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Milestone 1.A

Enable precision medicine research by supporting deep and longitudinal, molecular endophenotyping of existing and new, at-risk cohorts as well cohorts and/or individuals who resist disease despite high genetic risk (e.g. Down Syndrome, ApoE 4 homozygous, FAD mutation carriers). Ensure that these efforts include and prioritize molecular profiling in cohorts from special populations and patients with atypical AD and ADRD (Down Syndrome, early- and late-onset familial AD, early-onset non-autosomal dominant AD), ethnic minorities and other under-represented groups.

Success Criteria

Initiate at least 6 research programs to support:

-longitudinal as well as postmortem collection and rapid distribution of biosamples from brain and peripheral tissues in existing and newly launched cohorts across diverse population groups.
-generation of high-quality, multi-omic data (genomic, epigenomic, proteomic, metabolomics, microbiome) as a public/community resource to maximize data accessibility and usability for downstream analyses.
-collection of non-traditional data modalities to complement the rich phenotypic clinical and molecular data, using wearable sensors and mobile health technologies
-high quality data curation, annotation and data storage/big-data infrastructure to ensure that the data are made broadly and rapidly available as a public resource according to FAIR data standards.

Time Required

2016 to 2023

Research Implementation Area

Population Studies and Precision Medicine Research

CADRO Category

D. Epidemiology

Activities, Funding Initiatives, and Resources

NIH PAR-16-047: National Institute on Aging Genetics of Alzheimer's Disease Dat…
NIH PAR-16-205: The National Institute on Aging (NIA) Late Onset of Alzheimer's…
​​NIH RFA-AG-16-001: NIA Coordinating Center for Genetics and Genomics of Alzhe…
NIH RFA-AG-16-002: Alzheimer's Disease Sequencing Project (ADSP) Replication Ph…
NIH PAR-16-406: Limited Competition: Additional Sequencing for the Alzheimer's…
NIH PAR-15-356: Major Opportunities for Research in Epidemiology of Alzheimer's…
NIH PAR-15-316: Limited Competition for the Renewal of the National Cell Reposi…
​NIH RFA-AG-14-012: Human Cell Reprogramming for Functional Genetics of Alzheim…
NIH All of Us Research Program
NIH PAR-17-214: Limited Competition: Analysis of Data from NIA's Alzheimer's Di…