Skip to main content
U.S. flag

An official website of the United States government

Trial Design: Experimental medicine approach to primary prevention (Milestone 10.F)

Convene an advisory meeting to evaluate how assays and best practices developed in the context of the NIH Common Fund Science of Behavior Change and other related NIH activities could be incorporated into the design of primary prevention trials or for clinical trials targeting risk factors associated with increased risk of AD and AD-related dementias.

Success Criteria

  • Generate recommendations that would guide the inclusion of behavioral target engagement assays and best practices in NIH-supported prevention and treatment trials for AD and AD-related dementias.

  • Use results to inform the design of mid-life prevention trials in populations with high levels of behavioral/health profile AD risk.

Summary of Key Accomplishments

NIA supported an expert panel meeting in 2019 to explore the idea of approaching the development of primary prevention trials for AD/ADRD with deliberate attention to discovering the specific reasons behind successful behavior change. The goal of the workshop was to inform research efforts to increase adherence to AD prevention interventions. The recommendations generated by the panel informed two research funding opportunities (RFA-AG-22-016 and PAR-21-207) focused on approaches to promote initiation and long-term maintenance of lifestyle changes linked to AD risk prevention.

The key accomplishments summary is current as of March 2022. 

Research Implementation Area
Trial Design

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations

An official website of the National Institutes of Health