AD Related Dementias – Specific
Encourage basic science research to determine the impact of cardiovascular/cerebrovascular risk factors and genes on dementia-related brain changes, neurodegeneration and myelin biology.
Support new basic research that provides rigorous and novel insight into how cerebrovascular disease (small vessel) or cardiovascular and cerebrovascular risk factors (e.g. hypertension, diabetes mellitus/metabolic syndrome, dyslipidemia, genetic risk factors) impact the onset and progression of AD/ADRD‐related disease processes including in different brain vascular zones (arterioles, capillaries, venules), neurodegeneration, myelin and neural circuits in gray matter and white matter.
Summary of Key Accomplishments
New research indicates the importance of maintaining the best heart health possible for good cognitive health during aging. The results, from a clinical research study in an aging community-based population in the U.S., show that even small decreases in the amount of blood that the heart pumps may be tied to poorer cognitive outcomes during aging including for language, information processing speed, visuospatial skills, and episodic memory. While significant heart disease was already a known risk for brain heath, the discovery that even small changes in heart health may be a risk for cognitive decline during aging is new. Efforts to better understand genetic risks and, importantly for everyday life, to strive for optimal heart health, are further motivated by these findings.
This information is current as of July 2022.
- Research Implementation Area
- AD Related Dementias - Specific
- In Progress
- RFA-NS-19-039: Mechanistic Basis of Diffuse White Matter Disease in Vascular Contributions to Cognitive Impairment and Dementia (VCID)(R01)
- RFA-NS-19-012: Post-Stroke Vascular Contributions to Cognitive Impairment and Dementia (VCID) in the United States Including in Health Disparities Populations
- RFA-NS-20-013: White Matter Disease Etiology of Dementia in the U.S. Including in Health Disparities Populations
Research Programs and Resources
- Diverse VCID: White Matter Lesion Etiology of Dementia in Diverse Populations
- Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on Recovery (DISCOVERY)