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Milestone 4.E

Support the development of standardized, cost-effective, high throughput methods to isolate neural and glial cells for “omics” profiling and drug-screening.

Success Criteria

Create a repository of fully characterized, quality controlled, and fully sequenced reference iPSC lines accessible to the wide research community that can serve as:

  • A standard control for healthy genotypes and for generating edited-isogenic lines carrying specific AD risk variants.

  • A source of cell lines from individuals from diverse cohorts with AD-related phenotypes and specific naturally occurring mutations/risk alleles.

  • A resource to test and provide reference data on protocols to generate all CNS cell types.

Research Implementation Area
Translational Tools, Infrastructure and Capabilities
In Progress

Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations