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Milestone 4.Q

ADRD Specific Milestone

Develop better FTLD in vivo and cell-based model systems.


Success Criteria

  • Generate validated and standardized in vivo animal and cell-based models of TDP-43, FUS, GRN haploinsufficiency, and C9orf72 expansion disease, which recapitulate key biochemical, anatomical, neuropathological and functional aspects of FTD.
  • Develop and validate in vivo functional assays and neuropathological endpoints for mammalian models that are aligned with the anatomical sites affected in FTD.


Research Implementation Area
AD Related Dementias - Specific
Timeline
2016–2019
Status
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

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