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Milestone 4.A

Support the development of the next generation of animal models based on the current understanding of genetic and environmental risk and protective factors for AD and related dementias, using genome editing and other cutting edge technologies (optogenetics/deep brain stimulation/trans-magnetic stimulation, and next generation in vivo imaging) to facilitate assessment and validation of findings from human studies.


Success Criteria

  • Develop and characterize by deep molecular, behavioral, electrophysiologic and neuropathologic phenotyping at least 12 next generation animal models of sporadic AD/ADRD and make these available to all qualified researchers without IP restrictions for use in basic research and in preclinical drug development.


Research Implementation Area
Translational Tools, Infrastructure and Capabilities
Timeline
2016–2022
Status
In Progress

Implementation Activities

Funding Initiatives

Research Programs and Resources

Research Highlights

Relevant Recommendations