Develop improved iPSC protocols for all relevant cell types and human-based organoid model systems.
Support the development of co-culture systems utilizing 3D organoid-like spheres to recapitulate complex interactions in a dish and develop novel ex-vivo models of “cognition in a dish” and “ancestry in a dish” for precision medicine research.
Invest in the development of high-throughput systems of AD-relevant cells and organoids driven by robotics with digital read-outs (such as high content imaging) to leverage reinforcement learning techniques for more data-driven target discovery/screening.
Establish infrastructure to develop standardized and deeply phenotyped in vitro model resources, including iPSC-based and primary cells, brain slice and organoid models.
Establish the translational validity of these in vitro models to recapitulate the molecular/network perturbations identified in the individual (human or animal) from which the in vitro model was generated.
Ensure rapid and broad distribution of the cell-based and organoid research models, data, and analytical methods for use in basic research and therapy development, similar to the open-science/open source principles of the MODEL-AD Consortium.
- Research Implementation Area
- Translational Tools, Infrastructure and Capabilities
- In Progress
- RFA-AG-14-012: Human Cell Reprogramming for Functional Genetics of Alzheimer’s Disease (R01)
- RFA-AG-17-009: Impact of Aging in Human Cell Models of Alzheimer’s Disease (R01)
- PAR-18-516: Human Cell Biology of Alzheimer's Disease Genetic Variants (R01)
- RFA-AG-19-010: Alzheimer Centers for Discovery of New Medicines (U54)
Research Programs and Resources
- UC Irvine ADRC iPSC Core
- iPSCs and Fibroblast lines at NCRAD
- UCSD ADRC iPSC Core
- Examples of Funded Projects in FY19