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Translational Research and Clinical Interventions Milestones

5.A-5.E, 6.A-6.J, 7.A-7.F, 8.A-8.E, 10.A-10.H, 12.A-12.L

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46 Results

ID

Title

Status

Initiate first in human, Phase 1 drug trials for therapeutic agents against at least 6 existing therapeutic targets…

Status

In Progress

Initiate Phase 2 (proof of concept) drug trials for agents against 3-6 currently known therapeutic targets…

Status

In Progress

Initiate Phase 3 drug trials for agents against at least 3 currently known therapeutic targets…

Status

In Progress

Prepare for and initiate clinical trials that aim to alleviate or slow the course of LBD symptoms, and delay or prevent the onset of disease.

Status

In Progress

Develop disease-modifying interventions for LBD based on discovering biomarkers, molecular targets, and genetic and environmental modifiers that enhance, delay or prevent the onset of disease.

Status

In Progress

Establish a searchable, open access research database that contains all clinical, biomarker, and epidemiological data, and related genotypes and phenotypes from existing genetic studies…

Status

Achieved

Establish a consortium of genetics and genomics experts to develop and execute a large scale sequencing project to analyze the genomes of a large number of well characterized individuals…

Status

Achieved

Identify, characterize, and complete early validation for at least 6 novel therapeutic targets for AD and AD-related dementias…

Status

Achieved

Initiate drug discovery efforts to develop novel therapeutic agents against at least 6 novel therapeutic targets...

Status

In Progress

Initiate first in human, Phase 1 drug trials for therapeutic agents against at least 6 novel therapeutic targets...

Status

In Progress

Initiate Phase 2 (proof of concept) drug trials for agents against 3-6 novel therapeutic targets...

Status

In Progress

Initiate Phase 3 drug trials for agents against at least 3 novel therapeutic targets...

Status

To Be Initiated

Initiate interdisciplinary research programs that integrate clinical, genomic and mechanistic research...

Status

In Progress

Expand efforts to genotype patients with FTD and identify new genes and their functional relationship to FTLD pathogenesis.

Status

In Progress

Support a diverse portfolio of candidate therapeutics including reversal or regenerative therapeutics for the treatment of advanced disease.

Status

To Be Initiated

Expand existing and develop new systems biology and systems pharmacology research programs...

Status

Achieved

Initiate research programs for translational bioinformatics and network pharmacology...

Status

Achieved

Continue to develop resources, capabilities and partnerships to advance data-driven drug repositioning and combination therapy...

Status

In Progress

Initiate early clinical development for at least 6 existing drugs or drug combinations for the treatment or prevention of AD and AD-related dementias.

Status

In Progress

Initiate at least three Phase 3 trials with repurposed drugs or drug combinations...

Status

In Progress

Accelerate pre-clinical disease-modifying and symptomatic therapeutic development in FTD.  

Status

In Progress

Convene an advisory meeting to delineate an interdisciplinary research agenda focused on: advancing non-pharmacological interventions for the cognitive and behavioral symptoms...

Status

Achieved

Increase investment in clinical trials that robustly test a variety of lifestyle interventions...

Status

In Progress

Support studies that employ data-driven approaches to robustly test the efficacy of multi-modal interventions...

Status

To Be Initiated

Initiate at least one clinical trial for primary prevention of AD and AD-related dementias among high risk individuals...

Status

In Progress

Test for efficacy across the spectrum of VCID severity

Status

In Progress

Convene a meeting that brings together epidemiologists, clinical trialists, clinical practitioners, representatives from industry and patient advocates from diverse communities to formulate guidelines...

Status

In Progress

Establish a working group to identify standard outcome measures necessary for data comparisons across secondary prevention trials...

Status

Achieved

Initiate 3-4 clinical research studies using common standard outcome measures...

Status

Achieved

Create new research programs to implement innovative trial designs with a precision medicine research paradigm.

Status

In Progress

Support research on the effectiveness of dissemination methodologies to facilitate the implementation of effective prevention strategies.

Status

To Be Initiated

Convene an advisory meeting to evaluate how assays and best practices developed in the context of the NIH Common Fund Science of Behavior Change...

Status

Achieved

Enrich the design of trials of vascular health interventions to improve their application to AD/ADRD among aging diverse populations.

Status

In Progress

Implement culturally tailored multimodal intervention trials and drug therapy trials reduce AD/ADRD burden

Status

Achieved

Provide funding for clinical research studies to build diverse community partnerships needed to increase research participation.

Status

In Progress

Create synergies between federally funded programs such as PCORI and CTSAs to make community involvement less expensive...

Status

In Progress

Provide supplemental support for clinical research on AD and related dementias to overcome the major logistical barriers to participation...

Status

In Progress

Convene a meeting with key stakeholders and organizations including representatives from the NIH Precision Medicine Initiative ...

Status

To Be Initiated

Pilot the use of electronic consent which provides participants an option for broad sharing of de-identified data...

Status

In Progress

Develop and deploy citizen science methods to engage diverse and underrepresented populations...

Status

In Progress

Establish a partnership among NIH and other federal agencies to develop a national public education campaign...

Status

In Progress

Collaborate with research scientists to identify, evaluate and increase knowledge about best practices for recruitment and retention of research participants.

Status

Achieved

Establish a working group including clinical trial recruitment experts to dynamically evaluate and update the materials and information provided in the central resource.

Status

Achieved

Collaborate with external organizations to increase awareness of large-scale registries that encompass the spectrum of the disease ...

Status

Achieved

Develop novel and identify existing community engagement and outreach methods to facilitate engagement, understanding and partnership with health disparities populations.

Status

Achieved

Advance equity in AD/ADRD research via inclusion science to improve representative sampling and retention of diverse communities.

Status

In Progress

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