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Milestone 4.B

Create infrastructure/resources for extensive characterization of existing and new animal models and development of standardized and rigorous methods for preclinical efficacy testing including web-based resources for transparent reporting of both positive and negative findings.

Success Criteria

  • Create at least one translational center for animal model resources.
  • Support the generation of large longitudinal, multi-omic data on existing and newly developed transgenic mouse models necessary to build “molecular network maps” that connect molecular attributes of AD across mouse models and humans.
  • Enable comprehensive analyses of ‘clinical’ and deep omics profiles in panels of genetically diverse mice, to better model human genomes.
  • Create a publicly available database that houses experimental designs and analysis relating to the preclinical testing of candidate therapeutics in AD animal models. The data base should function as a knowledge platform for data sharing, mining and analysis and should help identify critical experimental design elements and methodology that impact the rigor and reproducibility of published studies.

Research Implementation Area
Translational Tools, Infrastructure and Capabilities

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations