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Milestone 1.A

Create research programs aimed at extensive molecular endophenotyping of existing, at-risk cohorts from longitudinal studies that are genetically, epigenetically, or otherwise at risk (e.g. due to cerebrovascular, metabolic, or neuroinflammatory compromise), as well cohorts and/or individuals who resist disease despite high genetic risk (e.g. Down Syndrome, ApoE 4 homozygous, FAD mutation carriers).

Success Criteria

Initiate at least 3 programs which include dense molecular phenotyping (genomic, epigenomic, proteomic, metabolomics, microbiome) and incorporate the collection of non-traditional data modalities using wearable sensors and mobile health technologies as dimensions of health and disease. These programs should include big-data infrastructure resources to ensure that the data are made available as a public resource and support for collection, storage and rapid distribution of biosamples including brain tissue.

Time Required

2016 to 2018

Research Implementation Area

Population Studies

CADRO Category

D. Epidemiology

Activities, Funding Initiatives, and Resources

NIH PAR-16-047: National Institute on Aging Genetics of Alzheimer's Disease Dat…
NIH PAR-16-205: The National Institute on Aging (NIA) Late Onset of Alzheimer's…
​​NIH RFA-AG-16-001: NIA Coordinating Center for Genetics and Genomics of Alzhe…
NIH RFA-AG-16-002: Alzheimer's Disease Sequencing Project (ADSP) Replication Ph…
NIH PAR-16-406: Limited Competition: Additional Sequencing for the Alzheimer's…
NIH PAR-15-356: Major Opportunities for Research in Epidemiology of Alzheimer's…
NIH PAR-15-316: Limited Competition for the Renewal of the National Cell Reposi…
​NIH RFA-AG-14-012: Human Cell Reprogramming for Functional Genetics of Alzheim…
NIH All of Us Research Program
NIH PAR-17-214: Limited Competition: Analysis of Data from NIA's Alzheimer's Di…

Funded Research Projects

IADRP – Category D. Epidemiology - 1. Genetic/Epigenetic Risk
​​NIH RFA-AG-16-001: NIA Coordinating Center for Genetics and Genomics of Alzhe…
NIH RFA-AG-16-002: Alzheimer's Disease Sequencing Project (ADSP) Replication Ph…
NIH PAR-15-356: Major Opportunities for Research in Epidemiology of Alzheimer's…
​​NIH PAR-15-316: Limited Competition for the Renewal of the National Cell Repo…
​NIH RFA-AG-14-012: Human Cell Reprogramming for Functional Genetics of Alzheim…