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Milestone 4.F

Create a network of translational centers that bring together expertise and technology needed for integration of multi-modal data analysis, mathematical modeling and empirical testing and apply a systems biology/systems pharmacology approach to the most challenging aspects in preclinical therapy development such as: (i) therapeutic target selection and initial target validation, (ii) predictive toxicology, (iii) rigorous preclinical efficacy testing and development of translatable, preclinical biomarkers. The centers will also provide training programs for the new generation of translational scientists. [2012 AD Summit: 2A and 2B]

Success Criteria

Creation of at least 3 Translational Centers that will apply the principles of quantitative and systems pharmacology to AD and ADRD drug development.

Time Required

2014 to 2018

Research Implementation Area

Translational Infrastructure and Capabilities

CADRO Category

F. Research Resources

Activities, Funding Initiatives, and Resources

NIH RFA-AG-16-014: Alzheimer's Disease Translational Center for Disease Model R…
NIH RFA-AG14-017: Planning Grants for Alzheimer's Disease Centers for Predicti…

Funded Research Projects

IADRP – Category F. Research Resources - 5. Infrastructure
​NIH RFA-AG-16-014: Alzheimer's Disease Translational Center for Disease Model …
NIH RFA-AG-14-017: Planning Grants for Alzheimer's Disease Centers for Predicti…