Data Sharing: Reporting and reproducibility (Milestone 3.C)
Timeline Start - End2016 - 2024
Research Implementation AreaData Sharing and Reproducibility
Increase transparency in reporting and reproducibility of research findings by incentivizing and enforcing rapid sharing of raw and processed data, analytical methods, and details of experimental design and by promoting early sharing of research observations through preprint servers.
- Develop a partnership across federal and non-federal AD funding agencies to align incentives and policies for data sharing, independent replication of research findings and unrestricted access to reagents and research tools.
Summary of Key Accomplishments
NIA is propagating expectations for rapid and broad sharing of data, methods, and research tools and enabling translational programs that operate under open-science/open-source principles. These are the AMP AD Consortia, the TREAT-AD and the MODEL-AD translational centers, and the Alzheimer’s Clinical Trials Consortium (ACTC). The rapid and broad sharing of data, methods, results, and research tools generated by these programs are enabled by these NIA-supported data resources: the AD Knowledge Portal, Agora, AlzPED, and Laboratory of Neuroimaging (LONI). In addition, NIA collaborates with other funding agencies to promote and expand open-science practices across the full spectrum of basic, translational, and clinical research.
The key accomplishments summary is current as of March 2022.
- RFA-AG-18-013: Continuation of the AMP AD Target Discovery and Preclinical Validation Consortium
- RFA-AG-18-014: Limited Competition: Data Coordinating Center for the Accelerating Medicines Partnership Target Discovery and Preclinical Validation Consortium AMP AD (U24)
Research Programs and Resources
- Agora: AMP AD web-based interactive platform
- Alzheimer’s Disease Preclinical Efficacy Database (AlzPED)
- NIA-AA Symposium at AAIC: Enabling Precision Medicine for Alzheimer’s through Open Science
- Webinar: Increasing research rigor, reproducibility, and translatability