Epidemiology / Population Studies Milestones
1.A-1.U
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ID
Title
Status
1.A
Population Studies: Endophenotyping at-risk and resistant cohorts
Enable precision medicine research by supporting deep and longitudinal, molecular endophenotyping of existing and new, at-risk cohorts as well cohorts and/or individuals…
Status
In Progress
1.B
Population Studies: Quantify the exposome
Quantify the exposome in existing and new AD cohorts to gain a more precise measure of environmental exposure factors…
Status
In Progress
1.C
Population Studies: Diverse cohorts
Continue to establish new cohorts that include participants across diverse racial, ethnic and socioeconomic backgrounds…
Status
In Progress
1.D
Population Studies: State-of-the-art protocol
Develop state-of-the-art protocol for assessing dementia on large nationally representative samples…
Status
Achieved
1.E
Population Studies: Expand profiling efforts
Expand existing large scale, open-science molecular profiling efforts
Status
Achieved
1.F
Population Studies: Inclusion of non-AD cohorts
Support the inclusion of measures of AD-related phenotypes and environmental exposures in non-AD cohorts...
Status
In Progress
1.G
Population Studies: Longitudinal immunological profiling
Augment current and future human cohorts with more advanced, longitudinal immunological profiling (e.g. Cytof) to enable precision medicine research...
Status
Achieved
1.H
Population Studies: EHR access and integration
Enable access to electronic health records data and provide support for their integration with clinical and molecular data...
Status
In Progress
1.I
Health Equity: Identify risk factors across diverse populations
Assess epidemiology and mechanistic pathways of disparities in health burden of AD/ADRD.
Status
In Progress
1.J
Health Equity: Monitor trends of different ADRDs in diverse populations
Develop a system to monitor the magnitude and trends in health disparities in incidence of AD/ADRD.
Status
In Progress
1.K
LBD: Characterize LBD brain pathology
Characterize nervous system changes in LBD cohorts that have come to autopsy to identify disease-specific underlying mechanisms to guide biomarker and therapeutic approaches.
Status
In Progress
1.L
LBD: Understand LBD genetic, epigenetic, and environmental influences
Identify novel common and rare genetic variants, epigenetic changes, and environmental influences that impact the risk for and clinical features of LBD.
Status
In Progress
1.M
FTD Studies: Understand the natural history of FTD
Understand phenotypic heterogeneity and natural history in FTD.
Status
Achieved
1.N
TBI in AD/ADRD: Encourage research collaborations
Encourage crosstalk and interdisciplinary collaboration between TBI and dementia researchers.
Status
In Progress
1.O
TBI in AD/ADRD: Develop infrastructure for risk factor identification
Establish infrastructure to study TBI as a risk factor for AD/ADRD.
Status
In Progress
1.P
Population Studies: Exposome studies and health disparities
Expand current efforts to address health disparities research questions relevant to AD/ADRD by leveraging new and existing exposome AD/ADRD studies, including the impact of institutional and policy-level drivers of health inequities in AD/ADRD risk
Status
In Progress
1.Q
Population Studies: Artificial intelligence
Support research that uses Artificial Intelligence (AI) and deep learning approaches for discovery and translational research.
Status
In Progress
1.R
Population Studies: Pollution and climate change
Support the research on the role of pollution and climate change on dementia risk.
Status
In Progress
1.S
Health Equity: Understand and reduce barriers to health equity
Assess the social, economic and structural impediments to equity in AD/ADRD assessment, diagnosis, and referrals, and impacts on health and economic outcomes.
Status
To Be Initiated
1.T
FTD: Studying FTD causes and risk factors in people
Understand FTD epidemiology and genetics in diverse populations, including how socioeconomic and ethnocultural status affects disease risk and manifestations.
Status
In Progress
1.U
MED COVID-19: Understanding barriers to health equity
Impact of COVID-19 on AD/ADRD: Understanding barriers to health equity
Status
In Progress