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Milestone 4.M

Support the development of genome-scale metabolic models to capture the heterogeneity of metabolic transitions from healthy to pathologic brain aging and use the metabolome as a functional readout for other omics data to delineate pathways implicated in disease initiation and progression and to identify disease subtypes.


Success Criteria

Provide support for:

  • generation of high-quality, targeted and non-targeted metabolomic profiling data across diverse, human cohorts (spanning midlife through extreme old age) for which genetic and rich clinical data are available. 
  • development of analytical methods needed to integrate metabolomic data with genetic, molecular imaging and other clinical data
  • development of open-source, genome-scale,  metabolic models for use in target validation and disease sub-classification.


Research Implementation Area
Translational Tools, Infrastructure and Capabilities
Timeline
2018–2022
Status
In Progress

Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations