TBI in AD/ADRD: Encourage research collaborations (Milestone 1.N)
In Progress
Timeline Start - End
2020 - 2026Research Implementation Area
Population Studies and Precision MedicineAD-Related Dementias Focus
Promote collaboration among TBI and dementia researchers through working groups, retrospective and prospective data and measurement harmonization, and interdisciplinary research.
Success Criteria
- Convene a meeting of TBI and AD/ADRD researchers including trainees and other interdisciplinary researchers with a focus on data harmonization and data sharing.
- Add TBI assessments to at least one AD/ADRD cohort study.
- Add AD/ADRD assessments to at least one TBI cohort study.
Summary of Key Accomplishments
NIH’s AD/ADRD program is exploring opportunities to develop cross-training and career enhancement programs such as K (PAR 19-238) awards. These opportunities have the potential to bring junior researchers with a diverse scientific background (e.g., TBI) into the field of AD/ADRD. In an effort to encourage interdisciplinary collaborations, NINDS also seeks opportunities to support existing TBI and AD/ADRD cohort studies such as NOT-NS-22-002.
The key accomplishments summary is current as of July 2022.
Accomplishments/Implementation Activities
Funding Initiatives
- RFA-NS-19-026: Clinical and Biological Measures of TBI-related dementia including Chronic Traumatic Encephalopathy (CTE) (R01)
- RFA-NS-19-030: Neuropathological Assessment of TBI-related Neurodegeneration and Neurocognitive Decline - Center Without Walls (NATBI CWOW) (U54)
- NOT-AG-20-043: Administrative Supplements for NIA-VA Mentored Physician-Scientist Award in Alzheimer’s Disease and its Related Dementias (AD/ADRD)
- NOT-NS-22-002: Adding TBI Assessments to AD/ADRD Cohorts
Research Programs and Resources
- NINDS Common Data Element Program
- Federal Interagency TBI Research (FITBIR) database
- Clinical and Biological Measures of TBI-related dementia including Chronic Traumatic Encephalopathy (CTE) (R01)
- Neuropathological Assessment of TBI-related Neurodegeneration and Neurocognitive Decline - Center Without Walls (NATBI CWOW) (U54)
- The Neuropathological Diagnosis of Chronic Traumatic Encephalopathy (CTE): Next Steps
- Select projects funded in FY21
- Select projects funded in FY22
Relevant Recommendations
- 2019 ADRD Summit: Emerging Scientific Topics, Focus Area 2: TBI and AD/ADRD Risk, Milestone 5
- 2022 ADRD Summit: Multiple Etiology Dementias (MED) Special Topic: Post-TBI AD/ADRD Milestone 1, Priority 1