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Drug Development/Novel Targets: Phase 1 trials (Milestone 6.E)

In Progress

Timeline Start - End

2017 - 2024

Research Implementation Area

Drug Development - Novel Targets

Initiate first in human, Phase 1 drug trials for therapeutic agents against at least 6 novel therapeutic targets. These trials will provide evidence of safety and target engagement.

Success Criteria

  • Completion of 12 Phase 1 drug trials for agents against 6 novel targets, providing conclusive evidence of safety and target engagement.

Summary of Key Accomplishments

Eight Phase 1 trials testing seven new drug candidates that target multiple aspects of the disease (neuroinflammation, metabolism, synaptic plasticity, neurogenesis, etc.) have been supported. Of these, three trials have been successfully completed. Results are pending from one additional trial, and three trials are ongoing.

The key accomplishments summary is current as of July 2022. 

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

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