Continue to develop animal models with higher predictive validity for use in preclinical drug development and to accelerate the discovery of translationally relevant disease mechanisms and treatment strategies.
Expand the existing open-source/open-science translational infrastructure for next generation AD animal models by developing:
New transgenic mouse models with humanized immune systems expressing AD risk related human genes for use in preclinical drug development and to gain a better understanding of the role of the immune system in risk and progression of AD/ADRD.
Non-murine models including non-human primates, for use in comparative aging biology and integrative physiology studies of AD pathophysiology.
Animal models for the neuropsychiatric symptoms of AD.
- Research Implementation Area
- Translational Tools, Infrastructure and Capabilities
- In Progress
- PAR-18-596: Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01)
- NOT-AG-18-001 (#9): Neuropsychiatric Symptoms in Alzheimer's Disease (NPS-AD)
- RFA-MH-19-510: Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R01)
- RFA MH-19-511: Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R21)
- RFA- AG-21-003: New Unconventional Animal Models of Alzheimer’s Disease (R24)
Research Programs and Resources
- MODEL-AD Resources
- Tau-associated Pathological Changes in Reward Networks For the Prediction of Neuropsychiatric Symptoms in Alzheimer’s Disease