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Milestone 4.T

AD Related Dementias – Specific

Use data and other resources from large-scale clinical research and trials to test hypothesized mechanisms of human VCID on basic science findings.

Success Criteria

  • Support VCID studies in model systems that leverage data, resources, and results from, and also test hypotheses from, human VCID clinical research and clinical trials.
  • Support the development of improved VCID model systems by leveraging data, resources, and results from human VCID clinical research and clinical trials.

Summary of Key Accomplishments

A large body of clinical studies, including the SPRINT-MIND randomized control clinical trial in 2019, demonstrate that controlling blood pressure in midlife decreases one's risk of cognitive decline and dementia. To better understand this direct link between blood pressure, brain and vascular health, and dementia, NIH supports several basic research studies in animal models that allow scientists to study this link at the molecular level and test hypotheses about how to reduce hypertension-related vascular damage that can lead to cognitive impairment. For example, a recent NINDS-funded study in rats showed that hypertension led to accumulation of the AD-related protein beta-amyloid coupled with deficits in the brain pathways, known as perivascular “glymphatic pathways,” that help clear waste (like beta-amyloid aggregates) from brain cells.

This information is current as of July 2022.

Research Implementation Area
AD Related Dementias - Specific
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations

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