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Disease Mechanisms: The microbiome (Milestone 2.I)

Enable a system biology approach to decipher the complex role of the microbiome in brain aging and AD/ADRD and as a modifier of responsiveness to treatment (pharmacologic and non-pharmacologic). Robust and rigorous study of the microbiome will require that relevant biosamples, high quality molecular data, and analytical tools are made available as a community resource.

Success Criteria

  • Support microbiome molecular profiling (metagenome, meta-transcriptome, metaproteome and metabolome) across diverse cohorts and in clinical trials to enable systems-based, data-driven approaches aimed at understanding the role of the microbiome in disease heterogeneity, gene-environment interactions, health disparities, and differential responsiveness to treatment.  Ensure that these efforts mandate rapid and broad sharing of data, analytical tools and biosamples and that they leverage the resources and knowledge generated by the NIH Common Fund Human Microbiome Program.

Summary of Key Accomplishments

NIA supports research to examine the role of the microbiome in brain aging and AD/ADRD and as a modifier of responsiveness to treatment, as well as a potential therapeutic target. The NIA-funded Alzheimer’s Gut Microbiome Project (AGMP), led by an international, cross-disciplinary team of investigators, brings together researchers from the Human Microbiome Project and the larger AD/ADRD field experience in metabolomics, systems biology, basic, translational, and clinical research, including investigators from over ten AD Research Centers. Over the course of five years, the AGMP will deliver a wealth of datasets from human cohorts and animal models and rich analytical tools to share with the greater research community.

This information is current as of July 2022.

Research Implementation Area
Research on Disease Mechanisms
In Progress

Accomplishments/Implementation Activities

Funding Initiatives

Research Programs and Resources

Relevant Recommendations

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