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Milestone 8.D

Initiate at least one clinical trial for primary prevention of AD and AD-related dementias among high risk individuals in midlife including a non-pharmacological treatment arm.

Success Criteria

Completion of at least one Phase II primary prevention trial for non-pharmacological interventions in midlife. Successful trials will provide evidence for potential therapeutic mechanisms and include the collection of biomarker data for future validation and longitudinal follow-up within the trial cohort.

Summary of Key Accomplishments

In 2021, NIA held a workshop to review non-pharmacological approaches for early prevention of AD/ADRD. The goal of this workshop was to address the core methodological challenges associated with developing and accumulating evidence to support preventive interventions for AD/ADRD with respect to the populations, targets, and outcomes that should be the focus of the prevention research agenda.

This information is current as of March 2022.

Research Implementation Area
Non-Pharmacological Interventions
In Progress

Accomplishments/Implementation Activities

Research Programs and Resources

Research Highlights

Relevant Recommendations

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