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Milestone 4.C

Continue to develop animal models with higher predictive validity for use in preclinical drug development and to accelerate the discovery of translationally relevant disease mechanisms and treatment strategies.


Success Criteria

Expand the existing open-source/open-science translational infrastructure for next generation AD animal models by developing:

  • New transgenic mouse models with humanized immune systems expressing AD risk related human genes for use in preclinical drug development and to gain a better understanding of the role of the immune system in risk and progression of AD/ADRD.

  • Non-murine models including non-human primates, for use in comparative aging biology and integrative physiology studies of AD pathophysiology.

  • Animal models for the neuropsychiatric symptoms of AD.


Research Implementation Area
Translational Tools, Infrastructure and Capabilities
Timeline
2018–2023
Status
In Progress

Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations