimulation to Improve Memory (STIM) | Benjamin Michael Hampstead, University of Michigan at Ann Arbor | Transcranial direct current stimulation (tDCS) to treat MCI | People with Mild Cognitive Impairment (Ages ≥65) | 2023 |
| Treating Mild Cognitive Impairment with Transcranial Direct Current Stimulation | STIM+: PET Biomarker Education & Disclosure (STIM+) | Benjamin Michael Hampstead, University of Michigan at Ann Arbor | Transcranial direct current stimulation | Older adults with MCI | 2023 |
| Gamma Induction for Amyloid Clearance in Alzheimer's Disease | Gamma Induction for Alzheimer's Disease | Emiliano Santarnecchi, Beth Israel Deaconess Medical Center | Transcranial Alternating Current Stimulation (tACS) to induce increase in gamma oscillations, and assess acute and long-lasting changes in Aβ and p-tau levels via PET imaging to investigate the clinical, neurophysiological and cognitive impact | Adults with mild to moderate AD (Ages ≥45) | 2023 |
| Treating Primary Progressive Aphasia And Elucidating Neurodegeneration In The Language Network Using Transcranial Direct Current Stimulation | Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS | Roy Hamilton, University of Pennsylvania | To investigate the effects of high density transcranial direct stimulation (tDCS) of the left frontal lobe on network and language function in participants with primary progressive aphasia (PPA), with the goal of developing a potential treatment and further understanding networks in PPA and the effect of tDCS on these networks. | Adults with either nonfluent, agrammatic PPA or logopenic variant PPA (Ages 45 - 80) | 2024 |
| Evaluating the Neurocomputational Mechanisms of Explore-Exploit Decision Making in Older Adults | Evaluating the Neurocomputational Mechanisms of Explore-Exploit Decision Making in Older Adults | Robert C. Wilson, University of Arizona | Transcranial Magnetic Stimulation (TMS) to vertex, right inferior frontal gyrus, and right frontal pole to explore effects on decision-making | Healthy younger adults (Ages 18 - 30) and older adults (Ages 65 - 74), with no subjective memory complaints. | 2024 |
| Improving Working Memory In Older Adults By Restoring Large-Scale Cortical Interactions | Improving Working Memory in Older Adults | Robert Reinhart, Boston University | High-definition transcranial alternating-current stimulation of the frontal and temporal cortex, to improve working memory and cognition | Younger adults (Ages 18 - 30) and older adults (Ages 68 - 80) | 2024 |
| Revitalizing Cognition In Older Adults At Risk For Alzheimer's Disease With Near-Infrared Photobiomodulation | The Revitalize Study | Dawn Bowers; Adam Woods; Gene Alexander, University of Florida | Infrared stimulation to assess improvements in cognition function and network connectivity | Older adults with subjective cognitive complains and family history of Alzheimer's disease (Ages 65 - 89) | 2024 |
| Enhancement of Hippocampal Plasticity Using Repetitive Transcranial Magnetic Stimulation | Enhancement of Hippocampal Plasticity Using Repetitive Transcranial Magnetic Stimulation | Ying-Hui Chou, University of Arizona | Repetitive Transcranial Magnetic Stimulation (rTMS) in hippocampus to determine its therapeutic effect on memory function and brain plasticity | People with Amnestic Mild Cognitive Impairment (Ages 50 - 80) | 2025 |
| Non-Invasive Home Neurostimulation for Mild to Moderate Alzheimer's Disease: Double-Blind, Sham Controlled Randomized Clinical Trial | NeurostImulation for Cognitive Enhancement in Alzheimer's Disease (NICE-AD) | Joe Verghese; Helena Knotkova, Albert Einstein College of Medicine | Transcranial direct current neurostimulation (tDCS) at home intervention to improve cognitive performance and symptoms in patients with mild to moderate Alzheimer’s Disease | People with AD (Ages ≥60) | 2025 |
| Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD) | Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD) | Dan Vlad Iosifescu; Paolo Cassano; Ricardo Osorio, New York University School of Medicine; Harvard University | Transcranial Photobiomodulation (t-PBM), which penetrates robustly into the cerebral cortex, stimulating the mitochondrial respiratory chain, and significantly increasing cerebral blood flow, to improve cognitive deficits | People with Amnestic Mild Cognitive Impairment (Ages 65 - 85) | 2025 |
| Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment | Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment | Nanthia A. Suthana; Andrew Leuchter, University of California, Los Angeles | Theta burst transcranial magnetic stimulation is a non-invasive neuromodulation method that shows promise for improving memory and may be applied to brain areas that are functionally connected to the hippocampus in order to restore memory function | People with Amnestic Mild Cognitive Impairment (Ages 60 - 90) | 2025 |
| Transcranial Direct Current Stimulation in Typical and Atypical Alzheimer's Disease | Effects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer's Disease | Kyrana Tsapkini, Johns Hopkins University | Transcranial direct current neurostimulation (tDCS) to improve clinical symptoms of MCI | People with probable AD (Ages ≥50) | 2025 |
| The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance | The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance (WALLe) | Heidi Irma Jacobs, Massachusetts General Hospital | Transcutaneous vagus nerve stimulation (tVNS) to improve cognitive function | At-risk older adults (Ages 60 - 85) | 2026 |
| Targeting language-specific and executive-control networks with transcranial direct current stimulation in aphasic AD | Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA | Kyrana Tsapkini, Johns Hopkins Bayview Medical Center (JHBMC) | Transcranial direct current stimulation (tDCS) | Individuals with primary progressive aphasia (50-80 years of age) | 2027 |
| The power of 40 Hz sound, music for older adults with mild cognitive impairment | Sound and Music for Mild Cognitive Impairment | Junxin Li, Johns Hopkins Bayview Medical Center (JHBMC) | 40 Hz sound, music | Older adults with amnestic MCI (65+ years of age) | 2024 |
| Interleaved TMS-fMRI for Hippocampal Stimulation: Modeling Dose-Response Relationship in Amnestic Mild Cognitive Impairment | Interleaved TMS-fMRI for Hippocampal Stimulation: Modeling Dose-Response Relationship in Amnestic Mild Cognitive Impairment (TMS-fMRI) | Ying-Hui Chou, University of Arizona | Spaced Theta burst stimulation (TBS) to improve memory performance and hippocampal function in MCI | Individuals with amnestic MCI | 2024 |
| Multifocal transcranial current stimulation for cognitive and motor dysfunction in dementia | TBD | Alvaro Pascual-Leone, Hebrew SeniorLife and Hebrew Rehabilitation Center | Transcranial alternating current stimulation targeting the left angular gyrus (tACS) at gamma frequency and transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex | Older adults with mild dementia (55+ years of age) | 2027 |
| Phase II clinical trial of transcranial direct current stimulation in the treatment of primary progressive aphasia | Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia | Roy Hamilton, University of Pennsylvania | Transcranial direct current stimulation (tDCS) therapy in primary progressive aphasia (PPA) | Older adults with primary progressive aphasia (50-80 years of age) | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Changing the Trajectory of Mild Cognitive Impairment with CPAP Treatment of Obstructive Sleep Apnea | MCI: CPAP Treatment of OSA (Memories2) (MCI:OSA) | Nalaka Gooneratne, University of Pennsylvania | Continuous positive airway pressure (CPAP) to treat people with obstructive sleep apnea in order to improve mild cognitive impairment | People with obstructive sleep apnea and amnestic Mild Cognitive Impairment (Ages 55 - 75) | 2023 |
| A Novel Couples-Based Sleep Health Intervention For Older Adults With Obstructive Sleep Apnea: Implications for Alzheimer's Disease Risk And Healthy Aging | We-PAP: A Couples-based Intervention for Sleep Apnea (We-PAP) | Kelly Baron, University of Utah | Couples-based sleep health education intervention to improve adherence to CPAP and improve couples' sleep experience | Older adults with obstructive sleep apnea (Ages 50 - 85) | 2023 |
| Device to Control Circadian-effective Light in Alzheimer's Disease Environments | TBD | Erik Page, Blue Iris Labs, Inc. | Daysimeter, a calibrated light meter that measures circadian light and circadian stimulus, to measure and optimize lighting to improve sleep and mood | Individuals with AD | 2024 |
| Napping, Sleep, Cognitive Decline and Risk of Alzheimer's Disease | Napping, Sleep, Cognitive Decline and Risk of Alzheimer's Disease | Yue Leng, University of California, San Francisco | Cognitive behavioral therapy for insomnia (CBT=I), which incorporates cognitive, behavioral and educational components to improve cognitive outcomes | Older adults with Mild Cognitive Impairment or mild AD (Ages 65+) | 2023 |
| Light, Metabolic Syndrome and Alzheimer’s Disease: A Non-pharmacological Approach | Light and the Effect on Metabolic Syndrome and Alzheimer's Disease | Mariana G Figueiro, Rensselaer Polytechnic Institute | 8-week Tailored Lighting intervention (TLI). The active TLI will provide high circadian stimulation during the day produced by light sources that provide moderate light levels of spectra that are tuned to the sensitivity of the circadian system. | Older adults with mild to moderate Alzheimer's Disease diagnosis and Type 2 diabetes (Ages 55+) | 2023 |
| Understanding Circadian Responses to Light in Persons with Mild Cognitive Impairment and Alzheimer's Disease | Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Lighting interventions to suppress melatonin and promote better sleep and cognition | Older adults with MCI | 2023 |
| A Non-pharmacological Multi-Modal Therapy to Improve Sleep and Cognition and Reduce Mild Cognitive Impairment Risk | Enhanced CBTi for Older Adult Sleep and Cognition | Daniel Gartenberg, Proactive Life, LLC | Internet of Things (IoT) devices, such as the FitBit, Apple Watch, and Oura Ring, to improve sleep and reduce MCI | Cognitively healthy older adults (Ages ≥65) | 2023 |
| Primary Prevention of Alzheimer's Disease: Examining the Effects of Cognitive Behavioral Therapy on Cognitive Function and Amyloid-beta in Older Adults with Symptoms of Insomnia | SIESTA: Sleep Intervention to Enhance Cognitive Status and Reduce Beta Amyloid | Catherine Siengsukon, University of Kansas Medical Center | Cognitive behavioral therapy for insomnia (CBT-I) | People with difficulty falling asleep, maintaining sleep, or waking up too early at least 3 nights per week for the past 3 months, (Ages 60 - 85) | 2024 |
| Personalized OSA treatment and effects on AD biomarkers and cognition among blacks | TBD | Girardin Jean-Louis, University of Miami School of Medicine | The proposed intervention is “Personalized OSA Treatment Adherence Model (PRAISE)” which is a personalized obstructive sleep apnea treatment adherence model. Participants will be exposed to either personalized OSA videos (intervention arm) or standard online videos (control arm). | Older black adults (60-85 years) newly diagnosed with obstructive sleep apnea | 2027 |
| The Long-term Impact of Light Intervention on Sleep Physiology and Cognition in Mild Cognitive Impairment` | The Long-term Impact of a Light Intervention on Sleep and Cognition in Mild Cognitive Impairment | Sara Carole Mednick; Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Light intervention to improve sleep and MCI | People with Amnestic Mild Cognitive Impairment or mild AD (Ages ≥ 65) | 2024 |
| The Impact of Sex Hormones on Sleep-Dependent Memory in Young and Midlife Men and Women | TBD | Fiona C Baker; Sara Carole Mednick, SRI International | Sound-stimulation sleep therapy to improve sleep quality and memory function in the context of the menopausal transition, supplemented with comprehensive evaluations of sex-hormone levels, sleep measures, and cognitive tasks | Women (Ages 46 - 54) | 2024 |
| Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease | Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease | Atul Malhotra, University of California San Diego (UCSD) | Supplemental oxygen and Continuous Positive Airway Pressure (CPAP) machine | Cognitively healthy older adults (Ages 65-85) | 2025 |
| Slow-wave Sleep Enhancement in Those at risk for Alzheimer's Disease: Links with Memory, Excitotoxicity, and Plasma A-beta | Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease (ALPS) | Kristine Ann Wilckens, University of Pittsburgh at Pittsburgh | Habitual slow-wave sleep enhancement to improve cognition | Older adults (Ages 65 - 85) | 2026 |
| The Use of Rhythmic Light Therapy to Entrain Gamma Oscillations and the Circadian System in Patients with Alzheimer's Disease and Related Dementias (ADRD) | Rhythmic Light Therapy for Alzheimer's Disease Patients | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Rhythmic Light Therapy to improve sleep and cognition | Older adults with MCI | 2026 |
| Cognition After OSA Treatment Among Native American People | TBD | Dedra Buchwald Ka'imi Alohilani Sinclair, Washington State University | Positive airway pressure therapy, a behavioral intervention for obstructive sleep apnea, to improve sleep quality, cognitive function, and vascular risk factors for AD/ADRD | American Indians (Ages 55+) from Strong Heart Study communities | 2026 |
| Home Sleep Therapy System for Mild Cognitive Impairment | TBD | Don Tucker, Brain Electrophysiology Laboratory Company, Llc | Neurosom® Electric Sleep Therapy (NEST) system to allow researchers to conduct transcranial electrical stimulation (TES) studies to improve sleep in seniors with MCI | Adults with amnestic MCI (aMCI) ages 55-85 | 2023 |
| Internet-based insomnia intervention to prevent cognitive decline in older adults with mild cognitive impairment | Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND) | Meghan Mattos, University of Virginia | Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention | Older adults (age 65+) with MCI and insomnia | 2027 |
| Light, metabolic syndrome and Alzheimer's disease: A non-pharmacological approach | Light, Metabolic Syndrome and Alzheimer's Disease - Aim 2 | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Tailored Lighting Intervention to improve sleep disturbances, inflammation, insulin sensitivity (Si), glucose disposal (Sg), and cognition in patients with MCI and mild ADRD and sleep disturbances | AD/ADRD patients who live in controlled environments (i.e., assisted living facilities and nursing homes) | 2023 |
| Use of 7T multimodal imaging to detect brain changes associated with light therapy in persons with mild cognitive impairment and mild Alzheimer's Disease | 7T MRI for Light Therapy in Patients With Mild Cognitive Impairment and Mild AD | Priti Balchandani, Icahn School of Medicine at Mount Sinai | High-resolution multi-modal 7T imaging to investigate the impact of lighting intervention therapy (LIT) on sleep physiology and brain structure, function, and connectivity in MCI and mild AD patients | 25 amnestic MCI or mild AD patients with a confirmed Aß+ PET scan | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Enhancing Social Engagement through Online Gameplay for Older Adults with and without Mild Cognitive Impairment | TBD | Dillon Myers, Potluck, LLC | OneClick, an online social engagement platform, to benefit health outcomes affected by social engagement (survival, onset of dementia) | Adults with MCI | 2023 |
| Project 1: Virtual Reality to Support Cognitive Health and Engagement and Socialization Among Aging Adults | TBD | Sara Czaja, Neils Charness, Weill Medical College of Cornell University, Florida State University | Virtual reality program for social activity and cognitive engagement | Older adults experiencing the impact of age-related changes | 2027 |
| Project 2: Technology Support for Cognition and Social Engagement for Aging Adults with Mild Cognitive Impairment (MCI) | TBD | Sara Czaja, Walter Boot, Weill Medical College of Cornell University, Florida State University | Intelligent Adaptive System, an innovative intelligent adaptive software package aimed at providing social and cognitive support to older adults with MCI | Community dwelling older adults with MCI | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Association of Perceived Stress and Cognition | TBD | Ambar Kulshreshtha, Emory University | A web-based multidisciplinary stress reduction program to examine the association of stress and cognition, role of cardiovascular disease risk factors, and related health disparities | African Americans and White adults with MCI | 2025 |
| Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease | TBD | Cynthia Ann Munro, Johns Hopkins University | Response to an acute stressor, (trier social stress test) in MCI | Adults with MCI | 2027 |
| Mindfulness Training For Mitigating Age-Related Cognitive Decline In The Elderly | Mind-body Interventions for Healthy Aging (HealthyAgers) | Ruchika Prakash, Ohio State University | Mindfulness-based cognitive training to prevent or mitigate age-related cognitive decline | RH healthy older adults (Ages 65-85) | 2023 |
| Optimizing a Closed-loop Digital Meditation Intervention for Remediating Cognitive Decline and Reducing Stress in Older Adults | TBD | David Ziegler, University of California, San Francisco | MediTrain, a digital meditation intervention to reduce cogntiive decline and emotional stress | Older adults | 2027 |
| PATH-Pain: A Primary Care-Based Psychosocial Intervention To Improve Cognitive and Depression Outcomes in Older Adults with MCI and Early Stage AD | A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD (PATH-Pain) | Dimitris Kiosses and Manney Carrington Reid, Cornell University | Problem Adaptation Therapy for Pain (PATH-Pain) primary-care based psychosocial intervention designed to reduce stress | Adults with MCI or early stage AD (Ages ≥60) | 2026 |
| Targeting Cognitive Function and Interoceptive Awareness to Improve Self-management in Patients with Co-morbid Heart Failure and Cognitive Impairment | Mind Your Heart-II (MYH-II) | Elena Salmoirago-Blotcher, Miriam Hospital | A mindfulness training intervention to improve cognitive function in patients with co-morbid heart failure and cognitive impairment | Individuals with MCI and heart failure | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Addressing the Chronic Pain-Early Cognitive Decline Comorbidity Among Older Adults; The Active Brains study | Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain | Ana-Maria Vranceanu, Massachusetts General Hospital | Active Brains-Digital (AB-D; the Active Brains-Fitbit program simplified by replacing the hip ActiGraph + Fitbit with a wrist ActiGraph) vs Health Enhancement Program (HEP), both delivered via live video to 260 older adults with CP-ECD. | Older adults with nonmalignant chronic pain (>=3 months) and early cognitive decline | 2027 |
| Hyperbaric Oxygen Therapy for Cognition in Diabetic Elderly at High Dementia Risk | Hyperbaric Oxygen Therapy for Cognition in Diabetic Elderly at High Dementia Risk | Michal Schnaider Beeri; Mary Sano, Icahn School of Medicine at Mount Sinai | Hyperbaric oxygen therapy intervention to improve cognitive function and increase cerebral blood flow and glucose utilization in MCI participants | People with Mild Cognitive Impairment and diabetes (Ages ≥65) | 2024 |
| Aging, Cognition, and Hearing Evaluation in Elders (ACHIEVE) Randomized Trial | Aging and Cognitive Health Evaluation in Elders (ACHIEVE) | Frank Lin; Josef Coresh, Johns Hopkins University | Hearing aid intervention to test effects on cognition | Adults (Ages 70 - 84) | 2023 |
| Long-term effects of hearing intervention on brain health in the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) randomized study | ACHIEVE Brain Health Follow-Up Study (ACHIEVE-BHFU) | Frank Lin, Johns Hopkins Bayview Medical Center (JHBMC) | Follow-up of ACHIEVE cohort for an additional three years to determine the long-term effects of hearing intervention (i.e., participants randomized to hearing intervention at Year 0) versus successful aging/delayed hearing intervention control (i.e., participants randomized to successful aging intervention at Year 0 and offered the hearing intervention after their Year 3 visit) on cognitive and brain outcomes. | Older adults aged 73-89 with mild-to-moderate hearing loss and a MMSE score greater than or equal to 23 | 2027 |
| Development and Evaluation of Computerized Olfactory Training Program (COT) for Cognitive Decline in Early Alzheimer's Disease (AD) | Development and Evaluation of Computerized Olfactory Training Program for Cognitive Decline in Early Alzheimer's Disease | Sumeet Seth, Evon Medics, LLC | Computerized Olfactory Training Program (COT), a portable, home-based product to prevent progressive cognitive decline and progressive dementia in early Alzheimer's Disease | Adults with diagnosis of probable mild AD (Ages 65 - 85) | 2023 |
| Optimizing anesthesia to prevent postoperative cognitive and functional decline in older adults | TBD | Katie Schenning, Oregon Health & Science University | IV vs. inhalational anesthesia on post-operative delirium, post-operative cognitive dysfunction, functional status, and patient-reported outcomes | Older adults 75+ years old undergoing elective inpatient non-cardiac surgery | 2027 |
| Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure | Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure | Miyeon Jung, Indiana University-Purdue University Indianapolis (IUPUI) | Intervention involving virtual reality-based cognitive restoration (Vita) coupled with computerized cognitive training (Com) | Dyads composed of older (65+ years) patients with HF (chronic HF Stage C validated from echocardiography or comparable measure) and MCI (MoCA score 23 and lower) and their informants | 2027 |
| Brain Safe: Consumer Intervention to Reduce Exposure to Drugs Linked to Alzheimer's Disease | Brain Safe: Consumer Intervention to Reduce Exposure to Drugs Linked to Alzheimer's Disease | Richard J. Holden, Indiana University-Purdue University at Indianapolis | Digital Brain Safe mobile app to reduce exposure to anticholinergic drugs | Adults who have taken at least 1 anticholinergic medication within the past 90 days (Ages ≥65) | 2024 |
| Reducing Risk of Dementia through De-prescribing (R2D2) | Reducing Risk of Dementia Through Deprescribing (R2D2) | Noll L. Campbell, Purdue University | Pharmacist-driven de-prescribing protocol focused only on targeted anticholinergic medications. | Older adults with subjective cognitive dysfunction and at least one order for a strong anticholinergic medication in the previous 12 months (Ages 65+) | 2024 |
| Impacts of Receiving Alzheimer's Disease Genetic Risk Information Among Latinos in Northern Manhattan | Information About Alzheimer's Disease for Latinos in New York City (IDEAL) | Ruth Ottman, Columbia University | Information about risk of AD will be given to participants based on their APOE genotypes, in addition to Latino ethnicity and family history | Latino or Hispanic adults (Ages 40 - 64) | 2024 |
| RETAIN: A Digital Therapeutic for Alzheimer's Risk Reduction | TBD | Mark Mcinnis, Retain Health Inc | Digital therapeutic designed to reduce risk of AD | Normal healthy volunteers with a family history of AD | 2024 |
| Returning Research Results that Indicate Risk of Alzheimer's Disease to Healthy Participants in Longitudinal Studies | Returning Research Results That Indicate Risk of Alzheimer's Disease Dementia to Healthy Participants in Longitudinal Studies (WeSHARE) | Sarah Hartz; Jessica Mozersky, Washington University | Returning research results to participants to measure impact on cognitive and psychosocial outcomes | Cognitively normal individuals who have had imaging studies within 18 months, APOE genotyping, and are scheduled for annual visits | 2025 |
| Neurocognitive Impairment Assessment in Symptomatic Carotid Occlusion Recanalized Endovascularly: NIA SCORE | NeuroCognition After Carotid Recanalization | David M Hasan, University Of Iowa | Stenting or hybrid carotid endartarectomy intervention, to determine the cognitive outcomes associated with endovascular balloon angioplasty | Inclusion criteria: 1) Age ≥ 21 and ≤ 70 years, 2) complete occlusion of cervical ICA on imaging studies (MRA or CTA) and confirmed with DSA, 3) History of TIA or stroke within 120 days of enrollment, 4) evidence of large penumbra on CTP, 5) all occlusion is due to atherosclerotic disease, and 6) a MoCA < 26 | 2025 |
| Enhancing Gamma Band Response to Improve Working Memory in Individuals with Mild Cognitive Impairment | Neurofeedback to Improve Working Memory in Mild Cognitive Impairment | Fiza Singh, University of California, San Diego | EEG-neurofeedback (EEG-NFB) computer-based brain training program to improve working memory in individuals with amnestic mild cognitive impairment | People with Amnestic Mild Cognitive Impairment (Ages 60 - 85) | 2025 |
| Health Beliefs, Glycemic Control, and Preventing Cognitive Decline in African Americans with Diabetes and Mild Cognitive Impairment: A Randomized Clinical Trial | Health Beliefs, Glycemic Control, and Preventing Cognitive Decline in African Americans With Diabetes and Mild Cognitive Impairment: A Randomized Clinical Trial (DREAM) | Barry Rovner, Thomas Jefferson University | Diabetes Mellitus (DM)-Specific Behavioral Activation (DM-BA) to prevent decline in verbal memory in African-Americans with amnestic multiple-domain MCI | African-Americans with amnestic MCI and poorly controlled DM (Ages ≥65) | 2025 |
| Compensation Training and Lifestyle Modifications to Promote Healthy Aging in Persons at Risk for Alzheimer's dDisease: A Digital Application Supported Intervention | Brain Boosters 2 in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention (BB2) | Sarah E. Tomaszewski-Farias; Maureen Schmitter-Edgecombre, University of California at Davis | Digital Memory Notebook intervention, an interactive application used to facilitate behavioral change and enhanced motivation | People with AD or mild cognitive impairment (Ages 65 - 90) | 2025 |
| ADRD Prevention Messaging to Increase Smoking Cessation Attempts in Older Adult Smokers | Older Smoker Motivational Intervention | Adrienne L Johnson, University of Wisconsin-Madison | Motivation to Quit Intervention to increase motivation to quit, quit attempts, and use of evidence-based smoking treatments (EBSTs) for older adult smokers | Older adult smokers (Ages 50 - 80) | 2026 |
| Clinical Trial of Vestibular Therapy to Reduce Falls in Patients with Alzheimer's disease | Vestibular Therapy in Alzheimer's Disease | Yuri Agrawal, Johns Hopkins University | Vestibular therapy to reduce falls and improve balance in older adults with mild to moderate AD and vestibular loss. | Adults with mild-moderate AD & vestibular loss (Ages 60+) | 2026 |
| Resilience and Brain Health of Older Adults During the COVID-19 Pandemic | Resilience and Brain Health of Older Adults During the COVID-19 Pandemic (MEDEX-2) (MEDEX-2) | Eric Lenze, Breno Diniz, Julie Wetherell, Washington University | Exercise and mindfulness interventions to measure the effects of COVID-induced stress on AD-related cognitive decline | Healthy, sedentary, community living individuals, (Age 65 - 84) | 2026 |
| Characterizing and Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging | Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging | Natalie Ebner, University of Florida | Neurofeedback training using real time fMRI to increase activity in the anterior cingulate gyrus to improve learning. | Individuals (Age 20 - 85) | 2027 |
| Intermittent Hypoxia Training: A Novel Therapy for Mild Cognitive Impairment | Intermittent Hypoxia Training: A Novel Therapy for Mild Cognitive Impairment | Xiangrong Shi, University of North Texas Health Science Center | An intermittent-hypoxia training (IHT) program to prevent or reverse cognitive decline and neurodegeneration in MCI | Individuals with amnestic MCI | 2025 |
| Mediators and Moderators of Auditory Training | TBD | Aaron Seitz, University of California, Riverside | An auditory training intervention to mitigate hearing issues that promote dementia risk | Older adults (ages 60-85) with no more than typical hearing loss for their age, no evidence of dementia) and comparison younger adults (age 18-30, normal hearing) | 2027 |
| Project 3: Technology Tools for Cognitive Support for Health Management Activities for Aging Adults with and without Mild Cognitive Impairment | TBD | Sara Czaja, Joseph Sharit, Weill Medical College of Cornell University, University of Miami | Intelligent Decision Support Tool, an innovative intelligent decision tool for health decisions aims at providing health management support for older adults with and without MCI | Cognitively diverse older adults | 2027 |
| A Pragmatic Crossover Trial to Test the Effectiveness of a Novel Lighting System to Reduce Nighttime Falls in Persons with Alzheimer’s Disease and Related Dementias | TBD | Sheryl Zimmerman, University of North Carolina Chapel Hill | A lighting intervention to reduce nighttime falls | Individuals with AD/ADRD | 2027 |
| My Healthy Brain: a mindfulness-based lifestyle intervention to modify early risk of dementia in older adults | TBD | Ryan Mace, Massachusetts General Hospital | My Healthy Brain (MHB) teaches education; mindfulness skills; and behavior change principles. All MHB skills were adapted to account for commonly reported SCD symptoms (e.g., forgetfulness) and co-morbid psychological barriers (e.g., low motivation) that can interfere with lifestyle behavior change. | Medical providers and older adults aged 60 and above at risk of AD/ADRD | 2027 |
| Early Age-Related Hearing Loss Investigation (EARHLI): A Randomized Controlled Trial to Assess Mechanisms Linking Early Age-Related Hearing Loss and Alzheimer's Disease and Related Dementias | TBD | Justin Golub, Columbia University | Hearing aids to prevent cognitive decline in those at risk for Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) | Older adults with early-stage age-related hearing loss (ARHL) and amnestic mild cognitive impairment (55-75 years) | 2027 |
Section 4: Dementia Care and Caregiver
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Preparation for End of Life Decision Making in Mild Alzheimer's Disease | Two-Phased Study of SPIRIT in Mild Dementia | Mi-Kyung Song Emory University | SPIRIT (Sharing Patient's Illness Representation to Increase Trust), a patient- and family-centered advanced care planning (ACP) intervention based on the Representational Approach to Patient Education to promote cognitive and emotional preparation for end-of-life decision making | Patient (mild AD)-surrogate dyads (Ages 18+) | 2023 |
| Pragmatic Trial to Improve Communication for Primary Care Patients with ADRD | Improving Communication for Primary Care Patients | Jennifer L Wolff, Johns Hopkins University | SHARING Choices (Sharing access to Health records, Agenda setting and RespectING Choices to Engage Families), a multicomponent communication intervention that seeks to proactively engage family members and support advance care planning (ACP) in primary care. | Adults with AD/ADRD (65+) | 2023 |
| POST Facilitation for Community Dwelling Older Adults with and without Dementia | POST Facilitation for Community Dwelling Older Adults (POST-RCT) | Alexia Mary Torke, Indiana University-Purdue University at Indianapolis | Physician Orders for Scope of Treatment (POST), a virtual at-home advanced care planning (ACP) intervention to make decisions about care goals and to record preferences in writing | Frail, older community dwelling adults (Ages 65+) and their surrogate decision maker | 2024 |
| Involving Family to Improve Advance Care Planning for Primary Care Patients with ADRD | SHARE: Sharing Healthcare Wishes in Primary Care | Jennier L Wolff, Johns Hopkins University | Sharing Healthcare Wishes in Primary Care (SHARE), a multicomponent communication intervention to proactively engage family members or friends to support advance care planning in primary care | Persons with cognitive impairment (Ages 80+) and family dyads | 2024 |
| Decision Making and Implementation of Aging-in-Place/Long Term Care Plans among Older Adults | Decision Making and Implementation of Aging-in-Place/Long Term Care Plans Among Older Adults | Lee A Lindquist, Northwestern University at Chicago | Plan Your Lifespan, a web-based decision-making and planning tool to examine the mediating/moderating factors involved in decision-making, timing of decision implementation, and goal concordance for older adults aging-in-place/long term care | Community-dwelling older adults (Ages 55+) | 2024 |
| Effectiveness of Engaging in Advance Care Planning Talks (ENACT) Group Visits Intervention in Primary Care for Older Adults with and without Alzheimer's Dementia | Effectiveness of Engaging in Advance Care Planning Talks (ENACT) Group Visits in Primary Care for Older Adults With and Without Alzheimer's Disease (ENACT) | Hillary Lum, University of Colorado, Denver | ENgaging in Advance Care planning Talks (ENACT) Group Visits intervention to increase advance care planning (ACP) documentation (one aspect of ACP) among older adults in primary care settings, including older adults with cognitive impairment | Older adults that have at least one primary care clinic visit in the past 12 months (Ages 70+) | 2026 |
| Implementation Strategies to Promote Advance Care Planning among Persons Living with ADRD and those with Mild Cognitive Impairment in Outpatient Primary Care Practices | TBD | Jennifer Lynn Gabbard, Wake Forest University Health Sciences | ACPdSmart is a dementia-specific portal-based tool for advance care planning engagement | ≥65 years old with recognized or probable MCI or mild dementia, yet retain decisional capacity to complete ACP. | 2027 |
| Hybrid efficacy-effectiveness trial to promote goals-of-care discussions for patients with Alzheimer's disease and related dementias and their family caregivers | Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers (PICSI-M) | Erin Kross, University of Washington | "Jumpstart," a one-page guide using patient-specific information to prompt and guide clinicians in goals-of-care discussions. | Adults over age 55 who have an ICD10 code for ADRD in the EHR in the prior two years | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| The PorchLight Project | The PorchLight Project | Joseph E. Gaugler, University of Minnesota | The Porchlight Project is multicomponent training delivered to volunteers and includes three established online training modules on person-centered dementia care; a four-session online training program that demonstrates to volunteers how to apply person-centered dementia care knowledge to their interactions with persons with dementia and their caregivers; and ongoing monthly coaching sessions. | 171 family caregivers, 171 persons with dementia and dementia; 171 senior volunteers | 2027 |
| Cognitive Training to Protect Immune Systems of Older Caregivers | Cognitive Training for Older Caregivers (CTC) | Kathi L. Heffner, University of Rochester | Computerized cognitive training to improve fluid cognitive abilities including processing speed and attention | Older caregivers of a family member with Alzheimer's Disease (AD) or AD-related dementia (ADRD) (Ages 60 - 80) | 2023 |
| Developing a Distance Education System to Train Savvy Caregiver Program Interventionists: Extending Access and Capacity in Community-Based Delivery of Evidence-Based Interventions | Savvy System Project | Ken W. Hepburn, Emory University | Web-based system to train interventionists on Savvy Caregiver, a dementia family caregiver psychoeducation program | Dementia family caregivers (Ages 18+) | 2023 |
| The Senior Companion Program Plus (SCP Plus): A Psychoeducational Intervention for African American Dementia Caregivers | The Senior Companion Program Plus (SCP Plus) | Noelle Fields, University of Texas, Arlington | Senior Companion Program Plus (SCP Plus), an in-home psychoeducational intervention | African-American caregivers for older adults with ADRD (Ages 55+) | 2023 |
| Developing a Screening Protocol for Family Caregivers of Older Persons with and without Dementia Seen in Primary Care | Implementing a Family Caregiver Checklist in Primary Care: A Pilot Study | Catherine Riffin, Weill Medical College of Cornell University | Caregiver screening-referral protocol for family caregivers who accompany older adults to their primary care visits. | Patient-caregiver dyads and healthcare providers | 2023 |
| The Caregiver Resource Room: Enhancing Support for Caregivers of Alzheimer's Disease and Related Dementias (ADRD) | TBD | Francesca Falzarano, Weill Medical College of Cornell University | Online self-assessment and tailored referral platform to support ADRD caregivers | ADRD caregivers | 2023 |
| Evaluating the Effectiveness of an Online Small-Group Self-Management Workshop for Rural Caregivers of Individuals with Alzheimer's Disease and Related Dementias | Rural Dementia Caregiver Project | Veronica Yank, University of California, San Francisco | Building Better Caregivers, an online, self-management and skills building intervention to support isolated dementia caregivers in rural areas | Rural dementia caregivers (Ages 18+) | 2023 |
| GamePlan4Care: Web-based Delivery System for REACH II | GamePlan4Care: Online Support for Family Caregivers (GP4C) | Alan B. Stevens, Baylor Research Institute | GamePlan4Care (GP4C), an internet-based system designed to provide immediate, tailored education and skills training to caregivers | Caregivers of veterans with ADRD admitted to the inpatient general medicine service at MEDVAMC | 2023 |
| GamePlan4Care: Web-based Delivery System for REACH II | TBD | Alan B. Stevens, Baylor Research Institute | Hospital GamePlan4Care (GP4C), an internet-based system designed to provide immediate, tailored education and skills training to caregivers in a hospital setting | Dementia caregivers in a hospital setting (Ages 18+) | 2023 |
| Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders: Creating Harmony at HOME: A pilot study of a telehealth-based program for rural caregivers’ ability to adapt home environments for adults with Alzheimer’s Disease and Related Disorders (ADRD) (Pilot) | Harmony at Home: A Pilot Telehealth Program for Rural ADRD Caregivers | Ken Hepburn, Emory University | Harmony at HOME, a telehealth-based intervention to develop and enhance caregiver competence related to home environment adaptation to promote functional behaviors for the person with dementia | Caregivers of persons living with AD/ADRD | 2024 |
| Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders: Primary Progressive Aphasia (PPA) Tele-Savvy (Pilot) | PPA Tele-Savvy: A Pilot Study of an Online Intervention for Caregivers of Persons Living With PPA | Ken Hepburn, Darby Morhardt, Emory University, Northwestern University | Psychoeducational program for caregivers of persons with primary progressive aphasia | Caregivers of persons living with a documented diagnosis of primary progressive aphasia (PPA) | 2024 |
| Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders: Producing a Fully Asynchronous Online Tele-Savvy Program (Pilot) | Producing a Fully Asynchronous Online Savvy Program | Ken Hepburn, Fayron Epps, Emory University | Fully online, self-administered psychoeducation program to enhance the caregiving mastery of family and friends who care for persons living with AD/ADRD | Family and friends who care for persons living with AD/ADRD | 2024 |
| Efficacy of the WeCareAdvisor: An Online Tool to Help Caregivers Manage Behavioral and Psychological Symptoms in Persons with Dementia | WeCareAdvisor Study for Caregivers of People Living With Dementia | Laura N. Gitlin, Drexel University | WeCareAdvisor, an online tool to help caregivers manage behavioral and psychological symptoms in persons with dementia | Caregivers (Ages 21+) | 2024 |
| Developing and Testing the Enhancing Active Caregiver Training (EnACT) Intervention for Dementia Family Caregivers | Developing and Testing the Enhancing Active Caregiver Training (EnACT) Intervention for Dementia Family Caregivers (EnACT) | Jacqueline Eaton, University of Utah | Enhancing Active Caregiver Training intervention to manage common behavioral symptoms associated with ADRD | Caregivers of persons living with AD/ADRD | 2025 |
| Impact of Adult Day Services on Psychosocial and Physiological Measures of Stress Among African American Dementia Family Caregivers | TBD | Lauren Parker, Johns Hopkins University | Mechanism study to identify how adult day services influences caregiving related stressors and needs for African American AD/ADRD caregivers | African American Caregivers | 2025 |
| Using Technology to Support Care Partners for Persons with Alzheimer's Disease: Tele-STELLA | Using Technology to Support Care Partners for Persons With Alzheimer's Disease: Tele-STELLA (Tele-STELLA) | Allison Lindauer, Oregon Health and Science University | Telehealth intervention using education and peer support to reduce stress and behavioral symptoms for family care partners for those with AD/ADRD | Rural, African American, and white care partners for those living with AD/ADRD | 2026 |
| Testing Dementia Caregiver TeleCoaching to Reduce Episodes of Abuse and Neglect by Recognizing and Managing Care-Resistant Behaviors | Coaching Dementia Caregivers to Master Care-Resistant Behavior (CuRB-IT) | Rita A. Jablonski, University of Alabama at Birmingham M | Care-Resistant Behavior Internet Training (CuRB-IT) to enhance coping skills of family caregivers and reduce elder abuse and neglect (EAN) | Caregivers for persons with ADRD | 2026 |
| An Assistive-technology Based Caregiver Training Program (CTP) to Enhance Caregiver Effectiveness, Well-being, and Quality of Life, Which Will Improve Overall Care for Individuals Living with AD/ADRD | TBD | Matthew Golden, MapHabit, Inc. | MapHabit System and Caregiver Training Program (CTP) to improve caregiver quality of life and overall patient care | Dyads, caregivers and individuals living with dementia | 2023 |
| Emergency Preparedness and Support of Caregivers of Persons with Dementia: The Disaster PrepWise Study | Emergency Preparedness for Caregivers of Persons With Dementia: Disaster PrepWise (DPW-Caregiver) | Sato Ashida, University of Iowa | Disaster PrepWise (DPW), an intervention program to enhance emergency preparedness and support networks to increase caregiver resilience and minimize distress | Caregivers to persons living with mid-stage AD/ADRD | 2027 |
| Learning Skills Together: A Randomized Controlled Trial of a Complex Care Skills Intervention to Improve AD/ADRD Caregiver Self-Efficacy | TBD | Kylie Meyer, University of Texas Health Science Center | Learning Skills Together (LST), a complex care skills intervention to improve caregiver self-efficacy | Family caregivers (aged 18 and older) of persons with Lewy Body Dementia | 2027 |
| Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders: (Pilot) | VOCALE LBD+ for Caregivers of Persons With Lewy Body Dementia | Ken Hepburn (Pilot PIs: Annie T. Chen & Oleg Zaslavsky), Emory University | Virtual Online Communities for Aging Life Experiences (VOCALE), is an 8-week online intervention that uses a web-based discussion platform and involves moderation, peer-to-peer support, didactic training, and problem-solving skill enactment. | Family caregivers (aged 18 and older) of persons with Lewy Body Dementia | 2024 |
| Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders: (Pilot) | Study of the Aliviado DSD Caregiving Mastery Program | Ken Hepburn (Pilot PIs: Shih-Yin Lin & Yong K. Choi), Emory University | Aliviado DSD Caregiving Mastery Program includes Family-centered training on delirium superimposed dementia (DSD) plus an mHealth app-based care plan of DSD prevention, detection, and management tasks and tailored mobile push notification task reminders and encouragements. | Family caregivers for individuals living with AD/ADRD | 2024 |
| eAlign: A Patient Portal-based Intervention to Align Medications With What Matters Most | TBD | Ariel Green, Johns Hopkins Bayview Medical Center (JHBMC) | eALIGN, a patient portal intervention to align medication decisions with persons living with ADRD and care partners' goals, provide care partner training in the use of nonpharmacologic methods to address behavioral and psychological symptoms of dementia, and reduce polypharmacy and potentially inappropriate medication use. | Older adults age 65 years and older, with diagnosis of ADRD who receive five or more chronic daily medications | 2027 |
| Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce | TBD | Sheryl Zimmerman, The University of North Carolina (UNC) at Chapel Hill | Two training arms (essentiALZ alone and essentiALZ + ECHO) in terms of adoption, reach, and reaction. The trial will determine effectiveness of two training arms in relation to each other and to a control arm. | Staff at Assisted Living Facilities | 2027 |
| Roybal Translational Research Center to Promote Context-specific Caregiving of Community-Dwelling Persons Living With Alzheimer's Disease or Related Disorders | The Couple in Control | Lindsay Prizer, Emory University | Couple in Control (CiC), a toolkit of communication skills and decisional strategies to help couples experiencing MCI cope with various challenges | Dyads of individuals diagnosed with MCI and their care partners | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Dyadic Telehealth Program for Alzheimer's Patients/Caregivers | A Dyadic Telehealth Program for Alzheimer's Patients/Caregivers | Yeonsu Song, UCLA | Manual-based sleep hygiene recommendations and a behavioral sleep intervention including sleep compression therapy | AD patient-caregiver dyads (Ages 60+) | 2023 |
| A Non-Pharmacological Intervention for Patients with Alzheimer's Disease and Family Caregivers | A Non-pharmacological Intervention for Patients with Alzheimer's Disease and Family Caregivers (Care Partners Program) (CPProgram) | Sara J. Czaja, Weill Medical College of Cornell University | Dyadic cognitive/functional training intervention delivered through a computer tablet to improve quality of life, distress, and caregiving efficacy, among other outcomes | Dyads of individuals with mild AD and their CGs (Ages 21+) | 2023 |
| A Dyadic Sleep Intervention for Alzheimer's Disease Patients and Their Caregivers | A Dyadic Sleep Intervention for Alzheimer's Disease Patients and Their Caregivers | Yeonsu Song, UCLA | Manual-based sleep hygiene recommendations and a behavioral sleep intervention including sleep compression therapy | AD patient-caregiver dyads (Ages 60+) | 2023 |
| Creating a Faith-Based Toolbox for African Americans Living with Moderate and Severe Dementia | Faith-Based Toolbox for African Americans With Dementia | Fayron Recha Epps, Emory University | Faith-based home activity toolkit (Faith-HAT), meaningful religious and spiritual activities for PLWD to engage in at home with their family caregiver | Dyads of persons living with dementia and caregiver (Ages 18+) | 2023 |
| Reducing Disability via a Family-centered Intervention for Acutely-ill Persons with Alzheimer's Disease and Related Dementias | A Family-centered Intervention for Acutely-ill Persons With Dementia | Marie Boltz, Pennsylvania State University - University Park | Family-centered Function-focused Care (Fam-FFC), an educational empowerment model for family caregivers that includes a care pathway, provided within a social-ecological in-patient framework promoting specialized care to patients with ADRD | Older persons with Alzheimer's disease and related dementias (ADRD) and their family CGs | 2023 |
| Old SCHOOL Hip Hop: A randomized controlled trial to improve dementia knowledge | Old SCHOOL Hip-Hop: Improve Alzheimer's Disease Knowledge | James Mccallum Noble, Columbia University Health Sciences | “Old SCHOOL Hip Hop” (Seniors Can Have Optimal aging and Ongoing Longevity [OSHH]), a brief multimedia culturally tailored school-based intervention designed to teach minority children (4th and 5th grade; ages 9-11y) key dementia signs and symptoms, and actions taken when dementia is recognized | Students at twenty schools (Ages 9-11; with their parents Ages 20+) | 2023 |
| STAR Caregivers - Virtual Training and Follow-up | STAR Caregivers - Virtual Training and Follow-up (STAR-C-VTF) | Robert B. Penfold, Kaiser Foundation Research Institute | STAR Virtual Training and Follow-up (STAR- VTF) - PWD caregiver training using web-based Electronic Health Record portal. | Caregiver-PWD dyads (Ages ≥55) | 2023 |
| A Training and Fidelity Model to Move and Scale Evidence-based Dementia Care and Caregiver Support Programs into Practice: The Case for COPE in PACE service settings | Care of Persons With Dementia in Their Environments (COPE) in Programs of All-Inclusive Care of the Elderly (PACE) | Nancy A. Hodgson, University of Pennsylvania | Care of Persons in the Environments (COPE), an online training program for caregivers and care staff of persons with dementia to improve care for persons with dementia | Dyads from PACE sites (Ages 21-100) | 2023 |
| Resilient Together for Dementia: A live video resiliency dyadic intervention for persons with dementia and their care-partners early after diagnosis | TBD | Sarah Bannon, Massachusetts General Hospital | Resilient Together for Dementia (RT-D), a live video dyadic resiliency intervention. | Persons Living With Dementia, and Spousal Partner (SP) dyads, along with staff employed at MGH Department of Neurology | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Dementia Caregiver Chronic Grief Management: A Live Online Video Intervention | Dementia Caregiver Chronic Grief Management: A Live Online Video Intervention (CGMI-V) | Olimpia Paun, Rush University Medical Center | Chronic Grief Management, a live streaming video to improve general well-being and satisfaction with care | ADRD caregivers (Ages 60+) | 2023 |
| Mindfulness based stress reduction for family caregivers of dementia patients | Improving Well-Being for Older Adult Family Dementia Caregivers | Kathi L. Heffner, University of Rochester | Mindfulness Based Stress Reduction (MBSR) for family caregivers | Adults who currently live with and are the primary caregivers for a community dwelling dementia patient (Ages 60+) | 2023 |
| The Caregiver Outcomes of Alzheimer's Disease Screening (COADS) Trial | Caregiver Outcomes of Alzheimer's Disease Screening (COADS) | Nicole R. Fowler, Indiana University - Purdue University at Indianapolis | An early screening intervention involving sending letters to dyads and the primary care PCP informing them of the results of the screening, for earlier diagnosis | Dyads of older adults (Ages 65+) and family members (Ages 21+) | 2023 |
| The Mindful and Self-Compassionate Care Program (MASC): Reducing Stress for Caregivers of Persons with Dementia | TBD | Christine Ritchie, Massachusetts General Hospital |
The Intervention is Intervention: The Mindful and Self-Compassionate Care Program (MASC), which combines evidence-based skills from mindfulness programs, self-compassion programs, and behavioral management programs. Participants are randomized to two arms: (1) The Intervention arm (MASC): will receive MASC delivered by a social worker with expertise working with ADRD caregivers. MASC content includes education around stress and caregiving, educational information on strategies to manage stress including exercise, sleep, and social support. (2) Control arm (HEP): will receive HEP, which is time-, dose-, and attention-matched to MASC. However, this program will not include any skills. |
Caregivers of persons living with dementia. | 2025 |
| To reduce the burden of caregiving on health outcomes of midlife women: Asian American family caregivers of persons living with Alzheimer's disease | Technology-based Information and Coaching Program Tailored for Asian American Midlife Women Who Are Family Caregivers of Persons With Alzheimer's Disease (TACAD) | Eun-Ok Im, Emory University | The intervention is BC-Care (BrainCheck), a cognitive care planning tool that integrates patient, provider, and caregiver input to generate personalized ADRD recommendations and follow-up care to be implemented during an ADRD patient's medical visit. | Asian American women who are family caregivers of persons living with Alzheimer’s disease, and experts in gerontology/geriatrics | 2024 |
| LEAF 2.0: Randomized trial of a technology-based positive emotion intervention for informal caregivers of individuals with Alzheimer's disease | Life Enhancing Activities for Family Caregivers (LEAF 2.0) | Judith T. Moskowitz, Northwestern University of Chicago | LEAF, Life Enhancing Activities technology-based intervention to reduce burden and increase well-being for family caregivers of persons living with AD/ADRD | Caregivers (Ages 34-87) | 2023 |
| Mobile, Web-based Behavioral Intervention for Improving Caregiver Well-being | Mobile Web-based Behavioral Intervention for Improving Caregiver Well-being | Brent T. Mausbach, University of California, San Diego | Mobile Pleasant Events Program (mPEP), a Behavioral Activation Therapy program to increase caregiver's engagement in pleasant activities | Dementia caregivers (Ages 40-90) | 2023 |
| Virtual Coaching to Maximize Dementia Caregivers Respite Time-Use: A Stage 1 Pilot Test for Feasibility and Efficacy | Virtual Coaching to Maximize Dementia Caregivers' Respite Time Use (TLC) | Rebecca Lynn Utz, University of Utah | Time for Living & Caring (TLC), an online, self-administered intervention to provide informal family caregivers with resources, support, and education to improve their respite time-use (respite is defined as planned time away from caregiving | Caregivers (Ages 18+) | 2023 |
| CuidaTXT: a Text Message Dementia-Caregiver Intervention for Latinos | CuidaTXT: a Text Message Dementia-caregiver Intervention for Latinos (CuidaTXT) | Jaime Perales, University of Kansas Medical Center | CuidaTXT (Spanish for self-care and texting), a culturally and linguistically tailored text message intervention for caregiver support of Latinos with dementia | Latino Caregivers of individuals with ADRD (Ages 18+) | 2023 |
| Mindfulness-based Cognitive Coping Mobile App Intervention for caregivers of individuals with Alzheimer's Disease | TBD | Bruno Kajiyama, Photozig, Inc | Caring Mind App, a mindfulness-based Cognitive Coping intervention to reduce caregiver stress and depressive symptoms | Caregivers of individuals living with ADRD | 2023 |
| Developing a Culturally-sensitive Volunteering Program to Reduce Stress of Dementia Caregivers in Chinese American Communities | Volunteering Program for Chinese Dementia Caregivers | Jinyu Liu, Columbia Univ New York Morningside | Peer Mentoring Program (PMP) for Chinese caregivers of persons living with dementia | Caregivers (Ages 21+) | 2024 |
| Midwest Roybal Center for Health Promotion and Translation: OCEAN: Optimizing Cognition via Exercise and Nutrition (pilot) | Optimizing Cognition Via Exercise and Nutrition (OCEAN) | Susan Hughes (Pilot PI: Aguinaga, Susan), University of Illinois at Chicago | BAILAMOS™ is a Latin dance program and MIND (Mediterranean-DASH) is a diet - the program with dance and diet aims to improve cognitive function | Older Latinos (ages 50+) | 2024 |
| Midwest Roybal Center for Health Promotion and Translation: VR-CogMoBal Training for Reducing Falls Among Older Adults With Mild Cognitive Impairment (supplement) | VR-CogMoBal Training for Reducing Falls Among Older Adults With Mild Cognitive Impairment | Susan Hughes (Pilot PI: Bhatt, Tanvi), University of Illinois at Chicago | VR-CogMoBal) is a virtual reality based cognitive-motor balance training | Community-dwelling older adults with mild cognitive impairment | 2024 |
| Midwest Roybal Center for Health Promotion and Translation: Piloting the i-PROACTIF program to preserve functioning and prevent cognitive decline (pilot) | Piloting the IPROACTIF Program to Preserve Functioning and Prevent Cognitive Decline | Susan Hughes (Pilot PI: (Mirza, Mansha), University of Illinois at Chicago | IPROACTIF is an occupational therapist-delivered primary care intervention for aging and chronic disease management | Community-dwelling men and women, ≥ 55 years of age | 2024 |
| Midwest Roybal Center for Health Promotion and Translation: We Walk Plus Study: A Walking Program using Physical Activity Monitors and Social Network for Older Adults with Intellectual Disabilities (pilot) | We Walk Plus Study for Older Adults With Intellectual Disabilities | Susan Hughes (Pilot PI: Hsieh, Kueifang (Kelly)), University of Illinois at Chicago | We Walk Plus intervention to promote physical activity and improve cognition for older adults with intellectual disabilities | Older adults with intellectual disabilities | 2024 |
| Midwest Roybal Center for Health Promotion and Translation: CogXergaming to Promote Physical Activity and Cognitive Function in Frail Older Adults (pilot) | CogXergaming to Promote Physical Activity and Cognitive Function in Frail Older Adults | Susan Hughes (Pilot PI: Bhatt, Tanvi), University of Illinois at Chicago | CogXergaming is a cognitive-motor exercise -gaming using Nintendo Wi-fit for frail older adults to improve balance, muscle fitness, cardiovascular fitness and global cognition | Frail older adults aged 60 and up | 2024 |
| Rochester Roybal Center for Social Ties and Aging Research: Social-Life Enhancing Activities for Caregivers(Pilot) | Social-Life Enhancing Activities for Caregivers | Kathi Heffner, University of Rochester | Social LEAF (Life Enhancing Activities for Family Caregivers), a group video-conference intervention to teach caregivers coping skills to improve social relationships and social connection | Caregivers of community-dwelling family member with dementia with Lewy Bodies (DLB) | 2024 |
| Rochester Roybal Center for Social Ties and Aging Research: Mindfulness to Reduce Loneliness in Older Caregivers (Pilot) | Mindfulness to Reduce Loneliness in Older Caregivers | Kathi Heffner, Autumn Gallegos, University of Rochester | Mindfulness training for the reduction of social isolation and feelings of loneliness in older caregivers of family members with ADRD | Caregiver for a community-dwelling family member with AD/ADRD (Ages 50+) | 2024 |
| Rochester Roybal Center for Social Ties and Aging Research: Study of a Behavioral Intervention for Older Advanced Cancer Patients and Their Caregivers (Pilot) | Study of a Behavioral Intervention for Older Advanced Cancer Patients and Their Caregivers | Kathi Heffner, University of Rochester | Life Review therapy, a behavioral intervention to address social connection in caregivers by focusing on the caregiving relationship | Caregivers (Ages 50+) and care receiver with MCI and advanced cancer | 2024 |
| Caregiver Speaks: A Technologically Mediated Storytelling Intervention for Family Caregivers of Individuals with Alzheimer's Disease and Other Dementias | Caregiver Speaks: A Technologically Mediated Storytelling Intervention | Debra Parker Oliver, Washington University | Caregiver Speakers, a technologically-mediated storytelling intervention using photos to illustrate various feelings and meanings | Adult hospice family caregivers of person's living with dementia (PLWD; ages 18-120) | 2024 |
| Using Twitter to Enhance the Social Support of Hispanic and Black Dementia Caregivers (Tweet-SS) | Twitter Based Social Support for Hispanic and Black Dementia Caregivers (Tweet-S2) | Sunmoo Yoon, Columbia University Health Sciences | Twitter-based intervention to enhance the social support (informational, instrumental, emotional, appraisal) for Hispanic and Black dementia caregivers | Black or Hispanic dementia caregivers (Ages 18+) | 2024 |
| Advancing Alzheimer's family caregiving interventions and research capacity in Vietnam: Pilot 1.2. A Multidomain Intervention for Older People with Vascular Dementia (Pilot) | Multidomain Intervention Programs for Older People with Dementia | Walter Ladson Hinton, University of California at Davis | Multidomain intervention program that includes physical and cognitive exercises led by physiotherapists and management of metabolic and vascular risk factors by a cardiologist to address cognitive decline, quality of life, and functional ability | Individuals living in the community who have a diagnosis of mild-moderate vascular dementia (Ages 60+) | 2024 |
| Supplement-Advancing Alzheimer's Family Caregiving Interventions and Research Capacity in Vietnam | A Phone Intervention for Family Dementia Caregivers in Vietnam | Walter Ladson Hinton, University of California at Davis | Adapted (i.e., Distant REACH VN) intervention training protocol for distance delivery to provide support for family caregivers of people living with dementia | Caregiver-care recipient dyads and other staff | 2024 |
| Advancing Alzheimer’s family caregiving interventions and research capacity in Vietnam: Efficacy of a Dementia Family Caregiver Support Intervention in Vietnam | Efficacy of a Dementia Family Caregiver Support Intervention in Vietnam | Walter Ladson Hinton, University of California at Davis | Vietnam Resources for Enhancing Alzheimer’s Caregiver’s Health (REACH VN), a culturally adapted behavioral intervention to support family caregivers of persons with dementia in Vietnam | Family caregivers (Ages 18+) | 2024 |
| Advancing Alzheimer’s Family Caregiving Interventions and Research Capacity in Vietnam: Efficacy of Paper-based Cognitive Training in Vietnamese Patients with Early Alzheimer's Disease (Pilot 2.3) | Efficacy of Paper-based Cognitive Training in Vietnamese Patients With Early Alzheimer's Disease | Walter Ladson Hinton, University of California at Davis | Paper-based cognitive training | Vietnamese patients with early Alzheimer's disease and their caregivers | 2024 |
| Evaluating the Feasibility of a Mobile Phone-based Intervention on Depression, Anxiety, and Stress of the Dementia Caregiver | Evaluating the Feasibility of a Mobile Phone-based Intervention on Depression, Anxiety, and Stress of the Dementia Patients' Caregivers | Walter Ladson Hinton, University of California at Davis | Information including knowledge and skills related to dementia patient care administered to the participants via a smartphone app (Zalo app). | Primary caregivers of patients with dementia | 2024 |
| CommunityRx-Dementia | CommunityRx for Caregivers (CRx-C) | Stacy Tessler Lindau, University of Chicago | Community Rx-Caregiver Resources - tailored resources addressing health-related social needs (HRSN) for caregivers. | ADRD caregivers (Ages 18+) | 2024 |
| Fostering Caregiver Connections via Intentional Technology Pairing for Caregivers of Patients with Alzheimer's Disease and Other Types of Dementia | TBD | Kevin M. Kramer, Minnesota Health Solutions Corporation | Algorithm to connect caregivers of people with dementia to each other for emotional support | Caregivers of persons living with dementia, such as Alzheimer’s disease, Lewy Body dementia and Frontotemporal degeneration | 2024 |
| Culturally Responsive Support Programming for Black Caregivers of Persons with Dementia | Culturally Responsive Caregiver Support | Sheria Grice Robinson-Lane, University of Michigan at Ann Arbor | Culturally tailored support intervention for African American caregivers of PLWD to reduce health disparities | African American caregivers of a PLWD (Ages 55+) | 2025 |
| Mobile app delivered Mentalizing Imagery Therapy to augment remote family dementia caregiver skills training: a pilot randomized, controlled trial with outcomes assessment using digital phenotyping | Mobile App Psychological Interventions for Family Dementia Caregivers | Felipe A. Jain, Massachusetts General Hospital | Guided imagery and mindfulness therapy delivered via mobile app to augment dementia caregiver skills training | Primary caregiver who is aged 60+ for a relative with ADRD that uses a smartphone at least 5 days/week | 2025 |
| A Home-based, Culturally and Language Specific Intervention for Dementia Family Caregivers: Stress Reduction and Education with Wearable Technology for Health | Dementia Family Caregiver Study | Jung-Ah Lee, University of California-Irvine | Stress reduction and dementia education intervention with wearable technology to measure behavioral and physiological measures | Adult family caregivers of PLWD | 2025 |
| Web-based CBT for Insomnia in Rural Dementia Caregivers: Examination of Sleep, Arousal, Mood, Cognitive, and Immune Outcomes | NiteCAPP: Web-based Interventions for Insomnia in Rural Dementia Caregivers (NiteCAPP) | Christina Mccrae, University of Missouri-Columbia | NiteCAPP, a web cognitive behavioral treatment for insomnia (CBT-I) for rural dementia caregivers to improve caregiver health, mood, burden and cognition | Rural dementia caregivers & PWDs | 2026 |
| Supporting Family Caregivers of Persons with Dementia | Supporting Family Caregivers of Persons With Dementia (ENCODE) | George Demiris, University of Pennsylvania | ENCODE (Empowering Caregivers of Patients with Dementia) is a behavioral intervention to support family caregivers in pain management for their hospice patients based on the transcriptional theory of stress and coping. | Caregivers of hospice patients with ADRD | 2026 |
| Addressing the Double Jeopardy of Stress and Hypertension Among African American Female Caregivers of Persons Living with Alzheimer's Disease and Related Dementias | TBD | Kathy Wright, Ohio State University | Mindfulness in Motion (MIM) plus the Dietary Approaches to Stop Hypertension (DASH) interventions to improve caregiver stress and quality of life | African American female caregivers (Ages 40+) with hypertension | 2024 |
| Biobehavioral Mechanisms of Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons with Alzheimer's Disease | TBD | Bryan Denny, Rice University | A smartphone-based cognitive emotion regulation training to improve caregiver health and well-being | AD/ADRD Caregivers | 2027 |
| Caring4Caregivers: A Theory-driven Mobile Solution to Promote Self-care and Well-being Among Caregivers of Individuals with Alzheimer’s and Related Dementias | TBD | Kerry Evers, Pro-Change Behavior Systems, Inc. | Caring4Caregivers (C4C), a theory-driven mobile solution to promote self-care and well-being among caregivers | Caregivers for individuals living with AD/ADRD | 2024 |
| Increasing Meaning to Reduce Loneliness in Care Partners of Persons with AD/ADRD | Reduce Loneliness in Care Partners of Persons With AD/ADRD | Allison Marziliano, Feinstein Institute for Medical Research | RELOAD-C, an intervention leveraging concepts from Meaning-Centered Psychotherapy to reduce loneliness | Individuals with AD/ADRD and their care partners | 2027 |
| Midwest Roybal Center for Health Promotion and Translation (Pilot) | Time Restricted Eating Plus Exercise for Weight Management | David Marquez (Pilot PI: Kelsey Gabel), University of Illinois at Chicago | Time restricted eating (TRE) is intermittent fasting which involves confining the eating window to 8-10 hours (h) and fasting for the remaining hours of the day. During the eating window, individuals are not required to count calories or monitor food intake in any way. | Older adults (Ages 50 - 85), who are overweight/obese, pre-diabetic | 2024 |
| Midwest Roybal Center for Health Promotion and Translation (Pilot) | TBD | David Marquez (Pilot PI: Naoko Muramatsu), University of Illinois at Chicago | Pro-Home MeC is a 12-week in-home PA program, delivered using an app on a tablet hat has built-in motivational enhancement (e.g., music), that consists of: motivational enhancement components, including initial PA discussion between the patient and the memory care clinician, and goal setting with the interventionist; 5 moves for aerobics, strength, flexibility, and balance exercises that target daily functions. | Adults aged 50+ diagnosed with MCI or mild dementia | 2024 |
| Rochester Roybal Center for Social Ties and Aging Research: (Pilot) | TBD | Kathi Heffner (Pilot PI: Kathi Heffner), University of Rochester | Social Engage Coaching (S-ENG): is a behavioral intervention that involves one-on-one coaching with a care manager to increase social engagement and reduce loneliness | Caregivers for individuals living with AD/ADRD | 2024 |
| Writing to Heal: Developing an Internet-Based Cognitive-Behavioral Writing Intervention for Alzheimer’s Disease Spousal Caregivers | TBD | Angie Leroy, Rice University | An internet-based cognitive-behavioral writing intervention to improve caregiver health and well-being | AD/ADRD Spousal Caregivers | 2027 |
| Developing a Culturally Immersive Psychoeducational Intervention for Black Immigrant Older Adults with Dementia and Their Caregivers: The Black Immigrant Project | TBD | Manka Nkimbeng, University of Minnesota Twin Cities | The proposed intervention is the Active Caregiving Empowering Skills (ACES) intervention, which is a psychoeducational program that is based on Cognitive Behavioral Therapy (CBT) to decrease caregiver stress and decrease behavioral distress in persons living with dementia. | Black older adult immigrants (= 50 years) living with dementia and their informal caregivers | 2027 |
| I-CARE 2 RCT: Mobile Telehealth to Reduce Alzheimer's-related Symptoms for Caregivers and Patients | TBD | Richard Holden, Indiana University | Brain CareNotes app, a mobile telehealth app used by informal caregivers for behavioral and psychological symptoms of dementia (BPSD) management. | ADRD patients and informal caregivers of people living with ADRD, and the care recipients | 2027 |
| Using Mobile Technology to Reduce Stress in Caregivers of Persons with Dementia. A Scalable Solution to A Growing Problem | TBD | Ana-Maria Vranceanu, Massachusetts General Hospital | "CALM," a smartphone-based meditation app that teaches users the basics of mindfulness and how to integrate it into daily life to promote sustained practice and provides 10-12-minute guided meditations with embedded behavioral principles [e.g., reminders] to facilitate adherence. | Older adults 60 and up with chronic pain (CP) comorbid with early cognitive decline (ECD) | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Decisions about Cancer Screening in Alzheimer's Disease | Decisions About Cancer Screening in Alzheimer's Disease (DECAD) | Nicole R. Fowler, Indiana University-Purdue University at Indianapolis | A mammography decision aid that will help caregivers of patients with Alzheimer's make decisions about stopping or continuing breast cancer screening | Dyads consisting of an older woman with AD (Ages 75+) and a family caregiver (Ages undefined) | 2023 |
| A Video Intervention to Improve Decision Making in Early-onset Dementia Caregivers | Care Planning for a Loved One With Dementia: Knowledge, Preparing for Decisions, and Emotions | Bradford C. Dickerson, Massachusetts General Hospital | Video-based decision aids (user manuals) to improve decision making skills for caregivers of persons with early-onset dementia | Caregivers of those with young-onset patients with ADRD (Patient ages ≤65; caregiver ages undefined) | 2023 |
| A Communication-based Intervention for Early Stage Dementia Patient-caregiver Dyads to Increase Engagement in Advance Care Planning and Reduce Caregiver Burden | ADRD Patient-Caregiver Intervention for Advance Care Planning | Sara Czaja, Weill Medical College of Cornell University | Communication-based intervention to improve preparedness for advance care planning (ACP) | ADRD patient and caregivers | 2023 |
| Safety in Dementia: An Online Caregiver Intervention. | "Safety in Dementia": An Online Caregiver Intervention | Marian Elizabeth Betz, University of Colorado Denver | RCT of the “Safety in Dementia” (SiD) online tool to address firearm access, thereby reducing injury risk, among informal caregivers of community-dwelling adults with dementia | Informal caregivers of community-dwelling adults with dementia | 2024 |
| Integration of Health Information Technology and Promotion of Personhood in Family-Centered Dementia Care | Integration of Health Information Technology and Promotion of Personhood in Family-Centered Dementia Care | Ellen Leslie Brown, Florida International University | Assistive alternative communication device for PLWD to communicate care preferences to caregiver and provider | Dyads of caregivers and persons living with dementia | 2025 |
| Designing a Culturally Tailored Formal Care Decision-Making Intervention for African American Dementia Dyads and Families | DECIDE: Dyads and Families | Kalisha Bonds Johnson, Emory University | Tailored strategies to support formal care decision-making processes | African-American parent-adult daughter dyad | 2026 |
| Adapting Supported Decision Making to Promote Well-being and Improve Health Outcomes for Persons Living with Alzheimer's Disease and Alzheimer's Disease Related Dementias | TBD | Emily Largent, University of Pennsylvania | A toolkit to improve decision-making | Individuals living with AD/ADRD, their care partners, and providers | 2027 |
| Enhancing Triadic Communication About Cognition for Older Adults with Alzheimer's Disease or Related Dementias Facing a Cancer Management Decision | TBD | Allison Magnuson, University of Rochester | COACH-Cog, an adapted tool to facilitate conversations about aging-related conditions, such as cognition, with older patients and their care partners | Dyads/people living with dementia and their care partners | 2027 |
| The Role of Visit Audio Recordings in Triadic Dementia Care | TBD | Paul Barr, Dartmouth College | HealthPAL, a visiting recording platform to improve tridiatic interpersonal communications | Individuals with AD/ADRD, care partners, and providers | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Nursing Home Pragmatic Clinical Trial of APPROACHES (Aligning Patient Preferences: a Role Offering Alzheimer's patient, Caregivers, and Healthcare providers Education and Support) | Aligning Patient Preferences: a Role Offering Alzheimer's Patients, Caregivers, and Healthcare Providers Education and Support | Susan E. Hickman, Indiana University School of Nursing | Advance Care Planning (ACP) Specialist Program (Aligning Patient Preferences: a Role Offering Alzheimer's patients, Caregivers, and Healthcare providers Education and Support (APPROACHES)) to improve care and reduce unwanted, burdensome hospitalizations through improved ACP procedures, standardized staff education on ACP, and systematic ACP facilitation delivered by existing NH staff | ADRD patients and their family caregivers, and nursing home providers | 2023 |
| Resident-to-Resident Elder Mistreatment Intervention for Dementia Care in Assisted Living | Resident-to-Resident Elder Mistreatment Intervention for Dementia Care in Assisted Living | Jeanne A. Teresi (Contact); Mark Steven Lachs; Karl A. Pillemer, Hebrew Home for the Aged at Riverdale | Resident-to-resident elder mistreatment (R-REM) training for front-line long-term care staff to aid in recognition, management and reporting of R-REM | Front-line long-term care staff | 2023 |
| Feasibility of the VOICES Elder Mistreatment Digital-Screening Tool for Older Adults with Cognitive Impairment | Feasibility of VOICES Elder Abuse Intervention in Primary Care Setting (VOICES-PC Feasibility) (VOICES-PC) | Fuad Abujarad, Yale University | VOICES elder mistreatment digital screening tool for older adults with cognitive Impairment | Older adults with cognitive Impairment | 2023 |
| Meeting the Challenges of COVID-19 by Expanding the Reach of Palliative Care: Proactive Advance Care Planning with Videos for the Elderly and all Patients with Dementia | Palliative Care Educator (VIDEO-PCE) | Michael Paasche Orlow, Boston Medical Center | COVID-19 advance care planning (ACP) Educator-led, video-assisted palliative care intervention to improve patient-clinician communication, increase ACP documentation, and lead to more patient-centered care at the end of life | Hospitalized patients and any patient with ADRD, as well as proxy decision-makers (Ages 65+) | 2023 |
| Optimal Medication Management in Alzheimer's Disease and Dementia | Optimal Medication Management in Alzheimer's Disease and Dementia (Optimize) | Elizabeth Bayliss, Kaiser Foundation Research Institute | Pragmatic deprescribing intervention to improve medication management and improve overall health | Older adults with AD/ADRD or Mild Cognitive Impairment (MCI) | 2023 |
| Enhanced Quality in Primary Care for Elders with Diabetes and Dementia (EQUIPED-ADRD) | Enhanced Quality in Primary Care for Elders with Diabetes and Dementia (EQUIPED-ADRD) | Joshua Chodosh, New York University School of Medicine | Care quality improvement intervention | Individuals with AD and AD/ADRD | 2023 |
| METRIcAL - Music & MEmory: A Pragmatic TRIal for Nursing Home Residents with ALzheimer's Disease | Music & MEmory: A Pragmatic TRial for Nursing Home Residents With ALzheimer's Disease (METRIcAL)_part2 (METRIcAL) | Vincent Mor, Brown University | MUSIC & MEMORY (M&M) Music Program, a personalized music program in which caregivers (nursing home staff, family, or others) provide people with dementia with music playlists tailored to their personal history of music preferences | Nursing home residents with moderate to severe dementia | 2023 |
| The Hospice Advanced dementia Symptom Management and Quality of Life Trial (HAS-QOL) | The Hospice Advanced Dementia Symptom Management and Quality of Life Trial (HAS-QOL) | Abraham Aizer Brody, New York University | Dementia Symptom Management at Home Program Hospice Edition (Aliviado Dementia Care-Hospice Edition), a multi-modal quality assurance performance improvement (QAPI) program for improving the quality of care provided to PWD and support to their informal caregivers through hospice | Hospice agencies | 2023 |
| Development of a Reminiscence Therapy Online Platform with Machine Learning to Increase Engagement with People Living with Dementia and Their Care Partners | LifeBio Memory Digital Reminiscence Platform | Lisbeth Sanders, Lifebio Inc | LifeBio Memory, an online platform that stores stories, videos, and photos and uses information to make personalized reminiscence therapy exercises | Adult staff (Ages 18+) in assisted living facility with dementia care residents in assisted living care setting (Ages 55+) | 2023 |
| Optimizing Mealtime (OPTIMAL): Development and Pilot Testing of a Person-Centered Mealtime Care Intervention for Nursing Home Residents with Alzheimer's Disease and Related Dementias (ADRD) | OPTIMAL in NH Residents With Dementia | Wen Liu, University of Iowa | Person-centered mealtime care intervention for nursing home residents with ADRD | Nursing Home residents living with ADRD and interventionalists (Ages 55+) | 2024 |
| Using the Electronic Health Record to Identify and Promote Goals-of-Care Communication for Older Patients with Serious Illness | Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1) (PICSI-H) | J Randall Curtis, University of Washington | EHR-based Clinician Jumpstart intervention to promote goals-of-care communication for older patients with serious illness. | Older Adults (Ages 80+, or 65+ with 1+ chronic condition) | 2024 |
| Using the Electronic Health Record to Identify and Promote Goals-of-Care Communication for Older Patients with Serious Illness | Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2) (PICSI-H) | J Randall Curtis, University of Washington | EHR-based Clinician Jumpstart intervention to promote goals-of-care communication for older patients with serious illness. | Older Adults (Ages 80+, or 65+ with 1+ chronic condition) | 2024 |
| Testing the Efficacy of FFC-AC-EIT in Patients with Alzheimer's Disease and Related Dementias | Implementation of Function Focused Care in Acute Care | Barbara Resnick, University of Maryland Baltimore | Function Focused Care for Acute Care (FFC-AC-EIT), a care interaction intervention to increase physical activity and prevent functional decline during hospitalization | Older adults with ADRD admitted to the hospital (Ages 55+) | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Can Value Champions Reduce Inappropriate Prescribing for People with Dementia? (Demonstration Project) | Can Value Champions Reduce Inappropriate Prescribing for People With Dementia? | Michael Parchman, Kaiser Permanente of Washington Health Research Institute | Intervention led by clinical value champions embedded within primary care settings to decrease the use of potentially inappropriate medications in patients living with dementia | Persons living with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Cognitive Stimulation Therapy for Mild to Moderate Dementia (Pilot) | TBD | Michael Lepore, LiveWell Alliance | Cognitive Stimulation Therapy (CST), an online group intervention to actively engage and stimulate cognitive processes of persons living with dementia to reduce depressive symptoms | Persons living with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Collaborative Care Coordination Program for Alzheimer’s Disease and Related Dementias (Co-CARE-AD) (Demonstration Project) | Collaborative Care Coordination Program for Alzheimer's Disease and Related Dementias (Co-CARE-AD) | Vincent Mor, Richard Platt, Xiaojuan Li, Brown University, Harvard Pilgrim Health Care Institute | Dementia Care Consultation (DCC) program, a collaborative care coordination program delivered by a care consultant to reduce patient healthcare utilization and improve caregiver knowledge and well-being | Dyads of persons living with dementia and their caregiver | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Deprescribing of Diabetes Treatment Regimens in Long Term Care Residents with ADRD (Pilot) | Deprescribing of Diabetes Regimens in Long Term Care Residents With Alzheimer's | Medha Munshi, Harvard Medical School | An educational intervention directed at Long Term Care Facility (LTCF) staff to deprescribe and reduce the number of high risk medications (HRMs) in long term care facility (LTCF) residents with diabetes and ADRD | Long-term care facility (LTCF) providers and LTCF residents with diabetes and ADRD | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Implementation of a Telehealth Palliative Care Model for Persons with Dementia (Pilot) | Implementation of a Telehealth Palliative Care Model for Persons With Dementia (IMPACT) | Joan Carpenter, University of Maryland School of Nursing | Telehealth intervention called Palliative Care Consultation in Post-Acute Care (PCC-PAC) to meet the needs of PLWD newly admitted to nursing homes | Persons living with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Patient Priorities Care for Hispanics with Dementia (Pilot) | Patient Priorities Care for Hispanics With Dementia (PPC-HD) | Aanand Naik, Baylor College of Medicine | Patient Priorities Care (PCC), an EHR-based intervention to improve care decision strategies and align with patient priorities, for older adults with multiple chronic conditions | Hispanic people living with dementia and chronic conditions | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Pilot Pragmatic Clinical Trial to Embed Tele-Savvy into Health Care Systems (Pilot) | Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems | Richard Fortinsky, University of Connecticut Health Center | Tele-Savvy, an online program to improve caregiver mastery | Family members/informal caregivers of people living with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Testing Critical Components for a Trial of Advance Care Planning in Primary Care for Dementia (Pilot) | Advance Care Planning (ACP) in Primary Care for Dementia (ADVANCE-PC) | Vincent Mor (Pilot PI: Totten, Annette), Brown University | ADVANCE-PC is Aligning Dementia & adVANce Care planning Education in Primary Care settings and ECHO is remote technology used to deliver the advanced care planning education | Clinicians/staff, PLWD | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Virtual Training for Latino Caregivers to Manage Symptoms of Dementia (Pilot) | Virtual Training for Latino Caregivers to Manage Symptoms of Dementia | Vincent Mor (Pilot PI: Ramirez, Magaly), Brown University | STAR-VTF is a program that teaches caregivers skills to reduce behavioral and psychological symptoms of dementia | Caregivers of PLWD | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Implementation of MIND at Home Program in Primary Care for Patients Living with Dementia (Pilot) | Implementation of MIND at Home Into Primary Care for People Living With Dementia | Vincent Mor (Pilot PI: Ciemins, Elizabeth), Brown University | MIND at Home is a dementia care coordination model that includes coordination between persons living with dementia, their care partner, a memory care coordinator and their provider | Dyads of caregivers and individuals with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Mindfulness-Based Dementia Care Partner Program to Reduce Depressive Symptoms (Pilot) | Mindfulness-based Dementia Care Partner Program to Reduce Depressive Symptoms | Vincent Mor (Pilot PI: Hanson, Leah R.), Brown University | The Mindfulness-Based Dementia Care (MBDC) is a program for care partners of persons living with dementia to incorporate mindfulness practices into day-to-day life to help cope with the challenges and stresses of dementia care | Care partners of persons living with dementia | 2024 |
| Improving Post-Diagnosis Dementia Care in Primary Care | TBD | Halima Amjad, Johns Hopkins University | Pragmatic intervention to facilitate high quality, comprehensive post-diagnosis care and improve quality of care and patient outcomes | Persons living with dementia, in traditional primary care settings | 2025 |
| Impact of a Novel Socially Assistive Robotic Architecture on Engaging Older Adults with Mild Cognitive Impairment, Alzheimer's Disease, and Related Dementia in Long Term Care Settings | Use of Socially Assistive Robots for Long Term Care Older Adults With Cognitive Impairment and Apathy | Nilanjan Sarkar, Vanderbilt University | Socially assistive robot to interact with long-term care setting residents with either dementia or mild cognitive impairment | Person living with dementia or mild cognitive impairment in assisted living or nursing home facilities (Ages 70+) | 2025 |
| Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) | Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) | Miguel Vazquez, UT Southwestern Medical Center | Pragmatic trial of intensive blood pressure management | Older adults (Ages 70+) | 2025 |
| Screening for Cognitive Impairment Following Critical Illness: Designing and Testing an Implementation Program to Support High Risk Older Adults | TBD | Jessica Palakshappa, Wake Forest University Health Sciences | Cognitive screening program for incident MCI or ADRD | Older adults with critical illness | 2026 |
| Changing Talk Online Training (CHATO): A National Trial to Reduce Behavioral Symptoms in Long Term Care Residents with Alzheimer's Disease and Other Dementias (Supplement) | Changing Talk Online Training (CHATO) National Trial | Kristine N. Williams, University of Kansas Medical Center | Elderspeak and communication training to reduce behavioral symptoms in long term care settings | Nursing home staff | 2026 |
| Development and pilot testing of a behavioral economics mobile health digital tool to improve adherence to non-pharmacologic strategies for behavioral and psychological symptoms of dementia | TBD | Hayley Belli, New York University School of Medicine | Behavioral economics mobile health (BE-mHealth) digital tool that will incorporate BE nudges into 2-3 evidence-based non-pharmacologic strategies for managing behavioral and psychological symptoms of dementia (BPSD). | Persons living with dementia (PLWD) and their primary care partners | 2027 |
| Enhancing Shared Decision-making to Prompt and Guide Individualized Care for People with Alzheimer's Disease and Diabetes | Enhancing Shared Decision-making to Guide Care for People With Dementia and Diabetes | April Savoy, Indiana University–Purdue University at Indianapolis | Shared Decision-Making Tool: new internet based interactive information visualizations designed to facilitate shared decision-making and | Individuals with Dementia and Diabetes and their caregivers | 2027 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: A Patient-facing Tool to Reduce Opioid-Psychotropic Polypharmacy in PLWD from investigator (Pilot) | A Patient-facing Tool To Reduce Opioid-Psychotropic Polypharmacy in People Living With Dementia (PLWD) | Vincent Mor (Pilot PI: Donovan T. Maust), Brown University | The intervention, EMPOWER, is an educational brochure focused on the risks associated with psychotropic and opioid polypharmacy that will be sent to participants (PLWD-CP dyads) via mail to "nudge”/encourage them to have discussions with the prescribing clinicians about the inappropriateness of the regimen to lower polypharmacy exposure for PLWD. | Persons living with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Deprescribing to reduce injurious falls among older adults with dementia from investigator (Pilot) | TBD | Vincent Mor (Pilot PI: Elizabeth A. Phelan), Brown University | STOP-FALLS-D is an educational intervention to inform and nudge patients, their care partner(s), and their PCPs to work together to reduce use of CNS-active medications and prevent adverse outcomes (falls and injuries) associated with their use. | Persons living with dementia, their care partners, and their primary care providers (PCPs) | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Embedded Clinical Trial of Patient Priorities Care Among Persons Living with MCI and Dementia (Pilot) | TBD | Vincent Mor (Pilot PI: Jennifer L. Carnahan), Brown University | Patient Priorities Care (PPC), is an evidence-based program to identify the goals and values of patients and care partners by 1) the clinician contacting the patient and care partner for a discussion of their priorities and 2) integration of priorities into the patient’s care plan. Clinicians will have up to 4 weeks to call eligible patients with an upcoming appointment and identify patient's medical care priorities. | Patients with MCI or dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Improving How People Living with Dementia Are Selected for Care Coordination (Demo) | TBD | Vincent Mor (Study PI: Lisa M. Kern), Brown University | Assigning care coordinators to people living with dementia (PLWD) - intervention participants will each receive an initial call from a care coordinator to provide care coordination services if they are identified by the ACO as eligible for them | Persons living with dementia | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Integration of Machine Learning and Clinical Decision Support to Prevent Postoperative Delirium in Patients with Cognitive Impairment (Demo) | TBD | Vincent Mor (Study PIs: Ira S. Hofer & Susana Vacas), Brown University | CDS prompts (intervention) - the anesthesia provider will be notified that the patient is at increased risk of postoperative delirium (POD) and will have a series of CDS prompts that promote best clinical practices for the prevention of postoperative delirium (POD). | Attending physicians and their adult patients with a history of cognitive impairment (CI) undergoing surgery | 2024 |
| NIA AD/ADRD Health Care Systems Research Collaboratory: Reducing Inappropriate Medication Use for BPSD and Improving Health Outcomes in PLWD from investigator (Pilot) | TBD | Vincent Mor (Pilot PI: Helen C. Kales), Brown University | Describe, Investigate, Create, Evaluate (DICE) is an intervention to manage behavioral and psychological symptoms of dementia (BPSD). DICE includes a 6-hour online modular training, manual, and additional training as needed coaching from a DICE trainer that will be completed by clinic social workers (called Onsite DICE Coordinators or ODCs). | Persons living with dementia and their care partner dyads | 2024 |
| The Care Ecosystem Response to COVID-19: Accelerating Research on Dementia Care that Meets the Needs of Caregivers and Persons with Dementia during COVID-19 | TBD | Katherine Possin, University of California, San Francisco | The Care Ecosystem, a team-based care model that can lead to quality improvements for family caregivers and formal care providers | Family caregivers and formal care providers | 2025 |
| Developing and Testing a Population Health Approach to Deprescribing and Optimizing Medications in Older Adults | TBD | Michelle Keller, Cedars-Sinai Medical Center | Pharmacist-led deprescribing intervention | Patients (Ages 65+) with with ≥ 5 medications prescribed and a face-to-face primary care encounter in the last year | |
| Developing, Implementing, and Evaluating a Caregiver and Elder Abuse Screening, Risk Assessment and Treatment to Improve Outcomes for Older and Vulnerable Adults with MCI/ADRD | TBD | Monique Pappadis, the University of Texas Medical Branch Galveston | Caregiver and Patient Abuse Assessment for Older and Vulnerable populations (CAPA-OV), a screening and intervention tool for use in primary care settings to screen for elder abuse among older and vulnerable adults with MCI/ADRD, as well as the inclusion of a risk assessment for accompanying caregivers | Caregivers of PLWD, PLWD 65+, and health care providers | 2024 |
| Primary Care Screening and Intervention for Elder Neglect in Patients with Dementia: An Evidence-Based Approach | TBD | Anthony Rosen, Joan & Sanford I Weill Medical College of Cornell University |
The interventions of this study include a novel primary care screening tool and a caregiver point-of-care technology-driven intervention Interventions by arm:
|
Older adults aged = 60 and their care giver dyads | 2024 |
| Risk Screening & Primary Prevention of Elder Abuse in People Living with Dementia | TBD | Laura Mosqueda, University of Southern California (USC) |
R61phase - development and feasibility test of a Risk Assessment Screen (RAS), an Outcome Tool, and a brief, multi-component intervention. Intervention of an R33 phase includes three groups for CPG. Control Group: No action with the CPG related to this study.
|
Self Identified primary Care Partner/caregiver role of PLWD residing in Southern California | 2024 |
| The Effect of Smart Ambient Bright Light for Nursing Home Residents with Alzheimer's Disease and Related Dementias | TBD | Ying-Ling Jao, Pennsylvania State University, The |
The intervention is a smart ambient bright light (SABL) intervention which includes tunable LED lights, photosensors, and controllers. Participating nursing homes will be randomly assigned to different sequences for intervention (SABL) and control (usual light). All participants will receive the SABL during the intervention period (4 weeks), and they will receive usual daylight for the rest of the study periods (9 weeks). |
NH residents aged 55, with AD/ADRD | |
| Making Connections Thru Music: A Group Music Therapy-Based Intervention for Persons with Dementia | TBD | Gregg Gorzelle, Hearthstone Alzheimer Care | Making Connections Thru Music (MCTM) sessions, an evidence-based music and discussion intervention to improve engagement, enhance quality of life, and reduce behavioral expressions in persons with dementia (PWD) | Caregiving Volunteers and Resident living Staff for PLWD | 2023 |
| NIA AD/ADRD Health Care Systems Research Collaboratory; Partnering with Providers to Understand the Individualized Positive Psychosocial Intervention Outcomes of Interest for PLWD | TBD | Katherine Abbott, Miami University | Individualized Positive Psychosocial Intervention (IPPI), which engages PLWD in brief one-to-one preference-based activities 2 times a week. To provide IPPI, care partners complete an online course on emotion-focused communication. | Persons Living With Dementia residing in nursing homes | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Older Adults Living with Alzheimer's Disease and their Caregivers: Testing an Evidence-Based Intervention for Underserved Populations | Innovations in Dementia Empowerment and Action (IDEA) | Karen Ilene Fredriksen-Goldsen ; Linda Teri, University of Washington | Standard and Enhanced versions of Reducing Disabilities in Alzheimer's Disease (RDAD) designed to increase exercise engagement and promote effective problem solving among caregivers (CGs) and their care recipients (CRs) with ADRD | Dyads of care recipients with AD/ADRD and their caregivers (Ages 50+) | 2023 |
| A Technology-Based Novel Functional Skills Assessment and Training Program for Adults with and without Cognitive Impairments. Develop the next generation software solution | A Novel Computer-Based Functional Skills Assessment and Training Program | Peter Kallestrup, I-Function, INC. | Technology-based integrated functional-skills assessment and tailored training program (CFSAT) to enhance functional skills, help prevent or treat functional declines, and foster the functional independence and well being of older adults | People with Mild Cognitive Impairment (Ages ≥ 60) | 2023 |
| K23 Study 3: A Feasibility Study of CAPABLE Transitions for Older Adults with ADRD | CAPABLE Transitions: A Home Health-Based Intervention for the Hospital or Post-Acute Care Facility-to-Home Transition | Adam C. Simning, University of Rochester | CAPABLE Transitions, an occupational therapy-led multidisciplinary in-home intervention to help older adults transition to their homes following hospital or post-acute care facility discharge. CAPABLE Transitions is based on the Community Aging in Place, Advancing Better Living for Elders (CAPABLE) intervention. | Adults recently discharged from a hospital or post-acute care facility and admitted to a Medicare-certified home health agency (CHHA) with and without dementia (Ages 65+) | 2023 |
| Meaningful Activity Intervention for Individuals With Early-Stage Dementia: Involving the End User in Intervention Design | User-Led Meaningful Activity and Early-Stage Dementia | Natalie Regier, Johns Hopkins University | Service user-led meaningful activity intervention to treat mild dementia | People that are mild or early stages of dementia (Ages ≥60) | 2023 |
| A Randomized Controlled Trial of Visual Cues, Signage, and Spaced-Retrieval Education within Long Term Care Communities to Assist with Wayfinding | Effects of Visual Cues and Education for People Who Live Within Long Term Care Communities to Assist in Wayfinding | Rebecca Davis, Grand Valley State University | Assistive cues (salient cues) plus spaced retrieval education to help older adults who live in senior communities remember the presence and function of the environmental wayfinding cues. | Residents from 12 senior assisted-living facilities (Ages 62+) | 2023 |
| MEMORI Corps: A novel activity-based companion care program to benefit community-living persons with dementia, their families, and senior volunteers | MEMORI Corps: Activity-based Companion Care for Dementia (MEMORI Corps) | Quincy Samus, Johns Hopkins University | Activity-based home healthcare to treat people with dementia | People with dementia (Ages 55+) and caregivers (Ages 18+) | 2024 |
| A Problem Solving Intervention for Post-ICU Cognitive Impairment in Older Adults | A Problem Solving Intervention for Post-ICU Cognitive Impairment in Older Adults (PIC-UPS) | Judith Tate, Ohio State University | Post Intensive Care Unit Problem Solving (PIC-UPS), an in-home strategy training intervention designed to overcome cognitive problems | Older adult ICU survivors who have cognitive impairment | 2023 |
| Improving Everyday Task Performance through Repeated Practice in Virtual Reality | Improving Everyday Task Performance Through Repeated Practice in Virtual Reality. (VKI) | Tania Giovannetti, Temple University | Virtual reality training intervention for persons with Alzheimer's Disease to improve performance of everyday tasks | Older adults with mild to moderate Alzheimer's Disease (Ages 65+); Informants with knowledge of person with AD's level of function | 2023 |
| Using Rendever to Improve the Quality of Life of Older Adults with Cognitive Impairments in Senior Living Communities and their Family Members who Live at a Distance. | Technology and Family Thriving Study (Thrive) | Kyle Patrick Rand, Rendever, Inc. | Rendever virtual reality (VR) platform designed to improve quality of life of residents with AD/ADRD in senior living communities and their adult children who live at a distance | Dyads of residents with AD/ADRD in senior living communities and their adult children | 2023 |
| Care4AD: A Comprehensive Care Coordination and Management Platform for Alzheimer's Disease and Related Dementias | Care Coordination System for People With Dementia | Ashkan Vaziri; Bijan Najafi, Biosensics, Llc | Care4AD, a comprehensive care platform to improve care for AD patients | Adults with mild to moderate AD (Ages ≥ 56) | 2023 |
| Impact of Novel Rehabilitative Approaches FOR Dysphagia in Patients with Alzheimer's Disease and Related Dementias | Interventions for Patients With Alzheimer's Disease and Dysphagia | Nicole Rogus-Pulia, University of Wisconsin-Madison | Dysphagia rehabilitative interventions (lingual strengthening and saliva substitute use) to improve swallowing-related outcomes | Older adults (Ages 55-90) with diagnosis of dementia, cognitive impairment, or memory loss | 2024 |
| Decision Making Among Older Adults: the AUTO study | Advancing Understanding of Transportation Options (AUTO) | Marian Elizabeth Betz, University of Colorado Denver | Web-based driving decision aid (DDA), an online tool that guides an individual to optimize decision-making | Older drivers without severe cognitive impairment (Ages 70+) and family members | 2024 |
| A Dyadic Approach for a Remote Physical Activity Intervention in Adults with Alzheimer’s Disease and their Caregivers | A Dyadic Approach for a Remote Physical Activity Intervention in Adults With AD and Their Caregivers | Lauren Taylor Ptomey, University of Kansas, Lawrence | Moderate physical activity intervention for adults with Alzheimer’s Disease and their Caregivers to improve mobility | Adults with mild moderate AD and their caregivers (Ages 55+) | 2024 |
| Developing a PRogram to Educate and Sensitize Caregivers to Reduce the Inappropriate Prescription Burden in Elderly with Alzheimer's Disease Study (D-PRESCRIBE-AD) | A Program to Reduce Inappropriate Medications Among Older Adults With Alzheimer's Disease (D-PRESCRIBE-AD) | Jerry Gurwitz, University of Massachusetts Medical School Worcester | Patient/caregiver-centered, multifaceted educational intervention on inappropriate prescribing | Older adults with AD/ADRD | 2025 |
| Using Design Thinking Approaches to Tailor a Dyadic Behavioral Sleep Intervention for Persons Living with Dementia and Their Caregivers | TBD | Glenna Shemida Brewster, Emory University | T-Dyadic Sleep, a cognitive behavioral therapy for insomnia (CBTI) intervention to examine acceptability and feasibility as well as preliminary efficacy on objective and subjective sleep outcomes | Persons living with mild cognitive impairment or early-stage dementia (PLwCI) and their caregivers | 2026 |
| Music-based Intervention for Insomnia in Persons Living with Dementia and their Caregivers | TBD | Darina V. Petrovsky, RBHS-School of Nursing | Tailored music-based mobile application aimed at improving insomnia symptoms in PLWD | Underrepresented community-dwelling PLWD and their caregivers | 2026 |
| A Dyadic Approach to Improve Sleep and Well-Being Among Persons with Alzheimer's Disease and Their Caregivers | A Dyadic Sleep Health Approach for Persons With Alzheimer's Disease and Caregivers | Yeonsu Song, University of California Los Angeles | Dyadic sleep intervention to improve subjective and objective sleep quality | Dyads/People living with dementia and their care partners | 2027 |
| Addressing Hearing Loss as a Common Unmet Contributor to Neuropsychiatric Symptoms | TBD | Esther Oh, Johns Hopkins University | A hearing care intervention to treating neuropsychiatric symptoms | Individuals living with AD/ADRD | 2027 |
| Improving Person-Environment Fit of Community-Residing Older Adults with Dementia Through Assessment and Individualized Intervention | TBD | Elizabeth Rhodus, University of Kentucky | Harmony at HOME will provide caregiver training for assessment of the environment as an antecedent to behaviors of the person with ADRD & implementation of environmental cueing as a tool to create a supportive environment for functional behaviors and activity participation. | Persons Living With Dementia and their care partners | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Improving Outcomes for Family Caregivers and Older Adults with Complex Conditions: The Adult Day Service Plus Program | Improving Outcome for Family Caregivers of Older Adults With Complex Conditions: The Adult Day Plus (ADS Plus) Program (ADS Plus) | Laura N. Gitlin, Johns Hopkins University | Adult day service (ADS) Plus, including care management, referral/linkage, education about dementia, situational counseling, emotional support, stress reduction techniques, and skills to manage behavioral symptoms | Caregivers initially enrolling their relative in one of the 30 ADS sites (Ages 21+) | 2023 |
| Home-delivered Meals for Persons with Dementia: Which Model Delays Nursing Home Placement? | Home-delivered Meals for Persons With Dementia: Which Model Delays Nursing Home Placement? | Kali St Marie Thomas, Brown University | Home food delivery comparison (frozen food bulk drop off by postal carrier vs daily drop off by meal provider) to delay nursing home placement | Persons living with dementia, mild cognitive impairment, or memory loss that are on waitlist for home-delivered meals (Ages 66+) | 2023 |
| The Care Ecosystem: Navigating Patients and Caregivers Through Stages of Dementia Care | Care Ecosystem: Navigating Patients and Families Through Stages of Care, Extension Trial | Katherine Laurel Possin, UCSF | Navigated Care, a comprehensive longitudinal continuing care program that supports model care for persons with dementia and their family caregivers | Persons with dementia (Ages 45+) and caregiver dyads | 2023 |
| A novel platform to facilitate provider adoption of cognitive care planning | TBD | Yael Katz, Braincheck, Inc. |
The proposed intervention is "BC-Care (BrainCheck)," a cognitive care planning tool that integrates patient, provider, and caregiver input to generate personalized ADRD recommendations and follow-up care to be implemented during an ADRD's patient's medical visit. Participants of the study will be assigned to BC-Care or care as usual (CAU). |
Patients 65 or older with an existing diagnosis of mild to moderate dementia, their caregiver and health care provider | 2024 |
| Training the Long-Term Services and Supports Dementia Care Workforce in Provision of Care to Sexual and Gender Minority Residents | MN Inclusive LTSS for LGBTQ Seniors (MILLS) | B R Simon Rosser, University of Minnesota Twin Cities |
|
Adult (18+) LTSS staff, SGM clients and their caregivers. | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Indiana Palliative Excellence in Alzheimer Care Efforts-RCT | Indiana Palliative Excellence in Alzheimer's Care Efforts (IN-PEACE) | Greg Sachs, Indiana University-Purdue University at Indianapolis | Palliative care to improve the care of community dwelling patients with dementia and their family caregivers through an innovative model of supportive care that combines an existing, evidence-based intervention for dementia care with an innovative intervention | People with moderate to severe stage dementia (Ages ≥65) | 2023 |
| Transforming Residential Palliative Care for Persons with Dementia Through Behavioral Economics and Data Science: Promoting Advance Care Planning Using a Prognosis and Outcome Information Sheet Among Persons with Advanced Dementia in Long-term Services and Support Facilities. (Pilot) | Pilot Study of an Advance Care Planning Intervention Among Persons With Dementia | Scott Halpern, University of Pennsylvania | intervention to test an education information sheet for the promotion of advanced care planning (ACP) among family members of persons with advanced dementia in long-term services and support facilities | Clinicians and family members of persons with advanced dementia in LTSS facilities | 2024 |
| Transforming Residential Palliative Care for Persons with Dementia Through Behavioral Economics and Data Science: Systematic Identification of NH Residents with 6-month Mortality Risk for Hospice Informational Referral (Pilot) | TBD | Scott Halpern, University of Pennsylvania | a machine-learning mortality prediction model to identify nursing residents with late-stage AD/ADRD appropriate for hospice informational referrals to reduce goal-discordant hospital transfers | Nursing home residents with late-stage AD/ADRD | 2024 |
| Transforming Residential Palliative Care for Persons with Dementia Through Behavioral Economics and Data Science: Understanding And Improving Uptake Of Tele-Palliative Care For Persons With Dementia In Long-Term Care Facilities During COVID-19 (Pilot) | TBD | Scott Halpern, University of Pennsylvania | intervention to identify barriers and facilitators of tele-palliative care (T-PC) for Persons With Dementia (PWD) in long-term services and support (LTSS) facilities | Stakeholders and family members of PWD | 2024 |
| Enhanced Dementia Instruction and Tool in Home Hospice Care (EDITH-HC) | TBD | Elizabeth Luth, Weill Medical Coll of Cornell University | Training program and tool to improve clinicians' knowledge of dementia-related challenges in home hospice care, reduce family caregiver burden, and reduce hospice disenrollment | Nurses or social workers who provide home hospice to PLWD; family caregivers | 2024 |
| PCplanner: Operationalizing Needs-focused Palliative Care for Older Adults in Intensive | A Needs-focused Palliative Care Intervention for Older Adults in ICUs (PCplanner) | Christopher Ethan Cox, Duke University | PCplanner-augmented care and PCplanner mobile, to will allow patients/family members to report their needs in a platform viewable by ICU physicians | Older adults (Ages 65+) managed in an ICU and their family members (Ages 18+), and physicians and nurses (Ages 18+) from academic and community settings. | 2024 |
| Palliative Care Needs and Outcomes for Dementia Patients | Supportive Care for Cognitively Impaired Patients and Families | Vyjeyanthi S. Periyakoil, Stanford University | Nurse-led early palliative care intervention (EPC) involving conducting systematic assessment and providing coaching to patients to improve care and well-being | N=200 community-dwelling Stanford ADRC participants Ages 60-100 | 2024 |
| Palliative Care for Persons with Late-stage Alzheimer's and Related Dementias and their Caregivers: a Randomized Clinical Trial | Palliative Care for Persons With Late-stage Alzheimer's and Related Dementias and Their Caregivers (ADRD-PC) | Laura C. Hanson, University of North Carolina, Chapel Hill | Dementia-specific palliative care intervention involving caregiver education and transitional care | Dyads of hospitalized patients with late stage ADRD and their family caregivers | 2025 |
| UPLIFT-AD (Utilizing Palliative Leaders in Facilities to Transform care for Alzheimer's Disease) intervention | Utilizing Palliative Leaders In Facilities to Transform Care for Alzheimer's Disease (UPLIFT-AD) | Kathleen T. Unroe, Indiana University-Purdue University at Indianapolis | Palliative care intervention utilizing palliative care champions to consult and help surrogate decision makers | Surrogate decision makers for PLWD in nursing homes | 2025 |
| LEADing End-of-Life Dementia Care Conversations | TBD | Kara Dassel, University of Utah | Health management support for older adults with and without MCI. | Community- dwelling pairs consisting of persons in the preclinical or early stage of ADRD and their care partner | 2027 |
| Palliative Care at Home for Patients With Dementia | Palliative Care at Home for Patients With Dementia | Nathan Goldstein, Icahn School of Medicine at Mount Sinai | For the Intervention, dyads will be cared for by a pyramid of palliative care and dementia care trained providers who will continue to work with the patient/caregiver through face-to-face visits, video visits, and (at least) weekly phone calls for 12 months. The control group includes caregivers who will meet with different community health workers (CHW) from the intervention CHWs who will act as traditional health coaches for caregivers (not patients). This CHW will perform monthly visits with the caregiver only. This CHW will not work with the patient and will not undergo training in palliative care or dementia. | Older adults age >65 with advanced dementia, based on Global Deterioration Score (GDS) >6, who are impaired in at least one activity of daily living (ADL), and their family caregiver | 2027 |
| Developing a novel intervention to collect and utilize sexual orientation and gender identity (SOGI) information in hospice | TBD | Carey Candrian, University of Colorado Anschutz Medical Campus |
|
Hospice interdisciplinary team (IDT) staff, sexual and gender minority (SGM) former/current patients, and SGM older adults current/former caregivers for people living with ADRD. | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Adapting an Evidence-Based Program that Improves Oral Hygiene and Health for Assisted Living Residents with Dementia | Oral Hygiene in Assisted Living | Sheryl Zimmerman, University of North Carolina, Chapel Hill | RCT to test a program to provide daily mouth care to reduce bacteria in the mouth that lead to aspiration pneumonia for assisted living residents | Residents with dementia, care staff, and dental hygienists (Ages 18+) | 2023 |
| Nursing Home Prevention of Injury in Dementia (NH PRIDE) | Nursing Home Prevention of Injury in Dementia (NH PRIDE) | Sarah Berry, Hebrew Rehabilitation Center for Aged | Centralized Injury Liaison Service (ISL) to decrease injurious falls in nursing home residents | Nursing home residents at high risk for injurious falls, and nursing home staff at participating facilities | 2023 |
| SPEEKO for Elderspeak: A Self-Monitoring App to Improve Communication and Do: Reduce Behavioral Symptoms in Care for Persons with Alzheimer's Disease and Other Dementias | Speeko for Elderspeak | Kristine N Williams, University of Kansas Medical Center | CHAT Training Program to educate staff about elderspeak and communication strategies with nursing home residents | Dyads (Ages 18+) | 2023 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Commercializing In-Home Supportive Technology for Dementia Caregivers | In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Spanish Language Homes | Gene Wang, People Power Company | People Power Caregiver is a newly developed hardware and software system that is designed to create a safer and more supportive home environment for caregivers and persons with dementia and mild cognitive impairment. People Power Caregiver combines modern Internet-of-Things and artificial intelligence technologies. | Dyads of caregivers and individuals with dementia or MCI who live in a Spanish language home (Study 2). Caregivers must have an iPhone or Android phone. | 2023 |
| Commercializing In-Home Supportive Technology for Dementia Caregivers | In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Rural Homes | Gene Wang, People Power Company | People Power Caregiver is a newly developed hardware and software system that is designed to create a safer and more supportive home environment for caregivers and persons with dementia and mild cognitive impairment. People Power Caregiver combines modern Internet-of-Things and artificial intelligence technologies. | Dyads of caregivers and individuals with dementia or MCI who live in a rural home (Study 1). Caregivers must have an iPhone or Android phone. | 2023 |
| Commercializing In-Home Supportive Technology for Dementia Caregivers | In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Wearables | Gene Wang, People Power Company | People Power Caregiver is a newly developed hardware and software system that is designed to create a safer and more supportive home environment for caregivers and persons with dementia and mild cognitive impairment. People Power Caregiver combines modern Internet-of-Things and artificial intelligence technologies. | Dyads of caregivers and individuals with dementia or MCI in homes with Apple Watch. Caregivers must have an iPhone or Android phone. | 2023 |
| Robot-Assisted Cognitive Training for Socially Isolated Older Adults with Mild Cognitive Impairment | Robot-Assisted Cognitive Training for Socially Isolated Older Adults with Mild Cognitive Impairment | Jenay Beer, Applied Universal Dynamics Corporation | Socially-assistive robot to deliver cognitive training in the form of a music (piano) learning intervention | Older adults (Ages 65+) | 2023 |
| Social Assistive Robot Interface for People with Alzheimer's and Other Dementias to Aid in Care Management | SimpleC Wellness Platform With Social Robot Interaction (Long-term) | Daniel S. Hedin, Advanced Medical Electronics Corporation | Socially-Assistive Robot (SAR) to engage PWD in a detailed natural language conversation as psychosocial support | PWD and their caregivers who live (or work) in an Assisted Living Facility. | 2023 |
| Extending Independence And Quality Of Life For People With Alzheimer's Disease Or Dementia Through Telehealth Program Delivery | Moving Together: An Online Group Movement Program for People Living With Memory Loss and Caregivers | Cynthia Louise Benjamin, Together Senior Health, Inc. | Moving Together, a livestream virtual group program delivery to improve quality of life for persons with dementia | Dyads of persons with mild ADRD or MCI and their primary caregivers | 2023 |
| Development and Usability Evaluation of a Mobile Health Intervention to Support Healthful Dietary Choices in Older Persons with Dementia | Mobile Health Intervention to Support Healthful Diet | Oleg Zaslavsky, University of Washington | Mobile-based Health Intervention to improve adherence to the Mediterranean Diet | Adults, with mild to moderate frailty, and own or have access to a cellphone (Ages 65+) | 2023 |
| Feasibility of the SmartPrompt for Improving Everyday Function in Dementia | Feasibility of the SmartPrompt for Improving Everyday Function in Dementia (SmartPrompt) | Tania Giovannetti, Temple University | SmartPrompt, an electronic reminder aid for persons living with dementia to target specific cognitive difficulties and help with everyday tasks | Diverse sample of older adults with mild dementia and their caregivers (Ages 65-90) | 2023 |
| LEAD IT! An App to Enable Persons with Early Stage Dementia to Lead Group Activities for Their Peers | LEAD IT! An App to Enable Persons With Early Stage Dementia to Lead Group Activities for Their Peers | Michael John Skrajner, Hearthstone Alzheimer's Care LTD | LEAD IT!, an app-based intervention to encourage persons with early stage dementia to lead group activities with their peers in nursing home or assisted living facilities | Persons living with early stage dementia in nursing homes or assisted living facilities (Ages 65+) | 2023 |
| Enhancing Quality of Life for Older Adults With and Without MCI through Social Engagement Over Video Technology | Enhancing Quality of Life for Older Adults With and Without Mild Cognitive Impairment (MCI) Through Social Engagement Over Video Technology | Dillon Myers, Potluck LLC | OneClick 3.0, social engagement over video technology platform for those with and without MCI to evaluate its efficacy in affecting social engagement and quality of life | Participants with and without mild cognitive impairment (Ages 65-85) | 2023 |
| A Mobile Informatics Solution to Aid in Memory | A Mobile Informatics Solution to Aid in Memory | Gary D Havey, Advanced Medical Electronics Corporation | Smartwatch Reminder (SR) system, to automatically transmit pictures and relevant information, such as name or relationship, to a smartwatch worn by the person with memory concerns when family or friends visit | Dyads of persons with memory concerns (Ages 30-70) and their care partners (Ages 21+) | 2023 |
| Using Gamification, Predictive Analytics, Artificial Intelligence, and Alexa Voice to Optimize User Experience for Individuals Living with AD/ADRD and Their Caregivers | Efficacy of Gamification in Enhancing User Engagement | Matthew Golden, MapHabit, Inc. | MapHabitTM system, an assistive technology app that helps accomplish activities of daily living, maintain independence, and improves overall quality of life for users | Older adults with AD/ADRD | 2023 |
| ORCASTRAIT Oregon Roybal Center for Care Support Translational Research Advantaged by Integrating Technology: Optimizing Dementia Caregivers' Biological Clock through Lifestyle Change (Pilot) | Self-Care for Dementia Caregivers: User-Centered Design | Jeffrey Kaye (Pilot PI: Sarah T. Stahl), Oregon Health & Science University | iCARE is a multicomponent intervention that uses mobile technology and motivational health coaching to optimize behaviors that keep the body’s biological clock in sync: sleep, exercise, and social activities | Caregivers of persons living with dementia | 2024 |
| ORCASTRAIT Oregon Roybal Center for Care Support Translational Research Advantaged by Integrating Technology: Protecting Alzheimer Caregivers using Technology through StayingSharp (PROACTS) (Pilot) | Protecting Alzheimer's Caregivers Using Technology Through Staying Sharp (PROACTS) | Jeffrey Kaye, Oregon Health & Science University | Staying Sharp, an online multi-component health intervention to promote a healthier lifestyle and improved skills for coping with the stress involved in dementia caregiving | Caregivers of persons with AD/ADRD | 2024 |
| ORCASTRAIT Oregon Roybal Center for Care Support Translational Research Advantaged by Integrating Technology: READyR: Remote Assessment and Dynamic Response Intervention to Support Couples in Planning for Changing Dementia Care Needs (Pilot) | REmote Assessment and Dynamic Response Intervention II (READyR-II) | Jeffrey Kaye, Oregon Health & Science University | Intervention to test a dynamically tailored needs assessment for care planning for PWD and their care partner | Care partners and persons living with dementia | 2024 |
| ORCASTRAIT Oregon Roybal Center for Care Support Translational Research Advantaged by Integrating Technology: Tele-STELLA: Using Technology to Advance ADRD Family Education and Support (Pilot) | Assessing Acceptability, Cost, and Efficacy of STELLA-Support Via Technology (STELLA) | Jeffrey Kaye, Allison Lindauer, Oregon Health & Science University | STELLA (Support via Technology Living and Learning with Advancing Alzheimer's disease and related dementias), a multicomponent video-conference based intervention to reduce upsetting behaviors and care partner burden | Caregivers who live together with a person living with mid-to-late stage AD/ADRD | 2024 |
| Multi-Stakeholder Engagement for Interdisciplinary Telehealth in Lewy Body Dementia | Telehealth in Lewy Body Dementia | Bhavana Patel, University of Florida | Telemedicine model of Lewy Body Dementia interdisciplinary care | Individuals living with Lewy Body Dementia and their caregivers | 2026 |
| Improving Alzheimer's Disease and Related Dementias Care in Rural Areas | TBD | Patricia Prusaczyk, Washington University | A communication and care coordination tool for providers of patients with AD/ADRD. The exact health information technology (HIT) tool to be tested is unknown and will be identified during Aim 2 of this proposal. | Providers of care for AD/ADRD | 2026 |
| Motor Learning of Fall Resistant Skills from Laboratory-induced Falling Among People with Alzheimer's Disease | Perturbation Training Reduces Falls in People With AD | Feng Yang, Georgia State University | A motor learning intervention (perturbation training) to prevent falls | Older adults with mild AD | 2024 |
| ORCASTRAIT Oregon Roybal Center for Care Support Translational Research Advantaged by Integrating Technology (Pilot) | TBD | Jeffrey Kaye (Pilot PI: Raina Croff), Oregon Health & Science University | On a group tablet handled by the caregiver or caregiver support person, triads access the SHARP Android application preloaded with 72 GPS-linked routes, each route with three “Memory Markers” (historical localized images with two associated questions) designed to prompt conversational reminiscence about local Black history, culture, and life experiences while walking. | Triads of 1) primary caregiver, 2) caregiver support person and 3) African American person with early-stage dementia | 2024 |
| Reducing Loneliness of Older Adults in Long Term Care Facilities through Collaborative Augmented Reality | TBD | Nilanjan Sarkar, Vanderbilt University | HMD-AR, a collaborative head mounted display augmented reality to maximize social connection and engagement | Older adults residing in LTC facilities, family members of the older adults, and formal staff caregivers employed in the Department of Recreational Activities | 2024 |
| Effectiveness and adoption of a Smart home-based social assistive robot for care of individuals with Alzheimer's Disease | TBD | Sajay Arthanat, University of New Hampshire | Mobile Assistive Robot with Smart Sensing (MARSS) is a smart home-based social assistive robot with multi modal care protocols which combines best practices and existing research on home automation, human-robot interaction, and AD care giving. | Individuals with Alzheimer’s diseases (IADs) & caregiver dyads | 2027 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Accessible Hearing Care for Reduction of Disruptive Behaviors and Caregiver Burden in Dementia | TBD | Carrie L. Nieman, Johns Hopkins University | Communication intervention delivered at home (counseling program combined with a low-cost, over-the-counter amplification device) to optimize hearing and communication for older adults with AD/ADRD | Older adults with dementia and their caregivers (Ages 18+) | 2023 |
| Novel Approaches to Identifying and Engaging Disadvantaged Patients with Alzheimer's Disease (AD) in Clinical Research | A Relational Research Recruitment and Engagement Intervention for Cognitive Aging Research | Andrea L. Gilmore-Bykovskyi, University of Wisconsin-Madison | Intervention to test a tailored clinical trial registry to inform best practices for acute care research recruitment as well as engagement/retention of research participants | Patient/caregiver dyads (Patient Ages 65+) | 2023 |
| Promoting Seniors Health with Home Care Aides: A Randomized Controlled Trial | Promoting Seniors' Health With Home Care Aides | Naoko Muramatsu, University of Illinois at Chicago | Healthy Moves for Aging Well (Healthy Moves), a safe physical activity program delivered by home care aides, which consists of a brief motivational enhancement and three movements to be performed in a seated position | Pairs of of eligible patients and their home care aides | 2023 |
| Pragmatic Trial of the Effectiveness and Cost-Effectiveness of Dementia Care | D-CARE - The Dementia Care Study: A Pragmatic Clinical Trial of Health System-Based Versus Community-Based Dementia Care (D-CARE) | David Reuben, University of California, Los Angeles | Pragmatic intervention to compare clinical effectiveness and cost-effectiveness of community-based dementia care and health system-based care | Dyads of persons with dementia and their primary caregivers (Ages 18+) | 2024 |
| PLAN: Dementia Literacy Education and Navigation for Korean Elders with Probable Dementia and their Caregivers | PLAN: Dementia Literacy Education and Navigation for Korean Elders With Probable Dementia and Their Caregivers (PLAN) | Hae-Ra Han, Johns Hopkins University | PLAN, a dementia literacy training using to train community health workers | Community health workers and dyads, i.e., patients with probable dementia (Ages 65+)/caregiver (Ages 18+) | 2024 |
| Behavioral Change Following Culturally-Informed Biomarker Disclosure in Alzheimer’s Disease | Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure (SHARED III) | Annalise Rahman-Filipiak, University of Michigan at Ann Arbor | Diagnostic Disclosure Protocol, where participants receive information about current cognitive performance to assess long-term behavior, safety, and efficacy in patients with amnestic Mild Cognitive Impairment (aMCI) following biomarker disclosure | Adults diagnosed with amnestic MCI within the past 12 months (Ages 50+) | 2026 |
| Primary Care Based Collaborative Approach to Care Management for Older Adults with Dementia | TBD | Stephanie Nothelle, Johns Hopkins University | Develop and implement a practical primary care based intervention to facilitate collaboration across care management programs | Older adults with AD/ADRD | 2026 |
| Indians Transforming Alzheimer's Care Training (INTACT) | TBD | Dedra Buchwald, Patrik Johansson, Washington State University, Rural Health Education Network | INTACT, a clinic-level intervention to improve AD/ADRD diagnosis and quality of care for AI/Ans | Rural clinics serving AI/ANs | 2026 |
| Promoting the Good Life among Nursing Home Residents with Alzheimer's Disease and Related Dementias: The Role of Special Care Units | TBD | Jessica Orth, University of Maryland, Baltimore (UMB) | The proposed intervention is “Good Life” which is a model of care designed to improve outcomes and enhance resident well-being/quality of life. | Nursing home residents with AD/ADRD, family members, and staff caring for residents with AD/ADRD | 2024 |
Section 5: Diagnostic Tools, Assessments, & Imaging Studies
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Digital Detection of Dementia Florida Replication Site Pragmatic Cluster-Randomized Controlled Comparative Effectiveness Trial (D3) | Digital Detection of Dementia (D Cubed) Studies (Dcubed) | Malaz Boustani, Indiana University-Purdue University Indianapolis (IUPUI) | The Passive Digital Marker (PDM), a Machine Learning (ML) algorithm, and the Quick Dementia Rating Scale (QDRS), a patient reported outcome (PRO) tool, to detect cognitive impairment and improve the annual rate of new documented ADRD diagnosis in primary care practices. | 10 eligible primary care clinics within the UMiami Health system; adults aged 65+ with at least one visit to PCP within the past year | 2025 |
| Digital Detection of Dementia Pragmatic Cluster-Randomized Controlled Comparative Effectiveness Trial (D2) | Digital Detection of Dementia (D Cubed) Studies (Dcubed) | Malaz Boustani, Indiana University-Purdue University Indianapolis (IUPUI) | The Passive Digital Marker (PDM), a Machine Learning (ML) algorithm, and the Quick Dementia Rating Scale (QDRS), a patient reported outcome (PRO) tool, to detect cognitive impairment and improve the annual rate of new documented ADRD diagnosis in primary care practices. | 10 eligible primary care clinics within the Eskenazi Health System; adults aged 65+ with at least one visit to PCP within the past year | 2025 |
| Biomarker Predictors of Memantine Sensitivity in patients with Alzheimer's Disease | Biomarker Predictors of Memantine Sensitivity in Patients With Alzheimer's Disease | Neal Swerdlow, University of California San Diego (UCSD) | Identify sensitivity levels of memantine, an NMDA receptor antagonist approved for treatment of moderate-to-severe AD | Older adults with AD | 2023 |
| Development of an Ophthalmic Diagnostic Probe for Cerebral Amyloid Angiopathy in Patients | TBD | Stella Sarraf, Amydis Diagnostics, Inc. | Ophthalmic diagnostic probe to detect cerebral amyloid angiopathy (vascular disease) | Healthy adults and Cerebral Amyloid Angiopathy adult patients | 2023 |
| Digital Detection of Dementia Studies (D cubed Studies) | Digital Detection of Dementia (D Cubed) Studies (Dcubed) | Malaz Boustani, Indiana University- Purdue University at Indianapolis | A machine learning and patient-reported outcome tool for early detection of cognitive impairment | Older adults receiving health services (Ages 65+) | 2025 |
| Emergency General Surgery Delirium Recovery Model: A Collaborative Care Intervention | Emergency General Surgery Delirium Recovery Model | Ben Zarzaur, Malaz Boustani, University of Wisconsin-Madison | Emergency General Surgery Delirium Recovery Program, a care collaborative program to cognitive, functional and psychological recovery after episode(s) of delirium | Surgery patients (Ages 65+) who suffer at least one episode of delirium in the post-operative period | 2027 |
| Enriching Clinical Trials Requiring Amyloid Positivity with Practice Effects | Enriching Clinical Trials Requiring Amyloid Positivity with Practice Effects | Kevin Duff, University of Utah | Explore relationship between short-term practice effects on cognitive tests and amyloid PET scan | Cognitively intact older adults, and those with MCI and AD (Ages 65+) | 2023 |
| Evaluating Cognitive Impairment as a Moderator of Locomotor Learning in Older Adults Post-stroke | Cognition and Motor Learning Post-stroke | Kristan Leech, University of Southern California | Biomechanical analyses, neuropsychological assessments, and brain imaging techniques to examine the structural integrity of the dorsolateral prefrontal cortex in explicit locomotor learning and inform the development of a gait rehabilitation intervention for older adults post-stroke. | Older adults with post-stroke cognitive impairment | 2026 |
| Identifying and Supporting Patients with Undiagnosed Dementia Using the EHR Risk of Alzheimer's and Dementia Assessment Rule (eRADAR): A Pilot Clinical Trial | The Brain Health Study: A Pragmatic, Patient-Centered Trial | Sascha Dublin, Kaiser Foundation Research Institute | EHR dementia screening tool to follow up with high risk patients with potential undiagnosed dementia | Older adults enrolled in Kaiser Washington or UCSF care within the past 2 years with no prior diagnosis of dementia (Ages 65+) | 2024 |
| Integrating Home-Based Video Teleneuropsychology into Clinical Practice: Typical Versus Atypical Alzheimer's Disease | VIdeo Telehealth in Alzheimer's: NeuroPsychology (VITAL-NP) (VITAL-NP) | Brianne Magouirk Bettcher, University of Colorado Denver | Home-based video Tele-neuropsychological assessment (TeleNP) versus a face-to-face (FF) neuropsychological assessment in older adults with suspected AD/ADRD for the delivery of neuropsychological evaluations. | Care recipient ≥age 60 years and <90 years who are undergoing evaluation for possible AD and whose severity ranges from MCI to mild dementia. care partner: (no inclusion criteria provided) | 2024 |
| Locus-coeruleus Function in Normal Elderly and AD Risk (LEAD) | Locus-coeruleus Function in Normal Elderly and AD Risk (LEAD) | Ricardo Osorio, New York University School of Medicine | Locus coeruleus (LC) targeted imaging coupled with other biomarker testing to determine whether LC dysfunction can be measured in preclinical AD stages | Cognitively normal older adults (Ages 60-75) | 2023 |
| Low-cost Detection of Dementia Using Electronic Health Records Data: Validation and Testing of the eRADAR Algorithm in a Pragmatic, Patient-centered Trial | The Brain Health Study: A Pragmatic, Patient-Centered Trial | Sascha Dublin, Kaiser Foundation Research Institute | EHR dementia screening tool to detect cognitive impairment | Older adults enrolled in Kaiser Washington or UCSF care within the past two years with no prior diagnosis of dementia (Ages 65+) | 2025 |
| Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History (PATH) | Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History (PATH) | Christian Lobue, University of Texas Southwestern Medical Center | Mechanistic study using high definition-transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. | Individuals with amnestic MCI with and without a history of mild TBI | 2027 |
| Quantitative Imaging of Brain Glymphatic Function in Humans | Quantitative Imaging of Brain Glymphatic Function in Humans | Manus Donahue, Vanderbilt University Medical Center | MRI and PET imaging to evaluate levels of Αβ burden and assess lymphatic drainage function | Older adults with Parkinson's Disease (Ages 55-80) | 2025 |
| Slow Wave Sleep (SWS) and the Effect of African Ancestry on Amyloid Burden, a Longitudinal Study | The Sleep Amyloid, Slow WAve Race and Ethnicity Study (Sleep AWARE) | Ricardo Osorio, New York University School of Medicine | Explore whether poor slow wave sleep is a predictor of amyloid burden | Cognitively normal African-American and White adults (Ages 55-75) | 2023 |
| ToolBox Detect: Low Cost Detection of Cognitive Decline in Primary Care Settings | ToolBox Detect: Low Cost Detection of Cognitive Decline in Primary Care Settings | Richard Gershon, Northwestern University at Chicago | Cognitive assessment toolbox to detect cognitive decline in Medicare Annual Wellness visits | Older Adults/Patients (Ages 65+) | 2025 |
| Using Routine Care Electronic Medical Record Data and Artificial Intelligence to Develop a Passive Digital Marker to Predict Postoperative Delirium | TBD | Sanjay Mohanty, Indiana University-Purdue University Indianapolis (IUPUI) | A clinical decision support tool incorporating a Passive Digital Marker (PDM) to predict postoperative delirium based on EHR data and machine learning techniques | Patients 50+ years old scheduled for elective major abdominal surgery requiring inpatient stay of more than 24 hours. | 2027 |
| Using the PROMIS Cognition Item Bank for Early Detection of Cognitive Decline in Primary Care | TBD | Maria Orlando Edelen, RAND Corporation | EHR dementia screening tool, implemented in clinical practice to increase early detection of cognitive impairment | Providers of patients (Ages 65+) | 2023 |
| A Cognitive Risk Calculator and Screening tool for Primary Care Settings | TBD | Darlene Floden, Cleveland Clinic Lerner College of Medicine-CWRU | Cognitive screening tools (EHR-based Cognitive Risk Calculator and iPad-based Brief Assessment of Cognitive Health) used in primary care settings to detect dementia | Providers caring for patients (Ages 60+) | 2025 |
| A Technology-Driven Intervention to Improve Early Detection and Management of Cognitive Impairment | TBD | Leah R. Hanson, HealthPartners Institute | EHR cognitive impairment clinical decision support tool to improve early detection and management of cognitive impairment | Patients with elevated dementia risk | 2025 |
| Cognitive Screening Made Easy for Primary Care Providers | Cognitive Screening Made Easy for PCPs | Robin C. Hilsabeck, University of Texas at Austin | Cognitive screening tool for primary care providers to conduct cognitive screenings on a regular basis | Adults who are cognitively normal, mild cognitive impairment, or have dementia (Ages 60+) | 2023 |
| First-in-Human evaluation of an astrocytic glutamate transporter (EAAT2) PET tracer in healthy and Alzheimer's diseased brain | First-in-human Evaluation of EAAT2 PET Tracer in Healthy and Alzheimer's Diseased Brain | David Wilson, University of California San Francisco (UCSF) | A novel PET imaging tracer, RP-115, to evaluate changes in astrocytes in healthy versus cognitively impaired AD patients by quantitative PET imaging of the excitatory amino acid transporter 2 (EAAT2; an astrocytic glutamate transporter). | Individuals with Alzheimer's disease and healthy older adults | 2026 |
Section 6: Treatments for Neuropsychiatric Symptoms
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| A Randomized Controlled Trial of Electroconvulsive Therapy Plus Usual Care versus Simulated-ECT plus Usual Care for the Acute Management of Severe Agitation in Alzheimer's Dementia (ECT-AD) | Electroconvulsive Therapy (ECT) for Agitation in Alzheimer's Dementia (AD) | Brent Peter Forester; Georgios Petrides, McLean Hospital; Zucker Hillside Hospital | Electroconvulsive Therapy to treat severe agitation in moderate to severe stage AD | People with moderate to severe stage Alzheimer's Disease (Ages ≥55) | 2024 |
| Methodology Issues in a Tailored Light Treatment for Persons with Dementia | Methodology Issues in a Tailored Light Treatment for Persons with Dementia | Mariana Figueiro, Icahn School of Medicine at Mount Sinai | Light treatment designed to improve sleep | Individuals with AD and sleep problems (Ages 65+) | 2025 |
| Problem Adaption Therapy for Mild Cognitive Impairment with Depression | Problem Adaptation Therapy for Mild Cognitive Impairment and Depression (PATH-MCI) | Dimitris Kiosses; Paul Rosenberg, Weill Medical College of Cornell University; Johns Hopkins University | Problem Adaptation Therapy (PATH), a novel psychosocial intervention designed to reduce depression and disability in older adults with major depression | People with Mild Cognitive Impairment and depression (Ages 60+) | 2023 |
| Circuit-specific neuromodulation for the treatment of apathy in Alzheimer's Disease | TMS as a Treatment for Apathy in Alzheimer's Disease | Mark Eldaief, Massachusetts General Hospital | Repetitive Transcranial Magnetic Stimulation (rTMS) to modulate cortico-striatal circuits in neurodegenerative patients with apathy | AD participants with apathy (50-80 years of age) | 2024 |
| Project Name | Trial Name | Principal Investigator/Institution | Trial Description | Population | Anticipated Completion Date |
|---|---|---|---|---|---|
| Bicarbonate Administration and Cognitive Function in Midlife and Older Adults with CKD | Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD | Jessica B Kendrick, University Of Colorado Denver | Sodium bicarbonate therapy treatment to improve cognitive function | Midlife and older men and women from all racial/ethnic backgrounds with chronic kidney disease (CKD) stage 3b-4 (Ages 50-75) | 2023 |
| Escitalopram for Agitation in Alzheimer's Disease | Escitalopram for Agitation in Alzheimer's Disease (S-CitAD) | Constantine Lyketsos; Anton Porsteinsson, Johns Hopkins University; University of Rochester | Escitalopram, a small molecule selective serotonin reuptake inhibitor (SSRIs) antidepressant to treat agitation in AD | People with Alzheimer's disease and agitation (Open to all adults meeting inclusion criteria) | 2023 |
| Lifes end Benefits of CannaBidol and TetrahYdrocannabinol (LiBBY) Trial | TBD | Jacobo Mintzer; Brigid Reynolds, Medical University of South Carolina | Cannabidol and Tetrahydrocannabinol, Cannabis chemotypes, to improve quality of life in adults with AD | Adults with AD | 2023 |
| Nighttime Agitation and Restless Legs Syndrome in People with Alzheimer's Disease | Nighttime Agitation and Restless Legs Syndrome in People With Alzheimer's Disease | Kathy Richards, University of Texas, Austin | Gabapentin Enacarbil, an antiepileptic drug to reduce nighttime agitation, reduce restless legs syndrome behaviors, and improve sleep | Older adults with dementia diagnosis and with nighttime agitation (Ages 55+) | 2023 |
| Pilot Trial of Dronabinol Adjunctive Treatment of Agitation in Alzheimer's Disease | Trial of Dronabinol Adjunctive Treatment of Agitation in Alzheimer's Disease (AD) (THC-AD) | Paul Rosenberg; Brent Forester, Johns Hopkins University; McLean Hospital | Dronabinol, a synthetic form of THC and partial agonist of CB1/2 endocannabinoid receptors to treat severe agitation in AD | People with Alzheimer's disease and agitation (Ages 60-90) | 2023 |