Data Sharing: Interoperability (Milestone 3.B)
Timeline Start - End2016 - 2024
Research Implementation AreaData Sharing and Reproducibility
Provide support to establish/improve the interoperability among relevant biomedical data repositories. Democratize the use of large scale molecular and clinical data by building computational infrastructure for sustainable data storage and processing that will be accessible to researchers world-wide.
Establish/improve the interoperability across disparate NIH-supported AD/ADRD data repositories by improving the data infrastructure and enabling data access through “passports” or similar authentication mechanisms.
Expand existing and build new computational infrastructure for sustainable data storage, data curation and data management to enable rapid and broad, high-fidelity data sharing accessible to researchers world-wide.
Democratize the use of large scale molecular and clinical data by supporting the development of:
Web-based tools and interfaces to allow data mining and analyses of summary results by data scientists, biologists, clinicians and citizen scientists.
Community-wide, open-source computational tools and pipelines for standardized data processing and analysis for diverse data types generated in AD/ADRD research, as well as their downstream integration into multi-scale models.
Summary of Key Accomplishments
The NIA-supported AD Knowledge Portal provides access to high quality multi-omic data from human and animal model biosamples. The Portal provides sustainable, cloud-based data storage and analytical workspace designed to make data discoverable, accessible, and usable by qualified researchers. These invaluable data resources are being used by researchers from more than 50 countries. A key component of the Portal data infrastructure is the web-based, open-source Agora platform, which provides an easy way for researchers without bioinformatics experience to mine the results from a variety of computational analyses. The Portal is interconnected with several NIA-supported data resources and repositories: Laboratory of Neuroimaging (LONI), the Rush AD Research Resource Sharing Hub, and AlzPED.
The key accomplishments summary is current as of July 2022.
- RFA-AG-18-014: Limited Competition: Data Coordinating Center for the Accelerating Medicines Partnership Target Discovery and Preclinical Validation Consortium AMP AD (U24)
- RFA-AG-20-043: SCAN: Standardized Centralized Alzheimer's and Related Dementias Neuroimaging (U24 Clinical Trials Not Allowed)
- PAR-20-110: National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (U24 Clinical Trial Not Allowed)
Research Programs and Resources
- NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS)
- NIAGADS Genomics Database
- AD Knowledge Portal
- Standardized Centralized Alzheimer's and Related Dementias Neuroimaging (SCAN)
- How Researchers Can Tap Into Data and Samples From Alzheimer’s Disease Research Centers
- Center for Alzheimer's and Related Dementias (CARD): Harmonized Data-Derived Resources for the Alzheimer's Disease and Related Dementias Community