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Milestone 4.V

AD Related Dementias – Specific

Build new animal models to advance knowledge about TDP-43 pathology in common dementias, capitalizing on lessons learned from animal models in FTLD/ALS, AD and other diseases.

Success Criteria

  • Develop, validate and make available to the broader scientific community two or more novel animal models that exhibit TDP-43 pathology aligned with the affected anatomical sites and functional changes that occur in common dementias such as the clinical syndrome of Alzheimer’s disease.

Summary of Key Accomplishments

TDP-43 neuropathology was not known to be significant in common dementias until recently. An important step toward understanding TDP-43's role in dementia and to identifying promising drug targets is to develop relevant animal models -- such models are a critical part of biomedical research because researchers are able to carry out experiments that would not be feasible or ethical in humans. Therefore, NIH is funding multiple projects to develop new animal models for TDP-43 pathology in dementia under two funding opportunity initiatives (PAR-19-167, RFA-NS-20-005). One funded research team has developed a new mouse model that carries a TDP-43-associated mutation (C9ORF72), and in a recent publication they showed that the mouse model develops accumulation of TDP-43 inside cells similar to that seen in humans with certain forms of dementia.

This information is current as of July 2022.

Research Implementation Area
AD Related Dementias - Specific
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations

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