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Milestone 4.E

Support the development of standardized, cost-effective, high throughput methods to isolate neural and glial cells for “omics” profiling and drug-screening.


Success Criteria

Create a repository of fully characterized, quality controlled, and fully sequenced reference iPSC lines accessible to the wide research community that can serve as:

  • A standard control for healthy genotypes and for generating edited-isogenic lines carrying specific AD risk variants.

  • A source of cell lines from individuals from diverse cohorts with AD-related phenotypes and specific naturally occurring mutations/risk alleles.

  • A resource to test and provide reference data on protocols to generate all CNS cell types.


Research Implementation Area
Translational Tools, Infrastructure and Capabilities
Timeline
2016–2023
Status
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations