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Milestone 6.B

Establish a consortium of genetics and genomics experts to develop and execute a large scale sequencing project to analyze the genomes of a large number of well characterized individuals including multi-ethnic subjects using next generation sequencing approaches; identify a broad range of AD and ADRD risk and protective gene variants in subjects with age-related dementias.  These efforts should incorporate diverse sample sets (including racial/ethnic groups, the oldest old, and other well characterized individuals from epidemiological/observational studies) and include replication studies and data harmonization.

Success Criteria

Identification of new risk and protective alleles for late onset AD and related dementias that lead to the identification of at least one novel therapeutic approach, drug target or pathway for prevention.

Time Required

2013 to 2020

Research Implementation Area

Drug Development - Novel Targets

CADRO Category

A. Molecular Pathogenesis and Physiology of Alzheimer's Disease

Activities, Funding Initiatives, and Resources

​NIH RFA-AG-16-002: Alzheimer's Disease Sequencing Project (ADSP) Replication P…
NIH RFA-AG-16-001: Coordinating ​Center for Genetics and Genomics of Alzheimer'…
NIH PAR-14-070: Alzheimer’s Disease Genetics Consortium

Funded Research Projects

IADRP – Category A. Molecular Pathogenesis and Physiology of Alzheimer's Diseas…
​NIH RFA-AG-16-002: Alzheimer's Disease Sequencing Project (ADSP) Replication P…
NIH RFA-AG-16-001: Coordinating ​Center for Genetics and Genomics of Alzheimer'…
NIH PAR-14-070: Alzheimer’s Disease Genetics Consortium – Research Projects