Skip to main content
U.S. flag

An official website of the United States government

Health Equity: Design culturally tailored interventions (Milestone 10.H)


Timeline Start - End

2020 - 2027

Research Implementation Area

Trial Design

AD-Related Dementias Focus

Implement culturally tailored multimodal intervention trials and drug therapy trials to reduce AD/ADRD burden in populations facing disparities.

Success Criteria

  • Initiate one new clinical trial targeting AD/ADRD specifically in a population that experiences health disparities in dementia.

Summary of Key Accomplishments

The ongoing NINDS-funded ARCADIA CSI study is a multicenter, biomarker-driven, randomized phase 3 clinical trial of apixaban, a type of blood thinner, versus aspirin in individuals who have had a recent stroke of unknown cause. More than 1,000 individuals are being recruited over 2.5 years at 120 sites in the NIH StrokeNet clinical trial network. Participants, including those from NIH defined health disparities populations, will be followed for 1.5-7 years to understand the effects of apixaban on recurrent stroke as well as dementia-related outcomes and determine its safety with respect to hemorrhaging in the brain. Dementia-related neuroimaging and key measures of cognitive decline were recently added to the ancillary study using AD/ADRD funds.

The key accomplishments summary is current as of July 2022.

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations

Related Milestones

Search all Research Categories

An official website of the National Institutes of Health