FTD Basic Mechanisms: Understand role of genetic mutations (Milestone 2.O)
AD Related Dementias Focus
Please note: This milestone was incorporated into Milestone 2-N in 2019.
Determine the molecular basis for C9ORF72 expansion-and GRN mutation-related neurodegeneration.
Identification of predominant mechanism(s) of C9ORF72 and GRN mutation-related FTD/ALS pathogenesis, with convergent findings in human tissues and model systems.
Prioritization of targets to move forward into therapy development after testing therapeutic hypotheses in model systems.
- Research Implementation Area
- Research on Disease Mechanisms
- In Progress
- RFA-NS-18-015: Structural Biology of Alzheimer's Disease Related Dementias (ADRDs) Proteinopathies (U01)