Skip to main content
U.S. flag

An official website of the United States government

Translational Tools, Infrastructure, and Capabilities Milestones

4.A-4.AA

Selected filters

No filters selected

Filter
27 Results

ID

Title

Status

Support the development of the next generation of animal models based on the current understanding of genetic and environmental risk and protective factors for AD and related dementias…

Status

Achieved

Create infrastructure/resources for extensive characterization of existing and new animal models…

Status

Achieved

Continue to develop animal models with higher predictive validity for use in preclinical drug development…

Status

In Progress

Expand biorepository infrastructure to enable storage and rapid distribution of clinical data and biosamples…

Status

In Progress

Support the development of standardized, cost-effective, high throughput methods…

Status

In Progress

Develop improved iPSC protocols for all relevant cell types and human-based organoid model systems...

Status

In Progress

Support quantitative systems pharmacology approaches that couple biological network and pathway analyses…

Status

In Progress

Institute an expedited review track for applications focused on drug discovery, preclinical, and clinical drug development...

Status

To Be Initiated

Create a National IRB.

Status

Achieved

Expand existing and create new integrative training programs for junior neuroscience, behavioral and social science researchers...

Status

In Progress

Leverage the power of human genetics to enable precision medicine research for AD...

Status

In Progress

Support standardized, single cell molecular profiling (genomic, proteomic, metabolomic)...

Status

In Progress

Support the development of genome-scale metabolic models to capture the heterogeneity of metabolic transitions...

Status

Achieved

Provide support for high-cost capital equipment/core facilities and staff training to make high-throughput technologies...

Status

To Be Initiated

De-risk novel candidate targets by supporting the development of high quality, open source, target enabling tools...

Status

Achieved

Create an international FTD clinical trial network.

Status

Achieved

Develop better FTLD in vivo and cell-based model systems.

Status

In Progress

Develop models that: reproduce small vessel disease; are relevant to VCID and AD; address white and grey matter VCID; or include genetic and acquired VCID. Verify models, including via imaging.

Status

In Progress

Improve and increase training, including for individuals who are members of under-represented populations, and of different career levels of scholars who conduct health disparities research in AD/ADRD.

Status

In Progress

Use data and other resources from large-scale clinical research and trials to test hypothesized mechanisms of human VCID in basic science models.

Status

In Progress

Incorporate VCID findings from basic science into the design of clinical research and trials targeting VCID-relevant cognitive impairment and dementia.

Status

In Progress

Build new animal models to advance knowledge about TDP-43 pathology in common dementias, capitalizing on lessons learned from animal models in FTLD/ALS, AD and other diseases.

Status

In Progress

Enable open drug development to generate innovative new medicines that are priced fairly for all.

Status

To Be Initiated

Create opportunities and avenues for closer interaction between researchers developing new INDs and researchers supported through NIA's enabling infrastructure programs involved in developing data resources, translational tools and new mechanistic insight

Status

In Progress

Evaluate and update current trial funding models to ensure the ability to test novel first-in-class therapeutics in the context of the full range of expenses and time frames required for robust evaluation and sharing.

Status

In Progress

Promote career development of biomedical, behavioral, and social scientists conducting AD/ADRD health equity research.  

Status

In Progress

Impact of COVID-19 on AD/ADRD: Building research infrastructure

Status

In Progress

Search all Research Categories

nia.nih.gov

An official website of the National Institutes of Health