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Research Resources Milestones

3.A-3.I, 4.A-4.AA, 14.A-14.P, 15.A

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ID

Title

Status

Provide resources to make datasets from existing and legacy clinical research studies on AD and related dementias widely accessible…

Status

In Progress

Provide support to establish/improve the interoperability among relevant biomedical data repositories.…

Status

In Progress

Increase transparency in reporting and reproducibility of research findings by incentivizing and enforcing rapid sharing…

Status

In Progress

Enable access to data and associated biosamples and biomarkers from completed, ongoing and future, federally and privately funded clinical trials...

Status

In Progress

Accelerate independent evaluation of research findings by mandating the open distribution of publicly and privately/philanthropically funded computational and experimental research tools...

Status

In Progress

Democratize the use of large scale molecular and clinical data by building computational infrastructure for sustainable data storage...

Status

Achieved

Develop data and resource infrastructures to support management and collaborative analysis of diverse resources from FTD basic science and clinical studies.

Status

Achieved

Improve rigor, reproducibility, and translatability of discovery research.

Status

In Progress

Best practices for ADRD research data sharing

Status

In Progress

Support the development of the next generation of animal models based on the current understanding of genetic and environmental risk and protective factors for AD and related dementias…

Status

Achieved

Create infrastructure/resources for extensive characterization of existing and new animal models…

Status

Achieved

Continue to develop animal models with higher predictive validity for use in preclinical drug development…

Status

In Progress

Expand biorepository infrastructure to enable storage and rapid distribution of clinical data and biosamples…

Status

In Progress

Support the development of standardized, cost-effective, high throughput methods…

Status

In Progress

Develop improved iPSC protocols for all relevant cell types and human-based organoid model systems...

Status

In Progress

Support quantitative systems pharmacology approaches that couple biological network and pathway analyses…

Status

In Progress

Institute an expedited review track for applications focused on drug discovery, preclinical, and clinical drug development...

Status

To Be Initiated

Create a National IRB.

Status

Achieved

Expand existing and create new integrative training programs for junior neuroscience, behavioral and social science researchers...

Status

In Progress

Leverage the power of human genetics to enable precision medicine research for AD...

Status

In Progress

Support standardized, single cell molecular profiling (genomic, proteomic, metabolomic)...

Status

In Progress

Support the development of genome-scale metabolic models to capture the heterogeneity of metabolic transitions...

Status

Achieved

Provide support for high-cost capital equipment/core facilities and staff training to make high-throughput technologies...

Status

To Be Initiated

De-risk novel candidate targets by supporting the development of high quality, open source, target enabling tools...

Status

Achieved

Create an international FTD clinical trial network.

Status

Achieved

Develop better FTLD in vivo and cell-based model systems.

Status

In Progress

Develop models that: reproduce small vessel disease; are relevant to VCID and AD; address white and grey matter VCID; or include genetic and acquired VCID. Verify models, including via imaging.

Status

In Progress

Improve and increase training, including for individuals who are members of under-represented populations, and of different career levels of scholars who conduct health disparities research in AD/ADRD.

Status

In Progress

Use data and other resources from large-scale clinical research and trials to test hypothesized mechanisms of human VCID in basic science models.

Status

In Progress

Incorporate VCID findings from basic science into the design of clinical research and trials targeting VCID-relevant cognitive impairment and dementia.

Status

In Progress

Build new animal models to advance knowledge about TDP-43 pathology in common dementias, capitalizing on lessons learned from animal models in FTLD/ALS, AD and other diseases.

Status

In Progress

Enable open drug development to generate innovative new medicines that are priced fairly for all.

Status

To Be Initiated

Create opportunities and avenues for closer interaction between researchers developing new INDs and researchers supported through NIA's enabling infrastructure programs involved in developing data resources, translational tools and new mechanistic insight

Status

In Progress

Evaluate and update current trial funding models to ensure the ability to test novel first-in-class therapeutics in the context of the full range of expenses and time frames required for robust evaluation and sharing.

Status

In Progress

Promote career development of biomedical, behavioral, and social scientists conducting AD/ADRD health equity research.  

Status

In Progress

Impact of COVID-19 on AD/ADRD: Building research infrastructure

Status

In Progress

Convene an advisory meeting focused on facilitating public-private partnerships aimed at accelerating the development and test of effective therapies for AD treatment and prevention...

Status

Achieved

Convene meetings of the working groups for (i) Rapid Data Sharing and Analysis, (ii) Enabling Bidirectional Translation in AD drug development, (iii) Eliminating IP barriers for Target Validation...

Status

Achieved

Develop partnerships to support novel/disruptive science that would incentivize students and early-career investigators to adopt a collaborative approach...

Status

In Progress

Develop partnerships that expand the precompetitive space through clinical proof of concept mechanism to accelerate translational learning...

Status

To Be Initiated

Develop a partnership among key stakeholders to implement the sharing of all data and biosamples from preclinical and clinical studies ...

Status

Achieved

Update consensus on AD/ADRD nomenclature necessary to identify target populations for intervention research...

Status

In Progress

Convene an advisory meeting of relevant stakeholders to develop a consensus regarding eliminating barriers to sharing, integrating, and reuse of data...

Status

In Progress

Alter institutional practices that impede team science and data sharing in academia

Status

In Progress

Develop and disseminate best practices for the collection, processing, and multi-omics molecular profiling of human and animal model biosamples.

Status

In Progress

Convene an advisory meeting of experts from the pharmaceutical industry, government, academia, the FDA, and the non-profit sector...

Status

In Progress

Establish effective communication between NIH and NGOs

Status

Achieved

Organize a working group of stakeholders, including health disparities communities, to develop more consistent nomenclature in dementia research and care.

Status

Achieved

Generate an AD/ADRD health disparities task force

Status

Achieved

Integrate and refine recommendations from working groups into standardized, acceptable and accurate nomenclature that works across the spectrum of stakeholders.

Status

In Progress

Collaboration to advance biomarkers and therapy development for AD/ADRD

Status

In Progress

Large international collaborations aimed at overcoming barriers to sharing of human data

Status

To Be Initiated

Develop a common Alzheimer’s disease research ontology...

Status

In Progress

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