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Milestone 1.O

AD Related Dementias – Specific

Establish infrastructure to study TBI as a risk factor for AD/ADRD.


Success Criteria

  • Support further development of national TBI research sharing infrastructure and best practices for clinical data (including cognitive outcomes), biospecimens (including autopsy), pathology, and imaging to promote broad cross-disciplinary discovery and validation of acute and chronic TBI-related risk stratification models of dementia. Ensure that data and samples represent the diversity of the population and the range and variability of TBI causing events and history.
  • Develop and/or identify collections of tissue and biofluid samples from existing or newly developed longitudinal case-control or cohort studies in which samples are collected using standardized protocols and in which the samples are linked to clinical data that include TBI and AD/ADRD cases.

Summary of Key Accomplishments

There is considerable research and public interest in the consequences of traumatic brain injury (TBI), particularly in relation to the risk of AD/ADRD in individuals with Chronic Traumatic Encephalopathy (CTE). Ongoing NIH studies funded under two recent FOAs (RFA-NS-19-030 an RFA-NS-19-026) are characterizing the post-mortem brain changes that are associated with neurodegeneration and cognitive decline in persons with a history of TBI. These studies support national TBI research sharing by requiring that researchers submit high-quality clinical data to the Federal Interagency of Traumatic Brain Injury Research (FITBIR) database, share biospecimens through the NINDS-sponsored BioSEND repository, and develop a digital resource for distributing brain tissue. Awardees funded under an FY22 FOA (PAR 22-024) will also investigate biological and clinical measures of TBI-related progressive neurodegeneration and cognitive decline while ensuring that individuals are recruited from diverse backgrounds.

This information is current as of July 2022.


Research Implementation Area
AD Related Dementias - Specific
Timeline
2020–2025
Status
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations

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An official website of the National Institutes of Health