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Milestone 4.Q

ADRD Specific Milestone

Develop better FTLD in vivo and cell-based model systems.

Success Criteria

  • Generate validated and standardized in vivo animal and cell-based models of TDP-43, FUS, GRN haploinsufficiency, and C9orf72 expansion disease, which recapitulate key biochemical, anatomical, neuropathological and functional aspects of FTD.
  • Develop and validate in vivo functional assays and neuropathological endpoints for mammalian models that are aligned with the anatomical sites affected in FTD.

Research Implementation Area
Translational Tools, Infrastructure and Capabilities
In Progress

Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations