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LBD: Characterize LBD brain pathology (Milestone 1.K)

In Progress

Timeline Start - End

2016 - 2027

Research Implementation Area

Population Studies and Precision Medicine

AD-Related Dementias Focus

Enhance and standardize the techniques for neuropathologic characterization of LBD and the use of LBD pathology cohorts including more diverse cohorts.  

Success Criteria

  • Optimize, standardize, and disseminate best practices for clinical data collection, donation, sampling, preparation, storage and distribution of post-mortem LBD tissue, including specific emphasis and guidance for best practices relevant to diverse populations.

  • At least one project or effort to increase donation and post-mortem clinical data on subjects who are at-risk for LBD and who are from diverse populations.

Summary of Key Accomplishments

NINDS and NIA continue to support the NIH NeuroBioBank and the Alzheimer's Disease Centers, which make brain tissue from hundreds of individuals with a pathological diagnosis of LBD available for sharing with researchers. Much of this brain tissue is associated with extensive clinical and neuroimaging information obtained when the individual was alive. NIH intramural staff initiated a collaboration with 17 European and 27 North American sites/consortia to collect brain tissue for genetic sequencing from 1789 individuals with LBD, resulting in the identification of important risk factors. An international effort to propose criteria and best practices for the evaluation of LBD pathology that included NIA/NINDS-funded researchers was published in 2021.

The key accomplishments summary is current as of July 2022.  

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