Non-Pharmacological Interventions: Prevention trials (Milestone 8.D)
Timeline Start - End2021 - 2025
Research Implementation AreaNon-Pharmacological Interventions
Initiate at least one clinical trial for primary prevention of AD and AD-related dementias among high risk individuals in midlife including a non-pharmacological treatment arm.
Completion of at least one Phase II primary prevention trial for non-pharmacological interventions in midlife. Successful trials will provide evidence for potential therapeutic mechanisms and include the collection of biomarker data for future validation and longitudinal follow-up within the trial cohort.
Summary of Key Accomplishments
In 2021, NIA held a workshop to review non-pharmacological approaches for early prevention of AD/ADRD. The goal of this workshop was to address the core methodological challenges associated with developing and accumulating evidence to support preventive interventions for AD/ADRD with respect to the populations, targets, and outcomes that should be the focus of the prevention research agenda.
The key accomplishments summary is current as of March 2022.
Research Programs and Resources
- Long-term Impact of Random Assignment to Intensive Lifestyle Intervention on Alzheimer’s Disease and Related Dementias: The Action for Health in Diabetes ADRD Study (Look AHEAD-MIND)
- Projects funded under RFA-AG-22-016