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Milestone 2.H

Continue to support cross-disciplinary research to discover and understand disease mechanisms that are common between AD and other neurodegenerative disorders including rare disorders and leverage these for therapy development. These efforts should include discovering new pathways leading to synaptic and neural damage understanding the structural variations of pathogenic peptides collected from well-phenotyped, diverse cohorts to inform the design of structure-specific imaging agents and inhibitors with therapeutic potential.

Success Criteria

  • Identify and preclinically validate at least three novel therapeutic targets that are common to AD and at least two other neurodegenerative disorders. 
  • Launch a minimum of three drug discovery projects targeting pathways common across AD at least two other neurodegenerative disorders.

Research Implementation Area
Research on Disease Mechanisms
In Progress

Accomplishments/Implementation Activities

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Research Programs and Resources

Research Highlights

Relevant Recommendations