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Milestone 4.F

Develop improved iPSC protocols for all relevant cell types and human-based organoid model systems.

Support the development of co-culture systems utilizing 3D organoid-like spheres to recapitulate complex interactions in a dish and develop novel ex-vivo models of “cognition in a dish” and “ancestry in a dish” for precision medicine research.

Invest in the development of high-throughput systems of AD-relevant cells and organoids driven by robotics with digital read-outs (such as high content imaging) to leverage reinforcement learning techniques for more data-driven target discovery/screening.

Success Criteria

Establish infrastructure to develop standardized and deeply phenotyped in vitro model resources, including iPSC-based and primary cells, brain slice and organoid models.

Establish the translational validity of these in vitro models to recapitulate the molecular/network perturbations identified in the individual (human or animal) from which the in vitro model was generated.

Ensure rapid and broad distribution of the cell-based and organoid research models, data, and analytical methods for use in basic research and therapy development, similar to the open-science/open source principles of the MODEL-AD Consortium.

Time Required

2016 to 2022

Research Implementation Area

Translational Tools, Infrastructure and Capabilities

Activities, Funding Initiatives, and Resources

NIH RFA-AG-16-014: Alzheimer's Disease Translational Center for Disease Model R…
NIH RFA-AG14-017: Planning Grants for Alzheimer's Disease Centers for Predicti…
NIH RFA-AG-14-017: Planning Grants for Alzheimer's Disease Translational Center…