FTD Studies: Understand the natural history of FTD (Milestone 1.M)
AD-Related Dementias Focus
Understand phenotypic heterogeneity and natural history including in populations that experience health disparities.
- At least one natural history study of pre-clinical, inherited FTD.
- At least one natural history sporadic FTLD.
Summary of Key Accomplishments
The ALLFTD study is a comprehensive natural history study covering inherited forms of FTD, where individuals have been followed from health to disease. Important findings from this study have shown that the type of causative mutation has a major impact on disease progression and biomarkers of disease progression.
The key accomplishments summary is current as of July 2022.
- Research Implementation Area
- Population Studies and Precision Medicine
- NOT-NS-18-082: Notice of the NINDS' Participation in PAR-18-296 and interest in Clinical Trial readiness applications for Frontotemporal Degeneration (FTD) by the National Institute on Aging and the National Institute of Neurological Disorders and Stroke
Research Programs and Resources
- Advancing Research & Treatment for Frontotemporal Lobar Degeneration – Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (ARTFL-LEFFTDS)
- National Centralized Repository for Alzheimer’s Disease and Related Dementias
- NINDS Human Cell and Data Repository (NHCDR)