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Milestone 2.W

AD Related Dementias – Specific

Promote basic and clinical research examining the development and progression of TBI AD/ADRD neuropathologies and associated clinical symptoms.

Success Criteria

  • Develop one or more new TBI-related dementia animal models (informed by neuropathologic and epidemiological studies of chronic TBI) and new translatable functional outcome measures that model both the static and progressive decline of cognitive, motor, and neurovascular function in humans.
  • Support basic research to identify mechanisms (e.g., immune response, neurovascular changes, blood-brain barrier breakdown) that initiate and maintain progressive neuropathological processes after TBI in human and animal models.
  • Support studies to identify potential neuropathological substrates of dementia in TBI. Characterize the relative burden of individual pathologies in relation to injury severity and mechanism and to identify similarities, differences, and common mechanisms of pathological protein isoforms with AD/ADRD.

Summary of Key Accomplishments

Epidemiological data suggest that a history of TBI is a significant risk factor for AD/ADRD and that the relative risk may be mediated by injury severity and frequency with increased severity and multiple insults resulting in higher risk. Ongoing NIH-funded studies are currently characterizing the neuropathological features of chronic TBI associated with neurodegeneration and neurocognitive decline. For example, a recent study demonstrated that long term TBI-related brain changes appeared to be subtle and involved non-traditional pathways of neurotoxicity and neurodegeneration.

Another NIH-funded study revealed that brain tissue from individuals who had suffered repetitive head injuries exhibited brain pathologies similar to those seen in AD/ADRD brains, including markers of immune reaction and tau pathology. Collectively, these findings inform future research on TBI-related dementia including CTE.

This information is current as of July 2022.

Research Implementation Area
AD Related Dementias - Specific
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

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