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VCID Clinical Research: Determine interrelationship between VCID and AD biomarkers in humans (Milestone 2.S)

In Progress

Timeline Start - End

2016 - 2029

Research Implementation Area

Research on Disease Mechanisms

AD-Related Dementias Focus

Understand the impact on VCID of other known dementia risk factors (e.g., aging, genetics) and co-morbid neurodegeneration along the life-course in diverse populations to establish VCID interactions with other dementia disease processes. 

Success Criteria

  • One or more studies to understand independent associations between biomarkers of VCID and biomarkers of other dementia-associated brain pathologies and comorbidities in a human cohort sufficiently powered to answer key questions in at least two populations that experience health disparities. 

Summary of Key Accomplishments

Over the past decade, new research has significantly changed our concept of dementia. Once thought to be a catch-all term describing a person’s loss of the ability to think, remember or reason, dementia is becoming better understood to include many, complex dementia disorders, including Alzheimer’s disease and several different ADRDs. Moreover, researchers are finding that most people diagnosed with dementia have multiple AD and ADRD-related disease markers, or “mixed pathologies.”

NIH-funded scientists recently discovered and coined a term for a new dementia-related pathology, which they call “LATE,” or limbic-predominant age-related TDP-43 encephalopathy. LATE is frequently found in individuals diagnosed with different forms of dementia, including Alzheimer’s-type dementia, vascular-related dementia, and mixed pathology dementia. This new understanding that multiple disease processes often underly dementia suggests the need to intervene in multiple dementia-related pathways in the same individual and provides new prevention and treatment targets for future research.

The key accomplishments summary is current as of July 2022.  

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