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Milestone 1.B

Quantify the exposome in existing and new AD cohorts to gain a more precise measure of environmental exposure factors and their relationship to AD risk and individual trajectories of disease progression. These studies should employ a life-course approach across diverse populations (e.g., race, ethnicity, immigration status, geographical region, education, age, gender) and incorporate methods aimed at understanding how ancestry, race/ethnicity and socioeconomic disparities interact with exposome factors to modulate AD risk.


Success Criteria

  • Provide supplemental funding to at least 6 clinical research studies to explore the impact of environmental exposure on the pathogenesis of AD and AD-related dementias and on responsiveness to treatment.

  • Launch at least three clinical research studies that incorporate deep molecular phenotyping, new environmental and behavioral sensors and cognitive assessment technologies to detect the impact of the exposome on AD risk and resilience. 

  • Provide funding to enhance existing data resources with information on early life exposures/events.

  • Provide funding to enhance administrative data linkages.


Research Implementation Area
Population Studies and Precision Medicine
Timeline
2016–2024
Status
In Progress

Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations