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Milestone 10.G

AD Related Dementias – Specific

Enrich the design of trials of vascular health interventions to improve their application to AD/ADRD among aging diverse populations.

Success Criteria

  • Develop and make widely available guidelines for brain health assessments in clinical trials of vascular interventions in aging diversity populations. These guidelines will include standardized outcome measures (e.g., clinical, imaging, neurological, cognitive, and vascular) in diverse populations that will facilitate meta-analyses of vascular health intervention trials, and will draw from expertise in cognitive impairment and dementia and related fields such as stroke, lipid metabolism, cardiovascular intervention, and immune function. The guidelines should provide tiers of assessments that are optimized for resources in different care settings, such as caregiver time and technology available, and should provide best practices for recruitment in diverse populations.

  • Implement and validate these guidelines, including standardized outcome measures relevant to AD/ADRD in vascular health intervention studies that include diverse populations.

Summary of Key Accomplishments

NIH supports research tools and biomarkers to detect vascular cognitive impairment (VCID) in diverse populations that can be used in clinical trials. Diverse-VCID is an NINDS funded 6-year national study of 2,250 Americans from diverse backgrounds to understand the role that cerebrovascular disease plays in developing Alzheimer’s disease and other dementias. Multiple clinical sites throughout the country with expertise in recruitment and retention of ethnic/racial minority adult participants have been selected. Diverse-VCID uses advanced brain imaging and blood-based techniques to understand how vascular changes in late life cause brain injuries that lead to cognitive decline. This project leverages resources from the NIH-funded MarkVCID initiative, which has developed and validated several VCID biomarker kits, which are designed to measure vascular changes that predict development of cognitive impairment and dementia and serve as biomarkers to test preventative therapies.

This information is current as of July 2022.

Research Implementation Area
AD Related Dementias - Specific
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Relevant Recommendations

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