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Milestone 1.A

Enable precision medicine research by supporting deep and longitudinal, molecular endophenotyping of existing and new, at-risk cohorts as well cohorts and/or individuals who resist disease despite high genetic risk (e.g. Down Syndrome, ApoE 4 homozygous, FAD mutation carriers). Ensure that these efforts include and prioritize molecular profiling in cohorts from special populations and patients with atypical AD and ADRD (Down Syndrome, early- and late-onset familial AD, early-onset non-autosomal dominant AD), ethnic minorities and other under-represented groups.

Success Criteria

Initiate at least 6 research programs to support:

-longitudinal as well as postmortem collection and rapid distribution of biosamples from brain and peripheral tissues in existing and newly launched cohorts across diverse population groups.
-generation of high-quality, multi-omic data (genomic, epigenomic, proteomic, metabolomics, microbiome) as a public/community resource to maximize data accessibility and usability for downstream analyses.
-collection of non-traditional data modalities to complement the rich phenotypic clinical and molecular data, using wearable sensors and mobile health technologies
-high quality data curation, annotation and data storage/big-data infrastructure to ensure that the data are made broadly and rapidly available as a public resource according to FAIR data standards.

Time Required

2016 to 2023

Research Implementation Area

Population Studies and Precision Medicine Research

Activities, Funding Initiatives, and Resources

NIH PAR-16-047: National Institute on Aging Genetics of Alzheimer's Disease Dat…
NIH PAR-16-205: The National Institute on Aging (NIA) Late Onset of Alzheimer's…
​​NIH RFA-AG-16-001: NIA Coordinating Center for Genetics and Genomics of Alzhe…
NIH RFA-AG-16-002: Alzheimer's Disease Sequencing Project (ADSP) Replication Ph…
NIH PAR-16-406: Limited Competition: Additional Sequencing for the Alzheimer's…
NIH PAR-15-356: Major Opportunities for Research in Epidemiology of Alzheimer's…
NIH PAR-15-316: Limited Competition for the Renewal of the National Cell Reposi…
​NIH RFA-AG-14-012: Human Cell Reprogramming for Functional Genetics of Alzheim…
NIH All of Us Research Program
NIH PAR-17-214: Limited Competition: Analysis of Data from NIA's Alzheimer's Di…

Relevant Recommendation(s)

2015 AD Summit Recommendations: 1A, 2A, 2B, and 3A