ADRD Specific Milestone
Develop next‐generation experimental models and translational imaging methods for VCID.
- Establish new small vessel VCID animal models suited for VCID and mixed dementias of aging research that: (i) reproduce small vessel disease and other key pathogenic processes thought to result in human cognitive impairment, (ii) are easily applicable to research on both VCID and AD dementia, (iii) address vascular contributions to damage of both white matter and gray matter; and (iv) include genetic and acquired conditions that cause and or are associated with VCID.
- Support development of in vitro, including cell-based, models to study specific molecular mechanisms of VCID that are not feasible in animal models.
- Support the development of new imaging and other tools that can be used to better understand VCID etiology at the behavioral (e.g. memory-based tasks), systems (e.g. hypoperfusion, chronic blood brain barrier breakdown), network (e.g. white matter lesions and network connectivity), pathology, cellular (e.g. variations and vulnerability in the vascular tree, neurovascular unit damage), synaptic (e.g. electrical activity), and molecular (e.g. chronic inflammation) levels.
- Research Implementation Area
- Translational Tools, Infrastructure and Capabilities
- In Progress
- RFA-NS-19-027: Human Three-Dimensional Cell Model Systems for Alzheimer's Disease-Related Dementias (ADRDs) (UG3/UH3)
- PAR-19-167: Development and Validation of Advanced Mammalian Models for Alzheimer's Disease-Related Dementias (ADRD) (R61/R33)
Research Programs and Resources
- Human Three-Dimensional Cell Model Systems for Alzheimer's Disease-Related Dementias (ADRDs) (UG3/UH3)
- Development and Validation of Advanced Mammalian Models for Alzheimer's Disease-Related Dementias (ADRD) (R61/R33)