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Milestone 8.E

AD Related Dementias – Specific

Test for efficacy across the spectrum of VCID severity: (i) interventions proven to reduce cardio- and cerebrovascular risk, (ii) established care models.


Success Criteria

  • Initiate at least one VCID clinical trial to test whether intervention(s) known to reduce cardiovascular and cerebrovascular risk also decrease VCID burden; this trial should use leading edge VCID biomarkers and cognitive measures, obtain VCID-relevant clinical data including on comorbidities, and when appropriate include others measures of neurologic function (e.g. walking test) that are relevant to cognitive outcomes.
  • Support research to determine whether the best existing models for delivering care to persons with AD/ADRD and supporting their caregivers are effective in persons affected by VCID.

Summary of Key Accomplishments

In 2019, the Phase 3 NIH sponsored SPRINT-MIND (Systolic Blood Pressure Intervention Trial-Memory and Cognition in Decreased Hypertension) trial showed that intensive blood pressure control (120/80) significantly decreased mild cognitive impairment and reduced small blood vessel damage in people with high blood pressure. The results demonstrate the promise of vascular risk factor intervention, especially in midlife, to help prevent cognitive impairment and dementia in aging individuals. In addition, results of a different blood pressure study suggest that higher cumulative blood pressure levels in Black individuals appear to explain Black-White disparities in later-life cognitive decline, emphasizing the importance of focusing on health equity when evaluating and developing treatments for cardiovascular and cerebrovascular risk factors for dementia.

This information is current as of July 2022.


Research Implementation Area
AD Related Dementias - Specific
Timeline
2016–2025
Status
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations

nia.nih.gov

An official website of the National Institutes of Health