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Milestone 4.V

ADRD Specific Milestone

Build new animal models to advance knowledge about TDP-43 pathology in common dementias, capitalizing on lessons learned from animal models in FTLD/ALS, AD and other diseases.


Success Criteria

  • Develop, validate and make available to the broader scientific community two or more novel animal models that exhibit TDP-43 pathology aligned with the affected anatomical sites and functional changes that occur in common dementias such as the clinical syndrome of Alzheimer’s disease.


Research Implementation Area
Translational Tools, Infrastructure and Capabilities
Timeline
2020–2027
Status
In Progress

Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations