Initiate research programs for translational bioinformatics and network pharmacology to support rational drug repositioning and combination therapy from discovery through clinical development.
Identification of at least 6 existing drugs suitable for repurposing and/or combination therapy for AD and ADRD prevention or treatment. The drugs selected for repurposing or combination therapy will be prioritized based on:
evidence that they modulate disease relevant pathways/networks gained from computational and empirical approaches.
preclinical proof-of-efficacy in a relevant model system.
availability of biomarkers to monitor target engagement in humans.
sufficient evidence of safety for the intended target population.
- Research Implementation Area
- Drug Repurposing and Combination Therapy Development
- PAR-17-032: Translational Bioinformatics Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimer’s Disease (R01)
- PAR-20-156: Translational Bioinformatics Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimer’s Disease (R01 Clinical Trial Optional)
Research Programs and Resources
- Translational Bioinformatics Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimer’s Disease
- Endophenotype Network-based Approaches to Prediction and Population-based Validation of in Silico Drug Repurposing for Alzheimer’s Disease
- Compound repositioning for Alzheimer’s Disease using knowledge graphs, insurance claims data, and gene expression complementarity
- Drug repurposing for Alzheimer's disease using structural systems pharmacology
- An Integrated Reverse Engineering Approach Toward Rapid Drug Repositioning for Alzheimer’s Disease
- Systematic Alzheimer's disease drug repositioning (SMART) based on bioinformatics-guided phenotype screening and image-omics
- ApoE Genotype-Directed Drug Repositioning and Combination Therapy for Alzheimer's Disease
- Harnessing Diverse BioInformatic Approaches to Repurpose Drugs for Alzheimers Disease