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Milestone 2.V

AD Related Dementias – Specific

Examine the pathologic phenotype(s) of TDP-43 pathology in asymptomatic persons and those with common dementias.


Success Criteria

  • Complete and report the results of one or more rigorously conducted studies that characterize TDP-43 dependent pathologic phenotypes in elderly individuals both with and without a clinical diagnosis of a common dementia to better understand the significance of TDP-43 pathology.

Summary of Key Accomplishments

TDP-43 is a protein normally found throughout the brain and is one of the proteins that tends to be found abnormally clumped inside the cells of individuals with dementia. This relationship between TDP-43 aggregation and dementia symptoms is not well understood. One way that NIH-funded researchers are hoping to understand this better is by asking when, how, how often, and where abnormalities in TDP-43 occur in normal aging as well as in dementia. By analyzing donated post-mortem brain tissue, researchers are studying and beginning to understand the relationship between TDP-43 and a dementia diagnosis. NIH is also currently funding the NeuroBioBank to increase the availability of donated human post-mortem brain tissue for research. Results from these studies will be informative for the development of future therapies and clinical trials.

This information is current as of July 2022.


Research Implementation Area
AD Related Dementias - Specific
Timeline
2020–2027
Status
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations

nia.nih.gov

An official website of the National Institutes of Health